| UniProt ID | TS101_HUMAN | |
|---|---|---|
| UniProt AC | Q99816 | |
| Protein Name | Tumor susceptibility gene 101 protein | |
| Gene Name | TSG101 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 390 | |
| Subcellular Localization |
Cytoplasm . Early endosome membrane Peripheral membrane protein Cytoplasmic side . Late endosome membrane Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody, Midbody ring . Nucleus . Mainly |
|
| Protein Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. [PubMed: 22660413 It may also play a role in the extracellular release of microvesicles that differ from the exosomes] | |
| Protein Sequence | MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAVSESQLK ------CCCCHHHHH | 17.34 | 22814378 | |
| 4 | Phosphorylation | ----MAVSESQLKKM ----CCCCHHHHHHH | 23.22 | 23401153 | |
| 6 | Phosphorylation | --MAVSESQLKKMVS --CCCCHHHHHHHHH | 33.05 | 25159151 | |
| 9 | Acetylation | AVSESQLKKMVSKYK CCCHHHHHHHHHHHH | 31.05 | 25953088 | |
| 9 | Ubiquitination | AVSESQLKKMVSKYK CCCHHHHHHHHHHHH | 31.05 | 33845483 | |
| 14 | Acetylation | QLKKMVSKYKYRDLT HHHHHHHHHHCCCCC | 34.06 | 18525581 | |
| 15 | Phosphorylation | LKKMVSKYKYRDLTV HHHHHHHHHCCCCCH | 13.02 | 20068231 | |
| 16 | Acetylation | KKMVSKYKYRDLTVR HHHHHHHHCCCCCHH | 37.23 | 18525589 | |
| 32 | Phosphorylation | TVNVITLYKDLKPVL HEEEEEEECCHHHHH | 8.19 | - | |
| 48 | Phosphorylation | SYVFNDGSSRELMNL HEECCCCCCCCHHHC | 29.14 | 30108239 | |
| 49 | Ubiquitination | YVFNDGSSRELMNLT EECCCCCCCCHHHCC | 34.99 | 27667366 | |
| 49 | Phosphorylation | YVFNDGSSRELMNLT EECCCCCCCCHHHCC | 34.99 | 30108239 | |
| 56 | Phosphorylation | SRELMNLTGTIPVPY CCCHHHCCCCCCCCC | 27.55 | 21214269 | |
| 63 | Phosphorylation | TGTIPVPYRGNTYNI CCCCCCCCCCCCCCC | 31.24 | 21214269 | |
| 90 | Acetylation | NPPICFVKPTSSMTI CCCEEEECCCCCCEE | 23.48 | 20167786 | |
| 101 | Ubiquitination | SMTIKTGKHVDANGK CCEEECCCCCCCCCE | 45.76 | 27667366 | |
| 110 | Phosphorylation | VDANGKIYLPYLHEW CCCCCEEECCCHHHC | 12.71 | 23898821 | |
| 132 (in isoform 2) | Ubiquitination | - | 2.22 | 21890473 | |
| 152 (in isoform 2) | Ubiquitination | - | 26.15 | 21890473 | |
| 185 | Ubiquitination | YPPNPSGYPGCPYPP CCCCCCCCCCCCCCC | 10.78 | 21890473 | |
| 191 | Ubiquitination | GYPGCPYPPGGPYPA CCCCCCCCCCCCCCC | 13.25 | 23000965 | |
| 205 | Ubiquitination | ATTSSQYPSQPPVTT CCCCCCCCCCCCEEE | 20.89 | 21890473 | |
| 217 | Ubiquitination | VTTVGPSRDGTISED EEEECCCCCCCCCHH | 49.89 | 24816145 | |
| 220 | Phosphorylation | VGPSRDGTISEDTIR ECCCCCCCCCHHHHH | 26.14 | 23401153 | |
| 222 | Phosphorylation | PSRDGTISEDTIRAS CCCCCCCCHHHHHHH | 29.29 | 20873877 | |
| 225 | Phosphorylation | DGTISEDTIRASLIS CCCCCHHHHHHHHHH | 14.33 | 26552605 | |
| 229 | Phosphorylation | SEDTIRASLISAVSD CHHHHHHHHHHHHHH | 19.18 | 20873877 | |
| 232 | Phosphorylation | TIRASLISAVSDKLR HHHHHHHHHHHHHHH | 28.10 | 29759185 | |
| 235 | Phosphorylation | ASLISAVSDKLRWRM HHHHHHHHHHHHHHH | 28.83 | 20873877 | |
| 237 (in isoform 1) | Ubiquitination | - | 32.23 | 21890473 | |
| 237 | Ubiquitination | LISAVSDKLRWRMKE HHHHHHHHHHHHHHH | 32.23 | 23000965 | |
| 237 | Acetylation | LISAVSDKLRWRMKE HHHHHHHHHHHHHHH | 32.23 | 23236377 | |
| 243 | Ubiquitination | DKLRWRMKEEMDRAQ HHHHHHHHHHHHHHH | 41.78 | 23000965 | |
| 256 (in isoform 2) | Ubiquitination | - | 3.62 | 21890473 | |
| 257 | Ubiquitination | QAELNALKRTEEDLK HHHHHHHHHCHHHHH | 55.66 | 22817900 | |
| 257 (in isoform 1) | Ubiquitination | - | 55.66 | 21890473 | |
| 269 | Ubiquitination | DLKKGHQKLEEMVTR HHHHHHHHHHHHHHH | 52.79 | 24816145 | |
| 286 | Ubiquitination | QEVAEVDKNIELLKK HHHHHHHHHHHHHHH | 66.07 | 29967540 | |
| 292 | Ubiquitination | DKNIELLKKKDEELS HHHHHHHHHHHHHHH | 71.10 | 33845483 | |
| 292 | 2-Hydroxyisobutyrylation | DKNIELLKKKDEELS HHHHHHHHHHHHHHH | 71.10 | - | |
| 293 | Ubiquitination | KNIELLKKKDEELSS HHHHHHHHHHHHHHH | 66.48 | 29967540 | |
| 294 | Ubiquitination | NIELLKKKDEELSSA HHHHHHHHHHHHHHH | 69.64 | 29967540 | |
| 299 | Phosphorylation | KKKDEELSSALEKME HHHHHHHHHHHHHHH | 19.49 | 20068231 | |
| 300 | Phosphorylation | KKDEELSSALEKMEN HHHHHHHHHHHHHHH | 49.88 | 20068231 | |
| 304 | Ubiquitination | ELSSALEKMENQSEN HHHHHHHHHHHCCCC | 52.98 | 29967540 | |
| 309 | Ubiquitination | LEKMENQSENNDIDE HHHHHHCCCCCCCCC | 54.60 | 21890473 | |
| 309 | Phosphorylation | LEKMENQSENNDIDE HHHHHHCCCCCCCCC | 54.60 | 29507054 | |
| 330 | Ubiquitination | PLYKQILNLYAEENA HHHHHHHHHHHHHCC | 32.41 | 24816145 | |
| 361 | Ubiquitination | IDLDVFLKHVRLLSR CCHHHHHHHHHHHCH | 28.70 | 22817900 | |
| 361 (in isoform 1) | Ubiquitination | - | 28.70 | 21890473 | |
| 379 | Ubiquitination | QLRALMQKARKTAGL HHHHHHHHHHHHCCC | 35.87 | 29967540 | |
| 379 | Acetylation | QLRALMQKARKTAGL HHHHHHHHHHHHCCC | 35.87 | 25953088 | |
| 382 | Ubiquitination | ALMQKARKTAGLSDL HHHHHHHHHCCCCCC | 47.81 | 24816145 | |
| 387 | Phosphorylation | ARKTAGLSDLY---- HHHHCCCCCCC---- | 25.34 | 24719451 | |
| 390 | Phosphorylation | TAGLSDLY------- HCCCCCCC------- | 22.84 | 19605366 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | MGRN1 | O60291 | PMID:17229889 |
| - | K | Ubiquitination | E3 ubiquitin ligase | LRSAM1 | Q6UWE0 | PMID:15256501 |
| - | K | Ubiquitination | E3 ubiquitin ligase | NEDD4 | P46934 | PMID:15126635 |
| - | K | Ubiquitination | E3 ubiquitin ligase | NEDD4L | Q96PU5 | PMID:18321968 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TS101_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TS101_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-220, AND MASSSPECTROMETRY. | |
| "Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-390, AND MASSSPECTROMETRY. | |
