T22D4_HUMAN - dbPTM
T22D4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID T22D4_HUMAN
UniProt AC Q9Y3Q8
Protein Name TSC22 domain family protein 4
Gene Name TSC22D4
Organism Homo sapiens (Human).
Sequence Length 395
Subcellular Localization Nucleus .
Protein Description Transcriptional repressor..
Protein Sequence MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRNGSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAGGRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAKAEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDMRLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationITSVTTDYEGPGSPG
EEEEEECCCCCCCCC		22.2427080861
24PhosphorylationTDYEGPGSPGASDPP
ECCCCCCCCCCCCCC		24.2426503514
28PhosphorylationGPGSPGASDPPTPQP
CCCCCCCCCCCCCCC		57.4727080861
37PhosphorylationPPTPQPPTGPPPRLP
CCCCCCCCCCCCCCC		69.8424719451
49PhosphorylationRLPNGEPSPDPGGKG
CCCCCCCCCCCCCCC		37.3223401153
57PhosphorylationPDPGGKGTPRNGSPP
CCCCCCCCCCCCCCC		23.6629255136
62PhosphorylationKGTPRNGSPPPGAPS
CCCCCCCCCCCCCCC		37.4729255136
69PhosphorylationSPPPGAPSSRFRVVK
CCCCCCCCCCEEEEE		33.3423403867
70PhosphorylationPPPGAPSSRFRVVKL
CCCCCCCCCEEEEEC		34.0923403867
104PhosphorylationERDLEPHSFGGLLEG
ECCCCCCCCHHHHHH		35.9825850435
116PhosphorylationLEGIRGASGGAGGRS
HHHHHCCCCCCCCCC		40.3523403867
123PhosphorylationSGGAGGRSLDSRLEL
CCCCCCCCHHHHHHH		39.5423401153
126PhosphorylationAGGRSLDSRLELASL
CCCCCHHHHHHHHHC		44.0223403867
132PhosphorylationDSRLELASLGLGAPT
HHHHHHHHCCCCCCC		35.2820068231
139PhosphorylationSLGLGAPTPPSGLSQ
HCCCCCCCCCCCCCC		47.5021712546
142PhosphorylationLGAPTPPSGLSQGPT
CCCCCCCCCCCCCCC		54.2728450419
145PhosphorylationPTPPSGLSQGPTSWL
CCCCCCCCCCCCCCC		36.2928450419
149PhosphorylationSGLSQGPTSWLRPPP
CCCCCCCCCCCCCCC		39.0828450419
150PhosphorylationGLSQGPTSWLRPPPT
CCCCCCCCCCCCCCC		27.5228450419
157PhosphorylationSWLRPPPTSPGPQAR
CCCCCCCCCCCCCCC		54.0122115753
158PhosphorylationWLRPPPTSPGPQARS
CCCCCCCCCCCCCCC		33.3621712546
165PhosphorylationSPGPQARSFTGGLGQ
CCCCCCCCCCCCCCC		30.1229255136
167PhosphorylationGPQARSFTGGLGQLV
CCCCCCCCCCCCCEE		31.4225463755
177PhosphorylationLGQLVVPSKAKAEKP
CCCEECCCCCCCCCC		33.3723927012
180AcetylationLVVPSKAKAEKPPLS
EECCCCCCCCCCCCC		61.907493427
187PhosphorylationKAEKPPLSASSPQQR
CCCCCCCCCCCCCCC		31.7029255136
189PhosphorylationEKPPLSASSPQQRPP
CCCCCCCCCCCCCCC		38.8929255136
190PhosphorylationKPPLSASSPQQRPPE
CCCCCCCCCCCCCCC		26.8429255136
200PhosphorylationQRPPEPETGESAGTS
CCCCCCCCCCCCCCC		57.8923403867
203PhosphorylationPEPETGESAGTSRAA
CCCCCCCCCCCCCCC		33.0929255136
206PhosphorylationETGESAGTSRAATPL
CCCCCCCCCCCCCCC		18.1129255136
207PhosphorylationTGESAGTSRAATPLP
CCCCCCCCCCCCCCC		21.0029255136
211PhosphorylationAGTSRAATPLPSLRV
CCCCCCCCCCCCCEE		25.1129255136
215PhosphorylationRAATPLPSLRVEAEA
CCCCCCCCCEEEEEC		36.1721082442
225PhosphorylationVEAEAGGSGARTPPL
EEEECCCCCCCCCCC		28.5025159151
229PhosphorylationAGGSGARTPPLSRRK
CCCCCCCCCCCCHHH		28.8223927012
233PhosphorylationGARTPPLSRRKAVDM
CCCCCCCCHHHHHHH		35.4923927012
260PhosphorylationGQVPPLDSRPSSPAL
CCCCCCCCCCCCCCE		54.4929255136
263PhosphorylationPPLDSRPSSPALYFT
CCCCCCCCCCCEEEE		48.0929255136
264PhosphorylationPLDSRPSSPALYFTH
CCCCCCCCCCEEEEC		19.5129255136
268PhosphorylationRPSSPALYFTHDASL
CCCCCCEEEECCHHH		14.4529255136
270PhosphorylationSSPALYFTHDASLVH
CCCCEEEECCHHHCC		12.8029255136
274PhosphorylationLYFTHDASLVHKSPD
EEEECCHHHCCCCCC		36.6629255136
279PhosphorylationDASLVHKSPDPFGAV
CHHHCCCCCCCCHHH		21.4719664994
292PhosphorylationAVAAQKFSLAHSMLA
HHHHHHHHHHHHHHH		31.5129514088
296PhosphorylationQKFSLAHSMLAISGH
HHHHHHHHHHHHHCC		15.1929514088
301PhosphorylationAHSMLAISGHLDSDD
HHHHHHHHCCCCCCC		17.9829514088
306PhosphorylationAISGHLDSDDDSGSG
HHHCCCCCCCCCCCC		49.6628464451
310PhosphorylationHLDSDDDSGSGSLVG
CCCCCCCCCCCCEEE		41.6829514088
312PhosphorylationDSDDDSGSGSLVGID
CCCCCCCCCCEEEEC		29.2129514088
314PhosphorylationDDDSGSGSLVGIDNK
CCCCCCCCEEEECHH		22.9129514088
345UbiquitinationREEVEVLKEQIRELA
HHHHHHHHHHHHHHH		53.39-
370PhosphorylationGLLRALASPEQLAQL
CHHHHHCCHHHHHCC		29.8029255136
394PhosphorylationPPAPNGPSV------
CCCCCCCCC------		41.6925159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of T22D4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of T22D4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of T22D4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FRMD6_HUMANFRMD6physical
16189514
ENKD1_HUMANENKD1physical
16189514
CCD42_HUMANCCDC42physical
16189514
LNX1_HUMANLNX1physical
16189514
UBCP1_HUMANUBLCP1physical
16189514
K1C40_HUMANKRT40physical
25416956
NRBP2_HUMANNRBP2physical
25416956
SMG8_HUMANSMG8physical
26186194
STK39_HUMANSTK39physical
26186194
P4HA1_HUMANP4HA1physical
26186194
T22D2_HUMANTSC22D2physical
26186194
T22D1_HUMANTSC22D1physical
26186194
T22D3_HUMANTSC22D3physical
26186194
CRTAP_HUMANCRTAPphysical
26186194
MD2L1_HUMANMAD2L1physical
26186194
ELOC_HUMANTCEB1physical
26186194
NRBP2_HUMANNRBP2physical
26186194
P3H1_HUMANP3H1physical
26186194
NRBP_HUMANNRBP1physical
26186194
IF172_HUMANIFT172physical
26186194
LRWD1_HUMANLRWD1physical
26186194
CUL1_HUMANCUL1physical
26186194
GDS1_HUMANRAP1GDS1physical
26186194
RHOA_HUMANRHOAphysical
26186194
PDPR_HUMANPDPRphysical
26186194
WNK3_HUMANWNK3physical
26186194
WNK1_HUMANWNK1physical
26186194
WNK2_HUMANWNK2physical
26186194
P4HA2_HUMANP4HA2physical
26186194
CPVL_HUMANCPVLphysical
26186194
TTL_HUMANTTLphysical
26186194
FBW1B_HUMANFBXW11physical
26186194
FBW1A_HUMANBTRCphysical
26186194
TBL1R_HUMANTBL1XR1physical
26186194
TBL1X_HUMANTBL1Xphysical
26186194
KEAP1_HUMANKEAP1physical
26186194
MD2BP_HUMANMAD2L1BPphysical
26186194
KPCD2_HUMANPRKD2physical
26186194
T22D1_HUMANTSC22D1physical
28514442
T22D2_HUMANTSC22D2physical
28514442
TTL_HUMANTTLphysical
28514442
NRBP_HUMANNRBP1physical
28514442
WNK2_HUMANWNK2physical
28514442
WNK3_HUMANWNK3physical
28514442
MD2BP_HUMANMAD2L1BPphysical
28514442
FBW1B_HUMANFBXW11physical
28514442
FBW1A_HUMANBTRCphysical
28514442
NRBP2_HUMANNRBP2physical
28514442
STK39_HUMANSTK39physical
28514442
RHOA_HUMANRHOAphysical
28514442
MD2L1_HUMANMAD2L1physical
28514442
WNK1_HUMANWNK1physical
28514442
KPCD2_HUMANPRKD2physical
28514442
CRTAP_HUMANCRTAPphysical
28514442
TBL1X_HUMANTBL1Xphysical
28514442
PDPR_HUMANPDPRphysical
28514442
GDS1_HUMANRAP1GDS1physical
28514442
P4HA1_HUMANP4HA1physical
28514442
CUL1_HUMANCUL1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of T22D4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; THR-211; SER-225;THR-229; SER-233; SER-279 AND SER-370, AND MASS SPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; SER-165; THR-211 ANDSER-279, AND MASS SPECTROMETRY.

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