NOCT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOCT_HUMAN
• UniProt AC: Q9UK39
• Protein Name: Nocturnin {ECO:0000250|UniProtKB:P79942, ECO:0000312|HGNC:HGNC:14254}
• Gene Name: NOCT {ECO:0000312|HGNC:HGNC:14254}
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
• Protein Description: Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity)..
• Protein Sequence: MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	PGLRRPLSPPAAVPR CCCCCCCCCCCCCCC	31.36	28555341
43	Phosphorylation	AAVPRPASPRLLAAA CCCCCCCCHHHHHHH	17.15	26055452
63	Phosphorylation	AARSCSRTVCSMGTG HHHHCCCEEECCCCC	15.01	28509920
66	Phosphorylation	SCSRTVCSMGTGTSR HCCCEEECCCCCHHH	18.86	28509920
69	Phosphorylation	RTVCSMGTGTSRLYS CEEECCCCCHHHHHH	28.75	-
71	Phosphorylation	VCSMGTGTSRLYSAL EECCCCCHHHHHHHH	15.54	-
72	Phosphorylation	CSMGTGTSRLYSALA ECCCCCHHHHHHHHH	22.95	28509920
75	Phosphorylation	GTGTSRLYSALAKTL CCCHHHHHHHHHHHH	7.26	27642862
84	Phosphorylation	ALAKTLNSSAASQHP HHHHHHCCHHHHHCC	25.19	28796482
85	Phosphorylation	LAKTLNSSAASQHPE HHHHHCCHHHHHCCC	27.12	28796482
88	Phosphorylation	TLNSSAASQHPEYLV HHCCHHHHHCCCEEC	28.83	28796482
93	Phosphorylation	AASQHPEYLVSPDPE HHHHCCCEECCCCHH	19.49	28796482
96	Phosphorylation	QHPEYLVSPDPEHLE HCCCEECCCCHHHCC	22.46	28796482
121	Methylation	CRAVLHTRPPRFQRD HHHHHHCCCCCHHHC	28.60	-
124	Methylation	VLHTRPPRFQRDFVD HHHCCCCCHHHCCEE	42.91	-
171	Ubiquitination	QCPVEALKWEERKCL ECCHHHHCHHHHHHH	60.65	29967540
274	Ubiquitination	IAQTLECKESGRQFC EEEEEEEHHHHCEEE	45.60	29967540
285	Phosphorylation	RQFCIAVTHLKARTG CEEEEEEEEEHHHHH	16.69	27251275
340	Phosphorylation	VYKHFASSSLNLNSA HHHHHHHCCCCCCHH	35.10	25627689
341	Phosphorylation	YKHFASSSLNLNSAY HHHHHHCCCCCCHHH	20.84	27251275
361	Phosphorylation	DGQSEPPYTTWKIRT CCCCCCCCCEEEEEE	27.76	27642862
365	Ubiquitination	EPPYTTWKIRTSGEC CCCCCEEEEEECCCC	21.88	-
365	Malonylation	EPPYTTWKIRTSGEC CCCCCEEEEEECCCC	21.88	26320211
365	Acetylation	EPPYTTWKIRTSGEC CCCCCEEEEEECCCC	21.88	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOCT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOCT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOCT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ODB2_HUMAN	DBT	physical	28514442
PINX1_HUMAN	PINX1	physical	28514442
EKI1_HUMAN	ETNK1	physical	28514442
NS1BP_HUMAN	IVNS1ABP	physical	28514442
NDK6_HUMAN	NME6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.