UniProt ID | DNJC1_HUMAN | |
---|---|---|
UniProt AC | Q96KC8 | |
Protein Name | DnaJ homolog subfamily C member 1 | |
Gene Name | DNAJC1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 554 | |
Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein. Nucleus membrane Single-pass type I membrane protein. Microsome membrane Single-pass type I membrane protein. |
|
Protein Description | May modulate protein synthesis.. | |
Protein Sequence | MTAPCSQPAQLPGRRQLGLVPFPPPPPRTPLLWLLLLLLAAVAPARGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGSKSVDVSKLGASEKNERLLMKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQYPRGSSDRWDKIARCVPSKSKEDCIARYKLLVELVQKKKQAKS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 | Phosphorylation | --MTAPCSQPAQLPG --CCCCCCCCCCCCC | 37.83 | 20068231 | |
89 | Phosphorylation | RKAYRKLSLTLHPDK HHHHHHHHCEECCCC | 23.49 | 27067055 | |
96 | Ubiquitination | SLTLHPDKNKDENAE HCEECCCCCCCCCHH | 71.05 | 29967540 | |
117 | Ubiquitination | VAIYEVLKDDERRQR HHHHHHHCCCHHHHH | 69.20 | - | |
184 | Phosphorylation | KQLDELLSRKKREKK HHHHHHHHHHHHHHH | 55.46 | 26074081 | |
197 | Ubiquitination | KKKKTGSKSVDVSKL HHCCCCCCCCCHHHC | 56.71 | 33845483 | |
202 | Phosphorylation | GSKSVDVSKLGASEK CCCCCCHHHCCCCHH | 20.07 | 29214152 | |
203 | Ubiquitination | SKSVDVSKLGASEKN CCCCCHHHCCCCHHH | 51.27 | 33845483 | |
203 | 2-Hydroxyisobutyrylation | SKSVDVSKLGASEKN CCCCCHHHCCCCHHH | 51.27 | - | |
207 | Phosphorylation | DVSKLGASEKNERLL CHHHCCCCHHHCCCC | 47.51 | 23403867 | |
209 | Ubiquitination | SKLGASEKNERLLMK HHCCCCHHHCCCCCC | 62.71 | 33845483 | |
216 | Ubiquitination | KNERLLMKPQWHDLL HHCCCCCCCCHHHHH | 33.74 | 29967540 | |
234 | Phosphorylation | LGIWFCLTLKALPHL HHHHHHHHHHHHHHH | 27.65 | - | |
249 | Phosphorylation | IQDAGQFYAKYKETR HHHHHHHHHHHHHHH | 8.36 | - | |
258 | Ubiquitination | KYKETRLKEKEDALT HHHHHHHHHHHHHHH | 64.55 | - | |
260 | 2-Hydroxyisobutyrylation | KETRLKEKEDALTRT HHHHHHHHHHHHHHH | 60.34 | - | |
260 | Ubiquitination | KETRLKEKEDALTRT HHHHHHHHHHHHHHH | 60.34 | 24816145 | |
274 | Ubiquitination | TELETLQKQKKVKKP HHHHHHHHHHCCCCC | 68.17 | 33845483 | |
295 | Phosphorylation | YTPLETTYIQSYDHG CCCCCCEEEEECCCC | 12.37 | 22817900 | |
299 | Phosphorylation | ETTYIQSYDHGTSIE CCEEEEECCCCCCHH | 8.79 | 22817900 | |
322 | Phosphorylation | WLENRNRTQKKQAPE HHHHCCHHHHHCCCC | 48.57 | 29083192 | |
325 | Ubiquitination | NRNRTQKKQAPEWTE HCCHHHHHCCCCCCH | 41.70 | 29967540 | |
331 | Phosphorylation | KKQAPEWTEEDLSQL HHCCCCCCHHHHHHH | 28.03 | 29083192 | |
339 | Phosphorylation | EEDLSQLTRSMVKFP HHHHHHHHHHHHCCC | 17.04 | 29083192 | |
349 | Phosphorylation | MVKFPGGTPGRWEKI HHCCCCCCCCHHHHH | 28.60 | 21815630 | |
363 | Phosphorylation | IAHELGRSVTDVTTK HHHHHCCCHHHHHHH | 27.80 | 28555341 | |
365 | Phosphorylation | HELGRSVTDVTTKAK HHHCCCHHHHHHHHH | 26.46 | 28348404 | |
375 | Malonylation | TTKAKQLKDSVTCSP HHHHHHHHHCCCCCC | 45.52 | 26320211 | |
377 | Phosphorylation | KAKQLKDSVTCSPGM HHHHHHHCCCCCCCE | 20.10 | 22199227 | |
379 | Phosphorylation | KQLKDSVTCSPGMVR HHHHHCCCCCCCEEE | 15.95 | 29255136 | |
381 | Phosphorylation | LKDSVTCSPGMVRLS HHHCCCCCCCEEEHH | 18.34 | 23401153 | |
384 | Sulfoxidation | SVTCSPGMVRLSELK CCCCCCCEEEHHHHH | 1.47 | 21406390 | |
388 | Phosphorylation | SPGMVRLSELKSTVQ CCCEEEHHHHHHHHH | 30.25 | 26074081 | |
391 | Ubiquitination | MVRLSELKSTVQNSR EEEHHHHHHHHHHCC | 39.78 | 29967540 | |
392 | Phosphorylation | VRLSELKSTVQNSRP EEHHHHHHHHHHCCC | 46.57 | 26074081 | |
393 | Phosphorylation | RLSELKSTVQNSRPI EHHHHHHHHHHCCCC | 25.23 | 26074081 | |
397 | Phosphorylation | LKSTVQNSRPIKTAT HHHHHHHCCCCCCCC | 23.49 | 26074081 | |
402 | Phosphorylation | QNSRPIKTATTLPDD HHCCCCCCCCCCCHH | 29.92 | 23186163 | |
404 | Phosphorylation | SRPIKTATTLPDDMI CCCCCCCCCCCHHHC | 33.81 | 30624053 | |
405 | Phosphorylation | RPIKTATTLPDDMIT CCCCCCCCCCHHHCC | 33.55 | 23917254 | |
412 | Phosphorylation | TLPDDMITQREDAEG CCCHHHCCCCHHCCC | 18.22 | 23186163 | |
430 | Phosphorylation | EEEQEGDSGEQETGA CHHCCCCCCCCCCCC | 55.90 | 29255136 | |
435 | Phosphorylation | GDSGEQETGATDARP CCCCCCCCCCCCCCC | 31.63 | 22167270 | |
438 | Phosphorylation | GEQETGATDARPRRR CCCCCCCCCCCCCCC | 31.38 | 22167270 | |
456 | Acetylation | RLLEATAKPEPEEKS HHHHHHCCCCHHHHH | 45.63 | 26051181 | |
456 | Ubiquitination | RLLEATAKPEPEEKS HHHHHHCCCCHHHHH | 45.63 | 24816145 | |
456 | Methylation | RLLEATAKPEPEEKS HHHHHHCCCCHHHHH | 45.63 | - | |
479 | Phosphorylation | DIAEQNESSDEESLR CHHHHCCCCCHHHHH | 51.11 | 29255136 | |
480 | Phosphorylation | IAEQNESSDEESLRK HHHHCCCCCHHHHHH | 42.75 | 29255136 | |
484 | Phosphorylation | NESSDEESLRKERAR CCCCCHHHHHHHHHH | 31.27 | 29255136 | |
487 | Acetylation | SDEESLRKERARSAE CCHHHHHHHHHHHCC | 57.77 | 7683449 | |
492 | Phosphorylation | LRKERARSAEEPWTQ HHHHHHHHCCCCCHH | 38.76 | 25159151 | |
498 | Phosphorylation | RSAEEPWTQNQQKLL HHCCCCCHHHHHHHH | 28.49 | 23898821 | |
539 | Phosphorylation | KEDCIARYKLLVELV HHHHHHHHHHHHHHH | 9.28 | 28152594 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DNJC1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DNJC1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DNJC1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
AACT_HUMAN | SERPINA3 | physical | 14668352 | |
GRP78_HUMAN | HSPA5 | physical | 26085089 | |
RMND1_HUMAN | RMND1 | physical | 28514442 | |
1C07_HUMAN | HLA-C | physical | 28514442 | |
COR1A_HUMAN | CORO1A | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...
Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, AND MASSSPECTROMETRY. | |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480 AND SER-484, ANDMASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381 AND SER-430, ANDMASS SPECTROMETRY. |