COMT_HUMAN - dbPTM
COMT_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COMT_HUMAN
UniProt AC P21964
Protein Name Catechol O-methyltransferase
Gene Name COMT
Organism Homo sapiens (Human).
Sequence Length 271
Subcellular Localization Isoform Soluble: Cytoplasm.
Isoform Membrane-bound: Cell membrane
Single-pass type II membrane protein
Extracellular side .
Protein Description Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol..
Protein Sequence MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81PhosphorylationSVLEAIDTYCEQKEW
HHHHHHHHHHHHHHH		24.7728796482
82PhosphorylationVLEAIDTYCEQKEWA
HHHHHHHHHHHHHHH		7.1128796482
86UbiquitinationIDTYCEQKEWAMNVG
HHHHHHHHHHHHHCC		32.69-
88UbiquitinationTYCEQKEWAMNVGDK
HHHHHHHHHHHCCCC		14.0921890473
89UbiquitinationYCEQKEWAMNVGDKK
HHHHHHHHHHCCCCC		4.8321890473
90SulfoxidationCEQKEWAMNVGDKKG
HHHHHHHHHCCCCCC		4.3530846556
95UbiquitinationWAMNVGDKKGKIVDA
HHHHCCCCCCCCHHH		58.45-
98UbiquitinationNVGDKKGKIVDAVIQ
HCCCCCCCCHHHHHH		48.73-
119GlutathionylationLLELGAYCGYSAVRM
HHHHHCCCCHHHHHH		4.0122833525
127 (in isoform 2)Ubiquitination-6.6021890473
128 (in isoform 2)Ubiquitination-27.1521890473
129 (in isoform 2)Ubiquitination-3.9421890473
131PhosphorylationVRMARLLSPGARLIT
HHHHHHCCCCCEEEE		26.3630266825
145GlutathionylationTIEINPDCAAITQRM
EEEECCCHHHHHHHH		2.6522833525
1592-HydroxyisobutyrylationMVDFAGVKDKVTLVV
HHHHCCCCCEEEEEE		51.41-
159SuccinylationMVDFAGVKDKVTLVV
HHHHCCCCCEEEEEE		51.4123954790
159UbiquitinationMVDFAGVKDKVTLVV
HHHHCCCCCEEEEEE		51.41-
169PhosphorylationVTLVVGASQDIIPQL
EEEEEECCCCHHHHH		23.5828348404
177UbiquitinationQDIIPQLKKKYDVDT
CCHHHHHHHHCCCCC		41.8121906983
177 (in isoform 1)Ubiquitination-41.8121890473
178UbiquitinationDIIPQLKKKYDVDTL
CHHHHHHHHCCCCCC		66.2221890473
178 (in isoform 1)Ubiquitination-66.2221890473
179UbiquitinationIIPQLKKKYDVDTLD
HHHHHHHHCCCCCCC		45.1321890473
179 (in isoform 1)Ubiquitination-45.1321890473
179AcetylationIIPQLKKKYDVDTLD
HHHHHHHHCCCCCCC		45.1327452117
180PhosphorylationIPQLKKKYDVDTLDM
HHHHHHHCCCCCCCE		30.0320068231
184PhosphorylationKKKYDVDTLDMVFLD
HHHCCCCCCCEEEHH		25.2220068231
194UbiquitinationMVFLDHWKDRYLPDT
EEEHHHHHHCCCCCC		28.98-
1942-HydroxyisobutyrylationMVFLDHWKDRYLPDT
EEEHHHHHHCCCCCC		28.98-
197PhosphorylationLDHWKDRYLPDTLLL
HHHHHHCCCCCCHHH		32.4927422710
201PhosphorylationKDRYLPDTLLLEECG
HHCCCCCCHHHHHHC		19.8427422710
207GlutathionylationDTLLLEECGLLRKGT
CCHHHHHHCCCCCCC		3.2122833525
209 (in isoform 2)Ubiquitination-6.7221890473
2122-HydroxyisobutyrylationEECGLLRKGTVLLAD
HHHCCCCCCCEEEEC		59.92-
212UbiquitinationEECGLLRKGTVLLAD
HHHCCCCCCCEEEEC		59.9222053931
213 (in isoform 2)Ubiquitination-18.0221890473
223GlutathionylationLLADNVICPGAPDFL
EEECCEECCCCCHHH		1.9022833525
236PhosphorylationFLAHVRGSSCFECTH
HHHHHCCCCCCCCCC		17.2327251275
237PhosphorylationLAHVRGSSCFECTHY
HHHHCCCCCCCCCCH		26.1627251275
242PhosphorylationGSSCFECTHYQSFLE
CCCCCCCCCHHHHHH		19.2028796482
244PhosphorylationSCFECTHYQSFLEYR
CCCCCCCHHHHHHHH		6.4128796482
246PhosphorylationFECTHYQSFLEYREV
CCCCCHHHHHHHHHH		25.3228796482
250PhosphorylationHYQSFLEYREVVDGL
CHHHHHHHHHHHHHH		17.7728152594
259AcetylationEVVDGLEKAIYKGPG
HHHHHHHHHHHCCCC		45.1627452117
259 (in isoform 1)Ubiquitination-45.1621890473
2592-HydroxyisobutyrylationEVVDGLEKAIYKGPG
HHHHHHHHHHHCCCC		45.16-
259UbiquitinationEVVDGLEKAIYKGPG
HHHHHHHHHHHCCCC		45.1621890473
262PhosphorylationDGLEKAIYKGPGSEA
HHHHHHHHCCCCCCC		18.1023403867
263UbiquitinationGLEKAIYKGPGSEAG
HHHHHHHCCCCCCCC		53.142190698
263 (in isoform 1)Ubiquitination-53.1421890473
267PhosphorylationAIYKGPGSEAGP---
HHHCCCCCCCCC---		27.6623401153
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COMT_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COMT_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COMT_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PCH2_HUMANTRIP13physical
16189514
PCH2_HUMANTRIP13physical
19060904
KRA59_HUMANKRTAP5-9physical
25416956
K1H1_HUMANKRT31physical
25416956
PCH2_HUMANTRIP13physical
25416956
K1C40_HUMANKRT40physical
25416956
CO1A2_HUMANCOL1A2physical
26496610
FGF2_HUMANFGF2physical
26496610
EXO1_HUMANEXO1physical
26496610
RIN1_HUMANRIN1physical
26496610
US6NL_HUMANUSP6NLphysical
26496610
HIG1A_HUMANHIGD1Aphysical
26496610
IPYR2_HUMANPPA2physical
26496610
ESYT1_HUMANESYT1physical
27173435
TMX1_HUMANTMX1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00095 Adrenaline (JP16); Epinephrine (USP/INN); Adrenalin (TN); Auvi-q (TN); Epipen (TN)
D00152 Phloroglucinol (JAN); Dilospan S (TN)
D00633 Dopamine hydrochloride (JP16/USP); Actopamin (TN); Intropin (TN)
D00781 Entacapone (JAN/USAN/INN); Comtan (TN)
D00786 Tolcapone (JAN/USAN/INN); Tasmar (TN)
D01259 Flopropione (JP16/INN); Ephtanon (TN)
D03241 Nitecapone (INN)
D07870 Dopamine (INN); Medopa (TN)
D08369 Polyphloroglucinol phosphate; Dealyd (TN)
DrugBank
DB00286Conjugated Estrogens
DB00255Diethylstilbestrol
DB00841Dobutamine
DB00988Dopamine
DB00494Entacapone
DB00968Methyldopa
DB01141Micafungin
DB00118S-Adenosylmethionine
DB01420Testosterone Propionate
DB00323Tolcapone
Regulatory Network of COMT_HUMAN

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Related Literatures of Post-Translational Modification

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