BL1S6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BL1S6_HUMAN
• UniProt AC: Q9UL45
• Protein Name: Biogenesis of lysosome-related organelles complex 1 subunit 6
• Gene Name: BLOC1S6
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . It can exist as a soluble protein as well as a peripheral membrane protein (PubMed:12019270).
• Protein Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process..
• Protein Sequence: MSVPGPSSPDGALTRPPYCLEAGEPTPGLSDTSPDEGLIEDLTIEDKAVEQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEFEREKQLTARPAKRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVPGPSSP ------CCCCCCCCC		-
7	Phosphorylation	-MSVPGPSSPDGALT -CCCCCCCCCCCCCC		28348404
8	Phosphorylation	MSVPGPSSPDGALTR CCCCCCCCCCCCCCC		28348404
14	Phosphorylation	SSPDGALTRPPYCLE CCCCCCCCCCCEECC		27251275
30	Phosphorylation	GEPTPGLSDTSPDEG CCCCCCCCCCCCCCC		27251275
32	Phosphorylation	PTPGLSDTSPDEGLI CCCCCCCCCCCCCCC		27251275
33	Phosphorylation	TPGLSDTSPDEGLIE CCCCCCCCCCCCCCC		27251275
68	Ubiquitination	LPDLQRSKQALQELT CHHHHHHHHHHHHHH		-
138	Acetylation	KLKKRALKLQQKRQK HHHHHHHHHHHHHHH		25953088
138	Ubiquitination	KLKKRALKLQQKRQK HHHHHHHHHHHHHHH		-
145	Acetylation	KLQQKRQKEELEREQ HHHHHHHHHHHHHHH		11717463
162	Ubiquitination	EKEFEREKQLTARPA HHHHHHHHHHHCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BL1S6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BL1S6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BL1S6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WASC3_HUMAN	CCDC53	physical	16189514
SKA1_HUMAN	SKA1	physical	16189514
PKHF2_HUMAN	PLEKHF2	physical	16189514
BL1S6_HUMAN	BLOC1S6	physical	16189514
EXOC8_HUMAN	EXOC8	physical	16189514
LURA1_HUMAN	LURAP1	physical	16189514
NTAQ1_HUMAN	WDYHV1	physical	16189514
AGGF1_HUMAN	AGGF1	physical	16189514
SNAPN_HUMAN	SNAPIN	physical	15102850
BL1S1_HUMAN	BLOC1S1	physical	15102850
BL1S2_HUMAN	BLOC1S2	physical	15102850
BL1S3_HUMAN	BLOC1S3	physical	15102850
DTBP1_HUMAN	DTNBP1	physical	15102850
BL1S5_HUMAN	BLOC1S5	physical	15102850
BL1S6_HUMAN	BLOC1S6	physical	15102850
BL1S4_HUMAN	BLOC1S4	physical	15102850
BL1S5_HUMAN	BLOC1S5	physical	12019270
STX12_HUMAN	STX12	physical	10610180
A4_HUMAN	APP	physical	21832049
BL1S6_HUMAN	BLOC1S6	physical	25416956
RABX5_HUMAN	RABGEF1	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
CORO6_HUMAN	CORO6	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
SKA1_HUMAN	SKA1	physical	25416956
SYCE3_HUMAN	SYCE3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.