| UniProt ID | P4HA2_HUMAN | |
|---|---|---|
| UniProt AC | O15460 | |
| Protein Name | Prolyl 4-hydroxylase subunit alpha-2 | |
| Gene Name | P4HA2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 535 | |
| Subcellular Localization | Endoplasmic reticulum lumen. | |
| Protein Description | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.. | |
| Protein Sequence | MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 31 | Phosphorylation | FTSIGHMTDLIYAEK HHHHHHHHHHHHHHH | 23.21 | 22617229 | |
| 35 | Phosphorylation | GHMTDLIYAEKELVQ HHHHHHHHHHHHHHH | 18.92 | 22617229 | |
| 43 | Phosphorylation | AEKELVQSLKEYILV HHHHHHHHHHHHHHH | 33.65 | 22617229 | |
| 45 | Ubiquitination | KELVQSLKEYILVEE HHHHHHHHHHHHHHH | 54.43 | 21906983 | |
| 45 (in isoform 2) | Ubiquitination | - | 54.43 | 21890473 | |
| 45 (in isoform 1) | Ubiquitination | - | 54.43 | 21890473 | |
| 54 | Ubiquitination | YILVEEAKLSKIKSW HHHHHHHHHHHHHHH | 57.48 | - | |
| 59 | Ubiquitination | EAKLSKIKSWANKME HHHHHHHHHHHHHHH | 43.62 | - | |
| 64 | Ubiquitination | KIKSWANKMEALTSK HHHHHHHHHHHHHCC | 30.30 | 21906983 | |
| 64 (in isoform 1) | Ubiquitination | - | 30.30 | 21890473 | |
| 64 (in isoform 2) | Ubiquitination | - | 30.30 | 21890473 | |
| 71 (in isoform 2) | Ubiquitination | - | 38.59 | - | |
| 71 | Ubiquitination | KMEALTSKSAADAEG HHHHHHCCCHHHHCC | 38.59 | - | |
| 79 | Phosphorylation | SAADAEGYLAHPVNA CHHHHCCCCCCHHHH | 7.69 | - | |
| 88 | Ubiquitination | AHPVNAYKLVKRLNT CCHHHHHHHHHHHCC | 44.38 | - | |
| 115 | N-linked_Glycosylation | SAAGFIANLSVQRQF CCCHHEEEHHHHHCC | 28.21 | UniProtKB CARBOHYD | |
| 134 (in isoform 1) | Ubiquitination | - | 41.33 | 21890473 | |
| 134 | Ubiquitination | EDEIGAAKALMRLQD HHHHHHHHHHHHHHC | 41.33 | 21890473 | |
| 134 (in isoform 2) | Ubiquitination | - | 41.33 | 21890473 | |
| 194 | Ubiquitination | LWMEQVLKQLDAGEE HHHHHHHHHCCCCCC | 50.38 | - | |
| 206 (in isoform 2) | Ubiquitination | - | 36.48 | 21890473 | |
| 206 (in isoform 1) | Ubiquitination | - | 36.48 | 21890473 | |
| 206 | Ubiquitination | GEEATTTKSQVLDYL CCCCCCCHHHHHHHH | 36.48 | 21906983 | |
| 235 | Phosphorylation | ELTRRLLSLDPSHER HHHHHHHCCCCCCCC | 35.01 | 29507054 | |
| 239 | Phosphorylation | RLLSLDPSHERAGGN HHHCCCCCCCCCCCC | 37.33 | 26503514 | |
| 264 | N-linked_Glycosylation | EREKTLTNQTEAELA HHHHHCCCHHHHHHC | 50.30 | UniProtKB CARBOHYD | |
| 272 | O-linked_Glycosylation | QTEAELATPEGIYER HHHHHHCCCCCCCCC | 34.20 | OGP | |
| 300 | Ubiquitination | LCRGEGVKLTPRRQK HHCCCCCCCCHHHHH | 58.46 | 21906983 | |
| 300 (in isoform 1) | Ubiquitination | - | 58.46 | 21890473 | |
| 300 (in isoform 2) | Ubiquitination | - | 58.46 | 21890473 | |
| 328 (in isoform 1) | Ubiquitination | - | 60.17 | 21890473 | |
| 328 (in isoform 2) | Ubiquitination | - | 60.17 | 21890473 | |
| 328 | Sumoylation | QLLIAPFKEEDEWDS EEEEECCCCCCCCCC | 60.17 | - | |
| 328 | Sumoylation | QLLIAPFKEEDEWDS EEEEECCCCCCCCCC | 60.17 | - | |
| 328 | Ubiquitination | QLLIAPFKEEDEWDS EEEEECCCCCCCCCC | 60.17 | 21906983 | |
| 345 | Sulfoxidation | IVRYYDVMSDEEIER CHHHEECCCHHHHHH | 3.69 | 30846556 | |
| 346 | Phosphorylation | VRYYDVMSDEEIERI HHHEECCCHHHHHHH | 41.54 | 26434776 | |
| 383 (in isoform 2) | Ubiquitination | - | 45.73 | 21890473 | |
| 383 (in isoform 1) | Ubiquitination | - | 45.73 | 21890473 | |
| 383 | Ubiquitination | VASYRVSKSSWLEED EEEEEEECCHHCCCC | 45.73 | 2190698 | |
| 421 | Phosphorylation | ELLQVANYGVGGQYE HHHHHHCCCCCCCCC | 11.94 | - | |
| 441 | Phosphorylation | SRNDERDTFKHLGTG CCCCCCCHHHHCCCC | 40.58 | - | |
| 443 (in isoform 2) | Ubiquitination | - | 39.76 | 21890473 | |
| 443 | Ubiquitination | NDERDTFKHLGTGNR CCCCCHHHHCCCCCH | 39.76 | - | |
| 447 | Phosphorylation | DTFKHLGTGNRVATF CHHHHCCCCCHHHHH | 37.33 | - | |
| 480 | Succinylation | GAAIWPKKGTAVFWY CCEECCCCCCEEEHH | 58.37 | - | |
| 480 | Succinylation | GAAIWPKKGTAVFWY CCEECCCCCCEEEHH | 58.37 | - | |
| 482 | Phosphorylation | AIWPKKGTAVFWYNL EECCCCCCEEEHHHH | 28.64 | - | |
| 487 | Phosphorylation | KGTAVFWYNLLRSGE CCCEEEHHHHHHCCC | 5.62 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of P4HA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of P4HA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of P4HA2_HUMAN !! | ||||||
loading...
