BL1S2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BL1S2_HUMAN
• UniProt AC: Q6QNY1
• Protein Name: Biogenesis of lysosome-related organelles complex 1 subunit 2
• Gene Name: BLOC1S2
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Lysosome membrane . Localizes to the centrosomes in a microtubule-dependent manner.
• Protein Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. [PubMed: 15102850]
• Protein Sequence: MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAEGVL ------CCCHHCCCC	13.05	25944712
11	Phosphorylation	AAEGVLATRSDEPAR HHCCCCCCCCCCCCC	26.92	24505115
30	Ubiquitination	VETAEEAKEPAEADI HHCHHHHCCCCCCCH	68.46	-
63	Phosphorylation	LTATSEDYKLLENMN CCCCHHHHHHHHHHH	10.24	18083107
64	Acetylation	TATSEDYKLLENMNK CCCHHHHHHHHHHHH	59.94	19826879
71	Ubiquitination	KLLENMNKLTSLKYL HHHHHHHHHHCCHHH	42.23	-
76	Ubiquitination	MNKLTSLKYLEMKDI HHHHHCCHHHHHHHH	47.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BL1S2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BL1S2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BL1S2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BL1S6_HUMAN	BLOC1S6	physical	15102850
BL1S5_HUMAN	BLOC1S5	physical	15102850
SNAPN_HUMAN	SNAPIN	physical	15102850
BL1S1_HUMAN	BLOC1S1	physical	15102850
BL1S3_HUMAN	BLOC1S3	physical	15102850
BL1S4_HUMAN	BLOC1S4	physical	15102850
A4_HUMAN	APP	physical	21832049
MIPT3_HUMAN	TRAF3IP1	physical	27173435
IFT20_HUMAN	IFT20	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330