dbPTM

IPYR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IPYR2_HUMAN
UniProt AC	Q9H2U2
Protein Name	Inorganic pyrophosphatase 2, mitochondrial
Gene Name	PPA2
Organism	Homo sapiens (Human).
Sequence Length	334
Subcellular Localization	Mitochondrion .
Protein Description	Hydrolyzes inorganic pyrophosphate. [PubMed: 27523597 This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function]
Protein Sequence	MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ALLRLLRTGAPAAAC HHHHHHHHCCCHHHH	37.35	20860994
22	Phosphorylation	AACLRLGTSAGTGSR HHHHHHCCCCCCCCH	21.72	20068231
22 (in isoform 4)	Phosphorylation	-	21.72	-
22 (in isoform 3)	Phosphorylation	-	21.72	-
22	O-linked_Glycosylation	AACLRLGTSAGTGSR HHHHHHCCCCCCCCH	21.72	30379171
23	Phosphorylation	ACLRLGTSAGTGSRR HHHHHCCCCCCCCHH	23.93	20068231
23 (in isoform 4)	Phosphorylation	-	23.93	-
23 (in isoform 2)	Phosphorylation	-	23.93	21406692
23 (in isoform 3)	Phosphorylation	-	23.93	-
23	O-linked_Glycosylation	ACLRLGTSAGTGSRR HHHHHCCCCCCCCHH	23.93	30379171
26	Phosphorylation	RLGTSAGTGSRRAMA HHCCCCCCCCHHHHH	31.53	20068231
26 (in isoform 4)	Phosphorylation	-	31.53	-
26 (in isoform 3)	Phosphorylation	-	31.53	-
28	Phosphorylation	GTSAGTGSRRAMALY CCCCCCCCHHHHHHE	20.59	20068231
28 (in isoform 4)	Phosphorylation	-	20.59	-
28 (in isoform 2)	Phosphorylation	-	20.59	21406692
28 (in isoform 3)	Phosphorylation	-	20.59	-
28	O-linked_Glycosylation	GTSAGTGSRRAMALY CCCCCCCCHHHHHHE	20.59	30379171
35	Phosphorylation	SRRAMALYHTEERGQ CHHHHHHEECHHCCC	9.35	20068231
37	Phosphorylation	RAMALYHTEERGQPC HHHHHEECHHCCCCC	26.45	20068231
37 (in isoform 4)	Phosphorylation	-	26.45	-
37 (in isoform 3)	Phosphorylation	-	26.45	-
45	Phosphorylation	EERGQPCSQNYRLFF HHCCCCCCCCEEEEE	28.30	20068231
45 (in isoform 4)	Phosphorylation	-	28.30	-
45 (in isoform 3)	Phosphorylation	-	28.30	-
48	Phosphorylation	GQPCSQNYRLFFKNV CCCCCCCEEEEEECC	10.89	20068231
53	Acetylation	QNYRLFFKNVTGHYI CCEEEEEECCCCEEC	43.08	19608861
53 (in isoform 3)	Acetylation	-	43.08	-
56	Phosphorylation	RLFFKNVTGHYISPF EEEEECCCCEECCCC	27.86	28152594
59	Phosphorylation	FKNVTGHYISPFHDI EECCCCEECCCCCCC	12.39	28152594
59 (in isoform 2)	Phosphorylation	-	12.39	27642862
61	Phosphorylation	NVTGHYISPFHDIPL CCCCEECCCCCCCCE	17.85	28152594
68 (in isoform 4)	Phosphorylation	-	11.19	-
69	Acetylation	PFHDIPLKVNSKEEN CCCCCCEECCCCCCC	33.73	25953088
69	Malonylation	PFHDIPLKVNSKEEN CCCCCCEECCCCCCC	33.73	26320211
73	Acetylation	IPLKVNSKEENGIPM CCEECCCCCCCCCCC	64.94	20167786
81	Acetylation	EENGIPMKKARNDEY CCCCCCCCHHCCHHH	37.62	20167786
81	Ubiquitination	EENGIPMKKARNDEY CCCCCCCCHHCCHHH	37.62	29967540
95 (in isoform 4)	Acetylation	-	2.36	-
95	Acetylation	YENLFNMIVEIPRWT HHHHHHHHHHCHHHC	2.36	19608861
105	Acetylation	IPRWTNAKMEIATKE CHHHCCCCCEECCCC	38.85	25953088
105	Malonylation	IPRWTNAKMEIATKE CHHHCCCCCEECCCC	38.85	26320211
105	Succinylation	IPRWTNAKMEIATKE CHHHCCCCCEECCCC	38.85	23954790
110 (in isoform 4)	Acetylation	-	41.42	-
110	Phosphorylation	NAKMEIATKEPMNPI CCCCEECCCCCCCHH	41.42	20068231
110	Acetylation	NAKMEIATKEPMNPI CCCCEECCCCCCCHH	41.42	19608861
111	Ubiquitination	AKMEIATKEPMNPIK CCCEECCCCCCCHHH	51.29	-
111	Acetylation	AKMEIATKEPMNPIK CCCEECCCCCCCHHH	51.29	26822725
111	Malonylation	AKMEIATKEPMNPIK CCCEECCCCCCCHHH	51.29	26320211
111	Succinylation	AKMEIATKEPMNPIK CCCEECCCCCCCHHH	51.29	27452117
114	Acetylation	EIATKEPMNPIKQYV EECCCCCCCHHHHHH	11.05	19608861
118	Acetylation	KEPMNPIKQYVKDGK CCCCCHHHHHHHCCC	36.51	25038526
120	Phosphorylation	PMNPIKQYVKDGKLR CCCHHHHHHHCCCEE	12.40	-
122	Acetylation	NPIKQYVKDGKLRYV CHHHHHHHCCCEEEE	56.69	23749302
122	Ubiquitination	NPIKQYVKDGKLRYV CHHHHHHHCCCEEEE	56.69	29967540
122	Succinylation	NPIKQYVKDGKLRYV CHHHHHHHCCCEEEE	56.69	23954790
126 (in isoform 2)	Ubiquitination	-	6.13	-
145	Ubiquitination	YIWNYGTLPQTWEDP EEEECCCCCCCCCCC	2.28	29967540
147 (in isoform 4)	Phosphorylation	-	63.46	-
149 (in isoform 4)	Phosphorylation	-	11.62	-
150 (in isoform 4)	Phosphorylation	-	66.12	-
151 (in isoform 4)	Phosphorylation	-	41.22	-
151	Phosphorylation	TLPQTWEDPHEKDKS CCCCCCCCCCCCCCC	41.22	32142685
154	Ubiquitination	QTWEDPHEKDKSTNC CCCCCCCCCCCCCCC	69.23	29967540
155	Acetylation	TWEDPHEKDKSTNCF CCCCCCCCCCCCCCC	68.38	25953088
155	Ubiquitination	TWEDPHEKDKSTNCF CCCCCCCCCCCCCCC	68.38	29967540
156 (in isoform 4)	Phosphorylation	-	47.34	-
157	Ubiquitination	EDPHEKDKSTNCFGD CCCCCCCCCCCCCCC	70.96	29967540
158	Phosphorylation	DPHEKDKSTNCFGDN CCCCCCCCCCCCCCC	34.68	27703031
159	Phosphorylation	PHEKDKSTNCFGDND CCCCCCCCCCCCCCC	41.57	29396449
159	Acetylation	PHEKDKSTNCFGDND CCCCCCCCCCCCCCC	41.57	19608861
174	Acetylation	PIDVCEIGSKILSCG CCCHHHHHHEECCCC	10.69	19608861
176	Ubiquitination	DVCEIGSKILSCGEV CHHHHHHEECCCCCC	42.31	29967540
179	Phosphorylation	EIGSKILSCGEVIHV HHHHEECCCCCCEEE	24.45	-
180	S-nitrosocysteine	IGSKILSCGEVIHVK HHHEECCCCCCEEEE	4.89	-
180	S-nitrosylation	IGSKILSCGEVIHVK HHHEECCCCCCEEEE	4.89	19483679
187	Acetylation	CGEVIHVKILGILAL CCCCEEEEEEEHHHC	20.32	19608861
187 (in isoform 3)	Acetylation	-	20.32	-
195	Ubiquitination	ILGILALIDEGETDW EEEHHHCEECCCCCE	3.64	29967540
205 (in isoform 3)	Phosphorylation	-	3.00	-
215	Phosphorylation	NANDPEASKFHDIDD ECCCHHHHHCCCHHH	33.90	19664994
216	Acetylation	ANDPEASKFHDIDDV CCCHHHHHCCCHHHH	54.49	19608861
216	Succinylation	ANDPEASKFHDIDDV CCCHHHHHCCCHHHH	54.49	-
216	Succinylation	ANDPEASKFHDIDDV CCCHHHHHCCCHHHH	54.49	-
216	Malonylation	ANDPEASKFHDIDDV CCCHHHHHCCCHHHH	54.49	26320211
218	Ubiquitination	DPEASKFHDIDDVKK CHHHHHCCCHHHHHH	34.55	29967540
224	Acetylation	FHDIDDVKKFKPGYL CCCHHHHHHCCCCHH	60.53	23236377
224	Ubiquitination	FHDIDDVKKFKPGYL CCCHHHHHHCCCCHH	60.53	29967540
224	2-Hydroxyisobutyrylation	FHDIDDVKKFKPGYL CCCHHHHHHCCCCHH	60.53	-
224	Succinylation	FHDIDDVKKFKPGYL CCCHHHHHHCCCCHH	60.53	23954790
225	Acetylation	HDIDDVKKFKPGYLE CCHHHHHHCCCCHHH	59.47	25953088
230	Phosphorylation	VKKFKPGYLEATLNW HHHCCCCHHHEEEEE	15.19	20068231
232 (in isoform 3)	Acetylation	-	30.99	-
232	Acetylation	KFKPGYLEATLNWFR HCCCCHHHEEEEEEE	30.99	19608861
234	Phosphorylation	KPGYLEATLNWFRLY CCCHHHEEEEEEEEE	15.96	20068231
241	Phosphorylation	TLNWFRLYKVPDGKP EEEEEEEEECCCCCC	12.99	28152594
242	Malonylation	LNWFRLYKVPDGKPE EEEEEEEECCCCCCC	52.46	26320211
247	Acetylation	LYKVPDGKPENQFAF EEECCCCCCCCCCEE	57.44	25038526
247 (in isoform 3)	Acetylation	-	57.44	-
247	Ubiquitination	LYKVPDGKPENQFAF EEECCCCCCCCCCEE	57.44	29967540
247	Malonylation	LYKVPDGKPENQFAF EEECCCCCCCCCCEE	57.44	26320211
259	Acetylation	FAFNGEFKNKAFALE CEECCEECCHHHHHH	53.92	25953088
259	Succinylation	FAFNGEFKNKAFALE CEECCEECCHHHHHH	53.92	-
259	Succinylation	FAFNGEFKNKAFALE CEECCEECCHHHHHH	53.92	-
261	Acetylation	FNGEFKNKAFALEVI ECCEECCHHHHHHHH	45.53	19608861
261	Malonylation	FNGEFKNKAFALEVI ECCEECCHHHHHHHH	45.53	26320211
269	Acetylation	AFALEVIKSTHQCWK HHHHHHHHHHHHHHH	55.25	25038526
276	Acetylation	KSTHQCWKALLMKKC HHHHHHHHHHHHHHC	36.46	23954790
276	Malonylation	KSTHQCWKALLMKKC HHHHHHHHHHHHHHC	36.46	26320211
284 (in isoform 3)	Phosphorylation	-	61.89	-
286 (in isoform 3)	Phosphorylation	-	14.86	-
287 (in isoform 3)	Phosphorylation	-	7.39	-
288 (in isoform 3)	Phosphorylation	-	5.00	-
288	Phosphorylation	KKCNGGAINCTNVQI HHCCCCCCCCEEEEE	5.00	32142685
291	Ubiquitination	NGGAINCTNVQISDS CCCCCCCEEEEECCC	33.66	29967540
293 (in isoform 3)	Phosphorylation	-	2.63	-
298	Phosphorylation	TNVQISDSPFRCTQE EEEEECCCCCCCCHH	21.10	20230923
309	Phosphorylation	CTQEEARSLVESVSS CCHHHHHHHHHHHHC	43.76	22115753
313	Phosphorylation	EARSLVESVSSSPNK HHHHHHHHHHCCCCC	21.59	22167270
315	Phosphorylation	RSLVESVSSSPNKES HHHHHHHHCCCCCCC	34.08	22167270
316	Phosphorylation	SLVESVSSSPNKESN HHHHHHHCCCCCCCC	47.89	22167270
317	Phosphorylation	LVESVSSSPNKESNE HHHHHHCCCCCCCCH	25.61	19664994
320	Acetylation	SVSSSPNKESNEEEQ HHHCCCCCCCCHHHH	66.94	25038526
320	Ubiquitination	SVSSSPNKESNEEEQ HHHCCCCCCCCHHHH	66.94	29967540
322	Phosphorylation	SSSPNKESNEEEQVW HCCCCCCCCHHHHHH	51.67	22167270
330 (in isoform 2)	Phosphorylation	-	14.81	21406692
331 (in isoform 2)	Phosphorylation	-	5.88	21406692
332 (in isoform 2)	Phosphorylation	-	5.74	21406692
334	Acetylation	QVWHFLGK------- HHHHHHCC-------	60.35	7675607

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IPYR2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IPYR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IPYR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF2M_HUMAN	MTIF2	physical	26186194
H13_HUMAN	HIST1H1D	physical	26186194
ACSF2_HUMAN	ACSF2	physical	26186194
CLU_HUMAN	CLUH	physical	26186194
ACADV_HUMAN	ACADVL	physical	26186194
ACS2L_HUMAN	ACSS1	physical	26186194
GLSK_HUMAN	GLS	physical	26186194
PNPT1_HUMAN	PNPT1	physical	26186194
CLPP_HUMAN	CLPP	physical	26186194
PCCB_HUMAN	PCCB	physical	26186194
NNTM_HUMAN	NNT	physical	26186194
ARPIN_HUMAN	ARPIN	physical	26186194
LYRM7_HUMAN	LYRM7	physical	26186194
NPS3A_HUMAN	NIPSNAP3A	physical	26186194
MECR_HUMAN	MECR	physical	26186194
PDPR_HUMAN	PDPR	physical	26186194
CATA_HUMAN	CAT	physical	26344197
CD2AP_HUMAN	CD2AP	physical	26344197
DUT_HUMAN	DUT	physical	26344197
HIBCH_HUMAN	HIBCH	physical	26344197
NEDD8_HUMAN	NEDD8	physical	26344197
PP1RB_HUMAN	PPP1R11	physical	26344197
RISC_HUMAN	SCPEP1	physical	26344197
TNG2_HUMAN	TANGO2	physical	26344197
H13_HUMAN	HIST1H1D	physical	28514442
ACS2L_HUMAN	ACSS1	physical	28514442
ACSF2_HUMAN	ACSF2	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
CLPP_HUMAN	CLPP	physical	28514442
MECR_HUMAN	MECR	physical	28514442
ARPIN_HUMAN	ARPIN	physical	28514442
NPS3A_HUMAN	NIPSNAP3A	physical	28514442
LYRM7_HUMAN	LYRM7	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IPYR2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53; LYS-216; LYS-261 ANDLYS-276, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317, AND MASSSPECTROMETRY.	18187866 [Abstract]