dbPTM

RL18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL18_HUMAN
UniProt AC	Q07020
Protein Name	60S ribosomal protein L18
Gene Name	RPL18
Organism	Homo sapiens (Human).
Sequence Length	188
Subcellular Localization	Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein Description	Component of the large ribosomal subunit..
Protein Sequence	MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPPLSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKILTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRASRGYKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MGVDIRHNKDRKV --CCCCCCCCCCCCC	23.90	115491775
19	Acetylation	KVRRKEPKSQDIYLR CCCCCCCCCHHHHHH	62.94	27452117
19	Ubiquitination	KVRRKEPKSQDIYLR CCCCCCCCCHHHHHH	62.94	-
20	Ubiquitination	VRRKEPKSQDIYLRL CCCCCCCCHHHHHHH	43.74	-
26	Methylation	KSQDIYLRLLVKLYR CCHHHHHHHHHHHHH	14.70	115491785
30	Acetylation	IYLRLLVKLYRFLAR HHHHHHHHHHHHHHH	39.51	25825284
30	2-Hydroxyisobutyrylation	IYLRLLVKLYRFLAR HHHHHHHHHHHHHHH	39.51	-
30	Ubiquitination	IYLRLLVKLYRFLAR HHHHHHHHHHHHHHH	39.51	21906983
39	Phosphorylation	YRFLARRTNSTFNQV HHHHHHHCCCCHHHH	28.15	28450419
41	Phosphorylation	FLARRTNSTFNQVVL HHHHHCCCCHHHHHH	33.49	28450419
42	Phosphorylation	LARRTNSTFNQVVLK HHHHCCCCHHHHHHH	28.77	28450419
49	Acetylation	TFNQVVLKRLFMSRT CHHHHHHHHHHHCCC	35.13	26051181
49	Ubiquitination	TFNQVVLKRLFMSRT CHHHHHHHHHHHCCC	35.13	21890473
62	Phosphorylation	RTNRPPLSLSRMIRK CCCCCCCCHHHHHHH	30.03	28450419
64	Phosphorylation	NRPPLSLSRMIRKMK CCCCCCHHHHHHHCC	19.20	28450419
65	Methylation	RPPLSLSRMIRKMKL CCCCCHHHHHHHCCC	29.82	115491805
78	Ubiquitination	KLPGRENKTAVVVGT CCCCCCCCEEEEEEE	32.86	21906983
79	Phosphorylation	LPGRENKTAVVVGTI CCCCCCCEEEEEEEE	35.94	23911959
85	Phosphorylation	KTAVVVGTITDDVRV CEEEEEEEECCCCCH	14.75	-
87	Phosphorylation	AVVVGTITDDVRVQE EEEEEEECCCCCHHC	26.45	22210691
91	Methylation	GTITDDVRVQEVPKL EEECCCCCHHCCCCC	31.25	115491795
97	Ubiquitination	VRVQEVPKLKVCALR CCHHCCCCCEEEEEH	67.14	21906983
97	Acetylation	VRVQEVPKLKVCALR CCHHCCCCCEEEEEH	67.14	25953088
97	2-Hydroxyisobutyrylation	VRVQEVPKLKVCALR CCHHCCCCCEEEEEH	67.14	-
99	Ubiquitination	VQEVPKLKVCALRVT HHCCCCCEEEEEHHH	41.20	21906983
99	Acetylation	VQEVPKLKVCALRVT HHCCCCCEEEEEHHH	41.20	27452117
106	Phosphorylation	KVCALRVTSRARSRI EEEEEHHHHHHHHHH	13.18	20363803
111	Phosphorylation	RVTSRARSRILRAGG HHHHHHHHHHHHCCC	23.76	20363803
119	2-Hydroxyisobutyrylation	RILRAGGKILTFDQL HHHHCCCEEEEEEEE	33.36	-
119	Sumoylation	RILRAGGKILTFDQL HHHHCCCEEEEEEEE	33.36	28112733
119	Ubiquitination	RILRAGGKILTFDQL HHHHCCCEEEEEEEE	33.36	21906983
119	Acetylation	RILRAGGKILTFDQL HHHHCCCEEEEEEEE	33.36	23236377
122	Phosphorylation	RAGGKILTFDQLALD HCCCEEEEEEEECCC	28.74	23403867
125	Acetylation	GKILTFDQLALDSPK CEEEEEEEECCCCCC	25.17	19608861
130	Phosphorylation	FDQLALDSPKGCGTV EEEECCCCCCCCCEE	29.39	19664994
132	Ubiquitination	QLALDSPKGCGTVLL EECCCCCCCCCEEEE	71.44	-
132	Acetylation	QLALDSPKGCGTVLL EECCCCCCCCCEEEE	71.44	26051181
134	S-palmitoylation	ALDSPKGCGTVLLSG CCCCCCCCCEEEECC	5.29	29575903
134	Glutathionylation	ALDSPKGCGTVLLSG CCCCCCCCCEEEECC	5.29	22555962
136	Phosphorylation	DSPKGCGTVLLSGPR CCCCCCCEEEECCCC	16.44	24732914
140	Phosphorylation	GCGTVLLSGPRKGRE CCCEEEECCCCCCHH	42.46	25159151
150	Methylation	RKGREVYRHFGKAPG CCCHHHHHHCCCCCC	24.67	115491765
154	Acetylation	EVYRHFGKAPGTPHS HHHHHCCCCCCCCCC	50.92	19608861
154	Ubiquitination	EVYRHFGKAPGTPHS HHHHHCCCCCCCCCC	50.92	19608861
158	Phosphorylation	HFGKAPGTPHSHTKP HCCCCCCCCCCCCCH	19.44	23927012
161	Phosphorylation	KAPGTPHSHTKPYVR CCCCCCCCCCCHHCC	33.77	23927012
163	Phosphorylation	PGTPHSHTKPYVRSK CCCCCCCCCHHCCCC	36.41	29496963
164	Sumoylation	GTPHSHTKPYVRSKG CCCCCCCCHHCCCCC	29.00	28112733
164	Acetylation	GTPHSHTKPYVRSKG CCCCCCCCHHCCCCC	29.00	25825284
164	Ubiquitination	GTPHSHTKPYVRSKG CCCCCCCCHHCCCCC	29.00	-
166	Phosphorylation	PHSHTKPYVRSKGRK CCCCCCHHCCCCCHH	15.28	28152594
183	Phosphorylation	RARGRRASRGYKN-- HHHHHHHCCCCCC--	25.15	23882029

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RL18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL19_HUMAN	RPL19	physical	22939629
RL21_HUMAN	RPL21	physical	22939629
RL22_HUMAN	RPL22	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL24_HUMAN	RPL24	physical	22939629
RL27A_HUMAN	RPL27A	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RL3_HUMAN	RPL3	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RL8_HUMAN	RPL8	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS14_HUMAN	RPS14	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RL30_HUMAN	RPL30	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
RL36_HUMAN	RPL36	physical	22939629
RL27_HUMAN	RPL27	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
RL35_HUMAN	RPL35	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RL38_HUMAN	RPL38	physical	22939629
RL32_HUMAN	RPL32	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
TEBP_HUMAN	PTGES3	physical	22939629
TBA1B_HUMAN	TUBA1B	physical	22939629
RM12_HUMAN	MRPL12	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
MCA3_HUMAN	EEF1E1	physical	22863883
UBIM_HUMAN	FAU	physical	22863883
SYIC_HUMAN	IARS	physical	22863883
CPSF5_HUMAN	NUDT21	physical	22863883
RL13_HUMAN	RPL13	physical	22863883
RL23A_HUMAN	RPL23A	physical	22863883
RL24_HUMAN	RPL24	physical	22863883
RLA0_HUMAN	RPLP0	physical	22863883
HNRPU_HUMAN	HNRNPU	physical	26344197
HNRL2_HUMAN	HNRNPUL2	physical	26344197
PABP1_HUMAN	PABPC1	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL18A_HUMAN	RPL18A	physical	26344197
RL19_HUMAN	RPL19	physical	26344197
RL23_HUMAN	RPL23	physical	26344197
RL26_HUMAN	RPL26	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL32_HUMAN	RPL32	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35_HUMAN	RPL35	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL36_HUMAN	RPL36	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RL7_HUMAN	RPL7	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS10_HUMAN	RPS10	physical	26344197
RS12_HUMAN	RPS12	physical	26344197
RS13_HUMAN	RPS13	physical	26344197
RS14_HUMAN	RPS14	physical	26344197
RS15_HUMAN	RPS15	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS25_HUMAN	RPS25	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RS9_HUMAN	RPS9	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197
CEBPZ_HUMAN	CEBPZ	physical	28514442
RRP5_HUMAN	PDCD11	physical	28514442
FNTB_HUMAN	FNTB	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
NLE1_HUMAN	NLE1	physical	28514442
NSUN4_HUMAN	NSUN4	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
RIOX2_HUMAN	MINA	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
CENPC_HUMAN	CENPC	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
TTC19_HUMAN	TTC19	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
NOL8_HUMAN	NOL8	physical	28514442
NP1L1_HUMAN	NAP1L1	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
ZC3HA_HUMAN	ZC3H10	physical	28514442
SPT2_HUMAN	SPTY2D1	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
RM48_HUMAN	MRPL48	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
FNTA_HUMAN	FNTA	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
NP1L4_HUMAN	NAP1L4	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
DDX51_HUMAN	DDX51	physical	28514442
ZNF22_HUMAN	ZNF22	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
DDX52_HUMAN	DDX52	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
RRP7A_HUMAN	RRP7A	physical	28514442
NOP56_HUMAN	NOP56	physical	28514442
RT33_HUMAN	MRPS33	physical	28514442
RM28_HUMAN	MRPL28	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
HERC5_HUMAN	HERC5	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
FCF1_HUMAN	FCF1	physical	28514442
RM13_HUMAN	MRPL13	physical	28514442
RT18C_HUMAN	MRPS18C	physical	28514442
RM32_HUMAN	MRPL32	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
NOC3L_HUMAN	NOC3L	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RM47_HUMAN	MRPL47	physical	28514442
NPA1P_HUMAN	URB1	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
RRP1_HUMAN	RRP1	physical	28514442
ZN771_HUMAN	ZNF771	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
PK1IP_HUMAN	PAK1IP1	physical	28514442
RM27_HUMAN	MRPL27	physical	28514442
RM24_HUMAN	MRPL24	physical	28514442
RL8_HUMAN	RPL8	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
DDX18_HUMAN	DDX18	physical	28514442
NEPRO_HUMAN	C3orf17	physical	28514442
RM20_HUMAN	MRPL20	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
RM17_HUMAN	MRPL17	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
RM03_HUMAN	MRPL3	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
GNL3_HUMAN	GNL3	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
RT10_HUMAN	MRPS10	physical	28514442
RM51_HUMAN	MRPL51	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL18_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-154, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND THR-158, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASSSPECTROMETRY.	16964243 [Abstract]