dbPTM

FLNB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLNB_HUMAN
UniProt AC	O75369
Protein Name	Filamin-B
Gene Name	FLNB
Organism	Homo sapiens (Human).
Sequence Length	2602
Subcellular Localization	Isoform 1: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the lo
Protein Description	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro..
Protein Sequence	MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPVTEKDLAED ----CCCCHHHHHCC	48.31	28857561
6	Acetylation	--MPVTEKDLAEDAP --CCCCHHHHHCCCC	48.99	27452117
6	Succinylation	--MPVTEKDLAEDAP --CCCCHHHHHCCCC	48.99	23954790
6	Ubiquitination	--MPVTEKDLAEDAP --CCCCHHHHHCCCC	48.99	32015554
15	Acetylation	LAEDAPWKKIQQNTF HHCCCCHHHHHHHHH	38.65	23954790
15	Methylation	LAEDAPWKKIQQNTF HHCCCCHHHHHHHHH	38.65	-
15	Succinylation	LAEDAPWKKIQQNTF HHCCCCHHHHHHHHH	38.65	23954790
15	Ubiquitination	LAEDAPWKKIQQNTF HHCCCCHHHHHHHHH	38.65	29967540
16	Malonylation	AEDAPWKKIQQNTFT HCCCCHHHHHHHHHH	41.71	26320211
16	Ubiquitination	AEDAPWKKIQQNTFT HCCCCHHHHHHHHHH	41.71	22505724
21	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH	23.26	23403867
23	Phosphorylation	KIQQNTFTRWCNEHL HHHHHHHHHHHHHHH	22.63	23186163
31	Acetylation	RWCNEHLKCVNKRIG HHHHHHHHHHHHHCC	37.74	26051181
31	Ubiquitination	RWCNEHLKCVNKRIG HHHHHHHHHHHHHCC	37.74	29967540
36	Methylation	HLKCVNKRIGNLQTD HHHHHHHHCCCCCCC	36.52	-
58	Phosphorylation	IALLEVLSQKRMYRK HHHHHHHHHHHHHHH	38.54	-
60	Ubiquitination	LLEVLSQKRMYRKYH HHHHHHHHHHHHHHC	35.44	-
60 (in isoform 8)	Ubiquitination	-	35.44	-
75	Sulfoxidation	QRPTFRQMQLENVSV CCCCHHHHHHHCHHH	4.24	28183972
91	Phosphorylation	LEFLDRESIKLVSID HHHCCHHCCEEEEEC	26.39	28060719
93	Acetylation	FLDRESIKLVSIDSK HCCHHCCEEEEECCC	52.71	25953088
93	Malonylation	FLDRESIKLVSIDSK HCCHHCCEEEEECCC	52.71	26320211
93	Ubiquitination	FLDRESIKLVSIDSK HCCHHCCEEEEECCC	52.71	27667366
96	Phosphorylation	RESIKLVSIDSKAIV HHCCEEEEECCCCEE	30.99	27499020
100	Acetylation	KLVSIDSKAIVDGNL EEEEECCCCEECCCH	38.08	23236377
100	Malonylation	KLVSIDSKAIVDGNL EEEEECCCCEECCCH	38.08	26320211
100	Ubiquitination	KLVSIDSKAIVDGNL EEEEECCCCEECCCH	38.08	32015554
142	Acetylation	DAKKQTPKQRLLGWI HHHHCCHHHHHHHHH	51.98	7427245
169	Acetylation	NQNWQDGKALGALVD CCCCCCCHHHHHHHH	49.04	24468001
177	Phosphorylation	ALGALVDSCAPGLCP HHHHHHHHCCCCCCC	12.52	-
188	Phosphorylation	GLCPDWESWDPQKPV CCCCCHHHCCCCCCC	32.31	28348404
193	Ubiquitination	WESWDPQKPVDNARE HHHCCCCCCCCHHHH	53.01	29967540
216	Phosphorylation	LGVPQVITPEEIIHP CCCCCCCCHHHCCCC	26.28	24275569
239	Ubiquitination	TYLSQFPKAKLKPGA HHHHHCCCCCCCCCC	60.48	25015289
241	Ubiquitination	LSQFPKAKLKPGAPL HHHCCCCCCCCCCCC	64.27	25015289
243	Ubiquitination	QFPKAKLKPGAPLKP HCCCCCCCCCCCCCC	40.47	25015289
249	Acetylation	LKPGAPLKPKLNPKK CCCCCCCCCCCCHHH	38.76	26051181
249	Ubiquitination	LKPGAPLKPKLNPKK CCCCCCCCCCCCHHH	38.76	25015289
251	Ubiquitination	PGAPLKPKLNPKKAR CCCCCCCCCCHHHHH	60.35	25015289
262	Methylation	KKARAYGRGIEPTGN HHHHHCCCCCCCCCC	30.18	-
267	Phosphorylation	YGRGIEPTGNMVKQP CCCCCCCCCCCCCCC	28.53	22817900
270	Sulfoxidation	GIEPTGNMVKQPAKF CCCCCCCCCCCCCEE	4.16	30846556
272	Ubiquitination	EPTGNMVKQPAKFTV CCCCCCCCCCCEEEE	39.53	33845483
306	Phosphorylation	NKEEAQVTPDSDKNK CCCCCEECCCCCCCC	14.86	21815630
309	Phosphorylation	EAQVTPDSDKNKTYS CCEECCCCCCCCEEE	52.25	21601212
311	Ubiquitination	QVTPDSDKNKTYSVE EECCCCCCCCEEEEE	65.38	33845483
313	Succinylation	TPDSDKNKTYSVEYL CCCCCCCCEEEEEEC	55.36	23954790
314	Phosphorylation	PDSDKNKTYSVEYLP CCCCCCCEEEEEECC	30.35	29759185
315	Phosphorylation	DSDKNKTYSVEYLPK CCCCCCEEEEEECCC	16.60	29759185
316	Phosphorylation	SDKNKTYSVEYLPKV CCCCCEEEEEECCCC	17.44	29759185
316 (in isoform 8)	Phosphorylation	-	17.44	27251275
319	Phosphorylation	NKTYSVEYLPKVTGL CCEEEEEECCCCCCC	26.58	-
322	Acetylation	YSVEYLPKVTGLHKV EEEEECCCCCCCCEE	50.24	26051181
326	Ubiquitination	YLPKVTGLHKVTVLF ECCCCCCCCEEEEEE	2.30	21890473
339	Phosphorylation	LFAGQHISKSPFEVS EECCCCCCCCCEEEE	25.59	27251275
339 (in isoform 8)	Phosphorylation	-	25.59	27251275
340	Acetylation	FAGQHISKSPFEVSV ECCCCCCCCCEEEEE	62.64	25953088
340	Malonylation	FAGQHISKSPFEVSV ECCCCCCCCCEEEEE	62.64	26320211
340	Ubiquitination	FAGQHISKSPFEVSV ECCCCCCCCCEEEEE	62.64	23000965
341	Phosphorylation	AGQHISKSPFEVSVD CCCCCCCCCEEEEEE	28.20	28464451
346	Phosphorylation	SKSPFEVSVDKAQGD CCCCEEEEEECCCCC	19.87	21815630
346 (in isoform 8)	Phosphorylation	-	19.87	27251275
349	Acetylation	PFEVSVDKAQGDASK CEEEEEECCCCCHHH	40.22	26051181
349	Malonylation	PFEVSVDKAQGDASK CEEEEEECCCCCHHH	40.22	26320211
349	Ubiquitination	PFEVSVDKAQGDASK CEEEEEECCCCCHHH	40.22	33845483
376	Phosphorylation	NIANKPTYFDIYTAG CCCCCCCEEEEEECC	14.05	-
401	O-linked_Glycosylation	EDPQGKNTVELLVED ECCCCCCEEEEEEEE	20.88	23301498
409	Acetylation	VELLVEDKGNQVYRC EEEEEEECCCEEEEE	46.37	25953088
419	Acetylation	QVYRCVYKPMQPGPH EEEEEEECCCCCCCE	17.39	25953088
436	Phosphorylation	KIFFAGDTIPKSPFV EEEECCCCCCCCCEE	37.96	22985185
436 (in isoform 8)	Phosphorylation	-	37.96	27251275
440	Phosphorylation	AGDTIPKSPFVVQVG CCCCCCCCCEEEEEC	20.44	25159151
440 (in isoform 8)	Phosphorylation	-	20.44	27251275
450	S-nitrosylation	VVQVGEACNPNACRA EEEECCCCCCCCCCC	8.28	2212679
458	Phosphorylation	NPNACRASGRGLQPK CCCCCCCCCCCCCCC	15.07	28555341
465	Succinylation	SGRGLQPKGVRIRET CCCCCCCCCCEEEEC	58.01	23954790
465	Ubiquitination	SGRGLQPKGVRIRET CCCCCCCCCCEEEEC	58.01	24816145
472	Phosphorylation	KGVRIRETTDFKVDT CCCEEEECCCCEEEE	23.09	-
473	Phosphorylation	GVRIRETTDFKVDTK CCEEEECCCCEEEEC	34.38	-
476	Acetylation	IRETTDFKVDTKAAG EEECCCCEEEECCCC	41.85	25953088
480	Acetylation	TDFKVDTKAAGSGEL CCCEEEECCCCCCCC	31.60	19814723
484	Phosphorylation	VDTKAAGSGELGVTM EEECCCCCCCCCCEE	25.11	27251275
484 (in isoform 8)	Phosphorylation	-	25.11	27251275
491	Sulfoxidation	SGELGVTMKGPKGLE CCCCCCEEECCCCHH	4.37	21406390
492	Acetylation	GELGVTMKGPKGLEE CCCCCEEECCCCHHH	63.80	25953088
492	Ubiquitination	GELGVTMKGPKGLEE CCCCCEEECCCCHHH	63.80	23000965
495	Ubiquitination	GVTMKGPKGLEELVK CCEEECCCCHHHHHH	82.10	21890473
495	Ubiquitination	GVTMKGPKGLEELVK CCEEECCCCHHHHHH	82.10	21890473
495	Ubiquitination	GVTMKGPKGLEELVK CCEEECCCCHHHHHH	82.10	21890473
495	Ubiquitination	GVTMKGPKGLEELVK CCEEECCCCHHHHHH	82.10	23000965
495 (in isoform 1)	Ubiquitination	-	82.10	21890473
495 (in isoform 2)	Ubiquitination	-	82.10	21890473
495 (in isoform 3)	Ubiquitination	-	82.10	21890473
495 (in isoform 4)	Ubiquitination	-	82.10	21890473
495 (in isoform 5)	Ubiquitination	-	82.10	21890473
495 (in isoform 6)	Ubiquitination	-	82.10	21890473
495 (in isoform 8)	Ubiquitination	-	82.10	-
495	Ubiquitination	GVTMKGPKGLEELVK CCEEECCCCHHHHHH	82.10	21890473
502	Acetylation	KGLEELVKQKDFLDG CCHHHHHHCCCCCCC	65.34	23236377
502	Ubiquitination	KGLEELVKQKDFLDG CCHHHHHHCCCCCCC	65.34	27667366
511	Phosphorylation	KDFLDGVYAFEYYPS CCCCCCEEEEEEECC	15.88	26657352
512	Ubiquitination	DFLDGVYAFEYYPST CCCCCEEEEEEECCC	6.59	21890473
515	Phosphorylation	DGVYAFEYYPSTPGR CCEEEEEEECCCCCC	17.77	23403867
516	Phosphorylation	GVYAFEYYPSTPGRY CEEEEEEECCCCCCE	5.41	23403867
518	Phosphorylation	YAFEYYPSTPGRYSI EEEEEECCCCCCEEE	30.98	27273156
519	Phosphorylation	AFEYYPSTPGRYSIA EEEEECCCCCCEEEE	25.84	22617229
519 (in isoform 8)	Phosphorylation	-	25.84	24719451
523	Phosphorylation	YPSTPGRYSIAITWG ECCCCCCEEEEEEEC	15.45	20068231
524	Phosphorylation	PSTPGRYSIAITWGG CCCCCCEEEEEEECC	12.27	20068231
528	Phosphorylation	GRYSIAITWGGHHIP CCEEEEEEECCCCCC	14.72	20068231
537	Phosphorylation	GGHHIPKSPFEVQVG CCCCCCCCCCEEECC	29.48	21406692
549	Sulfoxidation	QVGPEAGMQKVRAWG ECCCHHCHHHHHCCC	4.49	21406390
551	Ubiquitination	GPEAGMQKVRAWGPG CCHHCHHHHHCCCCC	25.46	-
551 (in isoform 8)	Ubiquitination	-	25.46	-
567	Phosphorylation	HGGIVGRSADFVVES CCCCCCCCCCEEEEE	26.68	22817900
596	Phosphorylation	PSQAKIEYNDQNDGS CCCCEEEECCCCCCC	27.75	22817900
603	Phosphorylation	YNDQNDGSCDVKYWP ECCCCCCCCEEEEEC	15.26	21712546
603 (in isoform 8)	Phosphorylation	-	15.26	27251275
604	S-nitrosocysteine	NDQNDGSCDVKYWPK CCCCCCCCEEEEECC	9.48	-
604	S-nitrosylation	NDQNDGSCDVKYWPK CCCCCCCCEEEEECC	9.48	19483679
604	S-palmitoylation	NDQNDGSCDVKYWPK CCCCCCCCEEEEECC	9.48	26865113
607	Acetylation	NDGSCDVKYWPKEPG CCCCCEEEEECCCCC	28.48	26051181
607	Ubiquitination	NDGSCDVKYWPKEPG CCCCCEEEEECCCCC	28.48	29967540
630	Phosphorylation	DDEDIKDSPYMAFIH CCHHCCCCCCEEEEE	16.96	22817900
632	Phosphorylation	EDIKDSPYMAFIHPA HHCCCCCCEEEEECC	12.67	27259358
640	Phosphorylation	MAFIHPATGGYNPDL EEEEECCCCCCCHHH	35.27	22817900
651	Phosphorylation	NPDLVRAYGPGLEKS CHHHHHHHCCCCCCC	17.18	28152594
657	Acetylation	AYGPGLEKSGCIVNN HHCCCCCCCCEEECC	58.13	26051181
657	Ubiquitination	AYGPGLEKSGCIVNN HHCCCCCCCCEEECC	58.13	29967540
658	Phosphorylation	YGPGLEKSGCIVNNL HCCCCCCCCEEECCC	29.53	22617229
658 (in isoform 8)	Phosphorylation	-	29.53	24719451
660	S-nitrosocysteine	PGLEKSGCIVNNLAE CCCCCCCEEECCCEE	3.97	-
660	Glutathionylation	PGLEKSGCIVNNLAE CCCCCCCEEECCCEE	3.97	22555962
660	S-nitrosylation	PGLEKSGCIVNNLAE CCCCCCCEEECCCEE	3.97	19483679
669	Phosphorylation	VNNLAEFTVDPKDAG ECCCEEEECCHHHCC	18.59	21406692
673	Acetylation	AEFTVDPKDAGKAPL EEEECCHHHCCCCCE	56.60	26051181
677	Acetylation	VDPKDAGKAPLKIFA CCHHHCCCCCEEEEE	48.85	25953088
677	Ubiquitination	VDPKDAGKAPLKIFA CCHHHCCCCCEEEEE	48.85	33845483
681	Ubiquitination	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	21890473
681	Ubiquitination	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	21890473
681	Ubiquitination	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	21890473
681	Acetylation	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	19608861
681	Malonylation	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	26320211
681	Ubiquitination	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	33845483
681 (in isoform 1)	Ubiquitination	-	34.42	21890473
681 (in isoform 2)	Ubiquitination	-	34.42	21890473
681 (in isoform 3)	Ubiquitination	-	34.42	21890473
681 (in isoform 4)	Ubiquitination	-	34.42	21890473
681 (in isoform 5)	Ubiquitination	-	34.42	21890473
681 (in isoform 6)	Ubiquitination	-	34.42	21890473
681	Ubiquitination	DAGKAPLKIFAQDGE HCCCCCEEEEEECCC	34.42	21890473
697	Acetylation	QRIDIQMKNRMDGTY CEEEEEECCCCCCEE	25.65	25953088
697	Malonylation	QRIDIQMKNRMDGTY CEEEEEECCCCCCEE	25.65	26320211
697	Ubiquitination	QRIDIQMKNRMDGTY CEEEEEECCCCCCEE	25.65	32015554
697 (in isoform 8)	Ubiquitination	-	25.65	-
703	Phosphorylation	MKNRMDGTYACSYTP ECCCCCCEEECCCCC	12.04	28985074
704	Phosphorylation	KNRMDGTYACSYTPV CCCCCCEEECCCCCH	15.90	25147952
704 (in isoform 8)	Phosphorylation	-	15.90	27642862
706	Glutathionylation	RMDGTYACSYTPVKA CCCCEEECCCCCHHH	1.94	22555962
707	Phosphorylation	MDGTYACSYTPVKAI CCCEEECCCCCHHHC	24.70	22199227
708	Phosphorylation	DGTYACSYTPVKAIK CCEEECCCCCHHHCC	18.23	22199227
708 (in isoform 8)	Phosphorylation	-	18.23	27642862
709	Phosphorylation	GTYACSYTPVKAIKH CEEECCCCCHHHCCC	12.81	25159151
709 (in isoform 8)	Phosphorylation	-	12.81	24719451
712	Acetylation	ACSYTPVKAIKHTIA ECCCCCHHHCCCEEE	45.67	26051181
717	Phosphorylation	PVKAIKHTIAVVWGG CHHHCCCEEEEEECC	12.96	24732914
730	Phosphorylation	GGVNIPHSPYRVNIG CCCCCCCCCCEEECC	20.48	25159151
730 (in isoform 8)	Phosphorylation	-	20.48	27251275
732	Phosphorylation	VNIPHSPYRVNIGQG CCCCCCCCEEECCCC	30.15	24732914
740	Phosphorylation	RVNIGQGSHPQKVKV EEECCCCCCCCEEEE	24.89	28674419
744	Acetylation	GQGSHPQKVKVFGPG CCCCCCCEEEEECCC	48.77	25953088
746	Malonylation	GSHPQKVKVFGPGVE CCCCCEEEEECCCCC	38.59	26320211
746	Ubiquitination	GSHPQKVKVFGPGVE CCCCCEEEEECCCCC	38.59	33845483
755	Phosphorylation	FGPGVERSGLKANEP ECCCCCCCCCCCCCC	34.66	25159151
769	Glutathionylation	PTHFTVDCTEAGEGD CCEEEEECCCCCCCC	3.01	22555962
789	Phosphorylation	KCDARVLSEDEEDVD EEEEEECCCCCCCCC	39.90	30266825
789 (in isoform 8)	Phosphorylation	-	39.90	27251275
827	Phosphorylation	TIKVLFASQEIPASP EEEEEEECCCCCCCC	22.47	24732914
827 (in isoform 8)	Phosphorylation	-	22.47	24719451
833	Phosphorylation	ASQEIPASPFRVKVD ECCCCCCCCCEEEEC	21.15	25159151
833 (in isoform 8)	Phosphorylation	-	21.15	24719451
838	Ubiquitination	PASPFRVKVDPSHDA CCCCCEEEECCCCCH	36.34	33845483
842	Phosphorylation	FRVKVDPSHDASKVK CEEEECCCCCHHHCC	29.54	23403867
846	Phosphorylation	VDPSHDASKVKAEGP ECCCCCHHHCCCCCC	44.00	26437602
864	Acetylation	KAGVENGKPTHFTVY CCCCCCCCCCEEEEE	59.32	26051181
873	Ubiquitination	THFTVYTKGAGKAPL CEEEEEECCCCCCCE	29.13	32015554
877	Acetylation	VYTKGAGKAPLNVQF EEECCCCCCCEEEEE	46.42	25953088
886	Phosphorylation	PLNVQFNSPLPGDAV CEEEEECCCCCCCCC	29.15	25159151
886 (in isoform 8)	Phosphorylation	-	29.15	27251275
902	Phosphorylation	DLDIIDNYDYSHTVK CCEEECCCCCCCEEE	16.71	28796482
902 (in isoform 8)	Phosphorylation	-	16.71	27642862
903	Phosphorylation	LDIIDNYDYSHTVKY CEEECCCCCCCEEEE	44.72	17016520
904	Phosphorylation	DIIDNYDYSHTVKYT EEECCCCCCCEEEEC	7.62	28102081
904 (in isoform 8)	Phosphorylation	-	7.62	27642862
905	Phosphorylation	IIDNYDYSHTVKYTP EECCCCCCCEEEECC	15.13	28796482
905 (in isoform 8)	Phosphorylation	-	15.13	27642862
907	Phosphorylation	DNYDYSHTVKYTPTQ CCCCCCCEEEECCCC	16.86	28796482
910	Phosphorylation	DYSHTVKYTPTQQGN CCCCEEEECCCCCCC	17.39	28674419
911	Phosphorylation	YSHTVKYTPTQQGNM CCCEEEECCCCCCCE	17.72	25159151
913	Phosphorylation	HTVKYTPTQQGNMQV CEEEECCCCCCCEEE	26.23	25627689
932	Phosphorylation	GGDPIPKSPFTVGVA CCCCCCCCCCEEEEE	21.64	25159151
932 (in isoform 8)	Phosphorylation	-	21.64	27251275
935	Phosphorylation	PIPKSPFTVGVAAPL CCCCCCCEEEEECCC	21.53	25627689
945	Phosphorylation	VAAPLDLSKIKLNGL EECCCCHHHCCCCCC	31.81	29396449
945 (in isoform 8)	Phosphorylation	-	31.81	27251275
946	Acetylation	AAPLDLSKIKLNGLE ECCCCHHHCCCCCCC	51.67	25953088
948	Acetylation	PLDLSKIKLNGLENR CCCHHHCCCCCCCCC	39.37	25953088
955	Methylation	KLNGLENRVEVGKDQ CCCCCCCCEEECCCC	19.32	-
960	Ubiquitination	ENRVEVGKDQEFTVD CCCEEECCCCCEEEE	62.51	24816145
965	Phosphorylation	VGKDQEFTVDTRGAG ECCCCCEEEECCCCC	19.40	22817900
968	Phosphorylation	DQEFTVDTRGAGGQG CCCEEEECCCCCCCC	27.02	22817900
969	Methylation	QEFTVDTRGAGGQGK CCEEEECCCCCCCCE	28.62	-
976	Acetylation	RGAGGQGKLDVTILS CCCCCCCEEEEEEEC	33.36	26051181
976	Ubiquitination	RGAGGQGKLDVTILS CCCCCCCEEEEEEEC	33.36	33845483
980	Phosphorylation	GQGKLDVTILSPSRK CCCEEEEEEECCCCC	18.83	25159151
983	Phosphorylation	KLDVTILSPSRKVVP EEEEEEECCCCCEEE	19.58	19664994
983 (in isoform 8)	Phosphorylation	-	19.58	24719451
985	Phosphorylation	DVTILSPSRKVVPCL EEEEECCCCCEEEEE	41.16	30266825
987	Malonylation	TILSPSRKVVPCLVT EEECCCCCEEEEEEE	52.50	26320211
994	Phosphorylation	KVVPCLVTPVTGREN CEEEEEEECCCCCCC	10.09	25159151
994 (in isoform 8)	Phosphorylation	-	10.09	24719451
997	Phosphorylation	PCLVTPVTGRENSTA EEEEECCCCCCCCCC	31.55	24732914
1002	Phosphorylation	PVTGRENSTAKFIPR CCCCCCCCCCCEECC	25.62	29514088
1003	Phosphorylation	VTGRENSTAKFIPRE CCCCCCCCCCEECCC	45.51	29514088
1005	Acetylation	GRENSTAKFIPREEG CCCCCCCCEECCCCC	43.87	25953088
1005	Ubiquitination	GRENSTAKFIPREEG CCCCCCCCEECCCCC	43.87	24816145
1014 (in isoform 8)	Phosphorylation	-	18.55	27642862
1020	Phosphorylation	LYAVDVTYDGHPVPG EEEEEEEECCEECCC	21.56	18669648
1028	Phosphorylation	DGHPVPGSPYTVEAS CCEECCCCCEEEEEE	14.52	25159151
1028 (in isoform 8)	Phosphorylation	-	14.52	27642862
1030	Phosphorylation	HPVPGSPYTVEASLP EECCCCCEEEEEECC	25.72	25159151
1031	Phosphorylation	PVPGSPYTVEASLPP ECCCCCEEEEEECCC	18.43	28348404
1035	Phosphorylation	SPYTVEASLPPDPSK CCEEEEEECCCCHHH	28.09	25159151
1044	Malonylation	PPDPSKVKAHGPGLE CCCHHHCCCCCCCCC	38.10	26320211
1057	Acetylation	LEGGLVGKPAEFTID CCCCCCCCCEEEEEE	33.31	26051181
1057	Ubiquitination	LEGGLVGKPAEFTID CCCCCCCCCEEEEEE	33.31	29967540
1081	Glutathionylation	GLTVEGPCEAKIECS CCEEECCCEEEEEEC	13.44	22555962
1081	S-nitrosylation	GLTVEGPCEAKIECS CCEEECCCEEEEEEC	13.44	2212679
1121	Phosphorylation	EEVHIPGSPFKADIE EEECCCCCCCCCEEE	23.08	25159151
1129	Sulfoxidation	PFKADIEMPFDPSKV CCCCEEECCCCHHHE	4.02	30846556
1139	Phosphorylation	DPSKVVASGPGLEHG CHHHEEEECCCCCCC	33.63	28674419
1147	Ubiquitination	GPGLEHGKVGEAGLL CCCCCCCCCCCCEEE	49.31	-
1172	Phosphorylation	ALGLEAVSDSGTKAE CEEEEEECCCCCEEE	32.86	28348404
1172 (in isoform 8)	Phosphorylation	-	32.86	27251275
1174	Phosphorylation	GLEAVSDSGTKAEVS EEEEECCCCCEEEEE	40.64	21712546
1181	Phosphorylation	SGTKAEVSIQNNKDG CCCEEEEEEEECCCC	15.23	22817900
1189	Phosphorylation	IQNNKDGTYAVTYVP EEECCCCCEEEEEEE	20.59	18452278
1198	Phosphorylation	AVTYVPLTAGMYTLT EEEEEEECCEEEEEE	18.33	22817900
1203	Phosphorylation	PLTAGMYTLTMKYGG EECCEEEEEEEEECC	13.58	22817900
1221	Acetylation	PHFPARVKVEPAVDT CCCCCEEEEECCCCC	35.01	26051181
1221	Ubiquitination	PHFPARVKVEPAVDT CCCCCEEEEECCCCC	35.01	33845483
1241	Ubiquitination	FGPGIEGKDVFREAT ECCCCCCCHHHHHCC	37.62	23000965
1259	Phosphorylation	TVDSRPLTQVGGDHI EECCCCCEEECCCCE	24.72	22817900
1274	Phosphorylation	KAHIANPSGASTECF EEEECCCCCCCEEEE	46.96	24719451
1274 (in isoform 8)	Phosphorylation	-	46.96	24719451
1277	Phosphorylation	IANPSGASTECFVTD ECCCCCCCEEEEEEE	28.41	28857561
1278	Phosphorylation	ANPSGASTECFVTDN CCCCCCCEEEEEEEC	35.92	28857561
1280	Glutathionylation	PSGASTECFVTDNAD CCCCCEEEEEEECCC	3.17	22555962
1283	Phosphorylation	ASTECFVTDNADGTY CCEEEEEEECCCCCE	11.86	28857561
1289	Phosphorylation	VTDNADGTYQVEYTP EEECCCCCEEEEEEC	16.01	28796482
1289 (in isoform 8)	Phosphorylation	-	16.01	27642862
1290	Phosphorylation	TDNADGTYQVEYTPF EECCCCCEEEEEECC	18.98	28796482
1290 (in isoform 8)	Phosphorylation	-	18.98	27642862
1294	Phosphorylation	DGTYQVEYTPFEKGL CCCEEEEEECCCCCE	22.36	28796482
1294 (in isoform 8)	Phosphorylation	-	22.36	27642862
1295	Phosphorylation	GTYQVEYTPFEKGLH CCEEEEEECCCCCEE	14.16	28796482
1307	Phosphorylation	GLHVVEVTYDDVPIP CEEEEEEEECCCCCC	14.02	29396449
1307 (in isoform 8)	Phosphorylation	-	14.02	27642862
1308	Phosphorylation	LHVVEVTYDDVPIPN EEEEEEEECCCCCCC	18.47	30266825
1308 (in isoform 8)	Phosphorylation	-	18.47	27642862
1316	Phosphorylation	DDVPIPNSPFKVAVT CCCCCCCCCCEEEEE	26.76	30266825
1316 (in isoform 8)	Phosphorylation	-	26.76	24719451
1319	Ubiquitination	PIPNSPFKVAVTEGC CCCCCCCEEEEECCC	32.44	32015554
1323	Phosphorylation	SPFKVAVTEGCQPSR CCCEEEEECCCCCHH	19.54	26270265
1326	S-nitrosocysteine	KVAVTEGCQPSRVQA EEEEECCCCCHHCCC	4.35	-
1326	Glutathionylation	KVAVTEGCQPSRVQA EEEEECCCCCHHCCC	4.35	22555962
1326	S-nitrosylation	KVAVTEGCQPSRVQA EEEEECCCCCHHCCC	4.35	20140087
1329	Phosphorylation	VTEGCQPSRVQAQGP EECCCCCHHCCCCCC	21.14	21712546
1345	Acetylation	LKEAFTNKPNVFTVV HHHHHCCCCCEEEEE	34.61	26051181
1345	Succinylation	LKEAFTNKPNVFTVV HHHHHCCCCCEEEEE	34.61	23954790
1364	Phosphorylation	GIGGLGITVEGPSES CCCCCEEEEECCCCC	15.65	21406692
1369	Phosphorylation	GITVEGPSESKINCR EEEEECCCCCCEECC	66.42	21406692
1371	Phosphorylation	TVEGPSESKINCRDN EEECCCCCCEECCCC	43.08	21406692
1372	Acetylation	VEGPSESKINCRDNK EECCCCCCEECCCCC	33.61	25953088
1372	Ubiquitination	VEGPSESKINCRDNK EECCCCCCEECCCCC	33.61	29967540
1379	Acetylation	KINCRDNKDGSCSAE CEECCCCCCCCCEEE	68.69	26051181
1400	Phosphorylation	GDYDVNITYGGAHIP CCCEEEEEECCCCCC	15.77	25627689
1409	Phosphorylation	GGAHIPGSPFRVPVK CCCCCCCCCCCCCCC	18.60	22199227
1409 (in isoform 8)	Phosphorylation	-	18.60	27251275
1416	Acetylation	SPFRVPVKDVVDPSK CCCCCCCCCCCCHHH	38.44	23954790
1422	O-linked_Glycosylation	VKDVVDPSKVKIAGP CCCCCCHHHCEECCC	45.69	23301498
1422	Phosphorylation	VKDVVDPSKVKIAGP CCCCCCHHHCEECCC	45.69	22817900
1423	Acetylation	KDVVDPSKVKIAGPG CCCCCHHHCEECCCC	53.59	26051181
1425	Malonylation	VVDPSKVKIAGPGLG CCCHHHCEECCCCCC	30.49	26320211
1433	Phosphorylation	IAGPGLGSGVRARVL ECCCCCCCCHHHHEE	38.87	25159151
1433 (in isoform 8)	Phosphorylation	-	38.87	24719451
1438	Methylation	LGSGVRARVLQSFTV CCCCHHHHEEEEEEC	21.08	-
1442	Phosphorylation	VRARVLQSFTVDSSK HHHHEEEEEECCCCC	20.80	20068231
1442 (in isoform 8)	Phosphorylation	-	20.80	27251275
1444	Phosphorylation	ARVLQSFTVDSSKAG HHEEEEEECCCCCCC	28.75	20068231
1447	Phosphorylation	LQSFTVDSSKAGLAP EEEEECCCCCCCCCC	29.42	20068231
1448	Phosphorylation	QSFTVDSSKAGLAPL EEEECCCCCCCCCCE	23.28	20068231
1449	Acetylation	SFTVDSSKAGLAPLE EEECCCCCCCCCCEE	50.88	23236377
1449	Ubiquitination	SFTVDSSKAGLAPLE EEECCCCCCCCCCEE	50.88	23000965
1467 (in isoform 8)	Phosphorylation	-	48.88	26657352
1469 (in isoform 8)	Phosphorylation	-	5.55	30266825
1471 (in isoform 8)	Phosphorylation	-	6.11	30266825
1474 (in isoform 8)	Phosphorylation	-	38.55	22496350
1477	Ubiquitination	NVVDNGDGTHTVTYT EEEECCCCCEEEEEC	22.31	33845483
1477 (in isoform 8)	Methylation	-	22.31	-
1480 (in isoform 8)	Phosphorylation	-	17.87	27251275
1484	Ubiquitination	GTHTVTYTPSQEGPY CCEEEEECCCCCCCE	13.70	33845483
1497	Phosphorylation	PYMVSVKYADEEIPR CEEEEEEECCCCCCC	19.68	23403867
1505	Phosphorylation	ADEEIPRSPFKVKVL CCCCCCCCCCEEEEE	29.36	30266825
1508	Ubiquitination	EIPRSPFKVKVLPTY CCCCCCCEEEEECCC	44.52	32015554
1510	Malonylation	PRSPFKVKVLPTYDA CCCCCEEEEECCCCC	38.35	26320211
1514	Phosphorylation	FKVKVLPTYDASKVT CEEEEECCCCCCCCE	29.85	30576142
1515	Phosphorylation	KVKVLPTYDASKVTA EEEEECCCCCCCCEE	13.94	30576142
1518	Phosphorylation	VLPTYDASKVTASGP EECCCCCCCCEECCC	25.43	30576142
1521	Phosphorylation	TYDASKVTASGPGLS CCCCCCCEECCCCHH	20.88	26356563
1523	Phosphorylation	DASKVTASGPGLSSY CCCCCEECCCCHHHC	35.83	26356563
1528	Phosphorylation	TASGPGLSSYGVPAS EECCCCHHHCCCCCC	27.68	26356563
1529	Phosphorylation	ASGPGLSSYGVPASL ECCCCHHHCCCCCCC	30.83	27259358
1530	Phosphorylation	SGPGLSSYGVPASLP CCCCHHHCCCCCCCC	20.83	25159151
1535	Phosphorylation	SSYGVPASLPVDFAI HHCCCCCCCCEEEEE	27.43	26356563
1536 (in isoform 8)	Phosphorylation	-	5.35	24719451
1539	Ubiquitination	VPASLPVDFAIDARD CCCCCCEEEEEECHH	25.89	32015554
1557	Phosphorylation	GLLAVQITDQEGKPK CEEEEEEECCCCCCC	17.97	21082442
1561 (in isoform 8)	Phosphorylation	-	46.03	27642862
1562	Ubiquitination	QITDQEGKPKRAIVH EEECCCCCCCEEEEE	46.76	24816145
1572	Acetylation	RAIVHDNKDGTYAVT EEEEEECCCCEEEEE	64.69	26051181
1572	Malonylation	RAIVHDNKDGTYAVT EEEEEECCCCEEEEE	64.69	26320211
1572	Ubiquitination	RAIVHDNKDGTYAVT EEEEEECCCCEEEEE	64.69	33845483
1576	Phosphorylation	HDNKDGTYAVTYIPD EECCCCEEEEEEECC	12.47	27259358
1579	Phosphorylation	KDGTYAVTYIPDKTG CCCEEEEEEECCCCC	13.94	22817900
1585	Phosphorylation	VTYIPDKTGRYMIGV EEEECCCCCCEEEEE	33.98	-
1589	Sulfoxidation	PDKTGRYMIGVTYGG CCCCCCEEEEEEECC	1.75	30846556
1593	O-linked_Glycosylation	GRYMIGVTYGGDDIP CCEEEEEEECCCCCC	15.96	23301498
1593	Phosphorylation	GRYMIGVTYGGDDIP CCEEEEEEECCCCCC	15.96	29759185
1593	Ubiquitination	GRYMIGVTYGGDDIP CCEEEEEEECCCCCC	15.96	24816145
1594	Phosphorylation	RYMIGVTYGGDDIPL CEEEEEEECCCCCCC	19.39	29759185
1602	O-linked_Glycosylation	GGDDIPLSPYRIRAT CCCCCCCCCCEEEEE	17.96	23301498
1602	Phosphorylation	GGDDIPLSPYRIRAT CCCCCCCCCCEEEEE	17.96	25159151
1603	Ubiquitination	GDDIPLSPYRIRATQ CCCCCCCCCEEEEEE	30.06	33845483
1604	Phosphorylation	DDIPLSPYRIRATQT CCCCCCCCEEEEEEC	18.46	22199227
1607 (in isoform 8)	Phosphorylation	-	23.68	27642862
1609	Phosphorylation	SPYRIRATQTGDASK CCCEEEEEECCCHHH	19.47	26657352
1611	Phosphorylation	YRIRATQTGDASKCL CEEEEEECCCHHHHC	32.45	23403867
1616	Acetylation	TQTGDASKCLATGPG EECCCHHHHCCCCCC	34.68	26051181
1616	Ubiquitination	TQTGDASKCLATGPG EECCCHHHHCCCCCC	34.68	33845483
1617	Glutathionylation	QTGDASKCLATGPGI ECCCHHHHCCCCCCE	2.64	22555962
1617	S-nitrosylation	QTGDASKCLATGPGI ECCCHHHHCCCCCCE	2.64	2212679
1633 (in isoform 8)	Phosphorylation	-	49.65	24719451
1641	Acetylation	VGFVVDAKTAGKGKV EEEEEEEECCCCCEE	34.15	7684469
1641	Ubiquitination	VGFVVDAKTAGKGKV EEEEEEEECCCCCEE	34.15	33845483
1647	Ubiquitination	AKTAGKGKVTCTVLT EECCCCCEEEEEEEC	37.55	33845483
1672	Ubiquitination	IENEDGTYDIFYTAA EECCCCCEEEEEEEE	16.75	33845483
1683	Phosphorylation	YTAAKPGTYVIYVRF EEEECCCEEEEEEEE	24.12	28102081
1684	Phosphorylation	TAAKPGTYVIYVRFG EEECCCEEEEEEEEC	7.26	27259358
1687	Phosphorylation	KPGTYVIYVRFGGVD CCCEEEEEEEECCEE	3.89	21253578
1717	Ubiquitination	TAVEEAPVNACPPGF EEEEECCCCCCCCCC	10.26	21890473
1718 (in isoform 8)	Phosphorylation	-	34.46	27251275
1733	Phosphorylation	PWVTEEAYVPVSDMN CCCCCEEEEEHHHCC	14.47	-
1733	Ubiquitination	PWVTEEAYVPVSDMN CCCCCEEEEEHHHCC	14.47	33845483
1733 (in isoform 2)	Ubiquitination	-	14.47	21890473
1733 (in isoform 6)	Ubiquitination	-	14.47	21890473
1746	Ubiquitination	MNGLGFKPFDLVIPF CCCCCCCCCCEEEEE	26.23	29901268
1746 (in isoform 7)	Ubiquitination	-	26.23	21890473
1756	Ubiquitination	LVIPFAVRKGEITGE EEEEEEEECCEEEEE	37.52	33845483
1757	Ubiquitination	VIPFAVRKGEITGEV EEEEEEECCEEEEEE	55.06	21906983
1757 (in isoform 1)	Ubiquitination	-	55.06	21890473
1757 (in isoform 3)	Ubiquitination	-	55.06	21890473
1757 (in isoform 4)	Ubiquitination	-	55.06	21890473
1757 (in isoform 5)	Ubiquitination	-	55.06	21890473
1759	Ubiquitination	PFAVRKGEITGEVHM EEEEECCEEEEEEEC	40.17	24816145
1764	Ubiquitination	KGEITGEVHMPSGKT CCEEEEEEECCCCCC	5.05	22817900
1766	Sulfoxidation	EITGEVHMPSGKTAT EEEEEEECCCCCCCC	3.23	21406390
1769	Ubiquitination	GEVHMPSGKTATPEI EEEECCCCCCCCCEE	26.01	33845483
1770	Ubiquitination	EVHMPSGKTATPEIV EEECCCCCCCCCEEE	39.05	24816145
1773	Phosphorylation	MPSGKTATPEIVDNK CCCCCCCCCEEECCC	27.04	22817900
1775	Ubiquitination	SGKTATPEIVDNKDG CCCCCCCEEECCCCC	51.82	21890473
1777	Ubiquitination	KTATPEIVDNKDGTV CCCCCEEECCCCCCE	6.73	24816145
1780	Acetylation	TPEIVDNKDGTVTVR CCEEECCCCCCEEEE	53.74	-
1780	Succinylation	TPEIVDNKDGTVTVR CCEEECCCCCCEEEE	53.74	23954790
1780	Ubiquitination	TPEIVDNKDGTVTVR CCEEECCCCCCEEEE	53.74	33845483
1783	Phosphorylation	IVDNKDGTVTVRYAP EECCCCCCEEEEECC	24.12	22817900
1785	Phosphorylation	DNKDGTVTVRYAPTE CCCCCCEEEEECCCC	10.09	22817900
1788	Phosphorylation	DGTVTVRYAPTEVGL CCCEEEEECCCCEEC	16.76	23312004
1788	Ubiquitination	DGTVTVRYAPTEVGL CCCEEEEECCCCEEC	16.76	33845483
1791	Phosphorylation	VTVRYAPTEVGLHEM EEEEECCCCEECEEE	34.82	22817900
1798	Sulfoxidation	TEVGLHEMHIKYMGS CCEECEEEEEEECCC	2.49	30846556
1801	Ubiquitination	GLHEMHIKYMGSHIP ECEEEEEEECCCCCC	17.95	24816145
1802	Phosphorylation	LHEMHIKYMGSHIPE CEEEEEEECCCCCCC	13.20	24275569
1804 (in isoform 8)	Phosphorylation	-	17.00	24719451
1810	Phosphorylation	MGSHIPESPLQFYVN CCCCCCCCCEEEEEE	26.09	28348404
1811	Ubiquitination	GSHIPESPLQFYVNY CCCCCCCCEEEEEEC	28.63	33845483
1818	Phosphorylation	PLQFYVNYPNSGSVS CEEEEEECCCCCCCE	8.18	24275569
1823	Phosphorylation	VNYPNSGSVSAYGPG EECCCCCCCEEECCC	16.84	24275569
1825	Phosphorylation	YPNSGSVSAYGPGLV CCCCCCCEEECCCEE	19.92	24275569
1827	Phosphorylation	NSGSVSAYGPGLVYG CCCCCEEECCCEEEE	19.15	24275569
1833	Phosphorylation	AYGPGLVYGVANKTA EECCCEEEEECCCEE	15.78	24275569
1841 (in isoform 8)	Phosphorylation	-	26.92	27251275
1848	Ubiquitination	TFTIVTEDAGEGGLD EEEEEECCCCCCCEE	50.97	29967540
1861	Ubiquitination	LDLAIEGPSKAEISC EEEEEECCCCEEEEE	21.62	29967540
1867	Phosphorylation	GPSKAEISCIDNKDG CCCCEEEEEEECCCC	9.13	21815630
1869	Ubiquitination	SKAEISCIDNKDGTC CCEEEEEEECCCCEE	5.37	23000965
1872	Ubiquitination	EISCIDNKDGTCTVT EEEEEECCCCEEEEE	54.51	29967540
1873	Ubiquitination	ISCIDNKDGTCTVTY EEEEECCCCEEEEEE	64.98	21890473
1882	Ubiquitination	TCTVTYLPTLPGDYS EEEEEEECCCCCCEE	22.83	23000965
1883	Phosphorylation	CTVTYLPTLPGDYSI EEEEEECCCCCCEEE	42.88	21712546
1886	Ubiquitination	TYLPTLPGDYSILVK EEECCCCCCEEEEEE	49.99	21890473
1886	Ubiquitination	TYLPTLPGDYSILVK EEECCCCCCEEEEEE	49.99	21890473
1889	Phosphorylation	PTLPGDYSILVKYND CCCCCCEEEEEEECC	17.74	21712546
1893	Ubiquitination	GDYSILVKYNDKHIP CCEEEEEEECCCCCC	34.59	23000965
1895	Ubiquitination	YSILVKYNDKHIPGS EEEEEEECCCCCCCC	46.25	33845483
1897	Ubiquitination	ILVKYNDKHIPGSPF EEEEECCCCCCCCCC	39.53	21890473
1897	Ubiquitination	ILVKYNDKHIPGSPF EEEEECCCCCCCCCC	39.53	21890473
1897	Acetylation	ILVKYNDKHIPGSPF EEEEECCCCCCCCCC	39.53	23236377
1897	Ubiquitination	ILVKYNDKHIPGSPF EEEEECCCCCCCCCC	39.53	23000965
1897 (in isoform 1)	Ubiquitination	-	39.53	21890473
1897 (in isoform 3)	Ubiquitination	-	39.53	21890473
1897 (in isoform 4)	Ubiquitination	-	39.53	21890473
1897 (in isoform 5)	Ubiquitination	-	39.53	21890473
1900	Ubiquitination	KYNDKHIPGSPFTAK EECCCCCCCCCCEEE	36.61	23000965
1902	Phosphorylation	NDKHIPGSPFTAKIT CCCCCCCCCCEEEEC	16.10	25159151
1903	Ubiquitination	DKHIPGSPFTAKITD CCCCCCCCCEEEECC	36.20	29967540
1904	Ubiquitination	KHIPGSPFTAKITDD CCCCCCCCEEEECCC	12.74	21890473
1905	Phosphorylation	HIPGSPFTAKITDDS CCCCCCCEEEECCCC	30.35	29083192
1908	Ubiquitination	GSPFTAKITDDSRRC CCCCEEEECCCCCCC	4.78	33845483
1909	Phosphorylation	SPFTAKITDDSRRCS CCCEEEECCCCCCCC	32.80	23882029
1912	Phosphorylation	TAKITDDSRRCSQVK EEEECCCCCCCCCCC	25.16	23403867
1916	Phosphorylation	TDDSRRCSQVKLGSA CCCCCCCCCCCCCHH	35.88	23403867
1919	Ubiquitination	SRRCSQVKLGSAADF CCCCCCCCCCHHHHH	39.22	33845483
1922	Phosphorylation	CSQVKLGSAADFLLD CCCCCCCHHHHHHHC	30.62	29691806
1924	Ubiquitination	QVKLGSAADFLLDIS CCCCCHHHHHHHCCC	15.13	23000965
1928	Ubiquitination	GSAADFLLDISETDL CHHHHHHHCCCCCCH	5.77	21890473
1928	Ubiquitination	GSAADFLLDISETDL CHHHHHHHCCCCCCH	5.77	21890473
1931	Ubiquitination	ADFLLDISETDLSSL HHHHHCCCCCCHHHC	33.83	23000965
1932	Ubiquitination	DFLLDISETDLSSLT HHHHCCCCCCHHHCC	46.83	29967540
1933 (in isoform 8)	Phosphorylation	-	35.13	24719451
1937	Phosphorylation	ISETDLSSLTASIKA CCCCCHHHCCEEEEC	36.72	22817900
1939	Phosphorylation	ETDLSSLTASIKAPS CCCHHHCCEEEECCC	21.95	24275569
1943	Ubiquitination	SSLTASIKAPSGRDE HHCCEEEECCCCCCC	52.31	29967540
1943 (in isoform 8)	Phosphorylation	-	52.31	27251275
1944	Ubiquitination	SLTASIKAPSGRDEP HCCEEEECCCCCCCC	11.21	23000965
1944	Ubiquitination	SLTASIKAPSGRDEP HCCEEEECCCCCCCC	11.21	21890473
1950	Ubiquitination	KAPSGRDEPCLLKRL ECCCCCCCCCCHHCC	36.23	33845483
1953 (in isoform 8)	Phosphorylation	-	10.39	24719451
1955	Ubiquitination	RDEPCLLKRLPNNHI CCCCCCHHCCCCCCE	38.65	21890473
1955	Ubiquitination	RDEPCLLKRLPNNHI CCCCCCHHCCCCCCE	38.65	21890473
1955	Acetylation	RDEPCLLKRLPNNHI CCCCCCHHCCCCCCE	38.65	26051181
1955	Ubiquitination	RDEPCLLKRLPNNHI CCCCCCHHCCCCCCE	38.65	23000965
1955 (in isoform 1)	Ubiquitination	-	38.65	21890473
1955 (in isoform 3)	Ubiquitination	-	38.65	21890473
1955 (in isoform 4)	Ubiquitination	-	38.65	21890473
1955 (in isoform 5)	Ubiquitination	-	38.65	21890473
1955 (in isoform 6)	Ubiquitination	-	38.65	21890473
1962	Ubiquitination	KRLPNNHIGISFIPR HCCCCCCEEEEEECH	5.95	21890473
1968	Ubiquitination	HIGISFIPREVGEHL CEEEEEECHHHHHEE	25.11	33845483
1974	Ubiquitination	IPREVGEHLVSIKKN ECHHHHHEEEEEEEC	26.13	29967540
1977	Phosphorylation	EVGEHLVSIKKNGNH HHHHEEEEEEECCCC	34.74	28348404
1979	Ubiquitination	GEHLVSIKKNGNHVA HHEEEEEEECCCCCC	32.45	33845483
1986	Ubiquitination	KKNGNHVANSPVSIM EECCCCCCCCCEEEE	11.84	21890473
1986	Ubiquitination	KKNGNHVANSPVSIM EECCCCCCCCCEEEE	11.84	23000965
1988	Phosphorylation	NGNHVANSPVSIMVV CCCCCCCCCEEEEEE	19.55	30278072
1991	Phosphorylation	HVANSPVSIMVVQSE CCCCCCEEEEEEECC	14.35	28857561
1997	Phosphorylation	VSIMVVQSEIGDARR EEEEEEECCCCCHHH	21.41	-
2010	Methylation	RRAKVYGRGLSEGRT HHHEEECCCCCCCCC	25.78	-
2010	Ubiquitination	RRAKVYGRGLSEGRT HHHEEECCCCCCCCC	25.78	33845483
2013	Phosphorylation	KVYGRGLSEGRTFEM EEECCCCCCCCCEEC	40.61	28355574
2017	Phosphorylation	RGLSEGRTFEMSDFI CCCCCCCCEECCCEE	34.50	28464451
2019 (in isoform 8)	Phosphorylation	-	36.84	24719451
2020	Sulfoxidation	SEGRTFEMSDFIVDT CCCCCEECCCEEEEC	3.99	21406390
2020	Ubiquitination	SEGRTFEMSDFIVDT CCCCCEECCCEEEEC	3.99	33845483
2021	Phosphorylation	EGRTFEMSDFIVDTR CCCCEECCCEEEECC	23.36	28464451
2027	Phosphorylation	MSDFIVDTRDAGYGG CCCEEEECCCCCCCC	21.39	23090842
2032	Phosphorylation	VDTRDAGYGGISLAV EECCCCCCCCEEEEE	17.56	18767875
2033	Ubiquitination	DTRDAGYGGISLAVE ECCCCCCCCEEEEEE	26.49	33845483
2034	Ubiquitination	TRDAGYGGISLAVEG CCCCCCCCEEEEEEC	9.60	29967540
2036	Phosphorylation	DAGYGGISLAVEGPS CCCCCCEEEEEECCC	17.35	22817900
2044	Ubiquitination	LAVEGPSKVDIQTED EEEECCCCEECCCCC	47.24	33845483
2044 (in isoform 8)	Phosphorylation	-	47.24	24719451
2047	Ubiquitination	EGPSKVDIQTEDLED ECCCCEECCCCCCCC	6.47	29967540
2048 (in isoform 8)	Phosphorylation	-	34.08	27251275
2058	Ubiquitination	DLEDGTCKVSYFPTV CCCCCEEEEEEECCC	33.77	29967540
2060	Phosphorylation	EDGTCKVSYFPTVPG CCCEEEEEEECCCCE	13.42	-
2061	Phosphorylation	DGTCKVSYFPTVPGV CCEEEEEEECCCCEE	19.30	-
2064	Ubiquitination	CKVSYFPTVPGVYIV EEEEEECCCCEEEEE	29.45	32015554
2075	Ubiquitination	VYIVSTKFADEHVPG EEEEEECCCCCCCCC	11.96	33845483
2077	Ubiquitination	IVSTKFADEHVPGSP EEEECCCCCCCCCCC	50.06	32015554
2083	Phosphorylation	ADEHVPGSPFTVKIS CCCCCCCCCEEEEEC	15.69	25159151
2086	Phosphorylation	HVPGSPFTVKISGEG CCCCCCEEEEECCCC	25.03	21712546
2088	Acetylation	PGSPFTVKISGEGRV CCCCEEEEECCCCCE	28.26	26051181
2088	Ubiquitination	PGSPFTVKISGEGRV CCCCEEEEECCCCCE	28.26	32015554
2089	Ubiquitination	GSPFTVKISGEGRVK CCCEEEEECCCCCEE	5.78	29967540
2096	Phosphorylation	ISGEGRVKESITRTS ECCCCCEEEEEEECC	44.37	32142685
2096	Ubiquitination	ISGEGRVKESITRTS ECCCCCEEEEEEECC	44.37	-
2098	Phosphorylation	GEGRVKESITRTSRA CCCCEEEEEEECCCC	24.44	23401153
2100	Phosphorylation	GRVKESITRTSRAPS CCEEEEEEECCCCCC	36.85	29691806
2102	Phosphorylation	VKESITRTSRAPSVA EEEEEEECCCCCCCE	17.57	23882029
2103	Phosphorylation	KESITRTSRAPSVAT EEEEEECCCCCCCEE	24.13	23403867
2107	Phosphorylation	TRTSRAPSVATVGSI EECCCCCCCEEHHHE	24.33	29255136
2110	Phosphorylation	SRAPSVATVGSICDL CCCCCCEEHHHEEEE	24.20	30266825
2113	Phosphorylation	PSVATVGSICDLNLK CCCEEHHHEEEEECC	18.73	30266825
2114 (in isoform 8)	Phosphorylation	-	1.42	24719451
2119	Ubiquitination	GSICDLNLKIPEINS HHEEEEECCCCCCCC	7.46	32015554
2126	Phosphorylation	LKIPEINSSDMSAHV CCCCCCCCCCCCCEE	33.12	23403867
2126	Ubiquitination	LKIPEINSSDMSAHV CCCCCCCCCCCCCEE	33.12	33845483
2127	Phosphorylation	KIPEINSSDMSAHVT CCCCCCCCCCCCEEE	32.61	23403867
2130	Phosphorylation	EINSSDMSAHVTSPS CCCCCCCCCEEECCC	21.88	23403867
2131 (in isoform 8)	Phosphorylation	-	8.43	24719451
2133 (in isoform 8)	Phosphorylation	-	5.92	27251275
2134	Phosphorylation	SDMSAHVTSPSGRVT CCCCCEEECCCCCEE	25.67	30278072
2135	Phosphorylation	DMSAHVTSPSGRVTE CCCCEEECCCCCEEE	18.91	30278072
2137	Phosphorylation	SAHVTSPSGRVTEAE CCEEECCCCCEEEEE	38.71	23403867
2138	Phosphorylation	AHVTSPSGRVTEAEI CEEECCCCCEEEEEE	31.31	32142685
2138 (in isoform 8)	Phosphorylation	-	31.31	24719451
2139	Ubiquitination	HVTSPSGRVTEAEIV EEECCCCCEEEEEEE	36.20	33845483
2141 (in isoform 8)	Phosphorylation	-	28.28	27251275
2144 (in isoform 8)	Phosphorylation	-	37.98	24719451
2146	Acetylation	RVTEAEIVPMGKNSH CEEEEEEEECCCCCC	1.69	19608861
2146	Ubiquitination	RVTEAEIVPMGKNSH CEEEEEEEECCCCCC	1.69	23000965
2148	Sulfoxidation	TEAEIVPMGKNSHCV EEEEEEECCCCCCEE	9.16	21406390
2150	Ubiquitination	AEIVPMGKNSHCVRF EEEEECCCCCCEEEE	49.37	33845483
2157	Ubiquitination	KNSHCVRFVPQEMGV CCCCEEEEECHHCCE	4.72	24816145
2159	Acetylation	SHCVRFVPQEMGVHT CCEEEEECHHCCEEE	23.00	19608861
2159	Ubiquitination	SHCVRFVPQEMGVHT CCEEEEECHHCCEEE	23.00	23000965
2162	Sulfoxidation	VRFVPQEMGVHTVSV EEEECHHCCEEEEEE	5.98	30846556
2165 (in isoform 8)	Phosphorylation	-	18.15	24719451
2166	Phosphorylation	PQEMGVHTVSVKYRG CHHCCEEEEEEEECC	16.45	20860994
2168	Phosphorylation	EMGVHTVSVKYRGQH HCCEEEEEEEECCEE	17.66	20860994
2170	Acetylation	GVHTVSVKYRGQHVT CEEEEEEEECCEECC	23.02	23954790
2170	Malonylation	GVHTVSVKYRGQHVT CEEEEEEEECCEECC	23.02	26320211
2170	Ubiquitination	GVHTVSVKYRGQHVT CEEEEEEEECCEECC	23.02	23000965
2171	Ubiquitination	VHTVSVKYRGQHVTG EEEEEEEECCEECCC	20.16	23000965
2172	Methylation	HTVSVKYRGQHVTGS EEEEEEECCEECCCC	32.36	-
2177	Phosphorylation	KYRGQHVTGSPFQFT EECCEECCCCCEEEE	29.80	25159151
2177	Ubiquitination	KYRGQHVTGSPFQFT EECCEECCCCCEEEE	29.80	23000965
2179	Phosphorylation	RGQHVTGSPFQFTVG CCEECCCCCEEEEEE	17.11	25159151
2181	Ubiquitination	QHVTGSPFQFTVGPL EECCCCCEEEEEECC	11.33	33845483
2184	Phosphorylation	TGSPFQFTVGPLGEG CCCCEEEEEECCCCC	17.48	23312004
2184	Ubiquitination	TGSPFQFTVGPLGEG CCCCEEEEEECCCCC	17.48	23000965
2195	Ubiquitination	LGEGGAHKVRAGGPG CCCCCCCEEECCCCC	32.65	23000965
2197	Methylation	EGGAHKVRAGGPGLE CCCCCEEECCCCCCC	32.11	-
2199 (in isoform 8)	Phosphorylation	-	32.06	27251275
2201	Acetylation	HKVRAGGPGLERGEA CEEECCCCCCCCCCC	43.19	19608861
2201	Ubiquitination	HKVRAGGPGLERGEA CEEECCCCCCCCCCC	43.19	23000965
2202	Ubiquitination	KVRAGGPGLERGEAG EEECCCCCCCCCCCC	43.37	23000965
2208 (in isoform 8)	Phosphorylation	-	27.40	27251275
2211	Ubiquitination	ERGEAGVPAEFSIWT CCCCCCCCCEEEEEE	25.75	33845483
2215	Phosphorylation	AGVPAEFSIWTREAG CCCCCEEEEEECCCC	14.55	28857561
2224	Ubiquitination	WTREAGAGGLSIAVE EECCCCCCCEEEEEE	36.34	33845483
2226	Ubiquitination	REAGAGGLSIAVEGP CCCCCCCEEEEEECC	3.07	23000965
2227	Phosphorylation	EAGAGGLSIAVEGPS CCCCCCEEEEEECCC	16.27	23403867
2235	Ubiquitination	IAVEGPSKAEITFDD EEEECCCCEEEEECC	53.85	33845483
2239	Phosphorylation	GPSKAEITFDDHKNG CCCCEEEEECCCCCC	16.71	22817900
2244	Acetylation	EITFDDHKNGSCGVS EEEECCCCCCCEEEE	70.74	26051181
2247	Phosphorylation	FDDHKNGSCGVSYIA ECCCCCCCEEEEEEE	19.66	21955146
2251	Phosphorylation	KNGSCGVSYIAQEPG CCCCEEEEEEECCCC	8.98	21955146
2252	Phosphorylation	NGSCGVSYIAQEPGN CCCEEEEEEECCCCC	9.62	21955146
2260	Phosphorylation	IAQEPGNYEVSIKFN EECCCCCEEEEEEEC	24.51	21955146
2263	Phosphorylation	EPGNYEVSIKFNDEH CCCCEEEEEEECCCC	14.23	21955146
2266	Ubiquitination	NYEVSIKFNDEHIPE CEEEEEEECCCCCCC	15.43	33845483
2274	Phosphorylation	NDEHIPESPYLVPVI CCCCCCCCCCEEEEE	17.31	28796482
2276	Phosphorylation	EHIPESPYLVPVIAP CCCCCCCCEEEEECC	29.61	28796482
2284	Phosphorylation	LVPVIAPSDDARRLT EEEEECCCHHHHHHE	38.82	23312004
2291	Phosphorylation	SDDARRLTVMSLQES CHHHHHHEEEEHHHC	16.61	21406692
2292	Ubiquitination	DDARRLTVMSLQESG HHHHHHEEEEHHHCC	2.65	22505724
2293	Sulfoxidation	DARRLTVMSLQESGL HHHHHEEEEHHHCCC	2.52	21406390
2294	Phosphorylation	ARRLTVMSLQESGLK HHHHEEEEHHHCCCC	23.67	28857561
2298	Phosphorylation	TVMSLQESGLKVNQP EEEEHHHCCCCCCCC	36.14	21406692
2305	Ubiquitination	SGLKVNQPASFAIRL CCCCCCCCCEEEEEE	25.35	22505724
2305 (in isoform 8)	Phosphorylation	-	25.35	27642862
2307	Phosphorylation	LKVNQPASFAIRLNG CCCCCCCEEEEEECC	23.15	23312004
2307 (in isoform 8)	Phosphorylation	-	23.15	27642862
2316	Ubiquitination	AIRLNGAKGKIDAKV EEEECCCCCEEEEEE	63.23	22505724
2318	Ubiquitination	RLNGAKGKIDAKVHS EECCCCCEEEEEEEC	36.38	29967540
2322 (in isoform 8)	Phosphorylation	-	36.41	27251275
2323	Ubiquitination	KGKIDAKVHSPSGAV CCEEEEEEECCCCCC	6.07	22505724
2325	Phosphorylation	KIDAKVHSPSGAVEE EEEEEEECCCCCCEE	24.61	25159151
2325 (in isoform 8)	Phosphorylation	-	24.61	27251275
2327	Phosphorylation	DAKVHSPSGAVEECH EEEEECCCCCCEEEE	42.26	28258704
2331	Ubiquitination	HSPSGAVEECHVSEL ECCCCCCEEEECHHC	55.14	29967540
2336	Phosphorylation	AVEECHVSELEPDKY CCEEEECHHCCCCCE	16.88	23312004
2342	Acetylation	VSELEPDKYAVRFIP CHHCCCCCEEEEEEE	45.91	25825284
2342	Malonylation	VSELEPDKYAVRFIP CHHCCCCCEEEEEEE	45.91	26320211
2342	Ubiquitination	VSELEPDKYAVRFIP CHHCCCCCEEEEEEE	45.91	29967540
2343	Phosphorylation	SELEPDKYAVRFIPH HHCCCCCEEEEEEEC	20.08	23312004
2347	Ubiquitination	PDKYAVRFIPHENGV CCCEEEEEEECCCCE	9.06	22505724
2356 (in isoform 8)	Phosphorylation	-	19.23	24719451
2364	Phosphorylation	IDVKFNGSHVVGSPF EEEEECCEEECCCCE	17.76	22199227
2367 (in isoform 8)	Phosphorylation	-	5.41	27251275
2369	Phosphorylation	NGSHVVGSPFKVRVG CCEEECCCCEEEECC	18.63	25159151
2372	Acetylation	HVVGSPFKVRVGEPG EECCCCEEEECCCCC	32.30	25953088
2373	Ubiquitination	VVGSPFKVRVGEPGQ ECCCCEEEECCCCCC	6.49	29967540
2400 (in isoform 8)	Phosphorylation	-	18.77	24719451
2402	Ubiquitination	EGGTTGIQSEFFINT CCCCCCCCEEEEEEC	37.95	33845483
2403	Phosphorylation	GGTTGIQSEFFINTT CCCCCCCEEEEEECC	34.16	22817900
2404	Ubiquitination	GTTGIQSEFFINTTR CCCCCCEEEEEECCC	28.35	33845483
2410	Phosphorylation	SEFFINTTRAGPGTL EEEEEECCCCCCCEE	17.65	22817900
2415	Ubiquitination	NTTRAGPGTLSVTIE ECCCCCCCEEEEEEE	38.07	33845483
2417	Ubiquitination	TRAGPGTLSVTIEGP CCCCCCEEEEEEECC	4.86	33845483
2418	Phosphorylation	RAGPGTLSVTIEGPS CCCCCEEEEEEECCC	19.63	28857561
2420	Phosphorylation	GPGTLSVTIEGPSKV CCCEEEEEEECCCCE	15.22	24719451
2425	Phosphorylation	SVTIEGPSKVKMDCQ EEEEECCCCEEEECC	62.02	30576142
2426	Ubiquitination	VTIEGPSKVKMDCQE EEEECCCCEEEECCC	49.35	33845483
2428	Acetylation	IEGPSKVKMDCQETP EECCCCEEEECCCCC	32.53	26051181
2428	Ubiquitination	IEGPSKVKMDCQETP EECCCCEEEECCCCC	32.53	33845483
2434	Phosphorylation	VKMDCQETPEGYKVM EEEECCCCCCCEEEE	10.76	27251275
2438	Phosphorylation	CQETPEGYKVMYTPM CCCCCCCEEEEEECC	9.96	30576142
2442	Phosphorylation	PEGYKVMYTPMAPGN CCCEEEEEECCCCCC	15.64	21406692
2443	Phosphorylation	EGYKVMYTPMAPGNY CCEEEEEECCCCCCE	6.62	20068231
2444	Ubiquitination	GYKVMYTPMAPGNYL CEEEEEECCCCCCEE	10.23	29967540
2449 (in isoform 8)	Phosphorylation	-	27.64	27251275
2450	Phosphorylation	TPMAPGNYLISVKYG ECCCCCCEEEEEEEC	16.01	20068231
2451 (in isoform 8)	Phosphorylation	-	2.46	24719451
2453	Phosphorylation	APGNYLISVKYGGPN CCCCEEEEEEECCCC	15.23	20068231
2454	Phosphorylation	PGNYLISVKYGGPNH CCCEEEEEEECCCCC	4.37	32645325
2456	Phosphorylation	NYLISVKYGGPNHIV CEEEEEEECCCCCCC	25.76	30266825
2457	Phosphorylation	YLISVKYGGPNHIVG EEEEEEECCCCCCCC	39.09	32142685
2457	Ubiquitination	YLISVKYGGPNHIVG EEEEEEECCCCCCCC	39.09	33845483
2459	Ubiquitination	ISVKYGGPNHIVGSP EEEEECCCCCCCCCC	25.51	33845483
2465	Phosphorylation	GPNHIVGSPFKAKVT CCCCCCCCCCEEEEE	19.10	30266825
2465 (in isoform 8)	Phosphorylation	-	19.10	27251275
2467	Phosphorylation	NHIVGSPFKAKVTGQ CCCCCCCCEEEEECC	14.92	32645325
2468	Malonylation	HIVGSPFKAKVTGQR CCCCCCCEEEEECCE	51.16	26320211
2468	Ubiquitination	HIVGSPFKAKVTGQR CCCCCCCEEEEECCE	51.16	29967540
2470	Phosphorylation	VGSPFKAKVTGQRLV CCCCCEEEEECCEEE	40.70	32142685
2472	Phosphorylation	SPFKAKVTGQRLVSP CCCEEEEECCEEECC	27.22	22817900
2474 (in isoform 8)	Phosphorylation	-	26.60	27251275
2478	Phosphorylation	VTGQRLVSPGSANET EECCEEECCCCCCCC	28.30	19664994
2481	Phosphorylation	QRLVSPGSANETSSI CEEECCCCCCCCCEE	31.16	25159151
2485	Phosphorylation	SPGSANETSSILVES CCCCCCCCCEEEEEE	27.81	30266825
2486	Phosphorylation	PGSANETSSILVESV CCCCCCCCEEEEEEE	14.81	30266825
2487	Phosphorylation	GSANETSSILVESVT CCCCCCCEEEEEEEC	27.62	30266825
2492	Phosphorylation	TSSILVESVTRSSTE CCEEEEEEECCCCCC	22.70	28176443
2494	Phosphorylation	SILVESVTRSSTETC EEEEEEECCCCCCHH	33.83	23403867
2494	Ubiquitination	SILVESVTRSSTETC EEEEEEECCCCCCHH	33.83	29967540
2496	Phosphorylation	LVESVTRSSTETCYS EEEEECCCCCCHHHH	32.04	21945579
2496 (in isoform 8)	Phosphorylation	-	32.04	24719451
2497	Phosphorylation	VESVTRSSTETCYSA EEEECCCCCCHHHHH	27.29	21945579
2498	Phosphorylation	ESVTRSSTETCYSAI EEECCCCCCHHHHHC	36.24	21945579
2499	Ubiquitination	SVTRSSTETCYSAIP EECCCCCCHHHHHCC	38.54	29967540
2500	Phosphorylation	VTRSSTETCYSAIPK ECCCCCCHHHHHCCC	19.48	21945579
2500	Ubiquitination	VTRSSTETCYSAIPK ECCCCCCHHHHHCCC	19.48	33845483
2501	Phosphorylation	TRSSTETCYSAIPKA CCCCCCHHHHHCCCC	1.74	17016520
2502	Phosphorylation	RSSTETCYSAIPKAS CCCCCHHHHHCCCCC	14.46	21945579
2503	Phosphorylation	SSTETCYSAIPKASS CCCCHHHHHCCCCCC	23.13	21945579
2506	Ubiquitination	ETCYSAIPKASSDAS CHHHHHCCCCCCCHH	26.36	33845483
2507	Acetylation	TCYSAIPKASSDASK HHHHHCCCCCCCHHH	55.58	26051181
2507	Ubiquitination	TCYSAIPKASSDASK HHHHHCCCCCCCHHH	55.58	29967540
2509	Phosphorylation	YSAIPKASSDASKVT HHHCCCCCCCHHHCC	34.57	32645325
2509 (in isoform 8)	Phosphorylation	-	34.57	24719451
2510	Phosphorylation	SAIPKASSDASKVTS HHCCCCCCCHHHCCC	41.89	22817900
2512	Phosphorylation	IPKASSDASKVTSKG CCCCCCCHHHCCCCC	17.13	32142685
2512 (in isoform 8)	Phosphorylation	-	17.13	24719451
2513	Ubiquitination	PKASSDASKVTSKGA CCCCCCHHHCCCCCC	32.42	33845483
2517	Phosphorylation	SDASKVTSKGAGLSK CCHHHCCCCCCCCCH	31.89	22817900
2518	Succinylation	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	-
2518	Succinylation	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	-
2518	Ubiquitination	DASKVTSKGAGLSKA CHHHCCCCCCCCCHH	43.33	29967540
2518 (in isoform 8)	Phosphorylation	-	43.33	27251275
2519	Ubiquitination	ASKVTSKGAGLSKAF HHHCCCCCCCCCHHH	25.33	33845483
2523	Phosphorylation	TSKGAGLSKAFVGQK CCCCCCCCHHHCCCC	22.48	22617229
2523 (in isoform 8)	Phosphorylation	-	22.48	27251275
2524	Acetylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	25953088
2524	Malonylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	26320211
2524	Succinylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	-
2524	Succinylation	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	-
2524	Ubiquitination	SKGAGLSKAFVGQKS CCCCCCCHHHCCCCC	51.38	33845483
2525 (in isoform 8)	Phosphorylation	-	10.86	24719451
2527 (in isoform 8)	Phosphorylation	-	10.69	27642862
2529 (in isoform 8)	Phosphorylation	-	36.84	24719451
2530	Malonylation	SKAFVGQKSSFLVDC CHHHCCCCCEEEEEC	41.98	26320211
2530	Ubiquitination	SKAFVGQKSSFLVDC CHHHCCCCCEEEEEC	41.98	33845483
2531	Phosphorylation	KAFVGQKSSFLVDCS HHHCCCCCEEEEECH	20.59	28857561
2531 (in isoform 8)	Phosphorylation	-	20.59	27251275
2532	Phosphorylation	AFVGQKSSFLVDCSK HHCCCCCEEEEECHH	29.63	28857561
2533 (in isoform 8)	Phosphorylation	-	11.28	27642862
2537	S-nitrosylation	KSSFLVDCSKAGSNM CCEEEEECHHCCCCE	3.33	2212679
2542	Phosphorylation	VDCSKAGSNMLLIGV EECHHCCCCEEEEEE	24.75	-
2549	Ubiquitination	SNMLLIGVHGPTTPC CCEEEEEEECCCCCC	3.60	29967540
2552	Acetylation	LLIGVHGPTTPCEEV EEEEEECCCCCCCCC	20.44	19608861
2552	Ubiquitination	LLIGVHGPTTPCEEV EEEEEECCCCCCCCC	20.44	33845483
2553	Phosphorylation	LIGVHGPTTPCEEVS EEEEECCCCCCCCCC	48.22	23403867
2554	Phosphorylation	IGVHGPTTPCEEVSM EEEECCCCCCCCCCC	29.13	27273156
2555	Ubiquitination	GVHGPTTPCEEVSMK EEECCCCCCCCCCCC	26.46	33845483
2556	S-nitrosylation	VHGPTTPCEEVSMKH EECCCCCCCCCCCCC	7.00	2212679
2560	Phosphorylation	TTPCEEVSMKHVGNQ CCCCCCCCCCCCCCC	25.95	28857561
2561	Ubiquitination	TPCEEVSMKHVGNQQ CCCCCCCCCCCCCCE	4.15	33845483
2562	Acetylation	PCEEVSMKHVGNQQY CCCCCCCCCCCCCEE	27.86	26051181
2562 (in isoform 8)	Phosphorylation	-	27.86	27251275
2563 (in isoform 8)	Phosphorylation	-	24.87	24719451
2565	Acetylation	EVSMKHVGNQQYNVT CCCCCCCCCCEEEEE	26.42	19608861
2565	Ubiquitination	EVSMKHVGNQQYNVT CCCCCCCCCCEEEEE	26.42	33845483
2569	Phosphorylation	KHVGNQQYNVTYVVK CCCCCCEEEEEEEEE	11.22	28152594
2572	Phosphorylation	GNQQYNVTYVVKERG CCCEEEEEEEEEECC	13.63	28152594
2573	Phosphorylation	NQQYNVTYVVKERGD CCEEEEEEEEEECCC	10.04	28152594
2576	Acetylation	YNVTYVVKERGDYVL EEEEEEEEECCCEEE	31.48	19608861
2576	Malonylation	YNVTYVVKERGDYVL EEEEEEEEECCCEEE	31.48	26320211
2576	Succinylation	YNVTYVVKERGDYVL EEEEEEEEECCCEEE	31.48	23954790
2576	Ubiquitination	YNVTYVVKERGDYVL EEEEEEEEECCCEEE	31.48	33845483
2581	Phosphorylation	VVKERGDYVLAVKWG EEEECCCEEEEEEEC	10.53	-
2585 (in isoform 8)	Phosphorylation	-	4.72	24719451
2600	Phosphorylation	PGSPFHVTVP----- CCCCCEEECC-----	20.63	24719451
2607	Acetylation	TVP------------ ECC------------		19608861
2607	Ubiquitination	TVP------------ ECC------------		33845483
2612 (in isoform 8)	Phosphorylation	-		27642862
2631 (in isoform 8)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ASB2	Q96Q27	PMID:19300455

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FLNB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLNB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSN1_HUMAN	PSEN1	physical	9437013
PSN2_HUMAN	PSEN2	physical	9437013
ITB1_HUMAN	ITGB1	physical	11807098
ITB3_HUMAN	ITGB3	physical	11807098
ITB6_HUMAN	ITGB6	physical	11807098
FBLI1_HUMAN	FBLIM1	physical	12496242
ROA0_HUMAN	HNRNPA0	physical	22939629
TERA_HUMAN	VCP	physical	22939629
ZC3H4_HUMAN	ZC3H4	physical	22939629
PO210_HUMAN	NUP210	physical	22939629
HNRPM_HUMAN	HNRNPM	physical	22939629
SEPT9_HUMAN	SEPT9	physical	22939629
DCTN2_HUMAN	DCTN2	physical	22863883
FLNC_HUMAN	FLNC	physical	22863883
LEO1_HUMAN	LEO1	physical	22863883
MD1L1_HUMAN	MAD1L1	physical	22863883
PSD12_HUMAN	PSMD12	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
SQSTM_HUMAN	SQSTM1	physical	22863883
AP1G1_HUMAN	AP1G1	physical	26344197
BASP1_HUMAN	BASP1	physical	26344197
4EBP1_HUMAN	EIF4EBP1	physical	26344197
FLNA_HUMAN	FLNA	physical	26344197
GGA1_HUMAN	GGA1	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
RSU1_HUMAN	RSU1	physical	26344197
SEC13_HUMAN	SEC13	physical	26344197
TLDC1_HUMAN	TLDC1	physical	26344197
UFD1_HUMAN	UFD1L	physical	26344197
PFD3_HUMAN	VBP1	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
	Note=Interaction with FLNA may compensate for dysfunctional FLNA homodimer in the periventricular nodular heterotopia (PVNH) disorder.
108720
108721	Atelosteogenesis 3 (AO3)
112310	Boomerang dysplasia (BOOMD)
150250	Larsen syndrome (LRS)
272460	Spondylocarpotarsal synostosis syndrome (SCT)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLNB_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-681; LYS-2170 AND LYS-2576,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983 AND SER-2478, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-519; SER-886; SER-983;SER-1028; SER-1316; SER-1433; SER-1505; SER-1602; SER-2083; SER-2107;SER-2478 AND SER-2481, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-658, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983 AND SER-2369, ANDMASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-983, AND MASSSPECTROMETRY.	16964243 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1530; TYR-1684 ANDTYR-2502, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1530, AND MASSSPECTROMETRY.	17389395 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2502, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2502, AND MASSSPECTROMETRY.	15592455 [Abstract]