DCA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCA11_HUMAN
• UniProt AC: Q8TEB1
• Protein Name: DDB1- and CUL4-associated factor 11
• Gene Name: DCAF11
• Organism: Homo sapiens (Human).
• Sequence Length: 546
• Protein Description: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQGGGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQLGLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTPFSSPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSRNSSSAG -----CCCCCCCCCC	27.30	-
6	Phosphorylation	--MGSRNSSSAGSGS --CCCCCCCCCCCCC	25.26	28450419
7	Phosphorylation	-MGSRNSSSAGSGSG -CCCCCCCCCCCCCC	27.96	21815630
8	Phosphorylation	MGSRNSSSAGSGSGD CCCCCCCCCCCCCCC	36.15	29255136
11	Phosphorylation	RNSSSAGSGSGDPSE CCCCCCCCCCCCCCC	29.51	25849741
11 (in isoform 2)	Phosphorylation	-	29.51	24719451
13	Phosphorylation	SSSAGSGSGDPSEGL CCCCCCCCCCCCCCC	41.54	25849741
17	Phosphorylation	GSGSGDPSEGLPRRG CCCCCCCCCCCCCCC	49.38	23186163
30 (in isoform 2)	Phosphorylation	-	42.81	26657352
30	Phosphorylation	RGAGLRRSEEEEEED CCCCCCCCHHHHHHC	42.81	26657352
49 (in isoform 2)	Phosphorylation	-	2.20	26657352
75	Phosphorylation	FIQALLDSEEENDRA HHHHHHCCHHHCCCC	47.04	30175587
91	Phosphorylation	DGRLGDRYNPPVDAT CCCCCCCCCCCCCCC	36.44	27642862
98	Phosphorylation	YNPPVDATPDTRELE CCCCCCCCCCCCEEC	19.75	21815630
121 (in isoform 2)	Phosphorylation	-	14.84	24719451
130	Phosphorylation	RRAAQKHSFPRMLHQ HHHHHHCCHHHHHHH	43.94	-
147	Phosphorylation	RGLCHRGSFSLGEQS CCCCCCCCCCHHCCH	16.18	28450419
149	Phosphorylation	LCHRGSFSLGEQSRV CCCCCCCCHHCCHHH	36.84	27251275
189	Phosphorylation	KDGQIFMSACQDQTI CCCCEEEHHHCCCEE	18.36	22210691
270	Phosphorylation	ERRFAVFSIAVSSDG CCCEEEEEEEECCCC	11.75	29514088
274	Phosphorylation	AVFSIAVSSDGREVL EEEEEEECCCCCEEC	17.43	29514088
275	Phosphorylation	VFSIAVSSDGREVLG EEEEEECCCCCEECC	37.17	29514088
346	Ubiquitination	TMREDDPKPVGALAG CCCCCCCCCCCHHCC	60.37	-
364	Ubiquitination	GITFIDSKGDARYLI CEEEECCCCCEEEEE	58.00	-
375	Ubiquitination	RYLISNSKDQTIKLW EEEEECCCCCEEEEE	59.09	-
380	Ubiquitination	NSKDQTIKLWDIRRF CCCCCEEEEEEHHHH	47.08	-
415	Ubiquitination	RWQQVPKKAWRKLKL CCCCCCHHHHHHCCC	47.30	-
478	Ubiquitination	LSGHIVKKLTNHKAC CCCCHHHHHCCCCCC	50.04	-
483	Ubiquitination	VKKLTNHKACVRDVS HHHHCCCCCCEECCC	45.62	-
497	Ubiquitination	SWHPFEEKIVSSSWD CCCCCCHHHCCCCCC	41.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCA11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCA11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDB1_HUMAN	DDB1	physical	16964240
CSN2_HUMAN	COPS2	physical	19295130
CSN3_HUMAN	COPS3	physical	19295130
CUL4A_HUMAN	CUL4A	physical	19295130
DDB1_HUMAN	DDB1	physical	19295130
DDA1_HUMAN	DDA1	physical	19295130
ASPC1_HUMAN	ASPSCR1	physical	22863883
LRBA_HUMAN	LRBA	physical	22863883
TERA_HUMAN	VCP	physical	22863883
DDB1_HUMAN	DDB1	physical	16949367
CUL4A_HUMAN	CUL4A	physical	16949367
CUL4B_HUMAN	CUL4B	physical	16949367
SLBP_HUMAN	SLBP	physical	27254819
CUL4A_HUMAN	CUL4A	physical	28514442
CUL4B_HUMAN	CUL4B	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
ODB2_HUMAN	DBT	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
DDB1_HUMAN	DDB1	physical	28514442
CSN7A_HUMAN	COPS7A	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
PLK1_HUMAN	PLK1	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
MICU2_HUMAN	MICU2	physical	28514442
DDA1_HUMAN	DDA1	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
CSN1_HUMAN	GPS1	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442
CSN4_HUMAN	COPS4	physical	28514442
CSN7B_HUMAN	COPS7B	physical	27173435
NF2L2_HUMAN	NFE2L2	physical	28453520
DDB1_HUMAN	DDB1	physical	28453520
CUL4A_HUMAN	CUL4A	physical	28453520

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.