NSDHL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSDHL_HUMAN
• UniProt AC: Q15738
• Protein Name: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
• Gene Name: NSDHL
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Lipid droplet . Trafficking through the Golgi is necessary for ER membrane localization.
• Protein Description: Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis..
• Protein Sequence: MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAMERTVQSFRHLRRVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPAVSEP -------CCCCCCCC	14.54	22223895
19	Phosphorylation	QVARTHLTEDTPKVN HHHHHHCCCCCCCCC	24.98	29214152
19	O-linked_Glycosylation	QVARTHLTEDTPKVN HHHHHHCCCCCCCCC	24.98	OGP
22	Phosphorylation	RTHLTEDTPKVNADI HHHCCCCCCCCCCCH	20.83	21129721
24	Ubiquitination	HLTEDTPKVNADIEK HCCCCCCCCCCCHHH	50.65	-
31	Ubiquitination	KVNADIEKVNQNQAK CCCCCHHHCCHHHHC	46.98	21906983
31	Acetylation	KVNADIEKVNQNQAK CCCCCHHHCCHHHHC	46.98	26051181
31	2-Hydroxyisobutyrylation	KVNADIEKVNQNQAK CCCCCHHHCCHHHHC	46.98	-
38	2-Hydroxyisobutyrylation	KVNQNQAKRCTVIGG HCCHHHHCCCEEECC	37.94	-
87	Phosphorylation	FFLGDLCSRQDLYPA HHHHHHHCHHHHHHH	40.03	21712546
96	Ubiquitination	QDLYPALKGVNTVFH HHHHHHHCCCCEEEE	64.02	21890473
96	Acetylation	QDLYPALKGVNTVFH HHHHHHHCCCCEEEE	64.02	26051181
106	Phosphorylation	NTVFHCASPPPSSNN CEEEEECCCCCCCCC	43.25	30266825
110	Phosphorylation	HCASPPPSSNNKELF EECCCCCCCCCCEEE	52.01	23312004
114	Acetylation	PPPSSNNKELFYRVN CCCCCCCCEEEEEEE	61.11	26051181
114	Ubiquitination	PPPSSNNKELFYRVN CCCCCCCCEEEEEEE	61.11	-
122	Phosphorylation	ELFYRVNYIGTKNVI EEEEEEEEEECHHHH	9.62	28152594
126	Ubiquitination	RVNYIGTKNVIETCK EEEEEECHHHHHHHH	43.96	-
126	2-Hydroxyisobutyrylation	RVNYIGTKNVIETCK EEEEEECHHHHHHHH	43.96	-
126	Malonylation	RVNYIGTKNVIETCK EEEEEECHHHHHHHH	43.96	26320211
126	Acetylation	RVNYIGTKNVIETCK EEEEEECHHHHHHHH	43.96	26051181
133	2-Hydroxyisobutyrylation	KNVIETCKEAGVQKL HHHHHHHHHHCCEEE	59.00	-
133	Ubiquitination	KNVIETCKEAGVQKL HHHHHHHHHHCCEEE	59.00	-
147	Phosphorylation	LILTSSASVIFEGVD EEEECCCEEEEECCC	20.07	-
159	Phosphorylation	GVDIKNGTEDLPYAM CCCCCCCCCCCCCCC	35.40	21406692
164	Phosphorylation	NGTEDLPYAMKPIDY CCCCCCCCCCCCCCE	26.99	20068231
167	Ubiquitination	EDLPYAMKPIDYYTE CCCCCCCCCCCEEHH	30.56	-
171	Phosphorylation	YAMKPIDYYTETKIL CCCCCCCEEHHHHHH	17.01	21406692
172	Phosphorylation	AMKPIDYYTETKILQ CCCCCCEEHHHHHHH	8.37	21406692
173	Phosphorylation	MKPIDYYTETKILQE CCCCCEEHHHHHHHH	30.83	21406692
175	Phosphorylation	PIDYYTETKILQERA CCCEEHHHHHHHHHH	18.65	21406692
176	Ubiquitination	IDYYTETKILQERAV CCEEHHHHHHHHHHH	34.88	-
191	Ubiquitination	LGANDPEKNFLTTAI HCCCCHHCCCEECCC	59.39	21890473
232	Ubiquitination	KFVIGNGKNLVDFTF EEEECCCCCCEEEEE	51.62	-
263	Ubiquitination	RDSTLGGKAFHITND CCCCCCCEEEEECCC	46.19	-
284	Phosphorylation	TFLSRILTGLNYEAP HHHHHHHHCCCCCCC	36.93	20068231
288	Phosphorylation	RILTGLNYEAPKYHI HHHHCCCCCCCCCCH	20.64	-
293	Phosphorylation	LNYEAPKYHIPYWVA CCCCCCCCCHHHHHH	12.15	23401153
297	Phosphorylation	APKYHIPYWVAYYLA CCCCCHHHHHHHHHH	16.35	23401153
308	Phosphorylation	YYLALLLSLLVMVIS HHHHHHHHHHHHHHH	21.45	23401153
345	Ubiquitination	YSCERAKKAMGYQPL EEHHHHHHHCCCCCE	42.49	-
349	Phosphorylation	RAKKAMGYQPLVTMD HHHHHCCCCCEEEHH	8.22	-
354	Phosphorylation	MGYQPLVTMDDAMER CCCCCEEEHHHHHHH	23.67	29978859
362	Phosphorylation	MDDAMERTVQSFRHL HHHHHHHHHHHHHHH	15.02	29978859
365	Phosphorylation	AMERTVQSFRHLRRV HHHHHHHHHHHHHCC	21.66	22468782
537	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSDHL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSDHL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSDHL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCHL_HUMAN	HCCS	physical	27173435
COMT_HUMAN	COMT	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H00496: Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
• H00577: Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Part
• OMIM Disease
• 308050: Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD)
• 300831: CK syndrome (CKS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.