| UniProt ID | DCAF1_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y4B6 | |
| Protein Name | DDB1- and CUL4-associated factor 1 {ECO:0000312|HGNC:HGNC:30911} | |
| Gene Name | DCAF1 {ECO:0000312|HGNC:HGNC:30911} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1507 | |
| Subcellular Localization | Cytoplasm. Nucleus. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. | |
| Protein Description | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex. [PubMed: 23063525 The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition] | |
| Protein Sequence | MTTVVVHVDSKAELTTLLEQWEKEHGSGQDMVPILTRMSQLIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQENKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGDQEEASGDMEISFHLDSGHKTSSRVNSTTKPEDGGLKKNKSAKQGDRENFRKAKQKLGFSSSDPDRMFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGTPRRKLPQNPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTKEADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIATRLGSHAAVGASAPSAPTAHPQPRPPQGPLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELANLLEEGEDGEDEDSDADEEVELILGDTDSSDNSDLEDDIILSLNE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | TVVVHVDSKAELTTL EEEEEECCHHHHHHH | 20068231 | ||
| 23 | Ubiquitination | TLLEQWEKEHGSGQD HHHHHHHHHHCCCCC | 29967540 | ||
| 44 | Ubiquitination | RMSQLIEKETEEYRK HHHHHHHHHHHHHHC | 29967540 | ||
| 134 | Ubiquitination | GIVENLFKWAREADQ CHHHHHHHHHHHCCC | - | ||
| 186 | Ubiquitination | LRELQLQEVALRQEN HHHHHHHHHHHHHCC | 24816145 | ||
| 197 | Phosphorylation | RQENKRPSPRKLSSE HHCCCCCCCCCCCCC | 30576142 | ||
| 198 | Ubiquitination | QENKRPSPRKLSSEP HCCCCCCCCCCCCCC | 17370265 | ||
| 202 | Phosphorylation | RPSPRKLSSEPLLPL CCCCCCCCCCCCCCC | 24275569 | ||
| 202 | Ubiquitination | RPSPRKLSSEPLLPL CCCCCCCCCCCCCCC | 24816145 | ||
| 203 | Phosphorylation | PSPRKLSSEPLLPLD CCCCCCCCCCCCCCC | 24275569 | ||
| 249 | Phosphorylation | HLDSGHKTSSRVNST EECCCCCCCCCCCCC | 23927012 | ||
| 250 | Phosphorylation | LDSGHKTSSRVNSTT ECCCCCCCCCCCCCC | 30576142 | ||
| 251 | Phosphorylation | DSGHKTSSRVNSTTK CCCCCCCCCCCCCCC | 25849741 | ||
| 255 | Phosphorylation | KTSSRVNSTTKPEDG CCCCCCCCCCCCCCC | 23401153 | ||
| 256 | Phosphorylation | TSSRVNSTTKPEDGG CCCCCCCCCCCCCCC | 29255136 | ||
| 257 | Phosphorylation | SSRVNSTTKPEDGGL CCCCCCCCCCCCCCC | 27273156 | ||
| 258 | Ubiquitination | SRVNSTTKPEDGGLK CCCCCCCCCCCCCCC | - | ||
| 264 | Ubiquitination | TKPEDGGLKKNKSAK CCCCCCCCCCCCCCC | 29967540 | ||
| 265 | Ubiquitination | KPEDGGLKKNKSAKQ CCCCCCCCCCCCCCC | 29967540 | ||
| 266 | Ubiquitination | PEDGGLKKNKSAKQG CCCCCCCCCCCCCCC | - | ||
| 267 | Ubiquitination | EDGGLKKNKSAKQGD CCCCCCCCCCCCCCC | 24816145 | ||
| 268 | Ubiquitination | DGGLKKNKSAKQGDR CCCCCCCCCCCCCCH | 24816145 | ||
| 279 | Ubiquitination | QGDRENFRKAKQKLG CCCHHHHHHHHHHHC | 17370265 | ||
| 280 | Ubiquitination | GDRENFRKAKQKLGF CCHHHHHHHHHHHCC | 17370265 | ||
| 283 | Ubiquitination | ENFRKAKQKLGFSSS HHHHHHHHHHCCCCC | 24816145 | ||
| 284 | Ubiquitination | NFRKAKQKLGFSSSD HHHHHHHHHCCCCCC | 24816145 | ||
| 288 | Phosphorylation | AKQKLGFSSSDPDRM HHHHHCCCCCCCCCE | 27732954 | ||
| 289 | Phosphorylation | KQKLGFSSSDPDRMF HHHHCCCCCCCCCEE | 27732954 | ||
| 290 | Phosphorylation | QKLGFSSSDPDRMFV HHHCCCCCCCCCEEE | 28355574 | ||
| 302 | Phosphorylation | MFVELSNSSWSEMSP EEEECCCCCHHHCCC | 27251275 | ||
| 303 | Phosphorylation | FVELSNSSWSEMSPW EEECCCCCHHHCCCE | 27251275 | ||
| 305 | Phosphorylation | ELSNSSWSEMSPWVI ECCCCCHHHCCCEEE | 27251275 | ||
| 308 | Phosphorylation | NSSWSEMSPWVIGTN CCCHHHCCCEEEECC | 27251275 | ||
| 314 | Phosphorylation | MSPWVIGTNYTLYPM CCCEEEECCCEEEEC | 27251275 | ||
| 316 | Phosphorylation | PWVIGTNYTLYPMTP CEEEECCCEEEECCH | 27251275 | ||
| 317 | Phosphorylation | WVIGTNYTLYPMTPA EEEECCCEEEECCHH | 27251275 | ||
| 359 | Phosphorylation | SRELMMFYIDLKQTN CCEEEEEEEEHHHCC | 20860994 | ||
| 385 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 469 | Phosphorylation | MFFSICFSFRAVLEL HHHHHHHHHHHHHHH | 24719451 | ||
| 487 | Ubiquitination | YDGLRRLVNLISTLE HHHHHHHHHHHHHHH | - | ||
| 539 | Ubiquitination | LAIKLEQVKQSLQRT HHHCHHHHHHHHHHC | 29967540 | ||
| 540 | Ubiquitination | AIKLEQVKQSLQRTE HHCHHHHHHHHHHCC | 29967540 | ||
| 578 | Phosphorylation | MMEFLIEYGPAQLYW HHHHHHHHCCHHHCC | - | ||
| 619 | Ubiquitination | TYYARNDTVRFALDV HHCCCCHHHHHHHHH | 27667366 | ||
| 648 | Acetylation | AESVDVLDEAGSTVS HHCCCCHHHCCCCCE | - | ||
| 653 | Phosphorylation | VLDEAGSTVSTVGIS CHHHCCCCCEEEEEE | - | ||
| 657 | Ubiquitination | AGSTVSTVGISIILG CCCCCEEEEEEEEEE | - | ||
| 663 | Ubiquitination | TVGISIILGVAEGEF EEEEEEEEEEEECCE | - | ||
| 678 | Ubiquitination | FIHDAEIQKSALQII EECCHHHHHHHHHHH | 21963094 | ||
| 687 | Phosphorylation | SALQIIINCVCGPDN HHHHHHHHHHHCCCC | - | ||
| 690 | Phosphorylation | QIIINCVCGPDNRIS HHHHHHHHCCCCCHH | - | ||
| 692 | Ubiquitination | IINCVCGPDNRISSI HHHHHHCCCCCHHHH | - | ||
| 700 | Ubiquitination | DNRISSIGKFISGTP CCCHHHHHHHHCCCC | 27667366 | ||
| 701 | Acetylation | NRISSIGKFISGTPR CCHHHHHHHHCCCCC | 23954790 | ||
| 701 | Ubiquitination | NRISSIGKFISGTPR CCHHHHHHHHCCCCC | 27667366 | ||
| 704 | Phosphorylation | SSIGKFISGTPRRKL HHHHHHHCCCCCCCC | 30266825 | ||
| 706 | Phosphorylation | IGKFISGTPRRKLPQ HHHHHCCCCCCCCCC | 30266825 | ||
| 709 | Ubiquitination | FISGTPRRKLPQNPK HHCCCCCCCCCCCCC | 21963094 | ||
| 710 | Ubiquitination | ISGTPRRKLPQNPKS HCCCCCCCCCCCCCC | 29967540 | ||
| 715 | Ubiquitination | RRKLPQNPKSSEHTL CCCCCCCCCCCHHHH | 29967540 | ||
| 716 | Ubiquitination | RKLPQNPKSSEHTLA CCCCCCCCCCHHHHH | 29967540 | ||
| 725 | Ubiquitination | SEHTLAKMWNVVQSN CHHHHHHHHHHHHHC | 21963094 | ||
| 737 | Ubiquitination | QSNNGIKVLLSLLSI HHCCHHHHHHHHHCC | 23000965 | ||
| 738 | Ubiquitination | SNNGIKVLLSLLSIK HCCHHHHHHHHHCCC | - | ||
| 740 | Phosphorylation | NGIKVLLSLLSIKMP CHHHHHHHHHCCCCC | 21406692 | ||
| 743 | Phosphorylation | KVLLSLLSIKMPITD HHHHHHHCCCCCCCC | 21406692 | ||
| 745 | Ubiquitination | LLSLLSIKMPITDAD HHHHHCCCCCCCCHH | - | ||
| 747 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 749 | Phosphorylation | LSIKMPITDADQIRA HCCCCCCCCHHHHHH | 21949786 | ||
| 752 | Ubiquitination | KMPITDADQIRALAC CCCCCCHHHHHHHHH | 33845483 | ||
| 754 | Ubiquitination | PITDADQIRALACKA CCCCHHHHHHHHHHH | - | ||
| 759 | Ubiquitination | DQIRALACKALVGLS HHHHHHHHHHHHCCC | 21963094 | ||
| 760 | Ubiquitination | QIRALACKALVGLSR HHHHHHHHHHHCCCC | 21963094 | ||
| 764 | Phosphorylation | LACKALVGLSRSSTV HHHHHHHCCCCHHHH | 20068231 | ||
| 766 | Ubiquitination | CKALVGLSRSSTVRQ HHHHHCCCCHHHHHH | - | ||
| 768 | Phosphorylation | ALVGLSRSSTVRQII HHHCCCCHHHHHHHH | 17081983 | ||
| 769 | Phosphorylation | LVGLSRSSTVRQIIS HHCCCCHHHHHHHHH | 17081983 | ||
| 770 | Phosphorylation | VGLSRSSTVRQIISK HCCCCHHHHHHHHHC | 17081983 | ||
| 772 | Phosphorylation | LSRSSTVRQIISKLP CCCHHHHHHHHHCCC | 20068231 | ||
| 775 | Phosphorylation | SSTVRQIISKLPLFS HHHHHHHHHCCCCCC | - | ||
| 775 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 776 | Phosphorylation | STVRQIISKLPLFSS HHHHHHHHCCCCCCH | 24719451 | ||
| 779 | Ubiquitination | RQIISKLPLFSSCQI HHHHHCCCCCCHHHH | 21963094 | ||
| 781 | Ubiquitination | IISKLPLFSSCQIQQ HHHCCCCCCHHHHHH | - | ||
| 782 | Phosphorylation | ISKLPLFSSCQIQQL HHCCCCCCHHHHHHH | 30622161 | ||
| 783 | Phosphorylation | SKLPLFSSCQIQQLM HCCCCCCHHHHHHHH | 30622161 | ||
| 790 | Ubiquitination | SCQIQQLMKEPVLQD HHHHHHHHHCCCCCC | 21963094 | ||
| 791 | Ubiquitination | CQIQQLMKEPVLQDK HHHHHHHHCCCCCCC | 21963094 | ||
| 800 | Phosphorylation | PVLQDKRSDHVKFCK CCCCCCCCHHHHHHH | 29083192 | ||
| 806 | Ubiquitination | RSDHVKFCKYAAELI CCHHHHHHHHHHHHH | 21963094 | ||
| 807 | Ubiquitination | SDHVKFCKYAAELIE CHHHHHHHHHHHHHH | 21963094 | ||
| 808 | Phosphorylation | DHVKFCKYAAELIER HHHHHHHHHHHHHHH | 29083192 | ||
| 808 | Ubiquitination | DHVKFCKYAAELIER HHHHHHHHHHHHHHH | - | ||
| 813 | Phosphorylation | CKYAAELIERVSGKP HHHHHHHHHHHCCCC | 32645325 | ||
| 817 | Phosphorylation | AELIERVSGKPLLIG HHHHHHHCCCCEEEE | 20068231 | ||
| 818 | Ubiquitination | ELIERVSGKPLLIGT HHHHHHCCCCEEEEC | 23000965 | ||
| 819 | Acetylation | LIERVSGKPLLIGTD HHHHHCCCCEEEECC | 21339330 | ||
| 819 | Ubiquitination | LIERVSGKPLLIGTD HHHHHCCCCEEEECC | 23000965 | ||
| 825 | Phosphorylation | GKPLLIGTDVSLARL CCCEEEECCCHHHHH | 20068231 | ||
| 826 | Phosphorylation | KPLLIGTDVSLARLQ CCEEEECCCHHHHHH | - | ||
| 828 | Phosphorylation | LLIGTDVSLARLQKA EEEECCCHHHHHHHC | 20068231 | ||
| 832 | Phosphorylation | TDVSLARLQKADVVA CCCHHHHHHHCCCEE | - | ||
| 833 | Ubiquitination | DVSLARLQKADVVAQ CCHHHHHHHCCCEEE | 33845483 | ||
| 833 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 834 | Ubiquitination | VSLARLQKADVVAQS CHHHHHHHCCCEEEC | 21906983 | ||
| 835 | Phosphorylation | SLARLQKADVVAQSR HHHHHHHCCCEEECC | 20068231 | ||
| 838 | Phosphorylation | RLQKADVVAQSRISF HHHHCCCEEECCCCC | - | ||
| 838 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 842 | Phosphorylation | ADVVAQSRISFPEKE CCCEEECCCCCCHHH | 18220336 | ||
| 845 | Phosphorylation | VAQSRISFPEKELLL EEECCCCCCHHHHHH | 18669648 | ||
| 848 | Ubiquitination | SRISFPEKELLLLIR CCCCCCHHHHHHHHH | - | ||
| 849 | Phosphorylation | RISFPEKELLLLIRN CCCCCHHHHHHHHHH | 18669648 | ||
| 860 | Ubiquitination | LIRNHLISKGLGETA HHHHHHHHCCCCCCC | 21963094 | ||
| 861 | Ubiquitination | IRNHLISKGLGETAT HHHHHHHCCCCCCCE | 21963094 | ||
| 871 | Ubiquitination | GETATVLTKEADLPM CCCCEEEEECCCCCC | 21963094 | ||
| 872 | Ubiquitination | ETATVLTKEADLPMT CCCEEEEECCCCCCC | 21963094 | ||
| 879 | Phosphorylation | KEADLPMTAASHSSA ECCCCCCCCCCCCCC | 22199227 | ||
| 882 | Phosphorylation | DLPMTAASHSSAFTP CCCCCCCCCCCCCCC | 22199227 | ||
| 884 | Phosphorylation | PMTAASHSSAFTPVT CCCCCCCCCCCCCCC | 30266825 | ||
| 885 | Phosphorylation | MTAASHSSAFTPVTA CCCCCCCCCCCCCCC | 30266825 | ||
| 888 | Phosphorylation | ASHSSAFTPVTAAAS CCCCCCCCCCCCCCC | 30266825 | ||
| 891 | O-linked_Glycosylation | SSAFTPVTAAASPVS CCCCCCCCCCCCCCC | 28657654 | ||
| 891 | Phosphorylation | SSAFTPVTAAASPVS CCCCCCCCCCCCCCC | 30266825 | ||
| 894 | Phosphorylation | FTPVTAAASPVSLPR CCCCCCCCCCCCCCC | 32645325 | ||
| 894 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 895 | Phosphorylation | TPVTAAASPVSLPRT CCCCCCCCCCCCCCC | 30266825 | ||
| 898 | Phosphorylation | TAAASPVSLPRTPRI CCCCCCCCCCCCCCC | 30266825 | ||
| 902 | Phosphorylation | SPVSLPRTPRIANGI CCCCCCCCCCCCCCH | 30576142 | ||
| 922 | Phosphorylation | SHAAVGASAPSAPTA CCCCCCCCCCCCCCC | 25002506 | ||
| 925 | Phosphorylation | AVGASAPSAPTAHPQ CCCCCCCCCCCCCCC | 25002506 | ||
| 926 | Phosphorylation | VGASAPSAPTAHPQP CCCCCCCCCCCCCCC | 19651622 | ||
| 928 | Phosphorylation | ASAPSAPTAHPQPRP CCCCCCCCCCCCCCC | 25002506 | ||
| 931 | Phosphorylation | PSAPTAHPQPRPPQG CCCCCCCCCCCCCCC | - | ||
| 932 | Phosphorylation | SAPTAHPQPRPPQGP CCCCCCCCCCCCCCC | - | ||
| 934 | Phosphorylation | PTAHPQPRPPQGPLA CCCCCCCCCCCCCCC | 19691289 | ||
| 946 | Phosphorylation | PLALPGPSYAGNSPL CCCCCCCCCCCCCCC | 25002506 | ||
| 947 | Phosphorylation | LALPGPSYAGNSPLI CCCCCCCCCCCCCCE | 20068231 | ||
| 950 | Phosphorylation | PGPSYAGNSPLIGRI CCCCCCCCCCCEEEE | 17081983 | ||
| 951 | Phosphorylation | GPSYAGNSPLIGRIS CCCCCCCCCCEEEEE | 29496963 | ||
| 958 | Phosphorylation | SPLIGRISFIRERPS CCCEEEEEEECCCCC | 26074081 | ||
| 979 | Phosphorylation | IRVLRQKSDHGAYSQ EEEEEECCCCCCCCC | 25159151 | ||
| 984 | Phosphorylation | QKSDHGAYSQSPAIK ECCCCCCCCCCHHHH | 22496350 | ||
| 985 | Phosphorylation | KSDHGAYSQSPAIKK CCCCCCCCCCHHHHH | 25159151 | ||
| 987 | Phosphorylation | DHGAYSQSPAIKKQL CCCCCCCCHHHHHHH | 25159151 | ||
| 1000 | Phosphorylation | QLDRHLPSPPTLDSI HHHHCCCCCCCHHHH | 29255136 | ||
| 1003 | Phosphorylation | RHLPSPPTLDSIITE HCCCCCCCHHHHHHH | 22617229 | ||
| 1006 | Phosphorylation | PSPPTLDSIITEYLR CCCCCHHHHHHHHHH | 22617229 | ||
| 1009 | Phosphorylation | PTLDSIITEYLREQH CCHHHHHHHHHHHHH | 23663014 | ||
| 1009 | Ubiquitination | PTLDSIITEYLREQH CCHHHHHHHHHHHHH | - | ||
| 1011 | Phosphorylation | LDSIITEYLREQHAR HHHHHHHHHHHHHHC | 23663014 | ||
| 1031 | Phosphorylation | ATCPPFSLFTPHQCP CCCCCCCCCCCCCCC | - | ||
| 1051 | Phosphorylation | RQAPINFTSRLNRRA CCCCCCCHHHHHHCC | 28152594 | ||
| 1052 | Phosphorylation | QAPINFTSRLNRRAS CCCCCCHHHHHHCCC | 28152594 | ||
| 1059 | Phosphorylation | SRLNRRASFPKYGGV HHHHHCCCCCCCCCC | 24719451 | ||
| 1062 | Ubiquitination | NRRASFPKYGGVDGG HHCCCCCCCCCCCCC | - | ||
| 1084 | Phosphorylation | FSRFRPISVFREANE CCCCEEEEEEECCCC | 22673903 | ||
| 1104 | Ubiquitination | TCCAFSARERFLMLG EEEEEEHHCCEEEEE | 21963094 | ||
| 1128 | Phosphorylation | NVFSGQEEASYNCHN ECCCCCCCCCEECCC | - | ||
| 1133 | Ubiquitination | QEEASYNCHNSAITH CCCCCEECCCCCCCC | - | ||
| 1142 | Ubiquitination | NSAITHLEPSRDGSL CCCCCCCCCCCCCCE | 21890473 | ||
| 1143 | Ubiquitination | SAITHLEPSRDGSLL CCCCCCCCCCCCCEE | - | ||
| 1171 | Ubiquitination | WGMKSVFDMKHSFTE HCCCCHHCCCCCCCC | - | ||
| 1175 | Phosphorylation | SVFDMKHSFTEDHYV CHHCCCCCCCCCCEE | - | ||
| 1177 | Phosphorylation | FDMKHSFTEDHYVEF HCCCCCCCCCCEEEE | - | ||
| 1181 | Phosphorylation | HSFTEDHYVEFSKHS CCCCCCCEEEECCCC | - | ||
| 1185 | Phosphorylation | EDHYVEFSKHSQDRV CCCEEEECCCCCCCE | - | ||
| 1185 | Ubiquitination | EDHYVEFSKHSQDRV CCCEEEECCCCCCCE | 21963094 | ||
| 1186 | Ubiquitination | DHYVEFSKHSQDRVI CCEEEECCCCCCCEE | 21963094 | ||
| 1195 | Ubiquitination | SQDRVIGTKGDIAHI CCCCEEECCCCEEEE | 29967540 | ||
| 1195 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 1196 | Ubiquitination | QDRVIGTKGDIAHIY CCCEEECCCCEEEEE | 21906983 | ||
| 1200 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 1201 | Ubiquitination | GTKGDIAHIYDIQTG ECCCCEEEEEECCCC | - | ||
| 1207 | Phosphorylation | AHIYDIQTGNKLLTL EEEEECCCCCEEEEE | - | ||
| 1223 | Phosphorylation | NPDLANNYKRNCATF CHHHHHCCCCCCCCC | 27732954 | ||
| 1223 | Ubiquitination | NPDLANNYKRNCATF CHHHHHCCCCCCCCC | 21890473 | ||
| 1223 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 1224 | Acetylation | PDLANNYKRNCATFN HHHHHCCCCCCCCCC | 26051181 | ||
| 1224 | Ubiquitination | PDLANNYKRNCATFN HHHHHCCCCCCCCCC | 23000965 | ||
| 1228 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 1245 | Ubiquitination | LNDGVLWDVRSAQAI ECCCCEEEHHHHHHH | 27667366 | ||
| 1253 | Ubiquitination | VRSAQAIHKFDKFNM HHHHHHHHHHCCCCC | 29967540 | ||
| 1254 | Ubiquitination | RSAQAIHKFDKFNMN HHHHHHHHHCCCCCE | 29967540 | ||
| 1261 | Ubiquitination | KFDKFNMNISGVFHP HHCCCCCEECCEECC | 21963094 | ||
| 1269 | Ubiquitination | ISGVFHPNGLEVIIN ECCEECCCCEEEEEE | 21963094 | ||
| 1274 | Ubiquitination | HPNGLEVIINTEIWD CCCCEEEEEECEECC | - | ||
| 1275 | Phosphorylation | PNGLEVIINTEIWDL CCCEEEEEECEECCH | - | ||
| 1290 | Ubiquitination | RTFHLLHTVPALDQC HHHHHHCCCCCHHHC | - | ||
| 1298 | Ubiquitination | VPALDQCRVVFNHTG CCCHHHCEEEECCCC | - | ||
| 1326 | Ubiquitination | DDLMEERMKSPFGSS CHHHHHHHCCCCCCC | 27667366 | ||
| 1327 | Ubiquitination | DLMEERMKSPFGSSF HHHHHHHCCCCCCCC | 27667366 | ||
| 1328 | Phosphorylation | LMEERMKSPFGSSFR HHHHHHCCCCCCCCC | 25159151 | ||
| 1332 | O-linked_Glycosylation | RMKSPFGSSFRTFNA HHCCCCCCCCCCCCC | 28657654 | ||
| 1332 | Phosphorylation | RMKSPFGSSFRTFNA HHCCCCCCCCCCCCC | 23186163 | ||
| 1333 | O-linked_Glycosylation | MKSPFGSSFRTFNAT HCCCCCCCCCCCCCC | 28657654 | ||
| 1333 | Phosphorylation | MKSPFGSSFRTFNAT HCCCCCCCCCCCCCC | 23186163 | ||
| 1342 | Ubiquitination | RTFNATDYKPIATID CCCCCCCCCCEEEEE | 21963094 | ||
| 1342 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 1343 | Acetylation | TFNATDYKPIATIDV CCCCCCCCCEEEEEE | 23236377 | ||
| 1343 | Ubiquitination | TFNATDYKPIATIDV CCCCCCCCCEEEEEE | 21963094 | ||
| 1347 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 1350 | Ubiquitination | KPIATIDVKRNIFDL CCEEEEEEECCHHHH | 21963094 | ||
| 1351 | Acetylation | PIATIDVKRNIFDLC CEEEEEEECCHHHHC | 30584037 | ||
| 1351 | Ubiquitination | PIATIDVKRNIFDLC CEEEEEEECCHHHHC | 21963094 | ||
| 1365 | Phosphorylation | CTDTKDCYLAVIENQ CCCCCCEEEEEEECC | - | ||
| 1387 | Phosphorylation | MDTVCRLYEVGRQRL HHHHHHHHHHHHHHH | - | ||
| 1421 | Phosphorylation | DDEDDDDTDDLDELD CCCCCCCCCCHHHCC | 22817901 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DCAF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DCAF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCAF1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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