RICTR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RICTR_HUMAN
• UniProt AC: Q6R327
• Protein Name: Rapamycin-insensitive companion of mTOR
• Gene Name: RICTOR {ECO:0000312|EMBL:EAW55980.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 1708
• Protein Description: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development..
• Protein Sequence: MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MAAIGRGRSLKNL --CCCCCCCCCCCCC	31.10	115491237
21	Phosphorylation	RVRGRNDSGEENVPL EECCCCCCCCCCCCC	52.21	19664994
21 (in isoform 3)	Phosphorylation	-	52.21	21406692
31	Phosphorylation	ENVPLDLTREPSDNL CCCCCCCCCCCCHHH	32.43	23927012
31 (in isoform 3)	Phosphorylation	-	32.43	21406692
34	Ubiquitination	PLDLTREPSDNLREI CCCCCCCCCHHHHHH	43.63	24816145
35	Phosphorylation	LDLTREPSDNLREIL CCCCCCCCHHHHHHH	34.08	23927012
44	Ubiquitination	NLREILQNVARLQGV HHHHHHHHHHHHHCC	26.43	24816145
56	Ubiquitination	QGVSNMRKLGHLNNF HCCCHHHHHCCCCHH	48.31	29967540
56 (in isoform 3)	Ubiquitination	-	48.31	-
65	Ubiquitination	GHLNNFTKLLCDIGH CCCCHHHHHHHHCCC	35.01	29967540
81	Ubiquitination	EEKLGFHYEDIIICL HHHCCCCHHHHHHHH	17.03	24816145
89	Ubiquitination	EDIIICLRLALLNEA HHHHHHHHHHHHHHH	17.32	21963094
97	Ubiquitination	LALLNEAKEVRAAGL HHHHHHHHHHHHHHH	51.03	24816145
97 (in isoform 3)	Ubiquitination	-	51.03	-
109	Phosphorylation	AGLRALRYLIQDSSI HHHHHHHHHHHCCHH	14.70	-
150	Ubiquitination	RTQALRLVRKMITVN HHHHHHHHHHHHHCC	4.46	21963094
160	Ubiquitination	MITVNASLFPSSVTN HHHCCHHHCCCCHHC	7.32	21963094
176	Ubiquitination	LIAVGNDGLQERDRM EEEECCCHHHHHHHH	33.01	21963094
186	Ubiquitination	ERDRMVRACIAIICE HHHHHHHHHHHHHHH	4.25	21963094
192	Ubiquitination	RACIAIICELALQNP HHHHHHHHHHHHCCH	2.61	29967540
197	Ubiquitination	IICELALQNPEVVAL HHHHHHHCCHHHHEE	58.80	21963094
211	Ubiquitination	LRGGLNTILKNVIDC ECCCHHHHHHHHHHH	5.12	21963094
213	Acetylation	GGLNTILKNVIDCQL CCHHHHHHHHHHHHH	45.37	18585227
213	Ubiquitination	GGLNTILKNVIDCQL CCHHHHHHHHHHHHH	45.37	21963094
221	Phosphorylation	NVIDCQLSRINEALI HHHHHHHHHHHHHHH	12.77	26846344
221	Ubiquitination	NVIDCQLSRINEALI HHHHHHHHHHHHHHH	12.77	21963094
222	Ubiquitination	VIDCQLSRINEALIT HHHHHHHHHHHHHHH	44.32	29967540
223	Ubiquitination	IDCQLSRINEALITT HHHHHHHHHHHHHHH	4.99	21963094
231	Ubiquitination	NEALITTILHLLNHP HHHHHHHHHHHHCCH	1.38	21963094
237	Ubiquitination	TILHLLNHPKTRQYV HHHHHHCCHHHHHHH	25.79	29967540
239	Ubiquitination	LHLLNHPKTRQYVRA HHHHCCHHHHHHHHC	49.11	21963094
243	Phosphorylation	NHPKTRQYVRADVEL CCHHHHHHHHCCHHH	6.65	-
258	Phosphorylation	ERILAPYTDFHYRHS HHHCCCCCCCCCCCC	31.00	27251275
258	Ubiquitination	ERILAPYTDFHYRHS HHHCCCCCCCCCCCC	31.00	21963094
262	Phosphorylation	APYTDFHYRHSPDTA CCCCCCCCCCCCCCC	15.26	18669648
265	Phosphorylation	TDFHYRHSPDTAEGQ CCCCCCCCCCCCCCC	18.57	29255136
268	Phosphorylation	HYRHSPDTAEGQLKE CCCCCCCCCCCCCCH	29.96	23663014
274	Ubiquitination	DTAEGQLKEDREARF CCCCCCCCHHHHHHH	50.08	21906983
274 (in isoform 1)	Ubiquitination	-	50.08	21890473
274 (in isoform 3)	Ubiquitination	-	50.08	21890473
284	Phosphorylation	REARFLASKMGIIAT HHHHHHHHHHCHHHH	25.89	-
297	Acetylation	ATFRSWAGIINLCKP HHHHHHHHHHHHCCC	18.30	19608861
311	Ubiquitination	PGNSGIQSLIGVLCI CCCCHHHHHHHHHHC	21.75	21963094
321	Ubiquitination	GVLCIPNMEIRRGLL HHHHCCCHHHHHHHH	3.67	21963094
358	Ubiquitination	LSVDPGRFQDSWRLS HCCCCCCCCCCEECC	13.51	21963094
374	Ubiquitination	GFVAAEAKTILPHRA CEEEHHHHHHCCCCH	27.83	21906983
374 (in isoform 1)	Ubiquitination	-	27.83	21890473
374 (in isoform 3)	Ubiquitination	-	27.83	21890473
383	Phosphorylation	ILPHRARSRPDLMDN HCCCCHHCCCCHHHH	47.37	21406692
424	Phosphorylation	DHISVRATILLGELL CCHHHHHHHHHHHHH	11.12	-
434	Ubiquitination	LGELLHMANTILPHS HHHHHHHHHHCCCCC	10.16	21963094
453	Ubiquitination	LHCLPTLMNMAASFD HCHHHHHHHHHHHCC	3.38	21963094
463	Ubiquitination	AASFDIPKEKRLRAS HHHCCCCHHHHHHHH	75.98	21963094
477	Ubiquitination	SAALNCLKRFHEMKK HHHHHHHHHHHHHHH	56.04	29967540
477 (in isoform 3)	Ubiquitination	-	56.04	-
479	Ubiquitination	ALNCLKRFHEMKKRG HHHHHHHHHHHHHHC	5.67	29967540
496	Ubiquitination	PYSLHLDHIIQKAIA CCCHHHHHHHHHHHH	25.97	29967540
500	Ubiquitination	HLDHIIQKAIATHQK HHHHHHHHHHHHHHH	31.21	21963094
506	Ubiquitination	QKAIATHQKRDQYLR HHHHHHHHHHHHHHH	37.82	29967540
507	Ubiquitination	KAIATHQKRDQYLRV HHHHHHHHHHHHHHE	50.79	29967540
516	Ubiquitination	DQYLRVQKDIFILKD HHHHHEECCEEEECC	50.35	21963094
522	Ubiquitination	QKDIFILKDTEEALL ECCEEEECCCCCEEE	58.76	29967540
524	Phosphorylation	DIFILKDTEEALLIN CEEEECCCCCEEEEE	33.85	30622161
528	Ubiquitination	LKDTEEALLINLRDS ECCCCCEEEEECCCH	5.81	33845483
541	Ubiquitination	DSQVLQHKENLEWNW CHHHHHCHHHCCCCH	35.02	29967540
545	Ubiquitination	LQHKENLEWNWNLIG HHCHHHCCCCHHHHH	50.80	29967540
553	Ubiquitination	WNWNLIGTILKWPNV CCHHHHHHHHHCCCC	19.01	21987572
566	Ubiquitination	NVNLRNYKDEQLHRF CCCCCCCCHHHHHHH	59.34	-
566 (in isoform 3)	Ubiquitination	-	59.34	-
571	Ubiquitination	NYKDEQLHRFVRRLL CCCHHHHHHHHHHHH	22.34	29967540
582	Acetylation	RRLLYFYKPSSKLYA HHHHHHHCCCCCEEE	28.64	19608861
584	Phosphorylation	LLYFYKPSSKLYANL HHHHHCCCCCEEEEC	35.63	21406692
584 (in isoform 3)	Phosphorylation	-	35.63	21406692
585	Phosphorylation	LYFYKPSSKLYANLD HHHHCCCCCEEEECC	34.90	21406692
588	Phosphorylation	YKPSSKLYANLDLDF HCCCCCEEEECCCHH	9.36	21406692
631	Ubiquitination	EDLVKDIVQWLNASS HHHHHHHHHHHHHCC	4.85	29967540
636	Ubiquitination	DIVQWLNASSGMKPE HHHHHHHHCCCCCCC	11.69	29967540
656	Ubiquitination	NGLLTTLSQHYFLFI CCCHHHHHCCEEEEE	16.90	21963094
666	Ubiquitination	YFLFIGTLSCHPHGV EEEEEEECCCCHHHH	4.30	21963094
694	Ubiquitination	NLCSLKNQDHLLKLT HHHHCCCCHHHHHHH	37.60	29967540
701	Phosphorylation	QDHLLKLTVSSLDYS CHHHHHHHHHHCCCC	19.43	23312004
701	Ubiquitination	QDHLLKLTVSSLDYS CHHHHHHHHHHCCCC	19.43	29967540
703	Phosphorylation	HLLKLTVSSLDYSRD HHHHHHHHHCCCCHH	21.68	23312004
703	Ubiquitination	HLLKLTVSSLDYSRD HHHHHHHHHCCCCHH	21.68	21963094
704	Phosphorylation	LLKLTVSSLDYSRDG HHHHHHHHCCCCHHH	22.41	23312004
719	Ubiquitination	LARVILSKILTAATD HHHHHHHHHHHHHHH	37.99	21963094
719 (in isoform 3)	Ubiquitination	-	37.99	-
733	Phosphorylation	DACRLYATKHLRVLL HHHHHHHHHHHHHHH	12.87	-
764	Ubiquitination	TQLHDKNKTISSEAL EEHHHCCCCCCHHHH	53.64	29967540
775	Ubiquitination	SEALDILDEACEDKA HHHHHHHHHHHCHHC	41.61	21987572
781	Ubiquitination	LDEACEDKANLHALI HHHHHCHHCCHHHHH	19.51	29967540
785	Ubiquitination	CEDKANLHALIQMKP HCHHCCHHHHHHCHH	20.49	21987572
791	Ubiquitination	LHALIQMKPALSHLG HHHHHHCHHHHHHCC	15.68	29967540
797	Ubiquitination	MKPALSHLGDKGLLL CHHHHHHCCHHHHHH	9.49	29967540
807	Ubiquitination	KGLLLLLRFLSIPKG HHHHHHHHHHCCCCC	30.35	33845483
810	Phosphorylation	LLLLRFLSIPKGFSY HHHHHHHCCCCCCHH	33.85	24719451
813	Ubiquitination	LRFLSIPKGFSYLNE HHHHCCCCCCHHHHH	71.56	33845483
813 (in isoform 3)	Ubiquitination	-	71.56	-
822	Ubiquitination	FSYLNERGYVAKQLE CHHHHHCCCHHHHHH	18.32	33845483
823	Phosphorylation	SYLNERGYVAKQLEK HHHHHCCCHHHHHHH	11.94	21214269
826	Ubiquitination	NERGYVAKQLEKWHR HHCCCHHHHHHHHHH	45.42	29967540
830	Ubiquitination	YVAKQLEKWHREYNS CHHHHHHHHHHHHHH	57.82	29967540
835	Phosphorylation	LEKWHREYNSKYVDL HHHHHHHHHHHHHHH	25.37	-
837	Phosphorylation	KWHREYNSKYVDLIE HHHHHHHHHHHHHHH	25.18	-
838	Ubiquitination	WHREYNSKYVDLIEE HHHHHHHHHHHHHHH	45.73	21987572
839	Phosphorylation	HREYNSKYVDLIEEQ HHHHHHHHHHHHHHH	10.06	25072903
840	Ubiquitination	REYNSKYVDLIEEQL HHHHHHHHHHHHHHH	5.77	29967540
852	Phosphorylation	EQLNEALTTYRKPVD HHHHHHHHHCCCCCC	28.91	25072903
853	Phosphorylation	QLNEALTTYRKPVDG HHHHHHHHCCCCCCC	23.37	25072903
854	Phosphorylation	LNEALTTYRKPVDGD HHHHHHHCCCCCCCC	16.05	25072903
856	Ubiquitination	EALTTYRKPVDGDNY HHHHHCCCCCCCCCH	38.69	29967540
856 (in isoform 3)	Ubiquitination	-	38.69	-
863	Phosphorylation	KPVDGDNYVRRSNQR CCCCCCCHHHCCCCC	10.48	18707149
863 (in isoform 3)	Phosphorylation	-	10.48	27642862
882	Ubiquitination	HVYLPIHLYGQLVHH CEEEEHHHHHHHHHC	5.49	29967540
892	Phosphorylation	QLVHHKTGCHLLEVQ HHHHCCCCCHHHHHH	11.14	33259812
899	Ubiquitination	GCHLLEVQNIITELC CCHHHHHHHHHHHHH	26.48	21963094
902	Ubiquitination	LLEVQNIITELCRNV HHHHHHHHHHHHHHC	3.00	22817900
916	Ubiquitination	VRTPDLDKWEEIKKL CCCCCHHHHHHHHHH	64.90	29967540
921	Ubiquitination	LDKWEEIKKLKASLW HHHHHHHHHHHHHHH	56.16	29967540
922	Ubiquitination	DKWEEIKKLKASLWA HHHHHHHHHHHHHHH	61.96	-
922 (in isoform 3)	Ubiquitination	-	61.96	-
979	Ubiquitination	LGLIAKTKQGCDILK HHHHHHCCCCCCEEE	43.94	29967540
980	Ubiquitination	GLIAKTKQGCDILKC HHHHHCCCCCCEEEC	64.08	29967540
986	Methylation	KQGCDILKCHNWDAV CCCCCEEECCCHHHH	33.51	100328843
986	Ubiquitination	KQGCDILKCHNWDAV CCCCCEEECCCHHHH	33.51	29967540
996	Ubiquitination	NWDAVRHSRKHLWPV CHHHHCCCHHHCCCC	32.24	29967540
999	Phosphorylation	AVRHSRKHLWPVVPD HHCCCHHHCCCCCCH	31.83	32142685
1019	Ubiquitination	CNELSSIPSTLSLNS HHHHHCCCCCCCCCC	24.18	29967540
1020	Phosphorylation	NELSSIPSTLSLNSE HHHHCCCCCCCCCCC	40.07	24275569
1026	Phosphorylation	PSTLSLNSESTSSRH CCCCCCCCCCCCCCC	37.91	22817900
1027	Ubiquitination	STLSLNSESTSSRHN CCCCCCCCCCCCCCC	57.89	21963094
1028	Phosphorylation	TLSLNSESTSSRHNS CCCCCCCCCCCCCCC	33.15	25159151
1030	Phosphorylation	SLNSESTSSRHNSES CCCCCCCCCCCCCCC	34.35	25159151
1031	Phosphorylation	LNSESTSSRHNSESE CCCCCCCCCCCCCCC	37.33	25159151
1035	Phosphorylation	STSSRHNSESESVPS CCCCCCCCCCCCCCC	36.05	29255136
1037	Phosphorylation	SSRHNSESESVPSSM CCCCCCCCCCCCCCE	34.68	23663014
1039	Phosphorylation	RHNSESESVPSSMFI CCCCCCCCCCCCEEE	48.91	20873877
1042	Phosphorylation	SESESVPSSMFILED CCCCCCCCCEEEEEC	32.07	27794612
1043	Phosphorylation	ESESVPSSMFILEDD CCCCCCCCEEEEECC	16.19	27794612
1044	Ubiquitination	SESVPSSMFILEDDR CCCCCCCEEEEECCC	2.58	27667366
1049	Ubiquitination	SSMFILEDDRFGSSS CCEEEEECCCCCCCC	49.27	33845483
1054	Ubiquitination	LEDDRFGSSSTSTFF EECCCCCCCCCEEEE	20.57	27667366
1059	Phosphorylation	FGSSSTSTFFLDINE CCCCCCEEEEEECCC	20.63	32142685
1073	Phosphorylation	EDTEPTFYDRSGPIK CCCCCCCCCCCCCCC	16.96	-
1080	Ubiquitination	YDRSGPIKDKNSFPF CCCCCCCCCCCCCCC	66.82	-
1080 (in isoform 3)	Ubiquitination	-	66.82	-
1082	Ubiquitination	RSGPIKDKNSFPFFA CCCCCCCCCCCCCCC	49.87	29967540
1084	Phosphorylation	GPIKDKNSFPFFASS CCCCCCCCCCCCCCC	39.78	29802988
1090	Phosphorylation	NSFPFFASSKLVKNR CCCCCCCCCHHHHCH	23.89	25159151
1091	Phosphorylation	SFPFFASSKLVKNRI CCCCCCCCHHHHCHH	26.95	25159151
1091	Ubiquitination	SFPFFASSKLVKNRI CCCCCCCCHHHHCHH	26.95	27667366
1092	Ubiquitination	FPFFASSKLVKNRIL CCCCCCCHHHHCHHH	55.60	33845483
1092 (in isoform 3)	Ubiquitination	-	55.60	-
1097	Ubiquitination	SSKLVKNRILNSLTL CCHHHHCHHHHCCCC	29.11	33845483
1100	Phosphorylation	LVKNRILNSLTLPNK HHHCHHHHCCCCCCC	32.38	32142685
1101	Phosphorylation	VKNRILNSLTLPNKK HHCHHHHCCCCCCCC	21.20	29255136
1103	Phosphorylation	NRILNSLTLPNKKHR CHHHHCCCCCCCCCC	39.73	29255136
1106	Ubiquitination	LNSLTLPNKKHRSSS HHCCCCCCCCCCCCC	69.95	21890473
1107	Ubiquitination	NSLTLPNKKHRSSSD HCCCCCCCCCCCCCC	48.28	33845483
1107 (in isoform 3)	Ubiquitination	-	48.28	-
1116	Acetylation	HRSSSDPKGGKLSSE CCCCCCCCCCCCCCC	82.41	83383999
1119	Acetylation	SSDPKGGKLSSESKT CCCCCCCCCCCCCCC	54.59	83384003
1121	O-linked_Glycosylation	DPKGGKLSSESKTSN CCCCCCCCCCCCCCC	35.23	30379171
1121	Phosphorylation	DPKGGKLSSESKTSN CCCCCCCCCCCCCCC	35.23	27174698
1121	Ubiquitination	DPKGGKLSSESKTSN CCCCCCCCCCCCCCC	35.23	21963094
1122	Phosphorylation	PKGGKLSSESKTSNR CCCCCCCCCCCCCCC	57.22	27174698
1124	Phosphorylation	GGKLSSESKTSNRRI CCCCCCCCCCCCCCC	43.09	27174698
1124	Ubiquitination	GGKLSSESKTSNRRI CCCCCCCCCCCCCCC	43.09	22817900
1125	Acetylation	GKLSSESKTSNRRIR CCCCCCCCCCCCCCC	52.50	83384001
1125	Ubiquitination	GKLSSESKTSNRRIR CCCCCCCCCCCCCCC	52.50	29967540
1126	Phosphorylation	KLSSESKTSNRRIRT CCCCCCCCCCCCCCC	40.28	27174698
1127	Phosphorylation	LSSESKTSNRRIRTL CCCCCCCCCCCCCCC	31.88	27174698
1130	Ubiquitination	ESKTSNRRIRTLTEP CCCCCCCCCCCCCCC	27.30	21890473
1131	Ubiquitination	SKTSNRRIRTLTEPS CCCCCCCCCCCCCCC	3.40	21963094
1133	Phosphorylation	TSNRRIRTLTEPSVD CCCCCCCCCCCCCCC	35.34	30266825
1134	Ubiquitination	SNRRIRTLTEPSVDF CCCCCCCCCCCCCCC	3.52	22817900
1135	Phosphorylation	NRRIRTLTEPSVDFN CCCCCCCCCCCCCCC	45.28	30266825
1138	Phosphorylation	IRTLTEPSVDFNHSD CCCCCCCCCCCCCCC	28.25	30266825
1144	Phosphorylation	PSVDFNHSDDFTPIS CCCCCCCCCCCCCHH	39.72	30266825
1148	Phosphorylation	FNHSDDFTPISTVQK CCCCCCCCCHHHHHH	27.06	30266825
1151	Phosphorylation	SDDFTPISTVQKTLQ CCCCCCHHHHHHHHE	24.59	30266825
1152	Phosphorylation	DDFTPISTVQKTLQL CCCCCHHHHHHHHEE	27.89	23403867
1156	Phosphorylation	PISTVQKTLQLETSF CHHHHHHHHEEEECC	11.57	28555341
1161	Phosphorylation	QKTLQLETSFMGNKH HHHHEEEECCCCCCC	35.54	29396449
1162	Phosphorylation	KTLQLETSFMGNKHI HHHEEEECCCCCCCC	12.12	25159151
1163	Ubiquitination	TLQLETSFMGNKHIE HHEEEECCCCCCCCC	10.70	29967540
1167	Ubiquitination	ETSFMGNKHIEDTGS EECCCCCCCCCCCCC	39.98	29967540
1168	Ubiquitination	TSFMGNKHIEDTGST ECCCCCCCCCCCCCC	32.44	21963094
1171	Ubiquitination	MGNKHIEDTGSTPSI CCCCCCCCCCCCCCC	56.62	22817900
1172	Phosphorylation	GNKHIEDTGSTPSIG CCCCCCCCCCCCCCC	21.90	29255136
1174	Phosphorylation	KHIEDTGSTPSIGEN CCCCCCCCCCCCCCC	38.96	29255136
1175	Phosphorylation	HIEDTGSTPSIGEND CCCCCCCCCCCCCCC	23.54	29255136
1177	Phosphorylation	EDTGSTPSIGENDLK CCCCCCCCCCCCCCH	43.23	29255136
1184	Ubiquitination	SIGENDLKFTKNFGT CCCCCCCHHHHCCCC	54.58	21906983
1184 (in isoform 1)	Ubiquitination	-	54.58	21890473
1184 (in isoform 3)	Ubiquitination	-	54.58	21890473
1187	Ubiquitination	ENDLKFTKNFGTENH CCCCHHHHCCCCCCC	54.11	22817900
1191	Phosphorylation	KFTKNFGTENHRENT HHHHCCCCCCCCCCC	29.49	23312004
1198	Phosphorylation	TENHRENTSRERLVV CCCCCCCCCCCEEEE	25.14	23312004
1199	Phosphorylation	ENHRENTSRERLVVE CCCCCCCCCCEEEEE	43.66	26437602
1208	Phosphorylation	ERLVVESSTSSHMKI CEEEEECCCCCCEEE	20.85	25159151
1209	Phosphorylation	RLVVESSTSSHMKIR EEEEECCCCCCEEEE	43.45	25627689
1210	Phosphorylation	LVVESSTSSHMKIRS EEEECCCCCCEEEEE	21.86	25159151
1211	Phosphorylation	VVESSTSSHMKIRSQ EEECCCCCCEEEEEE	27.91	23403867
1217	Phosphorylation	SSHMKIRSQSFNTDT CCCEEEEEECCCCCC	33.38	25159151
1219	Phosphorylation	HMKIRSQSFNTDTTT CEEEEEECCCCCCCC	23.01	25159151
1222	Phosphorylation	IRSQSFNTDTTTSGI EEEECCCCCCCCCCC	32.48	25159151
1224	Phosphorylation	SQSFNTDTTTSGISS EECCCCCCCCCCCCC	29.90	21955146
1225	Phosphorylation	QSFNTDTTTSGISSM ECCCCCCCCCCCCCC	23.05	21955146
1226	Phosphorylation	SFNTDTTTSGISSMS CCCCCCCCCCCCCCC	27.35	21955146
1227	Phosphorylation	FNTDTTTSGISSMSS CCCCCCCCCCCCCCC	31.85	21955146
1230	Phosphorylation	DTTTSGISSMSSSPS CCCCCCCCCCCCCCC	24.42	23663014
1231	Phosphorylation	TTTSGISSMSSSPSR CCCCCCCCCCCCCCC	22.29	30278072
1233	Phosphorylation	TSGISSMSSSPSRET CCCCCCCCCCCCCCC	29.61	23663014
1234	Phosphorylation	SGISSMSSSPSRETV CCCCCCCCCCCCCCC	37.31	22167270
1235	Phosphorylation	GISSMSSSPSRETVG CCCCCCCCCCCCCCC	21.42	22167270
1237	Phosphorylation	SSMSSSPSRETVGVD CCCCCCCCCCCCCCC	44.70	23663014
1249	Ubiquitination	GVDATTMDTDCGSMS CCCCEEECCCCCCCE	36.98	21963094
1259	Ubiquitination	CGSMSTVVSTKTIKT CCCCEEEEECCEECC	6.44	21963094
1265	Ubiquitination	VVSTKTIKTSHYLTP EEECCEECCCCCCCC	49.56	29967540
1266	Phosphorylation	VSTKTIKTSHYLTPQ EECCEECCCCCCCCC	19.52	29083192
1267	Phosphorylation	STKTIKTSHYLTPQS ECCEECCCCCCCCCC	12.72	29978859
1267	Ubiquitination	STKTIKTSHYLTPQS ECCEECCCCCCCCCC	12.72	21963094
1269	Phosphorylation	KTIKTSHYLTPQSNH CEECCCCCCCCCCCC	16.43	29978859
1269 (in isoform 3)	Phosphorylation	-	16.43	27642862
1271	Phosphorylation	IKTSHYLTPQSNHLS ECCCCCCCCCCCCCC	16.47	25159151
1271	Ubiquitination	IKTSHYLTPQSNHLS ECCCCCCCCCCCCCC	16.47	22505724
1274	Phosphorylation	SHYLTPQSNHLSLSK CCCCCCCCCCCCCCC	27.67	28450419
1276	Ubiquitination	YLTPQSNHLSLSKSN CCCCCCCCCCCCCCC	23.26	21963094
1278	Phosphorylation	TPQSNHLSLSKSNSV CCCCCCCCCCCCCCC	24.05	28450419
1280	Phosphorylation	QSNHLSLSKSNSVSL CCCCCCCCCCCCCEE	30.57	28450419
1281	Ubiquitination	SNHLSLSKSNSVSLV CCCCCCCCCCCCEEC	59.97	22505724
1282	Phosphorylation	NHLSLSKSNSVSLVP CCCCCCCCCCCEECC	30.84	25159151
1282 (in isoform 3)	Phosphorylation	-	30.84	21406692
1284	Phosphorylation	LSLSKSNSVSLVPPG CCCCCCCCCEECCCC	21.85	25159151
1286	Phosphorylation	LSKSNSVSLVPPGSS CCCCCCCEECCCCCC	24.38	23927012
1292	Phosphorylation	VSLVPPGSSHTLPRR CEECCCCCCCCCCHH	25.39	23927012
1293	Phosphorylation	SLVPPGSSHTLPRRA EECCCCCCCCCCHHH	26.80	25159151
1295	Phosphorylation	VPPGSSHTLPRRAQS CCCCCCCCCCHHHHH	40.17	25159151
1296	Ubiquitination	PPGSSHTLPRRAQSL CCCCCCCCCHHHHHC	2.32	21963094
1302	Phosphorylation	TLPRRAQSLKAPSIA CCCHHHHHCCCCCHH	30.74	23401153
1302 (in isoform 3)	Phosphorylation	-	30.74	21406692
1304	Methylation	PRRAQSLKAPSIATI CHHHHHCCCCCHHHH	64.60	115976665
1304	Ubiquitination	PRRAQSLKAPSIATI CHHHHHCCCCCHHHH	64.60	29967540
1305	Ubiquitination	RRAQSLKAPSIATIK HHHHHCCCCCHHHHH	14.36	21963094
1307	Phosphorylation	AQSLKAPSIATIKSL HHHCCCCCHHHHHHH	29.70	30266825
1307 (in isoform 3)	Phosphorylation	-	29.70	21406692
1310	Phosphorylation	LKAPSIATIKSLADC CCCCCHHHHHHHCCC	27.54	30266825
1312	Acetylation	APSIATIKSLADCNF CCCHHHHHHHCCCCC	34.75	7927337
1312	Methylation	APSIATIKSLADCNF CCCHHHHHHHCCCCC	34.75	7927337
1312	Ubiquitination	APSIATIKSLADCNF CCCHHHHHHHCCCCC	34.75	21963094
1312 (in isoform 3)	Ubiquitination	-	34.75	-
1313	Phosphorylation	PSIATIKSLADCNFS CCHHHHHHHCCCCCC	25.57	25159151
1314	Ubiquitination	SIATIKSLADCNFSY CHHHHHHHCCCCCCC	3.86	21963094
1317	Ubiquitination	TIKSLADCNFSYTSS HHHHHCCCCCCCCCC	4.63	29967540
1318	Ubiquitination	IKSLADCNFSYTSSR HHHHCCCCCCCCCCC	29.46	22505724
1320	Phosphorylation	SLADCNFSYTSSRDA HHCCCCCCCCCCCCH	17.32	26462736
1321	Phosphorylation	LADCNFSYTSSRDAF HCCCCCCCCCCCCHH	13.40	22817900
1321 (in isoform 3)	Phosphorylation	-	13.40	27642862
1322	Phosphorylation	ADCNFSYTSSRDAFG CCCCCCCCCCCCHHH	21.01	28348404
1323	Phosphorylation	DCNFSYTSSRDAFGY CCCCCCCCCCCHHHH	18.36	28348404
1324	Phosphorylation	CNFSYTSSRDAFGYA CCCCCCCCCCHHHHH	26.78	28348404
1329	Ubiquitination	TSSRDAFGYATLKRL CCCCCHHHHHHHHHH	16.94	21963094
1330	Phosphorylation	SSRDAFGYATLKRLQ CCCCHHHHHHHHHHH	7.03	25159151
1330 (in isoform 3)	Phosphorylation	-	7.03	27642862
1332	Phosphorylation	RDAFGYATLKRLQQQ CCHHHHHHHHHHHHH	25.07	23401153
1332 (in isoform 3)	Phosphorylation	-	25.07	27642862
1334	Methylation	AFGYATLKRLQQQRM HHHHHHHHHHHHHCC	46.86	82988291
1334	Ubiquitination	AFGYATLKRLQQQRM HHHHHHHHHHHHHCC	46.86	33845483
1334 (in isoform 3)	Ubiquitination	-	46.86	-
1338	Ubiquitination	ATLKRLQQQRMHPSL HHHHHHHHHCCCCCC	37.12	21963094
1344	Phosphorylation	QQQRMHPSLSHSEAL HHHCCCCCCCHHHHH	28.03	27794612
1346	Phosphorylation	QRMHPSLSHSEALAS HCCCCCCCHHHHHHC	29.33	21712546
1348	O-linked_Glycosylation	MHPSLSHSEALASPA CCCCCCHHHHHHCCC	22.61	30379171
1348	Phosphorylation	MHPSLSHSEALASPA CCCCCCHHHHHHCCC	22.61	27794612
1352	Ubiquitination	LSHSEALASPAKDVL CCHHHHHHCCCCCEE	22.10	21890473
1353	Phosphorylation	SHSEALASPAKDVLF CHHHHHHCCCCCEEE	26.66	25159151
1361	Phosphorylation	PAKDVLFTDTITMKA CCCCEEEECCEEEEC	28.24	-
1362	Ubiquitination	AKDVLFTDTITMKAN CCCEEEECCEEEECC	28.86	21890473
1363	Phosphorylation	KDVLFTDTITMKANS CCEEEECCEEEECCC	18.45	28555341
1367	Methylation	FTDTITMKANSFESR EECCEEEECCCHHCC	35.45	24129315
1370	Phosphorylation	TITMKANSFESRLTP CEEEECCCHHCCCCH	34.94	25159151
1373	Phosphorylation	MKANSFESRLTPSRF EECCCHHCCCCHHHH	30.49	22199227
1375	Ubiquitination	ANSFESRLTPSRFMK CCCHHCCCCHHHHHH	13.22	21890473
1376	Phosphorylation	NSFESRLTPSRFMKA CCHHCCCCHHHHHHH	20.36	25159151
1376 (in isoform 3)	Phosphorylation	-	20.36	26425664
1378	Phosphorylation	FESRLTPSRFMKALS HHCCCCHHHHHHHHH	32.68	22199227
1378 (in isoform 3)	Phosphorylation	-	32.68	-
1382	Ubiquitination	LTPSRFMKALSYASL CCHHHHHHHHHHHCC	43.39	33845483
1385	Phosphorylation	SRFMKALSYASLDKE HHHHHHHHHHCCCHH	24.42	29255136
1386	Phosphorylation	RFMKALSYASLDKED HHHHHHHHHCCCHHH	10.89	29255136
1388	Phosphorylation	MKALSYASLDKEDLL HHHHHHHCCCHHHHC	28.94	29255136
1391	Ubiquitination	LSYASLDKEDLLSPI HHHHCCCHHHHCCCC	59.42	23000965
1391 (in isoform 1)	Ubiquitination	-	59.42	21890473
1391 (in isoform 4)	Ubiquitination	-	59.42	21890473
1396	Phosphorylation	LDKEDLLSPINQNTL CCHHHHCCCCCHHHH	30.91	30266825
1399	Ubiquitination	EDLLSPINQNTLQRS HHHCCCCCHHHHHCC	32.22	21890473
1402	Phosphorylation	LSPINQNTLQRSSSV CCCCCHHHHHCCHHH	17.95	23927012
1406	Phosphorylation	NQNTLQRSSSVRSMV CHHHHHCCHHHHHHH	17.63	26074081
1407	Phosphorylation	QNTLQRSSSVRSMVS HHHHHCCHHHHHHHH	34.73	26074081
1408	Phosphorylation	NTLQRSSSVRSMVSS HHHHCCHHHHHHHHH	23.85	26074081
1409	Phosphorylation	TLQRSSSVRSMVSSA HHHCCHHHHHHHHHC	5.92	32142685
1409 (in isoform 3)	Phosphorylation	-	5.92	27642862
1410 (in isoform 3)	Phosphorylation	-	22.45	27642862
1411	Phosphorylation	QRSSSVRSMVSSATY HCCHHHHHHHHHCCC	22.75	26074081
1412	Phosphorylation	RSSSVRSMVSSATYG CCHHHHHHHHHCCCC	2.07	32645325
1412 (in isoform 3)	Phosphorylation	-	2.07	27642862
1414	Phosphorylation	SSVRSMVSSATYGGS HHHHHHHHHCCCCCC	12.96	26074081
1415	Phosphorylation	SVRSMVSSATYGGSD HHHHHHHHCCCCCCC	17.14	26074081
1415	Ubiquitination	SVRSMVSSATYGGSD HHHHHHHHCCCCCCC	17.14	21890473
1415 (in isoform 3)	Ubiquitination	-	17.14	21890473
1417	Phosphorylation	RSMVSSATYGGSDDY HHHHHHCCCCCCCCC	25.33	26074081
1418	Phosphorylation	SMVSSATYGGSDDYI HHHHHCCCCCCCCCE	21.14	26074081
1420 (in isoform 3)	Phosphorylation	-	19.93	27642862
1421	Phosphorylation	SSATYGGSDDYIGLA HHCCCCCCCCCEEEE	23.97	26074081
1424	Phosphorylation	TYGGSDDYIGLALPV CCCCCCCCEEEEEEC	11.24	27732954
1444	Phosphorylation	FQVKDIPYFQTKNIP CCCCCCCCEECCCCC	14.51	-
1447	Phosphorylation	KDIPYFQTKNIPPHD CCCCCEECCCCCCCC	19.03	-
1448	Ubiquitination	DIPYFQTKNIPPHDD CCCCEECCCCCCCCC	41.94	29967540
1470	Phosphorylation	HDAGGLPSGTGGLVK CCCCCCCCCCCHHHH	54.77	30266825
1472	Phosphorylation	AGGLPSGTGGLVKNS CCCCCCCCCHHHHHH	32.20	30266825
1472	Ubiquitination	AGGLPSGTGGLVKNS CCCCCCCCCHHHHHH	32.20	29967540
1477	Ubiquitination	SGTGGLVKNSFHLLR CCCCHHHHHHHHHHH	52.49	-
1479	Phosphorylation	TGGLVKNSFHLLRQQ CCHHHHHHHHHHHHC	14.34	27422710
1501 (in isoform 3)	Ubiquitination	-	25.33	-
1551	Ubiquitination	SDFQDIPYSDWCEQT CCCCCCCHHHCHHHH	21.42	21963094
1552	Ubiquitination	DFQDIPYSDWCEQTI CCCCCCHHHCHHHHC	21.20	21963094
1560	Ubiquitination	DWCEQTIHNPLEVVP HCHHHHCCCCCEECC	32.99	21963094
1561	Ubiquitination	WCEQTIHNPLEVVPS CHHHHCCCCCEECCC	38.71	21963094
1570	Ubiquitination	LEVVPSKFSGISGCS CEECCCCCCCCCCCC	10.70	21963094
1571	Phosphorylation	EVVPSKFSGISGCSD EECCCCCCCCCCCCC	38.67	22817900
1574	Phosphorylation	PSKFSGISGCSDGVS CCCCCCCCCCCCCCC	36.95	25262027
1574	Ubiquitination	PSKFSGISGCSDGVS CCCCCCCCCCCCCCC	36.95	21963094
1576	Ubiquitination	KFSGISGCSDGVSQE CCCCCCCCCCCCCCC	2.40	21963094
1577	Phosphorylation	FSGISGCSDGVSQEG CCCCCCCCCCCCCCC	40.71	25159151
1581	Phosphorylation	SGCSDGVSQEGSASS CCCCCCCCCCCCCCC	28.22	25262027
1583	Ubiquitination	CSDGVSQEGSASSTK CCCCCCCCCCCCCCC	47.84	21963094
1585	Phosphorylation	DGVSQEGSASSTKST CCCCCCCCCCCCCCC	24.99	23663014
1585	Ubiquitination	DGVSQEGSASSTKST CCCCCCCCCCCCCCC	24.99	21963094
1587	Phosphorylation	VSQEGSASSTKSTEL CCCCCCCCCCCCCEE	39.99	23663014
1588	Phosphorylation	SQEGSASSTKSTELL CCCCCCCCCCCCEEE	39.30	23663014
1589	Phosphorylation	QEGSASSTKSTELLL CCCCCCCCCCCEEEE	26.90	23663014
1590	Ubiquitination	EGSASSTKSTELLLG CCCCCCCCCCEEEEE	58.28	21963094
1591	Phosphorylation	GSASSTKSTELLLGV CCCCCCCCCEEEEEC	27.48	29255136
1592	Phosphorylation	SASSTKSTELLLGVK CCCCCCCCEEEEECE	32.01	30266825
1598	Ubiquitination	STELLLGVKTIPDDT CCEEEEECEECCCCC	5.08	21963094
1599	Ubiquitination	TELLLGVKTIPDDTP CEEEEECEECCCCCC	38.65	21963094
1605	Phosphorylation	VKTIPDDTPMCRILL CEECCCCCCHHHHHH	21.94	22817900
1607	Ubiquitination	TIPDDTPMCRILLRK ECCCCCCHHHHHHHH	2.32	21963094
1614	Ubiquitination	MCRILLRKEVLRLVI HHHHHHHHHHHHHHH	52.74	21963094
1614 (in isoform 3)	Ubiquitination	-	52.74	-
1615 (in isoform 3)	Phosphorylation	-	40.11	21406692
1616 (in isoform 3)	Phosphorylation	-	4.18	21406692
1623	Ubiquitination	VLRLVINLSSSVSTK HHHHHHHCCCCCCCC	3.45	21963094
1623 (in isoform 3)	Ubiquitination	-	3.45	-
1640	Ubiquitination	ETGLLTIKEKYPQTF CCCCEEEHHHCCCCH	42.81	29967540
1664	Ubiquitination	SHLLSHCTFRLPCRR HHHHHHCCCCCHHHH	13.33	29967540
1695	Phosphorylation	EAEAVLATPPKQPIV HHHHHHCCCCCCCCC	35.64	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1135	T	Phosphorylation	Kinase	AKT1	P31749	PSP
1135	T	Phosphorylation	Kinase	P70S6K	P23443	PSP
1135	T	Phosphorylation	Kinase	RPS6KB2	Q9UBS0	GPS
1135	T	Phosphorylation	Kinase	SGK1	O00141	PSP
1235	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
1695	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
1695	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1135	T	Phosphorylation	Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.	19995915

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RICTR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTOR_HUMAN	MTOR	physical	15467718
MTOR_HUMAN	MTOR	physical	15268862
MTOR_HUMAN	MTOR	physical	16919458
MTOR_HUMAN	MTOR	physical	16962653
MTOR_HUMAN	MTOR	physical	17043309
KS6B1_HUMAN	RPS6KB1	physical	15809305
SIN1_HUMAN	MAPKAP1	physical	16962653
PRR5_HUMAN	PRR5	physical	17461779
SIN1_HUMAN	MAPKAP1	physical	17461779
LST8_HUMAN	MLST8	physical	17461779
MTOR_HUMAN	MTOR	physical	17461779
CPSM_HUMAN	CPS1	physical	17461779
CLH1_HUMAN	CLTC	physical	17461779
HSP74_HUMAN	HSPA4	physical	17461779
TBA1A_HUMAN	TUBA1A	physical	17461779
TBA1B_HUMAN	TUBA1B	physical	17461779
TIA1_HUMAN	TIA1	physical	17461779
RS3A_HUMAN	RPS3A	physical	17461779
RL13_HUMAN	RPL13	physical	17461779
ABHGA_HUMAN	ABHD16A	physical	17461779
EHMT2_HUMAN	EHMT2	physical	17461779
DHX36_HUMAN	DHX36	physical	17461779
DHRS4_HUMAN	DHRS4	physical	17461779
PRR5L_HUMAN	PRR5L	physical	17461779
CUL1_HUMAN	CUL1	physical	20832730
SIN1_HUMAN	MAPKAP1	physical	20832730
RBX1_HUMAN	RBX1	physical	20832730
RL23_HUMAN	RPL23	physical	21045808
RS6_HUMAN	RPS6	physical	21045808
MTOR_HUMAN	MTOR	physical	21045808
SIN1_HUMAN	MAPKAP1	physical	21045808
RL23A_HUMAN	RPL23A	physical	21045808
RL26_HUMAN	RPL26	physical	21045808
RS5_HUMAN	RPS5	physical	21045808
FBXW7_HUMAN	FBXW7	physical	22285861
MTOR_HUMAN	MTOR	physical	22285861
MTOR_HUMAN	MTOR	physical	16603397
AKT1_HUMAN	AKT1	physical	16603397
AKT1_HUMAN	AKT1	physical	15718470
MTOR_HUMAN	MTOR	physical	17386266
SIN1_HUMAN	MAPKAP1	physical	17043309
MTOR_HUMAN	MTOR	physical	19145465
RPTOR_HUMAN	RPTOR	physical	19145465
MTOR_HUMAN	MTOR	physical	18566587
SIN1_HUMAN	MAPKAP1	physical	18566587
AKT1_HUMAN	AKT1	physical	18566587
KPCA_HUMAN	PRKCA	physical	18566587
AKT1_HUMAN	AKT1	physical	21177249
MTOR_HUMAN	MTOR	physical	21177249
SIN1_HUMAN	MAPKAP1	physical	21177249
PINK1_HUMAN	PINK1	physical	21177249
MTOR_HUMAN	MTOR	physical	19875983
SIN1_HUMAN	MAPKAP1	physical	19875983
STK38_HUMAN	STK38	physical	19875983
AKT1_HUMAN	AKT1	physical	22990118
MTOR_HUMAN	MTOR	physical	22990118
DDB1_HUMAN	DDB1	physical	23297343
MTOR_HUMAN	MTOR	physical	19446321
DPTOR_HUMAN	DEPTOR	physical	19446321
MTOR_HUMAN	MTOR	physical	17565979
PREX1_HUMAN	PREX1	physical	17565979
LST8_HUMAN	MLST8	physical	17565979
HSP74_HUMAN	HSPA4	physical	18505677
MTOR_HUMAN	MTOR	physical	18505677
LST8_HUMAN	MLST8	physical	18505677
SIN1_HUMAN	MAPKAP1	physical	18505677
PRR5L_HUMAN	PRR5L	physical	18505677
BRCA1_HUMAN	BRCA1	physical	22990118
GBB1_HUMAN	GNB1	physical	24462769
MTOR_HUMAN	MTOR	physical	18030348
PRR5L_HUMAN	PRR5L	physical	18030348
SIN1_HUMAN	MAPKAP1	physical	18030348
ILK_HUMAN	ILK	physical	18339839
MTOR_HUMAN	MTOR	physical	18339839
MTOR_HUMAN	MTOR	physical	18570873
SIN1_HUMAN	MAPKAP1	physical	18570873
PRR5L_HUMAN	PRR5L	physical	21964062
SGK1_HUMAN	SGK1	physical	20832730
AKT1_HUMAN	AKT1	physical	21343617
MTOR_HUMAN	MTOR	physical	21343617
SIN1_HUMAN	MAPKAP1	physical	21343617
MTOR_HUMAN	MTOR	physical	23872070
IKKB_HUMAN	IKBKB	physical	23872070
IKKA_HUMAN	CHUK	physical	23872070
AKT1_HUMAN	AKT1	physical	19402821
NBN_HUMAN	NBN	physical	23762398
LST8_HUMAN	MLST8	physical	22084251
MTOR_HUMAN	MTOR	physical	22084251
SIN1_HUMAN	MAPKAP1	physical	22084251
FBXW7_HUMAN	FBXW7	physical	25897075
LST8_HUMAN	MLST8	physical	18030348
AKT1_HUMAN	AKT1	physical	25241761
KS6B1_HUMAN	RPS6KB1	physical	25241761
PLK1_HUMAN	PLK1	physical	25714006
AKT1_HUMAN	AKT1	physical	22337773

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-582, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-1284; SER-1388AND SER-1411, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; THR-1175 ANDSER-1385, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1386 AND SER-1388, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-1282; TYR-1386;SER-1388 AND SER-1396, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-1353 ANDSER-1396, AND MASS SPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND THR-1295, ANDMASS SPECTROMETRY.
PubMed: 18220336

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 17081983

"mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 andregulates mTORC2 signaling.";
Julien L.A., Carriere A., Moreau J., Roux P.P.;
Mol. Cell. Biol. 30:908-921(2010).
Cited for: PHOSPHORYLATION AT THR-1135.
PubMed: 19995915