COG6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COG6_HUMAN
• UniProt AC: Q9Y2V7
• Protein Name: Conserved oligomeric Golgi complex subunit 6
• Gene Name: COG6
• Organism: Homo sapiens (Human).
• Sequence Length: 657
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein.
• Protein Description: Required for normal Golgi function..
• Protein Sequence: MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLRTRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQAAKEQTQDLIVKTTKLQSESQKLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETAYERLYRWAQSECRTLTQESCDVSPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTTQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIVGNSATALLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLMLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASNLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTVQQHKPEQGSLANMPNLDSVTLKAAMVQFDRYLSAPDNLLIPQLNFLLSATVKEQIVKQSTELVCRAYGEVYAAVMNPINEYKDPENILHRSPQQVQTLLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SGEVVAVSATGAANG CCEEEEEEECCCCCC	15.46	19690332
27	Phosphorylation	LNNGAGGTSATTCNP CCCCCCCCCCCCCCH	17.80	19690332
28	Phosphorylation	NNGAGGTSATTCNPL CCCCCCCCCCCCCHH	27.22	19690332
31	Phosphorylation	AGGTSATTCNPLSRK CCCCCCCCCCHHHHH	15.25	19690332
41	Ubiquitination	PLSRKLHKILETRLD HHHHHHHHHHHHCCC	60.46	-
51	Ubiquitination	ETRLDNDKEMLEALK HHCCCCCHHHHHHHH	51.80	-
68	Phosphorylation	STFFVENSLRTRRNL HHHHHHHHHHHHHHH	13.01	28857561
92	Phosphorylation	AINEEFVSIFKEVKE HHCHHHHHHHHHHHH	27.85	24719451
95	Ubiquitination	EEFVSIFKEVKEELE HHHHHHHHHHHHHHH	60.99	-
126	Ubiquitination	TSRLQAAKEQTQDLI HHHHHHHHHHHHHHH	54.06	-
129	Phosphorylation	LQAAKEQTQDLIVKT HHHHHHHHHHHHHHH	25.74	21406692
135	Acetylation	QTQDLIVKTTKLQSE HHHHHHHHHHHCCCH	43.41	69667
135	Ubiquitination	QTQDLIVKTTKLQSE HHHHHHHHHHHCCCH	43.41	-
136	Phosphorylation	TQDLIVKTTKLQSES HHHHHHHHHHCCCHH	20.47	21406692
137	Phosphorylation	QDLIVKTTKLQSESQ HHHHHHHHHCCCHHH	24.84	29759185
138	Ubiquitination	DLIVKTTKLQSESQK HHHHHHHHCCCHHHH	50.16	-
141	Phosphorylation	VKTTKLQSESQKLEI HHHHHCCCHHHHHHH	50.04	24719451
143	Phosphorylation	TTKLQSESQKLEIRA HHHCCCHHHHHHHHH	37.55	29759185
145	Ubiquitination	KLQSESQKLEIRAQV HCCCHHHHHHHHHHH	58.32	-
167	Sulfoxidation	FQLTSDEMSLLRGTR HCCCHHHHHHHCCCC	4.03	21406390
184	Ubiquitination	PITEDFFKALGRVKQ CCCHHHHHHHCHHHH	42.57	-
190	Ubiquitination	FKALGRVKQIHNDVK HHHHCHHHHHHCCHH	42.02	-
223	Phosphorylation	ALLQETAYERLYRWA HHHHHHHHHHHHHHH	14.70	-
264	Phosphorylation	DRPVLYKYTLDEFGT CCCEEEEEEHHHHCC	10.05	22468782
271	Phosphorylation	YTLDEFGTARRSTVV EEHHHHCCCCCHHHH	23.47	22468782
275	Phosphorylation	EFGTARRSTVVRGFI HHCCCCCHHHHHHHH	21.72	22167270
276	Phosphorylation	FGTARRSTVVRGFID HCCCCCHHHHHHHHH	22.62	22167270
286	Phosphorylation	RGFIDALTRGGPGGT HHHHHHHHCCCCCCC	29.05	-
293	Phosphorylation	TRGGPGGTPRPIEMH HCCCCCCCCCCCCCC	23.26	28555341
518	Phosphorylation	TLALFEFTDRRLEML HHHHHHHCHHHHHHH	22.77	-
614	Ubiquitination	TVKEQIVKQSTELVC HHHHHHHHHHHHHHH	39.91	-
638	Phosphorylation	VMNPINEYKDPENIL HCCCHHHCCCHHHCC	19.06	-
648	Phosphorylation	PENILHRSPQQVQTL HHHCCCCCHHHHHHH	19.13	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COG6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COG6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COG6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COG7_HUMAN	COG7	physical	22939629
COG8_HUMAN	COG8	physical	22939629
COG4_HUMAN	COG4	physical	19651599
COG1_HUMAN	COG1	physical	26344197
COG7_HUMAN	COG7	physical	26344197
COG8_HUMAN	COG8	physical	28514442
COG7_HUMAN	COG7	physical	28514442
PKN1_HUMAN	PKN1	physical	28514442
ATP7A_HUMAN	ATP7A	physical	28514442
COG2_HUMAN	COG2	physical	28514442
COG1_HUMAN	COG1	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
KIF5A_HUMAN	KIF5A	physical	28514442
POC1A_HUMAN	POC1A	physical	28514442
NAV1_HUMAN	NAV1	physical	28514442
COG4_HUMAN	COG4	physical	28514442
KLC4_HUMAN	KLC4	physical	28514442
POC1B_HUMAN	POC1B	physical	28514442
SAS6_HUMAN	SASS6	physical	28514442
BRE1A_HUMAN	RNF20	physical	28514442
TRAF6_HUMAN	TRAF6	physical	28514442
EXOC7_HUMAN	EXOC7	physical	28514442
KINH_HUMAN	KIF5B	physical	28514442
KLC1_HUMAN	KLC1	physical	28514442
BL1S2_HUMAN	BLOC1S2	physical	28514442
DTNA_HUMAN	DTNA	physical	28514442
VATD_HUMAN	ATP6V1D	physical	28514442
CCHCR_HUMAN	CCHCR1	physical	28514442
KIF5C_HUMAN	KIF5C	physical	28514442
BRE1B_HUMAN	RNF40	physical	28514442
DTNB_HUMAN	DTNB	physical	28514442
SNTB2_HUMAN	SNTB2	physical	28514442
TBD2B_HUMAN	TBC1D2B	physical	28514442
ABI1_HUMAN	ABI1	physical	28514442
EXOC5_HUMAN	EXOC5	physical	28514442
BICD2_HUMAN	BICD2	physical	28514442
CI016_HUMAN	C9orf16	physical	28514442
PKD2_HUMAN	PKD2	physical	28514442
EXOC1_HUMAN	EXOC1	physical	28514442
AMOL1_HUMAN	AMOTL1	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
CCD22_HUMAN	CCDC22	physical	28514442
SNAPN_HUMAN	SNAPIN	physical	28514442
NCKP1_HUMAN	NCKAP1	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
STX6_HUMAN	STX6	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614576: Congenital disorder of glycosylation 2L (CDG2L)
• 615328: Shaheen syndrome (SHNS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.