TXNL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXNL1_HUMAN
• UniProt AC: O43396
• Protein Name: Thioredoxin-like protein 1
• Gene Name: TXNL1
• Organism: Homo sapiens (Human).
• Sequence Length: 289
• Subcellular Localization: Cytoplasm . Nucleus . At least 85% of the cellular TXNL1 is proteasome-associated.
• Protein Description: Active thioredoxin with a redox potential of about -250 mV..
• Protein Sequence: MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MVGVKPVGSDPD ---CCCCCCCCCCCC	28.23	21906983
9	Phosphorylation	VGVKPVGSDPDFQPE CCCCCCCCCCCCCHH	46.32	28192239
18	Phosphorylation	PDFQPELSGAGSRLA CCCCHHHCCCCCCEE	25.57	20068231
22	Phosphorylation	PELSGAGSRLAVVKF HHHCCCCCCEEEEEE	24.48	20068231
28	Ubiquitination	GSRLAVVKFTMRGCG CCCEEEEEEECCCCC	28.63	21890473
34	S-nitrosylation	VKFTMRGCGPCLRIA EEEECCCCCHHHHHH	3.76	23010496
37	S-nitrosylation	TMRGCGPCLRIAPAF ECCCCCHHHHHHHHH	2.12	23010496
45	Phosphorylation	LRIAPAFSSMSNKYP HHHHHHHHHHCCCCC	27.51	20068231
46	Phosphorylation	RIAPAFSSMSNKYPQ HHHHHHHHHCCCCCC	21.56	20068231
47	Sulfoxidation	IAPAFSSMSNKYPQA HHHHHHHHCCCCCCE	5.05	21406390
48	Phosphorylation	APAFSSMSNKYPQAV HHHHHHHCCCCCCEE	31.92	20068231
102	Ubiquitination	DAVGLEEKIKQHLEN CCCCHHHHHHHHHHC	45.92	21906983
104	Ubiquitination	VGLEEKIKQHLENDP CCHHHHHHHHHHCCC	42.61	21906983
113	Phosphorylation	HLENDPGSNEDTDIP HHHCCCCCCCCCCCC	42.29	25159151
117	Phosphorylation	DPGSNEDTDIPKGYM CCCCCCCCCCCCCHH	29.65	30278072
121	Ubiquitination	NEDTDIPKGYMDLMP CCCCCCCCCHHHHHH	64.11	21906983
124	Sulfoxidation	TDIPKGYMDLMPFIN CCCCCCHHHHHHHHH	4.32	30846556
127	Sulfoxidation	PKGYMDLMPFINKAG CCCHHHHHHHHHHHC	1.91	30846556
141	Phosphorylation	GCECLNESDEHGFDN CCCCCCCCCCCCCCC	47.42	-
181	Ubiquitination	PVKLYSMKFQGPDNG CEEEEEEEEECCCCC	28.70	21890473
192	Ubiquitination	PDNGQGPKYVKIFIN CCCCCCCCEEEEEEE	70.29	-
192	Acetylation	PDNGQGPKYVKIFIN CCCCCCCCEEEEEEE	70.29	26051181
195	Ubiquitination	GQGPKYVKIFINLPR CCCCCEEEEEEECCC	28.89	-
204	Sulfoxidation	FINLPRSMDFEEAER EEECCCCCCHHHHHH	7.85	21406390
221	Phosphorylation	PTQALELTEDDIKED CCCCEECCHHHHCCC	28.17	-
226	Ubiquitination	ELTEDDIKEDGIVPL ECCHHHHCCCCEEEE	57.66	-
257	Phosphorylation	SNQGEEETTRISYFT CCCCCEEEEEEEEEE	25.34	20068231
258	Phosphorylation	NQGEEETTRISYFTF CCCCEEEEEEEEEEE	29.32	20068231
262	Phosphorylation	EETTRISYFTFIGTP EEEEEEEEEEECCCC	12.31	19702290
268	Phosphorylation	SYFTFIGTPVQATNM EEEEECCCCEECCCH	18.57	29214152
279	Ubiquitination	ATNMNDFKRVVGKKG CCCHHHHHHHHCCCC	47.34	21906983
279	Acetylation	ATNMNDFKRVVGKKG CCCHHHHHHHHCCCC	47.34	68341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXNL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXNL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXNL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSDE_HUMAN	PSMD14	physical	19781552
PSA1_HUMAN	PSMA1	physical	19349280
PSMD7_HUMAN	PSMD7	physical	19349280
PSMD4_HUMAN	PSMD4	physical	19349277
PRS6A_HUMAN	PSMC3	physical	19349277
PSDE_HUMAN	PSMD14	physical	19349277
EF1A1_HUMAN	EEF1A1	physical	19349277
UBE3A_HUMAN	UBE3A	physical	22939629
DX39B_HUMAN	DDX39B	physical	22939629
UBP5_HUMAN	USP5	physical	22939629
VATA_HUMAN	ATP6V1A	physical	22939629
VINC_HUMAN	VCL	physical	22939629
UBP7_HUMAN	USP7	physical	22939629
XPOT_HUMAN	XPOT	physical	22939629
URM1_HUMAN	URM1	physical	22939629
UBE2H_HUMAN	UBE2H	physical	22939629
UBP16_HUMAN	USP16	physical	22939629
XPO2_HUMAN	CSE1L	physical	22939629
ADRM1_HUMAN	ADRM1	physical	22863883
FLNB_HUMAN	FLNB	physical	22863883
CND1_HUMAN	NCAPD2	physical	22863883
PRS4_HUMAN	PSMC1	physical	22863883
PRS7_HUMAN	PSMC2	physical	22863883
PRS10_HUMAN	PSMC6	physical	22863883
PSD12_HUMAN	PSMD12	physical	22863883
PSMD1_HUMAN	PSMD1	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
PSMD4_HUMAN	PSMD4	physical	22863883
PSMD8_HUMAN	PSMD8	physical	22863883
SQSTM_HUMAN	SQSTM1	physical	22863883
UCHL5_HUMAN	UCHL5	physical	22863883
COR1B_HUMAN	CORO1B	physical	26344197
DHX9_HUMAN	DHX9	physical	26344197
LSM7_HUMAN	LSM7	physical	26344197
1433S_HUMAN	SFN	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.