EKI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EKI1_HUMAN
• UniProt AC: Q9HBU6
• Protein Name: Ethanolamine kinase 1
• Gene Name: ETNK1
• Organism: Homo sapiens (Human).
• Sequence Length: 452
• Subcellular Localization: Cytoplasm.
• Protein Description: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis..
• Protein Sequence: MLCGRPRSSSDNRNFLRERAGLSSAAVQTRIGNSAASRRSPAARPPVPAPPALPRGRPGTEGSTSLSAPAVLVVAVAVVVVVVSAVAWAMANYIHVPPGSPEVPKLNVTVQDQEEHRCREGALSLLQHLRPHWDPQEVTLQLFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQAHGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIPSSQILQEEMTWMKEILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQSQWLRAYLEAYKEFKGFGTEVTEKEVEILFIQVNQFALASHFFWGLWALIQAKYSTIEFDFLGYAIVRFNQYFKMKPEVTALKVPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	VQTRIGNSAASRRSP HHHHHCCCHHHCCCC	21.72	23532336
37	Phosphorylation	RIGNSAASRRSPAAR HHCCCHHHCCCCCCC	28.13	23532336
40	Phosphorylation	NSAASRRSPAARPPV CCHHHCCCCCCCCCC	20.13	28555341
100	Phosphorylation	YIHVPPGSPEVPKLN CCCCCCCCCCCCCCE	24.54	22199227
172	Ubiquitination	LVRIYGNKTELLVDR EEEEECCCEEEEECC	38.73	21890473
179	Methylation	KTELLVDRDEEVKSF CEEEEECCCHHHHHH	45.84	-
184	Acetylation	VDRDEEVKSFRVLQA ECCCHHHHHHHHHHH	47.35	25953088
184	Ubiquitination	VDRDEEVKSFRVLQA ECCCHHHHHHHHHHH	47.35	21906983
255	Ubiquitination	PKSNLWLKMGKYFSL CCCCEEEECCCEEEE	33.74	21906983
258	Acetylation	NLWLKMGKYFSLIPT CEEEECCCEEEECCC	39.36	25953088
258	Ubiquitination	NLWLKMGKYFSLIPT CEEEECCCEEEECCC	39.36	-
274	Ubiquitination	FADEDINKRFLSDIP CCCHHHHHHHHHCCC	44.88	21906983
314	Ubiquitination	CHNDLLCKNIIYNEK ECCCEEHHHCCEECC	51.67	-
321	Ubiquitination	KNIIYNEKQGDVQFI HHCCEECCCCCEEEE	56.81	-
360	Phosphorylation	SDVDYSLYPDRELQS CCCCCCCCCCHHHHH	9.35	27196784
378	Ubiquitination	RAYLEAYKEFKGFGT HHHHHHHHHHCCCCC	64.82	21906983
381	Ubiquitination	LEAYKEFKGFGTEVT HHHHHHHCCCCCCCC	55.19	-
446	Phosphorylation	FKMKPEVTALKVPE- CCCCCCCEEEECCC-	25.30	28857561
449	Acetylation	KPEVTALKVPE---- CCCCEEEECCC----	53.96	19608861
449	Ubiquitination	KPEVTALKVPE---- CCCCEEEECCC----	53.96	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EKI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EKI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EKI1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EKI1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-449, AND MASS SPECTROMETRY.
PubMed: 19608861