ITB6_HUMAN - dbPTM
ITB6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITB6_HUMAN
UniProt AC P18564
Protein Name Integrin beta-6
Gene Name ITGB6
Organism Homo sapiens (Human).
Sequence Length 788
Subcellular Localization Membrane
Single-pass type I membrane protein. Cell junction, focal adhesion .
Protein Description Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. [PubMed: 17158881; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1]
Protein Sequence MGIELLCLFFLFLGRNDHVQGGCALGGAETCEDCLLIGPQCAWCAQENFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48N-linked_GlycosylationCAWCAQENFTHPSGV
CCHHHHCCCCCCCCC		34.73UniProtKB CARBOHYD
97N-linked_GlycosylationLSVGRQKNSSDIVQI
CCCCCCCCCCCCEEE		38.11UniProtKB CARBOHYD
260N-linked_GlycosylationKEKIGWRNDSLHLLV
HHHHCCCCCCEEEEE		36.3928117447
270PhosphorylationLHLLVFVSDADSHFG
EEEEEEEECCCCCCC		18.6722210691
387N-linked_GlycosylationLGDTEGLNLSFTAIC
CCCCCCCCEEEEEEE		44.49UniProtKB CARBOHYD
396N-linked_GlycosylationSFTAICNNGTLFQHQ
EEEEEECCCCEEECC		40.18UniProtKB CARBOHYD
463N-linked_GlycosylationCQKEVEVNSSKCHHG
CCCEEEECCCCCCCC		27.36UniProtKB CARBOHYD
471N-linked_GlycosylationSSKCHHGNGSFQCGV
CCCCCCCCCCCEEEE		38.28UniProtKB CARBOHYD
541N-linked_GlycosylationGPYCQCDNFSCVRHK
CCCCCCCCCCCEEEC		38.05UniProtKB CARBOHYD
575N-linked_GlycosylationGWTGEYCNCTTSTDS
CCCCCCCCCCCCCCC		25.85UniProtKB CARBOHYD
657PhosphorylationKLAGATISEEEDFSK
HHCCCEECCCCCCCC		34.30-
735PhosphorylationCIWKLLVSFHDRKEV
HHHHHHHHHCCHHHH		19.4829083192
756PhosphorylationRSKAKWQTGTNPLYR
HHHCCCCCCCCCCCC		44.87-
758PhosphorylationKAKWQTGTNPLYRGS
HCCCCCCCCCCCCCC		36.7322617229
762PhosphorylationQTGTNPLYRGSTSTF
CCCCCCCCCCCCCCC		17.7425106551
765PhosphorylationTNPLYRGSTSTFKNV
CCCCCCCCCCCCCCC		15.3626657352
766PhosphorylationNPLYRGSTSTFKNVT
CCCCCCCCCCCCCCE		34.3123312004
767PhosphorylationPLYRGSTSTFKNVTY
CCCCCCCCCCCCCEE		33.2827251275
768PhosphorylationLYRGSTSTFKNVTYK
CCCCCCCCCCCCEEC		38.42-
773PhosphorylationTSTFKNVTYKHREKQ
CCCCCCCEECCCCCC		35.9224719451
785PhosphorylationEKQKVDLSTDC----
CCCCEECCCCC----		20.1028348404
786PhosphorylationKQKVDLSTDC-----
CCCEECCCCC-----		49.0028348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITB6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITB6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITB6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MK01_HUMANMAPK1physical
11857080
FHL2_HUMANFHL2physical
10906324
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616221Amelogenesis imperfecta 1H (AI1H)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITB6_HUMAN

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Related Literatures of Post-Translational Modification

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