dbPTM

TCPB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TCPB_HUMAN
UniProt AC	P78371
Protein Name	T-complex protein 1 subunit beta
Gene Name	CCT2
Organism	Homo sapiens (Human).
Sequence Length	535
Subcellular Localization	Cytoplasm .
Protein Description	Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin..
Protein Sequence	MASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 2)	Acetylation	-	5.29	22814378
2	Acetylation	------MASLSLAPV ------CCCCCCCCH	21.12	20068231
3	Phosphorylation	-----MASLSLAPVN -----CCCCCCCCHH	19.72	29255136
5	Phosphorylation	---MASLSLAPVNIF ---CCCCCCCCHHEE	21.71	29255136
13	Ubiquitination	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	21890473
13	Ubiquitination	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	21890473
13	Ubiquitination	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	21890473
13	Ubiquitination	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	21890473
13	Ubiquitination	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	21890473
13	2-Hydroxyisobutyrylation	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	-
13	Acetylation	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	19608861
13	Ubiquitination	LAPVNIFKAGADEER CCCHHEECCCCCHHH	41.96	21890473
13 (in isoform 2)	Phosphorylation	-	41.96	29507054
23	Phosphorylation	ADEERAETARLTSFI CCHHHHHHHHHHHHH	18.98	-
27	Phosphorylation	RAETARLTSFIGAIA HHHHHHHHHHHHHHH	18.95	27273156
28	Phosphorylation	AETARLTSFIGAIAI HHHHHHHHHHHHHHH	21.32	21601212
40	Ubiquitination	IAIGDLVKSTLGPKG HHHHHHHHHCCCCCC	45.05	21906983
46	Ubiquitination	VKSTLGPKGMDKILL HHHCCCCCCCCEEEE	66.13	-
50	Ubiquitination	LGPKGMDKILLSSGR CCCCCCCEEEECCCC	26.76	21890473
54	Phosphorylation	GMDKILLSSGRDASL CCCEEEECCCCCCEE	27.57	23403867
55	Phosphorylation	MDKILLSSGRDASLM CCEEEECCCCCCEEE	37.50	23403867
60	Phosphorylation	LSSGRDASLMVTNDG ECCCCCCEEEEECCC	22.68	30266825
62	Sulfoxidation	SGRDASLMVTNDGAT CCCCCEEEEECCCCH	3.02	21406390
64	Phosphorylation	RDASLMVTNDGATIL CCCEEEEECCCCHHH	17.39	30266825
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHCCCCCH	42.54	21890473
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHCCCCCH	42.54	21890473
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHCCCCCH	42.54	21890473
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHCCCCCH	42.54	21890473
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHCCCCCH	42.54	21890473
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHCCCCCH	42.54	21890473
82	Ubiquitination	GVDNPAAKVLVDMSR CCCCHHHEEEEEHHH	37.90	21890473
82	Ubiquitination	GVDNPAAKVLVDMSR CCCCHHHEEEEEHHH	37.90	21890473
82	Ubiquitination	GVDNPAAKVLVDMSR CCCCHHHEEEEEHHH	37.90	21890473
82	Ubiquitination	GVDNPAAKVLVDMSR CCCCHHHEEEEEHHH	37.90	21890473
82	Ubiquitination	GVDNPAAKVLVDMSR CCCCHHHEEEEEHHH	37.90	21890473
82	Ubiquitination	GVDNPAAKVLVDMSR CCCCHHHEEEEEHHH	37.90	21890473
99	Phosphorylation	DDEVGDGTTSVTVLA CCCCCCCHHHHHHHH	22.19	30622161
100	Phosphorylation	DEVGDGTTSVTVLAA CCCCCCHHHHHHHHH	27.08	30622161
101	Phosphorylation	EVGDGTTSVTVLAAE CCCCCHHHHHHHHHH	18.67	30622161
103	Phosphorylation	GDGTTSVTVLAAELL CCCHHHHHHHHHHHH	15.01	30622161
107	Acetylation	TSVTVLAAELLREAE HHHHHHHHHHHHHHH	12.10	19608861
107	Ubiquitination	TSVTVLAAELLREAE HHHHHHHHHHHHHHH	12.10	19608861
115	Phosphorylation	ELLREAESLIAKKIH HHHHHHHHHHHHHHC	31.93	21815630
119	Acetylation	EAESLIAKKIHPQTI HHHHHHHHHHCHHHE	45.31	25953088
119	Succinylation	EAESLIAKKIHPQTI HHHHHHHHHHCHHHE	45.31	23954790
119	Ubiquitination	EAESLIAKKIHPQTI HHHHHHHHHHCHHHE	45.31	-
120	Ubiquitination	AESLIAKKIHPQTII HHHHHHHHHCHHHEE	36.91	21890473
120	Ubiquitination	AESLIAKKIHPQTII HHHHHHHHHCHHHEE	36.91	21890473
120	Ubiquitination	AESLIAKKIHPQTII HHHHHHHHHCHHHEE	36.91	21890473
120	Ubiquitination	AESLIAKKIHPQTII HHHHHHHHHCHHHEE	36.91	21890473
120	Ubiquitination	AESLIAKKIHPQTII HHHHHHHHHCHHHEE	36.91	21890473
120	Ubiquitination	AESLIAKKIHPQTII HHHHHHHHHCHHHEE	36.91	21906983
134	Acetylation	IAGWREATKAAREAL ECCHHHHHHHHHHHH	19.23	19608861
134	Phosphorylation	IAGWREATKAAREAL ECCHHHHHHHHHHHH	19.23	22210691
143	Phosphorylation	AAREALLSSAVDHGS HHHHHHHHHHHHCCC	19.66	20068231
144	Phosphorylation	AREALLSSAVDHGSD HHHHHHHHHHHCCCC	32.08	20068231
150	Phosphorylation	SSAVDHGSDEVKFRQ HHHHHCCCCCHHHHH	27.46	20068231
154	Ubiquitination	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	21890473
154	Ubiquitination	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	21890473
154	Ubiquitination	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	21890473
154	Ubiquitination	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	21890473
154	Ubiquitination	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	21890473
154	Acetylation	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	19608861
154	Malonylation	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	26320211
154	Ubiquitination	DHGSDEVKFRQDLMN HCCCCCHHHHHHHHH	32.55	20639865
160	Sulfoxidation	VKFRQDLMNIAGTTL HHHHHHHHHHHCCCH	4.60	21406390
165	Phosphorylation	DLMNIAGTTLSSKLL HHHHHHCCCHHHHHH	18.62	23403867
166	Phosphorylation	LMNIAGTTLSSKLLT HHHHHCCCHHHHHHH	24.59	23403867
168	Phosphorylation	NIAGTTLSSKLLTHH HHHCCCHHHHHHHCC	24.28	23403867
169	Phosphorylation	IAGTTLSSKLLTHHK HHCCCHHHHHHHCCH	30.36	21815630
170	2-Hydroxyisobutyrylation	AGTTLSSKLLTHHKD HCCCHHHHHHHCCHH	44.11	-
170	Acetylation	AGTTLSSKLLTHHKD HCCCHHHHHHHCCHH	44.11	25953088
170	Ubiquitination	AGTTLSSKLLTHHKD HCCCHHHHHHHCCHH	44.11	-
176	Acetylation	SKLLTHHKDHFTKLA HHHHHCCHHHHHHHH	45.34	26051181
176	Ubiquitination	SKLLTHHKDHFTKLA HHHHHCCHHHHHHHH	45.34	-
181	Acetylation	HHKDHFTKLAVEAVL CCHHHHHHHHHHHHH	33.24	19608861
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	21890473
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	21890473
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	21890473
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	21890473
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	21890473
191	2-Hydroxyisobutyrylation	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	-
191	Acetylation	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	23749302
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	21890473
193	Phosphorylation	AVLRLKGSGNLEAIH HHHHHCCCCCHHHHH	23.95	23312004
203	Ubiquitination	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	21890473
203	Ubiquitination	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	21890473
203	Ubiquitination	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	21890473
203	Ubiquitination	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	21890473
203	Ubiquitination	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	21890473
203	2-Hydroxyisobutyrylation	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	-
203	Acetylation	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	25953088
203	Ubiquitination	LEAIHIIKKLGGSLA HHHHHHHHHHCCCCH	41.14	21890473
204	2-Hydroxyisobutyrylation	EAIHIIKKLGGSLAD HHHHHHHHHCCCCHH	41.79	-
204	Ubiquitination	EAIHIIKKLGGSLAD HHHHHHHHHCCCCHH	41.79	21906983
208	Phosphorylation	IIKKLGGSLADSYLD HHHHHCCCCHHHHHC	20.70	28152594
212	Phosphorylation	LGGSLADSYLDEGFL HCCCCHHHHHCCCCC	23.22	28152594
213	Nitration	GGSLADSYLDEGFLL CCCCHHHHHCCCCCC	20.79	-
213	Phosphorylation	GGSLADSYLDEGFLL CCCCHHHHHCCCCCC	20.79	28152594
222	Acetylation	DEGFLLDKKIGVNQP CCCCCCCCCCCCCCC	46.38	23236377
222	Ubiquitination	DEGFLLDKKIGVNQP CCCCCCCCCCCCCCC	46.38	21906983
223	Sumoylation	EGFLLDKKIGVNQPK CCCCCCCCCCCCCCC	44.34	-
223	2-Hydroxyisobutyrylation	EGFLLDKKIGVNQPK CCCCCCCCCCCCCCC	44.34	-
223	Sumoylation	EGFLLDKKIGVNQPK CCCCCCCCCCCCCCC	44.34	-
223	Ubiquitination	EGFLLDKKIGVNQPK CCCCCCCCCCCCCCC	44.34	-
230	Ubiquitination	KIGVNQPKRIENAKI CCCCCCCCHHHCCEE	57.13	-
236	Ubiquitination	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	21890473
236	Ubiquitination	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	21890473
236	Ubiquitination	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	21890473
236	Ubiquitination	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	21890473
236	Ubiquitination	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	21890473
236	2-Hydroxyisobutyrylation	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	-
236	Acetylation	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	25953088
236	Ubiquitination	PKRIENAKILIANTG CCHHHCCEEEEECCC	50.02	21906983
242	Phosphorylation	AKILIANTGMDTDKI CEEEEECCCCCHHHE	25.51	20860994
244	Sulfoxidation	ILIANTGMDTDKIKI EEEECCCCCHHHEEE	4.76	21406390
246	Phosphorylation	IANTGMDTDKIKIFG EECCCCCHHHEEECC	30.24	21815630
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	21890473
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	21890473
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	21890473
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	21890473
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	21890473
248	2-Hydroxyisobutyrylation	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	-
248	Acetylation	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	23954790
248	Sumoylation	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	28112733
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	21906983
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	21890473
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	21890473
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	21890473
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	21890473
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	21890473
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	21906983
254	Phosphorylation	DKIKIFGSRVRVDST HHEEECCCCEEECCC	19.49	25056879
260	Phosphorylation	GSRVRVDSTAKVAEI CCCEEECCCCHHHHH	27.66	27273156
261	Phosphorylation	SRVRVDSTAKVAEIE CCEEECCCCHHHHHH	26.49	28176443
263	2-Hydroxyisobutyrylation	VRVDSTAKVAEIEHA EEECCCCHHHHHHHH	41.91	-
263	Ubiquitination	VRVDSTAKVAEIEHA EEECCCCHHHHHHHH	41.91	21906983
272	Acetylation	AEIEHAEKEKMKEKV HHHHHHHHHHHHHHH	64.52	23749302
272	Succinylation	AEIEHAEKEKMKEKV HHHHHHHHHHHHHHH	64.52	23954790
272	Ubiquitination	AEIEHAEKEKMKEKV HHHHHHHHHHHHHHH	64.52	-
274	Ubiquitination	IEHAEKEKMKEKVER HHHHHHHHHHHHHHH	67.36	-
278	Ubiquitination	EKEKMKEKVERILKH HHHHHHHHHHHHHHH	43.83	-
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	21890473
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	21890473
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	21890473
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	21890473
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	21890473
284	Acetylation	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	25953088
284	Methylation	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	-
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	21906983
297	Phosphorylation	FINRQLIYNYPEQLF EECCHHHHCCHHHHH	19.75	22817900
342	2-Hydroxyisobutyrylation	FDHPELVKLGSCKLI CCCHHHHCCCCCCEE	60.81	-
342	Acetylation	FDHPELVKLGSCKLI CCCHHHHCCCCCCEE	60.81	25953088
342	Ubiquitination	FDHPELVKLGSCKLI CCCHHHHCCCCCCEE	60.81	21906983
347	Ubiquitination	LVKLGSCKLIEEVMI HHCCCCCCEEEEEEE	54.95	-
353	Sulfoxidation	CKLIEEVMIGEDKLI CCEEEEEEECCCCEE	3.54	21406390
379	Phosphorylation	TIVLRGATQQILDEA HHHHCHHHHHHHHHH	24.67	21406692
389	Phosphorylation	ILDEAERSLHDALCV HHHHHHHHHHHHHHH	22.89	28450419
395	Glutathionylation	RSLHDALCVLAQTVK HHHHHHHHHHHHHHC	2.24	22555962
395	S-palmitoylation	RSLHDALCVLAQTVK HHHHHHHHHHHHHHC	2.24	29575903
402	Acetylation	CVLAQTVKDSRTVYG HHHHHHHCCCCCEEC	54.06	25953088
402	Ubiquitination	CVLAQTVKDSRTVYG HHHHHHHCCCCCEEC	54.06	21906983
404	Phosphorylation	LAQTVKDSRTVYGGG HHHHHCCCCCEECCC	24.92	22210691
406	Phosphorylation	QTVKDSRTVYGGGCS HHHCCCCCEECCCHH	23.25	23403867
408	Phosphorylation	VKDSRTVYGGGCSEM HCCCCCEECCCHHHH	14.94	22210691
413	Phosphorylation	TVYGGGCSEMLMAHA CEECCCHHHHHHHHH	29.34	22210691
415	Sulfoxidation	YGGGCSEMLMAHAVT ECCCHHHHHHHHHHH	1.46	30846556
417	Sulfoxidation	GGCSEMLMAHAVTQL CCHHHHHHHHHHHHH	2.19	30846556
422	Phosphorylation	MLMAHAVTQLANRTP HHHHHHHHHHHHCCC	20.74	25627689
427	Methylation	AVTQLANRTPGKEAV HHHHHHHCCCCCHHH	36.37	-
428	Phosphorylation	VTQLANRTPGKEAVA HHHHHHCCCCCHHHH	35.88	25159151
431	Acetylation	LANRTPGKEAVAMES HHHCCCCCHHHHHHH	43.64	26051181
431	Ubiquitination	LANRTPGKEAVAMES HHHCCCCCHHHHHHH	43.64	21906983
436	Sulfoxidation	PGKEAVAMESYAKAL CCCHHHHHHHHHHHH	2.56	30846556
438	Phosphorylation	KEAVAMESYAKALRM CHHHHHHHHHHHHHH	19.80	21712546
439	Phosphorylation	EAVAMESYAKALRML HHHHHHHHHHHHHHH	9.98	23403867
441	Ubiquitination	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	21890473
441	Ubiquitination	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	21890473
441	Ubiquitination	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	21890473
441	Ubiquitination	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	21890473
441	Ubiquitination	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	21890473
441	2-Hydroxyisobutyrylation	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	-
441	Acetylation	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	25953088
441	Ubiquitination	VAMESYAKALRMLPT HHHHHHHHHHHHHCH	39.46	21890473
445	Sulfoxidation	SYAKALRMLPTIIAD HHHHHHHHHCHHHHC	5.67	30846556
448	Phosphorylation	KALRMLPTIIADNAG HHHHHHCHHHHCCCC	22.51	-
456	Phosphorylation	IIADNAGYDSADLVA HHHCCCCCCHHHHHH	12.33	-
458	Phosphorylation	ADNAGYDSADLVAQL HCCCCCCHHHHHHHH	18.39	-
470	Phosphorylation	AQLRAAHSEGNTTAG HHHHHHHHCCCCCCC	42.33	28985074
480	Sulfoxidation	NTTAGLDMREGTIGD CCCCCCCCCCCCHHH	5.16	21406390
500	Ubiquitination	ITESFQVKRQVLLSA CCCCHHHHHHHHHHH	26.74	-
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	21890473
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	21890473
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	21890473
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	21890473
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	21890473
522	Acetylation	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	25953088
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	21890473
527	Ubiquitination	IIKAAPRKRVPDHHP HHHHCCCCCCCCCCC	57.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
260	S	Phosphorylation	Kinase	AKT1	P31749	PSP
260	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
260	S	Phosphorylation	Kinase	RPS6KB1	P23443	GPS
260	S	Phosphorylation	Kinase	RSK-SUBFAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TCPB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TCPB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNE1_HUMAN	CCNE1	physical	9819444
PACRG_HUMAN	PACRG	physical	14532270
TCPD_HUMAN	CCT4	physical	22939629
TCPE_HUMAN	CCT5	physical	22939629
TCPG_HUMAN	CCT3	physical	22939629
TCPQ_HUMAN	CCT8	physical	22939629
TCPZ_HUMAN	CCT6A	physical	22939629
TCPH_HUMAN	CCT7	physical	22939629
TCPW_HUMAN	CCT6B	physical	22939629
TIF1B_HUMAN	TRIM28	physical	22939629
TXNL1_HUMAN	TXNL1	physical	22939629
ACTS_HUMAN	ACTA1	physical	23190606
TBA1B_HUMAN	TUBA1B	physical	23190606
EF2_HUMAN	EEF2	physical	23190606
RS3_HUMAN	RPS3	physical	23190606
ENPL_HUMAN	HSP90B1	physical	23190606
ERLN2_HUMAN	ERLIN2	physical	23190606
TERA_HUMAN	VCP	physical	23190606
PSMD2_HUMAN	PSMD2	physical	23190606
XIAP_HUMAN	XIAP	physical	23190606
CASP7_HUMAN	CASP7	physical	23190606
HS90B_HUMAN	HSP90AB1	physical	23190606
PRS10_HUMAN	PSMC6	physical	23190606
HS90A_HUMAN	HSP90AA1	physical	23190606
TCPG_HUMAN	CCT3	physical	22863883
TCPZ_HUMAN	CCT6A	physical	22863883
TCPH_HUMAN	CCT7	physical	22863883
EF1D_HUMAN	EEF1D	physical	22863883
IQGA1_HUMAN	IQGAP1	physical	22863883
PSB8_HUMAN	PSMB8	physical	22863883
TCPA_HUMAN	TCP1	physical	22863883
TCPQ_HUMAN	CCT8	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
IMA3_HUMAN	KPNA4	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TCPB_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-13; LYS-154 AND LYS-181, ANDMASS SPECTROMETRY.	19608861 [Abstract]