dbPTM

STX12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STX12_HUMAN
UniProt AC	Q86Y82
Protein Name	Syntaxin-12
Gene Name	STX12
Organism	Homo sapiens (Human).
Sequence Length	276
Subcellular Localization	Endosome membrane Single-pass type IV membrane protein . Golgi apparatus membrane Single-pass type IV membrane protein . Endomembrane system Single-pass type IV membrane protein Cytoplasmic side . Early endosome membrane Single-pass type IV membra
Protein Description	SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)..
Protein Sequence	MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQRLQKERLMNDFSAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERATEQLQRAAYYQKKSRKKMCILVLVLSVIILILGLIIWLVYKTK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYGPLDMY ------CCCCCCCCC	38.50	30108239
2	Acetylation	------MSYGPLDMY ------CCCCCCCCC	38.50	22223895
3	Phosphorylation	-----MSYGPLDMYR -----CCCCCCCCCC	22.82	25106551
9	Phosphorylation	SYGPLDMYRNPGPSG CCCCCCCCCCCCCCC	13.60	27259358
15	Phosphorylation	MYRNPGPSGPQLRDF CCCCCCCCCHHHHCH	69.85	27251275
44	Ubiquitination	SQATAQIKNLMSQLG HHHHHHHHHHHHHHC	31.76	21906983
44	Ubiquitination	SQATAQIKNLMSQLG HHHHHHHHHHHHHHC	31.76	21890473
53	Ubiquitination	LMSQLGTKQDSSKLQ HHHHHCCCCCHHHHH	50.76	21906983
58	Ubiquitination	GTKQDSSKLQENLQQ CCCCCHHHHHHHHHH	59.13	21890473
58	Ubiquitination	GTKQDSSKLQENLQQ CCCCCHHHHHHHHHH	59.13	22053931
75	Ubiquitination	HSTNQLAKETNELLK HHHHHHHHHHHHHHH	73.91	25015289
82	Ubiquitination	KETNELLKELGSLPL HHHHHHHHHHCCCCC	64.61	21906983
92	Phosphorylation	GSLPLPLSTSEQRQQ CCCCCCCCCHHHHHH	28.13	25850435
93	Phosphorylation	SLPLPLSTSEQRQQR CCCCCCCCHHHHHHH	43.92	25850435
94	Phosphorylation	LPLPLSTSEQRQQRL CCCCCCCHHHHHHHH	28.49	25850435
127	Ubiquitination	VQRRVSEKEKESIAR HHHHCCHHHHHHHHH	67.58	24816145
129	Ubiquitination	RRVSEKEKESIARAR HHCCHHHHHHHHHHH	68.76	-
139	Phosphorylation	IARARAGSRLSAEER HHHHHHHCCCCHHHH	29.12	29255136
142	Phosphorylation	ARAGSRLSAEERQRE HHHHCCCCHHHHHHH	32.31	29255136
218	Phosphorylation	DQGDLIDSIEANVES CCCCHHHHHHHHCCC	18.48	26657352
225	Phosphorylation	SIEANVESSEVHVER HHHHHCCCCCHHHHH	27.76	26471730
226	Phosphorylation	IEANVESSEVHVERA HHHHCCCCCHHHHHH	30.08	27251275
234	Phosphorylation	EVHVERATEQLQRAA CHHHHHHHHHHHHHH	30.41	21949786
242	Phosphorylation	EQLQRAAYYQKKSRK HHHHHHHHHHHHCHH	12.87	21949786
245	Ubiquitination	QRAAYYQKKSRKKMC HHHHHHHHHCHHHHH	36.27	33845483
245	2-Hydroxyisobutyrylation	QRAAYYQKKSRKKMC HHHHHHHHHCHHHHH	36.27	-
246	Ubiquitination	RAAYYQKKSRKKMCI HHHHHHHHCHHHHHH	39.71	23503661
247	Phosphorylation	AAYYQKKSRKKMCIL HHHHHHHCHHHHHHH	57.26	29083192
249	Ubiquitination	YYQKKSRKKMCILVL HHHHHCHHHHHHHHH	52.53	23503661
250	Ubiquitination	YQKKSRKKMCILVLV HHHHCHHHHHHHHHH	37.58	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STX12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STX12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STX12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNP29_HUMAN	SNAP29	physical	9852078
ABCA1_HUMAN	ABCA1	physical	15469992
DTX2_HUMAN	DTX2	physical	25416956
EI2BE_HUMAN	EIF2B5	physical	26186194
RNF13_HUMAN	RNF13	physical	26186194
F234B_HUMAN	KIAA1467	physical	26186194
YKT6_HUMAN	YKT6	physical	26186194
EI2BA_HUMAN	EIF2B1	physical	26186194
SEC20_HUMAN	BNIP1	physical	26186194
EI2BD_HUMAN	EIF2B4	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	26186194
BZW2_HUMAN	BZW2	physical	26186194
ZKSC1_HUMAN	ZKSCAN1	physical	26186194
VPS45_HUMAN	VPS45	physical	26186194
SNAB_HUMAN	NAPB	physical	26186194
SNAA_HUMAN	NAPA	physical	26186194
STX4_HUMAN	STX4	physical	26186194
USE1_HUMAN	USE1	physical	26186194
STX18_HUMAN	STX18	physical	26186194
SCFD2_HUMAN	SCFD2	physical	26186194
NOP14_HUMAN	NOP14	physical	26186194
GORS1_HUMAN	GORASP1	physical	26186194
SNAG_HUMAN	NAPG	physical	26186194
STX5_HUMAN	STX5	physical	26186194
STXB5_HUMAN	STXBP5	physical	26186194
NBAS_HUMAN	NBAS	physical	26186194
STX10_HUMAN	STX10	physical	26186194
F234A_HUMAN	ITFG3	physical	26186194
TXLNA_HUMAN	TXLNA	physical	26186194
SNP23_HUMAN	SNAP23	physical	26186194
TBC15_HUMAN	TBC1D15	physical	26186194
SNP47_HUMAN	SNAP47	physical	26186194
MSPD2_HUMAN	MOSPD2	physical	26186194
TBK1_HUMAN	TBK1	physical	26186194
NOC4L_HUMAN	NOC4L	physical	26186194
VTI1A_HUMAN	VTI1A	physical	26186194
OPTN_HUMAN	OPTN	physical	26186194
ADPGK_HUMAN	ADPGK	physical	26186194
EI2BG_HUMAN	EIF2B3	physical	26186194
TBC17_HUMAN	TBC1D17	physical	26186194
VAMP4_HUMAN	VAMP4	physical	26186194
SNP29_HUMAN	SNAP29	physical	26186194
STX8_HUMAN	STX8	physical	26186194
GOSR2_HUMAN	GOSR2	physical	26186194
VAMP2_HUMAN	VAMP2	physical	26186194
VAMP3_HUMAN	VAMP3	physical	26186194
EI2BB_HUMAN	EIF2B2	physical	26186194
GOSR1_HUMAN	GOSR1	physical	26186194
VAMP8_HUMAN	VAMP8	physical	26186194
ANM9_HUMAN	PRMT9	physical	26186194
FRMD5_HUMAN	FRMD5	physical	26186194
VAMP7_HUMAN	VAMP7	physical	26186194
ZN219_HUMAN	ZNF219	physical	26186194
PPAL_HUMAN	ACP2	physical	26186194
CC138_HUMAN	CCDC138	physical	26186194
BET1_HUMAN	BET1	physical	26344197
EHD1_HUMAN	EHD1	physical	26344197
OPTN_HUMAN	OPTN	physical	28514442
STXB5_HUMAN	STXBP5	physical	28514442
SNAG_HUMAN	NAPG	physical	28514442
VTI1A_HUMAN	VTI1A	physical	28514442
GOSR1_HUMAN	GOSR1	physical	28514442
ZKSC1_HUMAN	ZKSCAN1	physical	28514442
SNAB_HUMAN	NAPB	physical	28514442
VAMP8_HUMAN	VAMP8	physical	28514442
GOGA2_HUMAN	GOLGA2	physical	28514442
TBC17_HUMAN	TBC1D17	physical	28514442
TBK1_HUMAN	TBK1	physical	28514442
STX10_HUMAN	STX10	physical	28514442
GOSR2_HUMAN	GOSR2	physical	28514442
ZN219_HUMAN	ZNF219	physical	28514442
USE1_HUMAN	USE1	physical	28514442
SNP47_HUMAN	SNAP47	physical	28514442
STX8_HUMAN	STX8	physical	28514442
SNAA_HUMAN	NAPA	physical	28514442
YKT6_HUMAN	YKT6	physical	28514442
MSPD2_HUMAN	MOSPD2	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
NOP14_HUMAN	NOP14	physical	28514442
NBAS_HUMAN	NBAS	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
FRMD5_HUMAN	FRMD5	physical	28514442
SCFD2_HUMAN	SCFD2	physical	28514442
CC138_HUMAN	CCDC138	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442
VAMP7_HUMAN	VAMP7	physical	28514442
RNF13_HUMAN	RNF13	physical	28514442
VAMP2_HUMAN	VAMP2	physical	28514442
STX5_HUMAN	STX5	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442
CTR1_HUMAN	SLC7A1	physical	28514442
STX4_HUMAN	STX4	physical	28514442
STX18_HUMAN	STX18	physical	28514442
SNP29_HUMAN	SNAP29	physical	28514442
SNP23_HUMAN	SNAP23	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
EI2BB_HUMAN	EIF2B2	physical	28514442
EI2BA_HUMAN	EIF2B1	physical	28514442
ADPGK_HUMAN	ADPGK	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
F234A_HUMAN	ITFG3	physical	28514442
F234B_HUMAN	KIAA1467	physical	28514442
TXLNA_HUMAN	TXLNA	physical	28514442
BZW2_HUMAN	BZW2	physical	28514442
COG6_HUMAN	COG6	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STX12_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139 AND SER-142, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142, AND MASSSPECTROMETRY.	17081983 [Abstract]