HAUS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HAUS1_HUMAN
• UniProt AC: Q96CS2
• Protein Name: HAUS augmin-like complex subunit 1
• Gene Name: HAUS1
• Organism: Homo sapiens (Human).
• Sequence Length: 278
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Localizes with the spindle poles in mitotic cells. In metaphase, localizes to the mitotic aste
• Protein Description: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex..
• Protein Sequence: MEPQEERETQVAAWLKKIFGDHPIPQYEVNPRTTEILHHLSERNRVRDRDVYLVIEDLKQKASEYESEAKYLQDLLMESVNFSPANLSSTGSRYLNALVDSAVALETKDTSLASFIPAVNDLTSDLFRTKSKSEEIKIELEKLEKNLTATLVLEKCLQEDVKKAELHLSTERAKVDNRRQNMDFLKAKSEEFRFGIKAAEEQLSARGMDASLSHQSLVALSEKLARLKQQTIPLKKKLESYLDLMPNPSLAQVKIEEAKRELDSIEAELTRRVDMMEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	TQVAAWLKKIFGDHP HHHHHHHHHHHCCCC	32.87	32015554
17 (in isoform 1)	Ubiquitination	-	40.89	21890473
17	Ubiquitination	QVAAWLKKIFGDHPI HHHHHHHHHHCCCCC	40.89	22817900
27	Phosphorylation	GDHPIPQYEVNPRTT CCCCCCCCCCCHHHH	19.25	27642862
52	Phosphorylation	RVRDRDVYLVIEDLK CCCCCCHHEEHHHHH	10.27	27642862
59	Ubiquitination	YLVIEDLKQKASEYE HEEHHHHHHHHHHHH	63.17	21906983
59 (in isoform 1)	Ubiquitination	-	63.17	21890473
61	Ubiquitination	VIEDLKQKASEYESE EHHHHHHHHHHHHHH	52.90	22817900
92	Phosphorylation	ANLSSTGSRYLNALV CCCCCHHHHHHHHHH	20.17	29116813
121 (in isoform 2)	Ubiquitination	-	44.73	21906983
132	Ubiquitination	DLFRTKSKSEEIKIE HHHCCCCCCHHHHHH	64.54	27667366
145	Ubiquitination	IELEKLEKNLTATLV HHHHHHHHHHHHHHH	68.63	-
147 (in isoform 2)	Ubiquitination	-	5.23	21906983
155	Ubiquitination	TATLVLEKCLQEDVK HHHHHHHHHHHHHHH	35.76	-
162	Ubiquitination	KCLQEDVKKAELHLS HHHHHHHHHHHHHHH	59.60	-
163	Ubiquitination	CLQEDVKKAELHLST HHHHHHHHHHHHHHH	47.11	29967540
169	Phosphorylation	KKAELHLSTERAKVD HHHHHHHHHHHHHHH	19.92	25627689
186	Ubiquitination	RQNMDFLKAKSEEFR HHHHHHHHHHCHHHH	54.48	32015554
186	Methylation	RQNMDFLKAKSEEFR HHHHHHHHHHCHHHH	54.48	-
188	Ubiquitination	NMDFLKAKSEEFRFG HHHHHHHHCHHHHHH	57.73	29967540
188	Methylation	NMDFLKAKSEEFRFG HHHHHHHHCHHHHHH	57.73	-
197 (in isoform 1)	Ubiquitination	-	41.76	21890473
197	Ubiquitination	EEFRFGIKAAEEQLS HHHHHHHHHHHHHHH	41.76	21906983
204	Phosphorylation	KAAEEQLSARGMDAS HHHHHHHHHCCCCCC	18.66	21406692
211	Phosphorylation	SARGMDASLSHQSLV HHCCCCCCCCHHHHH	26.58	28555341
223	Ubiquitination	SLVALSEKLARLKQQ HHHHHHHHHHHHHHC	44.03	22817900
223 (in isoform 1)	Ubiquitination	-	44.03	21890473
228	Ubiquitination	SEKLARLKQQTIPLK HHHHHHHHHCCCCCH	34.50	22817900
231	Phosphorylation	LARLKQQTIPLKKKL HHHHHHCCCCCHHHH	23.28	24719451
235	Ubiquitination	KQQTIPLKKKLESYL HHCCCCCHHHHHHHH	42.37	27667366
236	Ubiquitination	QQTIPLKKKLESYLD HCCCCCHHHHHHHHH	70.98	29967540
237	Ubiquitination	QTIPLKKKLESYLDL CCCCCHHHHHHHHHC	56.77	22505724
240	Phosphorylation	PLKKKLESYLDLMPN CCHHHHHHHHHCCCC	41.24	26503514
241	Phosphorylation	LKKKLESYLDLMPNP CHHHHHHHHHCCCCC	8.54	26503514
254	Ubiquitination	NPSLAQVKIEEAKRE CCHHHHHHHHHHHHH	32.11	29967540
264	Phosphorylation	EAKRELDSIEAELTR HHHHHHHHHHHHHHH	34.65	24719451
270	Phosphorylation	DSIEAELTRRVDMME HHHHHHHHHHCHHHC	14.13	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HAUS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HAUS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HAUS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAUS6_HUMAN	HAUS6	physical	19369198
KDM1A_HUMAN	KDM1A	physical	23455924
ACTB_HUMAN	ACTB	physical	23443559
TBA4A_HUMAN	TUBA4A	physical	23443559
TBA1A_HUMAN	TUBA1A	physical	23443559
TBB5_HUMAN	TUBB	physical	23443559
RFIP5_HUMAN	RAB11FIP5	physical	23443559
HSP7C_HUMAN	HSPA8	physical	23443559
PABP1_HUMAN	PABPC1	physical	23443559
ROA2_HUMAN	HNRNPA2B1	physical	23443559
SEPT9_HUMAN	SEPT9	physical	23443559
ML12B_HUMAN	MYL12B	physical	23443559
HAUS6_HUMAN	HAUS6	physical	23443559
IF4A3_HUMAN	EIF4A3	physical	23443559
PGAM5_HUMAN	PGAM5	physical	23443559
HNRPM_HUMAN	HNRNPM	physical	23443559
HSPB1_HUMAN	HSPB1	physical	23443559
HAUS1_HUMAN	HAUS1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
TRI69_HUMAN	TRIM69	physical	25416956
MIPO1_HUMAN	MIPOL1	physical	25416956
KAD8_HUMAN	AK8	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
CAGE1_HUMAN	CAGE1	physical	25416956
CC062_HUMAN	C3orf62	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
LURA1_HUMAN	LURAP1	physical	25416956
SYCE3_HUMAN	SYCE3	physical	25416956
NUP62_HUMAN	NUP62	physical	21516116
WASC3_HUMAN	CCDC53	physical	21516116
SKA2_HUMAN	SKA2	physical	28514442
COG6_HUMAN	COG6	physical	28514442
VTI1A_HUMAN	VTI1A	physical	28514442
ASB7_HUMAN	ASB7	physical	28514442
STIM1_HUMAN	STIM1	physical	28514442
STX5_HUMAN	STX5	physical	28514442
VTI1B_HUMAN	VTI1B	physical	28514442
PXDN_HUMAN	PXDN	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
BET1_HUMAN	BET1	physical	28514442
STX6_HUMAN	STX6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.