CSN8_HUMAN - dbPTM
CSN8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSN8_HUMAN
UniProt AC Q99627
Protein Name COP9 signalosome complex subunit 8
Gene Name COPS8
Organism Homo sapiens (Human).
Sequence Length 209
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively..
Protein Sequence MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationVMAESAFSFKKLLDQ
EECCCCCCHHHHHHH		35.5524719451
65UbiquitinationKRIPPAIKSANSELG
HHCCHHHHHCCCCCC		45.69-
66PhosphorylationRIPPAIKSANSELGG
HCCHHHHHCCCCCCC		26.9425693802
69PhosphorylationPAIKSANSELGGIWS
HHHHHCCCCCCCCCC		33.6421712546
90PhosphorylationQRDFPGIYTTINAHQ
HCCCCCCEEEECHHH		12.0722210691
99PhosphorylationTINAHQWSETVQPIM
EECHHHHHHHHHHHH		19.4722210691
101PhosphorylationNAHQWSETVQPIMEA
CHHHHHHHHHHHHHH		20.9422210691
117UbiquitinationRDATRRRAFALVSQA
HHHHHHHHHHHHHHH		7.7021890473
129UbiquitinationSQAYTSIIADDFAAF
HHHHHHHHHHCHHHH		3.2621890473
157PhosphorylationEQGWQADSTTRMVLP
HCCCCCCCCCEEEEC		34.3925693802
158PhosphorylationQGWQADSTTRMVLPR
CCCCCCCCCEEEECC		20.9728348404
159PhosphorylationGWQADSTTRMVLPRK
CCCCCCCCEEEECCC		22.2528348404
166UbiquitinationTRMVLPRKPVAGALD
CEEEECCCCCCEEEE		41.7421890473
166UbiquitinationTRMVLPRKPVAGALD
CEEEECCCCCCEEEE		41.7421890473
175PhosphorylationVAGALDVSFNKFIPL
CCEEEEEECCCCCCC		23.8325159151
178UbiquitinationALDVSFNKFIPLSEP
EEEEECCCCCCCCCC		42.5321890473
178UbiquitinationALDVSFNKFIPLSEP
EEEEECCCCCCCCCC		42.5321890473
201PhosphorylationEQQLARLTDYVAFLE
HHHHHHHHHHHHHHC		21.5227642862
203PhosphorylationQLARLTDYVAFLEN-
HHHHHHHHHHHHCC-		6.6127642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CSN8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSN8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSN8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSN1_HUMANGPS1physical
9707402
CSN2_HUMANCOPS2physical
9707402
CSN3_HUMANCOPS3physical
9707402
CSN4_HUMANCOPS4physical
9707402
CSN5_HUMANCOPS5physical
9707402
CSN6_HUMANCOPS6physical
9707402
CSN8_HUMANCOPS8physical
9707402
CSN7A_HUMANCOPS7Aphysical
9707402
CSN7B_HUMANCOPS7Bphysical
9707402
CSN7A_HUMANCOPS7Aphysical
10903862
CSN2_HUMANCOPS2physical
22863883
CSN3_HUMANCOPS3physical
22863883
CSN4_HUMANCOPS4physical
22863883
CSN6_HUMANCOPS6physical
22863883
CSN7A_HUMANCOPS7Aphysical
22863883
CSN1_HUMANGPS1physical
22863883
VIME_HUMANVIMphysical
22863883
MEP50_HUMANWDR77physical
22863883
USBP1_HUMANUSHBP1physical
25416956
CSN3_HUMANCOPS3physical
28514442
CSN5_HUMANCOPS5physical
28514442
CSN2_HUMANCOPS2physical
28514442
CSN6_HUMANCOPS6physical
28514442
DDB2_HUMANDDB2physical
28514442
CSN1_HUMANGPS1physical
28514442
CSN7A_HUMANCOPS7Aphysical
28514442
CSN4_HUMANCOPS4physical
28514442
LLR1_HUMANLRR1physical
28514442
APBP2_HUMANAPPBP2physical
28514442
BTBD1_HUMANBTBD1physical
28514442
DCAF4_HUMANDCAF4physical
28514442
DCA11_HUMANDCAF11physical
28514442
CUL4A_HUMANCUL4Aphysical
28514442
CUL4B_HUMANCUL4Bphysical
28514442
FEM1B_HUMANFEM1Bphysical
28514442
DTL_HUMANDTLphysical
28514442
DCAF1_HUMANVPRBPphysical
28514442
CRBN_HUMANCRBNphysical
28514442
RN138_HUMANRNF138physical
28514442
BTBD2_HUMANBTBD2physical
28514442
CUL2_HUMANCUL2physical
28514442
CSN3_HUMANCOPS3physical
27173435
CSN1_HUMANGPS1physical
27173435
CSN6_HUMANCOPS6physical
27173435
CSN2_HUMANCOPS2physical
27173435
CSN4_HUMANCOPS4physical
27173435
CSN5_HUMANCOPS5physical
27173435
CSN7B_HUMANCOPS7Bphysical
27173435
NHRF2_HUMANSLC9A3R2physical
27173435
DCA11_HUMANDCAF11physical
27173435
CUL4A_HUMANCUL4Aphysical
27173435
CUL4B_HUMANCUL4Bphysical
27173435
CUL2_HUMANCUL2physical
27173435
USH1C_HUMANUSH1Cphysical
27173435
PRP31_HUMANPRPF31physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSN8_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, AND MASSSPECTROMETRY.
"Characterization of the human COP9 signalosome complex using affinitypurification and mass spectrometry.";
Fang L., Wang X., Yamoah K., Chen P.L., Pan Z.Q., Huang L.;
J. Proteome Res. 7:4914-4925(2008).
Cited for: IDENTIFICATION IN THE CSN COMPLEX, CLEAVAGE OF INITIATOR METHIONINE,AND PHOSPHORYLATION AT SER-175.

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