NOC4L_HUMAN - dbPTM
NOC4L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOC4L_HUMAN
UniProt AC Q9BVI4
Protein Name Nucleolar complex protein 4 homolog
Gene Name NOC4L
Organism Homo sapiens (Human).
Sequence Length 516
Subcellular Localization Nucleus membrane
Multi-pass membrane protein . Nucleus, nucleolus .
Protein Description
Protein Sequence MEREPGAAGVRRALGRRLEAVLASRSEANAVFDILAVLQSEDQEEIQEAVRTCSRLFGALLERGELFVGQLPSEEMVMTGSQGATRKYKVWMRHRYHSCCNRLGELLGHPSFQVKELALSALLKFVQLEGAHPLEKSKWEGNYLFPRELFKLVVGGLLSPEEDQSLLLSQFREYLDYDDTRYHTMQAAVDAVARVTGQHPEVPPAFWNNAFTLLSAVSLPRREPTVSSFYVKRAELWDTWKVAHLKEHRRVFQAMWLSFLKHKLPLSLYKKVLLIVHDAILPQLAQPTLMIDFLTRACDLGGALSLLALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELDADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGRPGELCAQHFTLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationQEAVRTCSRLFGALL
HHHHHHHHHHHHHHH		31.26-
79PhosphorylationPSEEMVMTGSQGATR
CCHHHCCCCCCCCCH		23.4420860994
81PhosphorylationEEMVMTGSQGATRKY
HHHCCCCCCCCCHHH		19.1020860994
85PhosphorylationMTGSQGATRKYKVWM
CCCCCCCCHHHHHHH		34.2220860994
87AcetylationGSQGATRKYKVWMRH
CCCCCCHHHHHHHHH		45.1024471271
89AcetylationQGATRKYKVWMRHRY
CCCCHHHHHHHHHCH		32.2424471281
89UbiquitinationQGATRKYKVWMRHRY
CCCCHHHHHHHHHCH		32.24-
115UbiquitinationGHPSFQVKELALSAL
CCCCHHHHHHHHHHH		35.9121963094
124UbiquitinationLALSALLKFVQLEGA
HHHHHHHHHHHHCCC		44.32-
136UbiquitinationEGAHPLEKSKWEGNY
CCCCCCCCCCCCCCC		66.0922817900
138UbiquitinationAHPLEKSKWEGNYLF
CCCCCCCCCCCCCCC		61.4022817900
138AcetylationAHPLEKSKWEGNYLF
CCCCCCCCCCCCCCC		61.4026051181
143PhosphorylationKSKWEGNYLFPRELF
CCCCCCCCCCCHHHH		22.15-
174PhosphorylationLLSQFREYLDYDDTR
HHHHHHHHCCCCCHH		10.70-
218PhosphorylationFTLLSAVSLPRREPT
HHHHHHHCCCCCCCC		32.1624719451
232UbiquitinationTVSSFYVKRAELWDT
CEEEEEEEHHHHHHH		34.2127667366
2322-HydroxyisobutyrylationTVSSFYVKRAELWDT
CEEEEEEEHHHHHHH		34.21-
241UbiquitinationAELWDTWKVAHLKEH
HHHHHHHHHHHHHHH		31.4729967540
246UbiquitinationTWKVAHLKEHRRVFQ
HHHHHHHHHHHHHHH		41.42-
2462-HydroxyisobutyrylationTWKVAHLKEHRRVFQ
HHHHHHHHHHHHHHH		41.42-
253UbiquitinationKEHRRVFQAMWLSFL
HHHHHHHHHHHHHHH		27.7027667366
258PhosphorylationVFQAMWLSFLKHKLP
HHHHHHHHHHHHCCC		17.0224719451
263UbiquitinationWLSFLKHKLPLSLYK
HHHHHHHCCCHHHHH		50.6529967540
267PhosphorylationLKHKLPLSLYKKVLL
HHHCCCHHHHHHHHH		27.9325867546
269PhosphorylationHKLPLSLYKKVLLIV
HCCCHHHHHHHHHHH		12.8525867546
270AcetylationKLPLSLYKKVLLIVH
CCCHHHHHHHHHHHH		41.5226051181
270UbiquitinationKLPLSLYKKVLLIVH
CCCHHHHHHHHHHHH		41.5227667366
288PhosphorylationLPQLAQPTLMIDFLT
HHHHCCCHHHHHHHH		19.5124043423
295PhosphorylationTLMIDFLTRACDLGG
HHHHHHHHHHCCHHH		19.0624043423
323PhosphorylationIHKHNLEYPDFYRKL
HHHCCCCCHHHHHHH		15.9722817900
327PhosphorylationNLEYPDFYRKLYGLL
CCCCHHHHHHHHHHC		17.7622817900
329AcetylationEYPDFYRKLYGLLDP
CCHHHHHHHHHHCCH		34.3826051181
331PhosphorylationPDFYRKLYGLLDPSV
HHHHHHHHHHCCHHH		14.5729496907
342AcetylationDPSVFHVKYRARFFH
CHHHHHHHHHHHHHH		22.0525953088
342UbiquitinationDPSVFHVKYRARFFH
CHHHHHHHHHHHHHH		22.05-
343PhosphorylationPSVFHVKYRARFFHL
HHHHHHHHHHHHHHH		14.3922817900
418PhosphorylationPELDADPYDPGEEDP
CCCCCCCCCCCCCCH		35.0027642862
485UbiquitinationIFERDLKKKGPEPVP
HHHHHHHHHCCCCCC		70.97-
486UbiquitinationFERDLKKKGPEPVPL
HHHHHHHHCCCCCCC		77.4529967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOC4L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOC4L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOC4L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
T22D4_HUMANTSC22D4physical
16189514
USBP1_HUMANUSHBP1physical
16189514
NOP58_HUMANNOP58physical
22939629
PESC_HUMANPES1physical
22939629
RPC3_HUMANPOLR3Cphysical
22939629
RL29_HUMANRPL29physical
22939629
ZN148_HUMANZNF148physical
22939629
PRAF3_HUMANARL6IP5physical
22939629
KRR1_HUMANKRR1physical
26344197
NOP58_HUMANNOP58physical
26344197
RS7_HUMANRPS7physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOC4L_HUMAN

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Related Literatures of Post-Translational Modification

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