1C07_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1C07_HUMAN
• UniProt AC: P10321
• Protein Name: HLA class I histocompatibility antigen, Cw-7 alpha chain
• Gene Name: HLA-C
• Organism: Homo sapiens (Human).
• Sequence Length: 366
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Involved in the presentation of foreign antigens to the immune system..
• Protein Sequence: MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	Glutathionylation	RAYLEGTCVEWLRRY HHHHHCHHHHHHHHH	3.72	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1C07_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1C07_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1C07_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1C07_HUMAN	HLA-C	physical	12794140
CD8A_HUMAN	CD8A	physical	10809759
KI2L1_HUMAN	KIR2DL1	physical	11163076
KI2L1_HUMAN	KIR2DL1	physical	9768753
KI2L3_HUMAN	KIR2DL3	physical	9768753
KI2S2_HUMAN	KIR2DL3	physical	9768753
GRP78_HUMAN	HSPA5	physical	7957306
YBOX1_HUMAN	YBX1	physical	21988832
TANK_HUMAN	TANK	physical	21988832
TMG4_HUMAN	PRRG4	physical	21988832
F213A_HUMAN	FAM213A	physical	26186194
AT1A3_HUMAN	ATP1A3	physical	26186194
HLAF_HUMAN	HLA-F	physical	26186194
1A02_HUMAN	HLA-A	physical	26186194
1A03_HUMAN	HLA-A	physical	26186194
1A01_HUMAN	HLA-A	physical	26186194
1A26_HUMAN	HLA-A	physical	26186194
HLAG_HUMAN	HLA-G	physical	26186194
HLAE_HUMAN	HLA-E	physical	26186194
SCAP_HUMAN	SCAP	physical	26186194
E2AK3_HUMAN	EIF2AK3	physical	26186194
ARV1_HUMAN	ARV1	physical	26186194
NSDHL_HUMAN	NSDHL	physical	26186194
CNNM1_HUMAN	CNNM1	physical	26186194
SCRB1_HUMAN	SCARB1	physical	26186194
DJC16_HUMAN	DNAJC16	physical	26186194
PMGT1_HUMAN	POMGNT1	physical	26186194
HMR1_HUMAN	MR1	physical	26186194
UFSP2_HUMAN	UFSP2	physical	26186194
NETO2_HUMAN	NETO2	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
TECT2_HUMAN	TCTN2	physical	26186194
TIP_HUMAN	ITFG1	physical	26186194
ITA6_HUMAN	ITGA6	physical	26186194
TM223_HUMAN	TMEM223	physical	26186194
FAM3C_HUMAN	FAM3C	physical	26186194
MD2L2_HUMAN	MAD2L2	physical	26186194
DNJC1_HUMAN	DNAJC1	physical	26186194
TM206_HUMAN	TMEM206	physical	26186194
B2MG_HUMAN	B2M	physical	26186194
CISD2_HUMAN	CISD2	physical	26186194
MTR1L_HUMAN	GPR50	physical	26186194
LRFN3_HUMAN	LRFN3	physical	26186194
1A02_HUMAN	HLA-A	physical	28514442
1A03_HUMAN	HLA-A	physical	28514442
1A01_HUMAN	HLA-A	physical	28514442
1A26_HUMAN	HLA-A	physical	28514442
HLAE_HUMAN	HLA-E	physical	28514442
CNNM1_HUMAN	CNNM1	physical	28514442
HLAF_HUMAN	HLA-F	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
MD2L2_HUMAN	MAD2L2	physical	28514442
ITA6_HUMAN	ITGA6	physical	28514442
B2MG_HUMAN	B2M	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
FAM3C_HUMAN	FAM3C	physical	28514442
SCRB1_HUMAN	SCARB1	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
NETO2_HUMAN	NETO2	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
TECT2_HUMAN	TCTN2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.