ABHGA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABHGA_HUMAN
• UniProt AC: O95870
• Protein Name: Protein ABHD16A {ECO:0000305}
• Gene Name: ABHD16A {ECO:0000312|HGNC:HGNC:13921}
• Organism: Homo sapiens (Human).
• Sequence Length: 558
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MAKLLSCVLG -----CHHHHHHHHC	48.97	-
6	Phosphorylation	--MAKLLSCVLGPRL --CHHHHHHHHCHHH	16.77	24719451
15	Ubiquitination	VLGPRLYKIYRERDS HHCHHHHHHHHHCCC	37.54	-
22	Phosphorylation	KIYRERDSERAPASV HHHHHCCCCCCCCCC	34.89	28634298
28	Phosphorylation	DSERAPASVPETPTA CCCCCCCCCCCCCCE	36.83	30108239
32	Phosphorylation	APASVPETPTAVTAP CCCCCCCCCCEECCC	21.62	25159151
34	Phosphorylation	ASVPETPTAVTAPHS CCCCCCCCEECCCCC	40.97	25159151
37	Phosphorylation	PETPTAVTAPHSSSW CCCCCEECCCCCCCC	31.82	30108239
41	Phosphorylation	TAVTAPHSSSWDTYY CEECCCCCCCCCCCC	25.63	29978859
42	Phosphorylation	AVTAPHSSSWDTYYQ EECCCCCCCCCCCCC	32.20	29978859
43	Phosphorylation	VTAPHSSSWDTYYQP ECCCCCCCCCCCCCH	31.80	29978859
46	Phosphorylation	PHSSSWDTYYQPRAL CCCCCCCCCCCHHHH	20.19	28060719
47	Phosphorylation	HSSSWDTYYQPRALE CCCCCCCCCCHHHHH	9.53	28060719
48	Phosphorylation	SSSWDTYYQPRALEK CCCCCCCCCHHHHHH	17.71	28060719
87	Phosphorylation	FYLYRKGYLSLSKVV HHHHHCCCCCHHHCC	8.99	27080861
89	Phosphorylation	LYRKGYLSLSKVVPF HHHCCCCCHHHCCCC	23.32	24719451
91	Phosphorylation	RKGYLSLSKVVPFSH HCCCCCHHHCCCCHH	21.74	27080861
129	Phosphorylation	PQYRQFITILEATHR HHHHHHHHHHHHHHC	22.31	26503514
134	Phosphorylation	FITILEATHRNQSSE HHHHHHHHHCCCCCH	16.40	26503514
205	S-palmitoylation	NRVKKLPCQITSYLV HHHHHCCHHHHHHHH	7.10	29575903
222	Phosphorylation	TLGRRMLYPGSVYLL HCCCCCCCCCHHHHH	9.01	24043423
225	Phosphorylation	RRMLYPGSVYLLQKA CCCCCCCHHHHHHHH	11.77	24043423
227	Phosphorylation	MLYPGSVYLLQKALM CCCCCHHHHHHHHHH	11.91	24043423
418	Phosphorylation	NAEQLCRYQGPVLLI CHHHHHHCCCCEEEE	19.47	-
419	Ubiquitination	AEQLCRYQGPVLLIR HHHHHHCCCCEEEEE	30.29	21890473
443	Phosphorylation	TVPEDIMSNRGNDLL ECCHHHHCCCCCHHH	24.57	-
452	Ubiquitination	RGNDLLLKLLQHRYP CCCHHHHHHHHHCCC	47.31	21890473
452	Acetylation	RGNDLLLKLLQHRYP CCCHHHHHHHHHCCC	47.31	25953088
487	Phosphorylation	LEEASIYSRWEVEED HCCCCHHHCEEECCH	29.28	24719451
498	Phosphorylation	VEEDWCLSVLRSYQA ECCHHHHHHHHHHHH	18.90	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABHGA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABHGA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABHGA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFM1_HUMAN	IFITM1	physical	14667819
RNF5_HUMAN	RNF5	physical	14667819
HM13_HUMAN	HM13	physical	14667819
TM147_HUMAN	TMEM147	physical	14667819
TM222_HUMAN	TMEM222	physical	14667819
DNJC1_HUMAN	DNAJC1	physical	14667819
GPC5C_HUMAN	GPRC5C	physical	14667819
SPAG7_HUMAN	SPAG7	physical	14667819
SAFB1_HUMAN	SAFB	physical	14667819
AT5G3_HUMAN	ATP5G3	physical	14667819
DTX2_HUMAN	DTX2	physical	25416956
RETR3_HUMAN	FAM134C	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.