dbPTM

PO210_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PO210_HUMAN
UniProt AC	Q8TEM1
Protein Name	Nuclear pore membrane glycoprotein 210
Gene Name	NUP210
Organism	Homo sapiens (Human).
Sequence Length	1887
Subcellular Localization	Nucleus, nuclear pore complex . Nucleus membrane Single-pass type I membrane protein . Endoplasmic reticulum membrane Single-pass type I membrane protein .
Protein Description	Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity..
Protein Sequence	MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVLETGRLYEITIEVFDKFSNKVYVSDNIRIETVLPAEFFEVLSSSQNGSYHRIRALKRGQTAIDAALTSVVDQDGGVHILQVPVWNQQEVEIHIPITLYPSILTFPWQPKTGAYQYTIRAHGGSGNFSWSSSSHLVATVTVKGVMTTGSDIGFSVIQAHDVQNPLHFGEMKVYVIEPHSMEFAPCQVEARVGQALELPLRISGLMPGGASEVVTLSDCSHFDLAVEVENQGVFQPLPGRLPPGSEHCSGIRVKAEAQGSTTLLVSYRHGHVHLSAKITIAAYLPLKAVDPSSVALVTLGSSKEMLFEGGPRPWILEPSKFFQNVTAEDTDSIGLALFAPHSSRNYQQHWILVTCQALGEQVIALSVGNKPSLTNPFPAVEPAVVKFVCAPPSRLTLAPVYTSPQLDMSCPLLQQNKQVVPVSSHRNPRLDLAAYDQEGRRFDNFSSLSIQWESTRPVLASIEPELPMQLVSQDDESGQKKLHGLQAILVHEASGTTAITATATGYQESHLSSARTKQPHDPLVPLSASIELILVEDVRVSPEEVTIYNHPGIQAELRIREGSGYFFLNTSTADVVKVAYQEARGVAMVHPLLPGSSTIMIHDLCLVFPAPAKAVVYVSDIQELYIRVVDKVEIGKTVKAYVRVLDLHKKPFLAKYFPFMDLKLRAASPIITLVALDEALDNYTITFLIRGVAIGQTSLTASVTNKAGQRINSAPQQIEVFPPFRLMPRKVTLLIGATMQVTSEGGPQPQSNILFSISNESVALVSAAGLVQGLAIGNGTVSGLVQAVDAETGKVVIISQDLVQVEVLLLRAVRIRAPIMRMRTGTQMPIYVTGITNHQNPFSFGNAVPGLTFHWSVTKRDVLDLRGRHHEASIRLPSQYNFAMNVLGRVKGRTGLRVVVKAVDPTSGQLYGLARELSDEIQVQVFEKLQLLNPEIEAEQILMSPNSYIKLQTNRDGAASLSYRVLDGPEKVPVVHVDEKGFLASGSMIGTSTIEVIAQEPFGANQTIIVAVKVSPVSYLRVSMSPVLHTQNKEALVAVPLGMTVTFTVHFHDNSGDVFHAHSSVLNFATNRDDFVQIGKGPTNNTCVVRTVSVGLTLLRVWDAEHPGLSDFMPLPVLQAISPELSGAMVVGDVLCLATVLTSLEGLSGTWSSSANSILHIDPKTGVAVARAVGSVTVYYEVAGHLRTYKEVVVSVPQRIMARHLHPIQTSFQEATASKVIVAVGDRSSNLRGECTPTQREVIQALHPETLISCQSQFKPAVFDFPSQDVFTVEPQFDTALGQYFCSITMHRLTDKQRKHLSMKKTALVVSASLSSSHFSTEQVGAEVPFSPGLFADQAEILLSNHYTSSEIRVFGAPEVLENLEVKSGSPAVLAFAKEKSFGWPSFITYTVGVLDPAAGSQGPLSTTLTFSSPVTNQAIAIPVTVAFVVDRRGPGPYGASLFQHFLDSYQVMFFTLFALLAGTAVMIIAYHTVCTPRDLAVPAALTPRASPGHSPHYFAASSPTSPNALPPARKASPPSGLWSPAYASH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	GPSAAAAKLNIPKVL CCCHHHHHCCCCEEE	37.02	22817900
32	Ubiquitination	AAKLNIPKVLLPFTR HHHCCCCEEEEECCC	41.54	21890473
32 (in isoform 1)	Ubiquitination	-	41.54	21890473
32 (in isoform 2)	Ubiquitination	-	41.54	21890473
44	N-linked_Glycosylation	FTRATRVNFTLEASE CCCCEEEEEEEEECC	22.39	UniProtKB CARBOHYD
79	Ubiquitination	DEQQCSQKAVVQARL CHHHHCHHHHHHHHH	27.19	21963094
112	Ubiquitination	QVLRCDAIVDLIHDI CCCCCCHHHHHHHHE	1.26	22817900
117	Ubiquitination	DAIVDLIHDIQIVST CHHHHHHHHEEEEEE	33.16	21963094
124	Ubiquitination	HDIQIVSTTRELYLE HHEEEEEECCEEEEC	20.98	22817900
125	Ubiquitination	DIQIVSTTRELYLED HEEEEEECCEEEECC	18.03	21963094
129	Phosphorylation	VSTTRELYLEDSPLE EEECCEEEECCCCCE	11.86	23312004
129	Ubiquitination	VSTTRELYLEDSPLE EEECCEEEECCCCCE	11.86	21963094
133	Phosphorylation	RELYLEDSPLELKIQ CEEEECCCCCEEEEE	23.24	23312004
135	Ubiquitination	LYLEDSPLELKIQAL EEECCCCCEEEEEEE	16.24	22817900
137	Ubiquitination	LEDSPLELKIQALDS ECCCCCEEEEEEEEC	8.57	21963094
140	Ubiquitination	SPLELKIQALDSEGN CCCEEEEEEEECCCC	33.99	21963094
148	Ubiquitination	ALDSEGNTFSTLAGL EEECCCCCHHHHHHH	29.80	21963094
168	Ubiquitination	IVKDSEADRFSDSHN EEECCCCHHCCCHHC	48.37	21963094
169	Methylation	VKDSEADRFSDSHNA EECCCCHHCCCHHCH	39.76	115485833
171	Phosphorylation	DSEADRFSDSHNALR CCCCHHCCCHHCHHH	38.81	-
180	Ubiquitination	SHNALRILTFLESTY HHCHHHHHHHHHHCC	1.93	21963094
191	Ubiquitination	ESTYIPPSYISEMEK HHCCCCHHHHHHHHH	29.73	21963094
194	Phosphorylation	YIPPSYISEMEKAAK CCCHHHHHHHHHHHH	23.74	-
201	2-Hydroxyisobutyrylation	SEMEKAAKQGDTILV HHHHHHHHCCCEEEE	60.72	-
201	Ubiquitination	SEMEKAAKQGDTILV HHHHHHHHCCCEEEE	60.72	-
205	Phosphorylation	KAAKQGDTILVSGMK HHHHCCCEEEECCCC	24.04	21406692
209	Phosphorylation	QGDTILVSGMKTGSS CCCEEEECCCCCCCH	29.71	21406692
212	Ubiquitination	TILVSGMKTGSSKLK EEEECCCCCCCHHHH	53.94	21906983
212 (in isoform 1)	Ubiquitination	-	53.94	21890473
212 (in isoform 2)	Ubiquitination	-	53.94	21890473
215	Phosphorylation	VSGMKTGSSKLKARI ECCCCCCCHHHHHHH	29.54	30631047
217	Ubiquitination	GMKTGSSKLKARIQE CCCCCCHHHHHHHHH	56.56	22817900
228	Ubiquitination	RIQEAVYKNVRPAEV HHHHHHHCCCCHHHH	42.22	21890473
228 (in isoform 1)	Ubiquitination	-	42.22	21890473
228 (in isoform 2)	Ubiquitination	-	42.22	21890473
337	N-linked_Glycosylation	QGASRLPNSTIYVVE CCCCCCCCCEEEEEC	57.27	UniProtKB CARBOHYD
363	Ubiquitination	DRWVLETGRLYEITI CEEEECCCCEEEEEE	14.28	21890473
375	Ubiquitination	ITIEVFDKFSNKVYV EEEEEEHHHCCEEEE	38.95	21890473
379	Ubiquitination	VFDKFSNKVYVSDNI EEHHHCCEEEECCCE	33.47	22817900
379 (in isoform 1)	Ubiquitination	-	33.47	21890473
379 (in isoform 2)	Ubiquitination	-	33.47	21890473
383	O-linked_Glycosylation	FSNKVYVSDNIRIET HCCEEEECCCEEEEE	13.78	30379171
386	Ubiquitination	KVYVSDNIRIETVLP EEEECCCEEEEEEEE	5.87	21890473
405	N-linked_Glycosylation	EVLSSSQNGSYHRIR HHHCCCCCCCHHHHH	43.24	19159218
475	Phosphorylation	KTGAYQYTIRAHGGS CCCCEEEEEEECCCC	6.61	24719451
484	N-linked_Glycosylation	RAHGGSGNFSWSSSS EECCCCCCCCCCCCC	29.49	UniProtKB CARBOHYD
504	Phosphorylation	VTVKGVMTTGSDIGF EEEEEEEECCCCCCC	26.12	-
505	Phosphorylation	TVKGVMTTGSDIGFS EEEEEEECCCCCCCE	19.32	-
602	Phosphorylation	PGRLPPGSEHCSGIR CCCCCCCCCCCCCEE	29.91	29255136
606	Phosphorylation	PPGSEHCSGIRVKAE CCCCCCCCCEEEEEE	38.88	29255136
649	Phosphorylation	PLKAVDPSSVALVTL CCCCCCHHHEEEEEE	32.74	20068231
650	Phosphorylation	LKAVDPSSVALVTLG CCCCCHHHEEEEEEC	19.46	20068231
652	Ubiquitination	AVDPSSVALVTLGSS CCCHHHEEEEEECCC	9.77	22817900
655	Phosphorylation	PSSVALVTLGSSKEM HHHEEEEEECCCCHH	26.67	20068231
658	Phosphorylation	VALVTLGSSKEMLFE EEEEEECCCCHHCCC	41.15	20068231
659	Phosphorylation	ALVTLGSSKEMLFEG EEEEECCCCHHCCCC	30.73	20068231
660	Ubiquitination	LVTLGSSKEMLFEGG EEEECCCCHHCCCCC	49.17	29967540
664	Ubiquitination	GSSKEMLFEGGPRPW CCCCHHCCCCCCCCE	8.71	22817900
675	Ubiquitination	PRPWILEPSKFFQNV CCCEECCHHHHCCCC	39.10	22817900
681	N-linked_Glycosylation	EPSKFFQNVTAEDTD CHHHHCCCCCCCCCC	28.13	UniProtKB CARBOHYD
774	Ubiquitination	CPLLQQNKQVVPVSS CHHHHCCCCEECCCC	39.88	-
781	Phosphorylation	KQVVPVSSHRNPRLD CCEECCCCCCCCCCC	27.05	20068231
801	N-linked_Glycosylation	QEGRRFDNFSSLSIQ CCCCCCCCCCCEEEE	35.67	UniProtKB CARBOHYD
812	O-linked_Glycosylation	LSIQWESTRPVLASI EEEEEEECCCEEECC	27.72	OGP
829	Ubiquitination	ELPMQLVSQDDESGQ CCCCEEEECCCCCCC	36.16	21963094
841	Ubiquitination	SGQKKLHGLQAILVH CCCEEECCEEEEEEE	29.89	21963094
852	Ubiquitination	ILVHEASGTTAITAT EEEEECCCCEEEEEE	33.85	21963094
866	Phosphorylation	TATGYQESHLSSART EECCCCHHHCCCCCC	17.75	18452278
869	Phosphorylation	GYQESHLSSARTKQP CCCHHHCCCCCCCCC	19.27	18452278
903	O-linked_Glycosylation	RVSPEEVTIYNHPGI CCCHHHEEEECCCCC	22.48	OGP
926	N-linked_Glycosylation	GSGYFFLNTSTADVV CCCEEEEECCCCHHH	27.16	19159218
926	N-linked_Glycosylation	GSGYFFLNTSTADVV CCCEEEEECCCCHHH	27.16	20068230
937	Phosphorylation	ADVVKVAYQEARGVA CHHHHHHHHHHCCEE	15.18	-
988	Ubiquitination	LYIRVVDKVEIGKTV EEEEEEEECCCCCHH	30.11	-
993	Ubiquitination	VDKVEIGKTVKAYVR EEECCCCCHHHHHEE	56.67	29967540
994	Phosphorylation	DKVEIGKTVKAYVRV EECCCCCHHHHHEEH	23.25	24719451
996	Ubiquitination	VEIGKTVKAYVRVLD CCCCCHHHHHEEHHH	38.95	-
998	Phosphorylation	IGKTVKAYVRVLDLH CCCHHHHHEEHHHHC	5.31	24719451
1006	Ubiquitination	VRVLDLHKKPFLAKY EEHHHHCCCCHHHHH	70.23	29967540
1007	Ubiquitination	RVLDLHKKPFLAKYF EHHHHCCCCHHHHHC	30.19	22817900
1012	Ubiquitination	HKKPFLAKYFPFMDL CCCCHHHHHCCCCCH	49.96	21963094
1020	Ubiquitination	YFPFMDLKLRAASPI HCCCCCHHHHCCCCE	31.50	21963094
1039	N-linked_Glycosylation	ALDEALDNYTITFLI EHHHHHHHCEEEEEE	36.38	UniProtKB CARBOHYD
1063	Ubiquitination	LTASVTNKAGQRINS EEEEEECCCCCCCCC	44.52	21906983
1063 (in isoform 1)	Ubiquitination	-	44.52	21890473
1116	N-linked_Glycosylation	NILFSISNESVALVS CEEEEECCCHHHHHH	43.84	UniProtKB CARBOHYD
1135	N-linked_Glycosylation	VQGLAIGNGTVSGLV CCEEEECCCCEEEEE	36.53	UniProtKB CARBOHYD
1223	Methylation	KRDVLDLRGRHHEAS CCHHECCCCCCCEEE	39.50	115485841
1235	Phosphorylation	EASIRLPSQYNFAMN EEECCCCHHHCCHHH	50.30	20068231
1237	Phosphorylation	SIRLPSQYNFAMNVL ECCCCHHHCCHHHHH	19.31	20068231
1246	Dimethylation	FAMNVLGRVKGRTGL CHHHHHHCCCCCCCC	23.86	-
1246	Methylation	FAMNVLGRVKGRTGL CHHHHHHCCCCCCCC	23.86	115372693
1258	Ubiquitination	TGLRVVVKAVDPTSG CCCEEEEEEECCCCC	30.96	21963094
1258 (in isoform 1)	Ubiquitination	-	30.96	21890473
1263	Phosphorylation	VVKAVDPTSGQLYGL EEEEECCCCCHHHHH	40.81	24114839
1264	Phosphorylation	VKAVDPTSGQLYGLA EEEECCCCCHHHHHH	29.90	28152594
1268	Phosphorylation	DPTSGQLYGLARELS CCCCCHHHHHHHHCC	11.38	28152594
1301	Phosphorylation	EAEQILMSPNSYIKL CHHHHHCCCCCEEEE	19.93	-
1304	Phosphorylation	QILMSPNSYIKLQTN HHHCCCCCEEEEEEC	31.45	-
1305	Phosphorylation	ILMSPNSYIKLQTNR HHCCCCCEEEEEECC	14.55	-
1310	Phosphorylation	NSYIKLQTNRDGAAS CCEEEEEECCCCCCE	42.53	21712546
1319	Phosphorylation	RDGAASLSYRVLDGP CCCCCEEEEEECCCC	14.38	21712546
1320	Phosphorylation	DGAASLSYRVLDGPE CCCCEEEEEECCCCC	15.27	22210691
1328	Acetylation	RVLDGPEKVPVVHVD EECCCCCCCCEEEEC	55.78	26051181
1328	Ubiquitination	RVLDGPEKVPVVHVD EECCCCCCCCEEEEC	55.78	29967540
1348	Phosphorylation	ASGSMIGTSTIEVIA ECCCEECCCEEEEEE	16.27	24275569
1350	Phosphorylation	GSMIGTSTIEVIAQE CCEECCCEEEEEEEC	22.46	24275569
1362	N-linked_Glycosylation	AQEPFGANQTIIVAV EECCCCCCCEEEEEE	39.65	UniProtKB CARBOHYD
1380	Phosphorylation	PVSYLRVSMSPVLHT CCCEEEEECCCEECC	13.70	-
1437	Ubiquitination	DDFVQIGKGPTNNTC CCCEEECCCCCCCCE	64.44	-
1441	N-linked_Glycosylation	QIGKGPTNNTCVVRT EECCCCCCCCEEEEE	44.97	19159218
1448	Phosphorylation	NNTCVVRTVSVGLTL CCCEEEEEEECCEEE	12.91	21406692
1450	Phosphorylation	TCVVRTVSVGLTLLR CEEEEEEECCEEEEE	15.17	21406692
1454	Phosphorylation	RTVSVGLTLLRVWDA EEEECCEEEEEEECC	20.16	21406692
1547	2-Hydroxyisobutyrylation	AGHLRTYKEVVVSVP CCCCCEEEEEEEECC	43.34	-
1547	Ubiquitination	AGHLRTYKEVVVSVP CCCCCEEEEEEEECC	43.34	22817900
1547 (in isoform 1)	Ubiquitination	-	43.34	21890473
1576	Ubiquitination	FQEATASKVIVAVGD HHHHHCCEEEEEECC	33.25	-
1584	Methylation	VIVAVGDRSSNLRGE EEEEECCCCCCCCCC	35.74	115485857
1589	Methylation	GDRSSNLRGECTPTQ CCCCCCCCCCCCHHH	43.01	115485849
1724	Ubiquitination	VLENLEVKSGSPAVL HHHCCEECCCCCCCH	39.46	21963094
1725	Phosphorylation	LENLEVKSGSPAVLA HHCCEECCCCCCCHH	50.07	-
1727	Phosphorylation	NLEVKSGSPAVLAFA CCEECCCCCCCHHHH	19.44	-
1735	Ubiquitination	PAVLAFAKEKSFGWP CCCHHHHHCCCCCCC	60.26	-
1782	O-linked_Glycosylation	QAIAIPVTVAFVVDR CCEEEEEEEEEEECC	10.77	OGP
1844	Phosphorylation	LAVPAALTPRASPGH HCCCCHHCCCCCCCC	13.15	19664994
1848	Phosphorylation	AALTPRASPGHSPHY CHHCCCCCCCCCCCC	32.47	23401153
1852	Phosphorylation	PRASPGHSPHYFAAS CCCCCCCCCCCEECC	21.20	23927012
1855	Phosphorylation	SPGHSPHYFAASSPT CCCCCCCCEECCCCC	9.78	23927012
1859	Phosphorylation	SPHYFAASSPTSPNA CCCCEECCCCCCCCC	33.16	25159151
1860	Phosphorylation	PHYFAASSPTSPNAL CCCEECCCCCCCCCC	27.72	23927012
1862	Phosphorylation	YFAASSPTSPNALPP CEECCCCCCCCCCCC	59.78	23927012
1863	Phosphorylation	FAASSPTSPNALPPA EECCCCCCCCCCCCC	21.38	23927012
1872	Ubiquitination	NALPPARKASPPSGL CCCCCCCCCCCCCCC	56.15	33845483
1874	Phosphorylation	LPPARKASPPSGLWS CCCCCCCCCCCCCCC	40.14	25159151
1877	Phosphorylation	ARKASPPSGLWSPAY CCCCCCCCCCCCCCC	50.32	25159151
1881	Phosphorylation	SPPSGLWSPAYASH- CCCCCCCCCCCCCC-	12.51	30266825
1884	Phosphorylation	SGLWSPAYASH---- CCCCCCCCCCC----	16.42	23927012
1886	Phosphorylation	LWSPAYASH------ CCCCCCCCC------	19.63	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PO210_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1881	S	Phosphorylation		18669648
Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PO210_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NOCT_HUMAN	CCRN4L	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PO210_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-405; ASN-926 AND ASN-1441,AND MASS SPECTROMETRY.	19159218 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874; SER-1877 ANDSER-1881, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844; SER-1874; SER-1881AND SER-1886, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1844, AND MASSSPECTROMETRY.	16565220 [Abstract]

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