dbPTM

GGA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GGA1_HUMAN
UniProt AC	Q9UJY5
Protein Name	ADP-ribosylation factor-binding protein GGA1
Gene Name	GGA1
Organism	Homo sapiens (Human).
Sequence Length	639
Subcellular Localization	Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein. Endosome membrane Peripheral membrane protein.
Protein Description	Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif..
Protein Sequence	MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPSLDGTGWNSFQSSDATEPPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETWGSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPAMEPE -------CCCCCCHH	14.54	22814378
15	Ubiquitination	ETLEARINRATNPLN HHHHHHHHHHCCCCH	23.21	21963094
23	Ubiquitination	RATNPLNKELDWASI HHCCCCHHCCCHHHH	68.30	-
23	Ubiquitination	RATNPLNKELDWASI HHCCCCHHCCCHHHH	68.30	23000965
28	Ubiquitination	LNKELDWASINGFCE CHHCCCHHHHHHHHH	10.53	21890473
28	Ubiquitination	LNKELDWASINGFCE CHHCCCHHHHHHHHH	10.53	23000965
46	Ubiquitination	EDFEGPPLATRLLAH CCCCCCHHHHHHHHH	9.52	25015289
54 (in isoform 2)	Ubiquitination	-	36.51	21890473
54	Ubiquitination	ATRLLAHKIQSPQEW HHHHHHHHCCCHHHH	36.51	-
57 (in isoform 6)	Phosphorylation	-	31.83	24043423
57 (in isoform 5)	Phosphorylation	-	31.83	24043423
68 (in isoform 6)	Phosphorylation	-	26.51	24043423
68 (in isoform 5)	Phosphorylation	-	26.51	24043423
69	Ubiquitination	EAIQALTVLETCMKS HHHHHHHHHHHHHHH	4.77	24816145
73	Glutathionylation	ALTVLETCMKSCGKR HHHHHHHHHHHCCHH	2.06	22555962
88	Ubiquitination	FHDEVGKFRFLNELI HHHHHHHHHHHHHHH	5.70	23000965
92	Ubiquitination	VGKFRFLNELIKVVS HHHHHHHHHHHHHHC	39.04	21890473
92	Ubiquitination	VGKFRFLNELIKVVS HHHHHHHHHHHHHHC	39.04	22817900
93	Ubiquitination	GKFRFLNELIKVVSP HHHHHHHHHHHHHCH	54.76	21890473
96	Ubiquitination	RFLNELIKVVSPKYL HHHHHHHHHHCHHHC	49.56	23000965
99	Phosphorylation	NELIKVVSPKYLGSR HHHHHHHCHHHCCCC	20.75	-
101	Ubiquitination	LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC	45.67	23000965
101	Ubiquitination	LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC	45.67	21890473
101 (in isoform 1)	Ubiquitination	-	45.67	21890473
101	Malonylation	LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC	45.67	30639696
101	Malonylation	LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC	45.67	26320211
101	Acetylation	LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC	45.67	25953088
105	Ubiquitination	VSPKYLGSRTSEKVK HCHHHCCCCCCHHHH	29.77	23000965
105	Phosphorylation	VSPKYLGSRTSEKVK HCHHHCCCCCCHHHH	29.77	22798277
108	Phosphorylation	KYLGSRTSEKVKNKI HHCCCCCCHHHHHHH	34.02	22798277
110	Ubiquitination	LGSRTSEKVKNKILE CCCCCCHHHHHHHHH	59.27	23000965
113	Ubiquitination	RTSEKVKNKILELLY CCCHHHHHHHHHHHH	39.32	23000965
118	Ubiquitination	VKNKILELLYSWTVG HHHHHHHHHHHHHCC	4.95	23000965
122	Ubiquitination	ILELLYSWTVGLPEE HHHHHHHHHCCCCHH	4.99	29967540
125	Ubiquitination	LLYSWTVGLPEEVKI HHHHHHCCCCHHHHH	28.30	32015554
132 (in isoform 2)	Ubiquitination	-	5.17	21890473
133	Ubiquitination	LPEEVKIAEAYQMLK CCHHHHHHHHHHHHH	6.94	24816145
140	Acetylation	AEAYQMLKKQGIVKS HHHHHHHHHCCCCCC	37.39	25953088
141	Acetylation	EAYQMLKKQGIVKSD HHHHHHHHCCCCCCC	50.20	25953088
141 (in isoform 2)	Ubiquitination	-	50.20	21890473
141	Ubiquitination	EAYQMLKKQGIVKSD HHHHHHHHCCCCCCC	50.20	-
147	Phosphorylation	KKQGIVKSDPKLPDD HHCCCCCCCCCCCCC	48.53	28348404
155	Phosphorylation	DPKLPDDTTFPLPPP CCCCCCCCCCCCCCC	37.40	28348404
156	Phosphorylation	PKLPDDTTFPLPPPR CCCCCCCCCCCCCCC	30.19	20068231
157	Ubiquitination	KLPDDTTFPLPPPRP CCCCCCCCCCCCCCC	6.76	21890473
158	Ubiquitination	LPDDTTFPLPPPRPK CCCCCCCCCCCCCCC	41.69	-
165 (in isoform 2)	Ubiquitination	-	66.19	21890473
165	Ubiquitination	PLPPPRPKNVIFEDE CCCCCCCCCCCCCCH	66.19	21890473
165	Ubiquitination	PLPPPRPKNVIFEDE CCCCCCCCCCCCCCH	66.19	22817900
165 (in isoform 1)	Ubiquitination	-	66.19	21890473
174 (in isoform 1)	Ubiquitination	-	54.02	21890473
174	Ubiquitination	VIFEDEEKSKMLARL CCCCCHHHHHHHHHH	54.02	21906983
175	Ubiquitination	IFEDEEKSKMLARLL CCCCHHHHHHHHHHH	26.95	25015289
182	Ubiquitination	SKMLARLLKSSHPED HHHHHHHHHCCCHHH	4.16	22817900
183	Ubiquitination	KMLARLLKSSHPEDL HHHHHHHHCCCHHHH	55.28	33845483
183	Methylation	KMLARLLKSSHPEDL HHHHHHHHCCCHHHH	55.28	-
184	Phosphorylation	MLARLLKSSHPEDLR HHHHHHHCCCHHHHH	33.57	30108239
185	Phosphorylation	LARLLKSSHPEDLRA HHHHHHCCCHHHHHH	41.28	30108239
191	Ubiquitination	SSHPEDLRAANKLIK CCCHHHHHHHHHHHH	43.93	33845483
191	Ubiquitination	SSHPEDLRAANKLIK CCCHHHHHHHHHHHH	43.93	21890473
192	Ubiquitination	SHPEDLRAANKLIKE CCHHHHHHHHHHHHH	23.76	25015289
195	Acetylation	EDLRAANKLIKEMVQ HHHHHHHHHHHHHHH	47.03	25953088
195	Ubiquitination	EDLRAANKLIKEMVQ HHHHHHHHHHHHHHH	47.03	29967540
198	Ubiquitination	RAANKLIKEMVQEDQ HHHHHHHHHHHHHHH	50.63	33845483
198 (in isoform 1)	Ubiquitination	-	50.63	21890473
200	Ubiquitination	ANKLIKEMVQEDQKR HHHHHHHHHHHHHHH	2.99	33845483
200	Ubiquitination	ANKLIKEMVQEDQKR HHHHHHHHHHHHHHH	2.99	-
206	Ubiquitination	EMVQEDQKRMEKISK HHHHHHHHHHHHHHH	67.06	24816145
215	Ubiquitination	MEKISKRVNAIEEVN HHHHHHHHHHHHHHH	6.97	21890473
215	Ubiquitination	MEKISKRVNAIEEVN HHHHHHHHHHHHHHH	6.97	33845483
223	Ubiquitination	NAIEEVNNNVKLLTE HHHHHHHHHHHHHHH	60.90	24816145
223	Ubiquitination	NAIEEVNNNVKLLTE HHHHHHHHHHHHHHH	60.90	-
236	Phosphorylation	TEMVMSHSQGGAAAG HHHHHHCCCCCCCCC	24.18	17525332
244	Phosphorylation	QGGAAAGSSEDLMKE CCCCCCCCHHHHHHH	26.31	28348404
245	Phosphorylation	GGAAAGSSEDLMKEL CCCCCCCHHHHHHHH	33.92	28348404
262	Phosphorylation	RCERMRPTLFRLASD HHHHHCHHHHHHHCC	28.32	-
268	Phosphorylation	PTLFRLASDTEDNDE HHHHHHHCCCCCCHH	50.05	28348404
270	Phosphorylation	LFRLASDTEDNDEAL HHHHHCCCCCCHHHH	42.62	27273156
355	Phosphorylation	EQPSASVSLLDDELM CCCCCEEEECCHHHH	22.25	12060753
359	Ubiquitination	ASVSLLDDELMSLGL CEEEECCHHHHHCCC	51.39	29967540
373	Ubiquitination	LSDPTPPSGPSLDGT CCCCCCCCCCCCCCC	65.62	29967540
412	Phosphorylation	ESRPPAQTSLPASSG CCCCCCCCCCCCCCC	34.05	24275569
418	Phosphorylation	QTSLPASSGLDDLDL CCCCCCCCCCCHHHH	45.54	14702039
434	Phosphorylation	GKTLLQQSLPPESQQ HHHHHHHCCCHHHHH	29.86	28857561
446	Ubiquitination	SQQVRWEKQQPTPRL HHHCHHHHCCCCCCE	47.47	29967540
450	Phosphorylation	RWEKQQPTPRLTLRD HHHHCCCCCCEEHHH	19.39	-
463	Ubiquitination	RDLQNKSSSCSSPSS HHHCCCCCCCCCCCH	36.65	-
478	Phosphorylation	SATSLLHTVSPEPPR HHHHHHHHCCCCCCC	23.73	26074081
480	Phosphorylation	TSLLHTVSPEPPRPP HHHHHHCCCCCCCCC	25.38	26074081
493	Phosphorylation	PPQQPVPTELSLASI CCCCCCCCEEEEEEE	50.20	30243723
496	Phosphorylation	QPVPTELSLASITVP CCCCCEEEEEEEEEE	18.69	30243723
499	Phosphorylation	PTELSLASITVPLES CCEEEEEEEEEEHHH	24.88	30243723
501	Phosphorylation	ELSLASITVPLESIK EEEEEEEEEEHHHCC	17.36	30243723
506	Phosphorylation	SITVPLESIKPSNIL EEEEEHHHCCHHHEE	43.53	30243723
546	Phosphorylation	DVLVVVVSMLSTAPQ CEEEEEEECCCCCCC	11.46	19276368
550	Phosphorylation	VVVSMLSTAPQPIRN EEEECCCCCCCCHHH	38.09	19276368

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
355	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
355	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GGA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GGA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NECP2_HUMAN	NECAP2	physical	14665628
ARF1_HUMAN	ARF1	physical	12636914
CLH1_HUMAN	CLTC	physical	11301005
SYNRG_HUMAN	SYNRG	physical	10814529
RABE1_HUMAN	RABEP1	physical	12505986
RABX5_HUMAN	RABGEF1	physical	12505986
BACE2_HUMAN	BACE2	physical	12135764
ARF3_HUMAN	ARF3	physical	10749927
VPS18_HUMAN	VPS18	physical	16996030
UBC_HUMAN	UBC	physical	14660606
RABX5_HUMAN	RABGEF1	physical	15143060
ARF1_HUMAN	ARF1	physical	15143060
UBC_HUMAN	UBC	physical	15143060
TS101_HUMAN	TSG101	physical	15143060
BACE1_HUMAN	BACE1	physical	15466887
RABE1_HUMAN	RABEP1	physical	15457209
RABE1_HUMAN	RABEP1	physical	14636058
CCD91_HUMAN	CCDC91	physical	12808037
MPRD_HUMAN	M6PR	physical	15044437
ADIPO_MOUSE	Adipoq	physical	16407204
MPRI_HUMAN	IGF2R	physical	11859376
SORT_HUMAN	SORT1	physical	11859376
BACE1_HUMAN	BACE1	physical	15117318
MPRI_HUMAN	IGF2R	physical	15117318
CLH1_HUMAN	CLTC	physical	17344219
CLH1_HUMAN	CLTC	physical	17052248
CCD91_HUMAN	CCDC91	physical	12858163
SYNRG_HUMAN	SYNRG	physical	12858163
BACE1_HUMAN	BACE1	physical	15886016
ARF3_HUMAN	ARF3	physical	14690499
A4_HUMAN	APP	physical	17151287
RABE1_HUMAN	RABEP1	physical	16473621
SORT_HUMAN	SORT1	physical	20015111
SORL_HUMAN	SORL1	physical	20015111
GGA1_HUMAN	GGA1	physical	17506864
SYNRG_HUMAN	SYNRG	physical	17506864
EPN4_HUMAN	CLINT1	physical	17506864
RABE1_HUMAN	RABEP1	physical	17506864
CLH1_HUMAN	CLTC	physical	17506864
GGA2_HUMAN	GGA2	physical	14638859
GGA3_HUMAN	GGA3	physical	14638859
LRP3_HUMAN	LRP3	physical	11390366
SORT_HUMAN	SORT1	physical	11390366
MPRI_HUMAN	IGF2R	physical	11390366
MON2_YEAST	MON2	physical	18418388
MON2_HUMAN	MON2	physical	18418388
ARF1_MOUSE	Arf1	physical	12679809
MAP1A_HUMAN	MAP1A	physical	10747088
RABE1_HUMAN	RABEP1	physical	10747088
SYNRG_HUMAN	SYNRG	physical	10747088
RNF11_HUMAN	RNF11	physical	25195858
ARF1_HUMAN	ARF1	physical	11950392
ARF3_HUMAN	ARF3	physical	11950392
ARF5_HUMAN	ARF5	physical	11950392
ARF6_HUMAN	ARF6	physical	11950392
CA216_HUMAN	C1orf216	physical	25416956
UBC_HUMAN	UBC	physical	17494868
TOLIP_HUMAN	TOLLIP	physical	15047686
DHX15_HUMAN	DHX15	physical	26344197
4EBP1_HUMAN	EIF4EBP1	physical	26344197
GIPC1_HUMAN	GIPC1	physical	26344197
LIX1L_HUMAN	LIX1L	physical	26344197
RABEK_HUMAN	RABEPK	physical	26344197
SORL_HUMAN	SORL1	physical	26053850
ARF6_HUMAN	ARF6	physical	21198641
ARF1_HUMAN	ARF1	physical	21198641
CEP72_HUMAN	CEP72	physical	28514442
CLCN3_HUMAN	CLCN3	physical	28514442
E2F5_HUMAN	E2F5	physical	28514442
TFDP1_HUMAN	TFDP1	physical	28514442
CEP44_HUMAN	CEP44	physical	28514442
CCD91_HUMAN	CCDC91	physical	28514442
RBGP1_HUMAN	RABGAP1	physical	28514442
FP100_HUMAN	C17orf70	physical	28514442
DTBP1_HUMAN	DTNBP1	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
MAP1S_HUMAN	MAP1S	physical	28514442
RBG10_HUMAN	RABGAP1L	physical	28514442
RBG1L_HUMAN	RABGAP1L	physical	28514442
TMM9B_HUMAN	TMEM9B	physical	28514442
EXOC4_HUMAN	EXOC4	physical	28514442
CENPH_HUMAN	CENPH	physical	28514442
SNP47_HUMAN	SNAP47	physical	27173435
ECHD1_HUMAN	ECHDC1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GGA1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, AND MASSSPECTROMETRY.	17525332 [Abstract]