PCCB_HUMAN - dbPTM
PCCB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCCB_HUMAN
UniProt AC P05166
Protein Name Propionyl-CoA carboxylase beta chain, mitochondrial
Gene Name PCCB
Organism Homo sapiens (Human).
Sequence Length 539
Subcellular Localization Mitochondrion matrix .
Protein Description
Protein Sequence MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRCADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCNLRDFFNYLPLSSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45PhosphorylationRIENKRRTALLGGGQ
HHHHHHHHHHCCCCC		26.2021406692
45O-linked_GlycosylationRIENKRRTALLGGGQ
HHHHHHHHHHCCCCC		26.2030379171
60AcetylationRRIDAQHKRGKLTAR
HHHHHCHHCCCCCHH		51.2592187
71PhosphorylationLTARERISLLLDPGS
CCHHHHHHHHCCCCC		21.1324275569
99AcetylationDFGMAADKNKFPGDS
CCCCCCCCCCCCCCC		58.2625953088
99SuccinylationDFGMAADKNKFPGDS
CCCCCCCCCCCCCCC		58.26-
99SuccinylationDFGMAADKNKFPGDS
CCCCCCCCCCCCCCC		58.26-
99UbiquitinationDFGMAADKNKFPGDS
CCCCCCCCCCCCCCC		58.2623503661
101AcetylationGMAADKNKFPGDSVV
CCCCCCCCCCCCCEE		59.6925953088
101UbiquitinationGMAADKNKFPGDSVV
CCCCCCCCCCCCCEE		59.6923503661
143UbiquitinationAHAQKICKIMDQAIT
HHHHHHHHHHHHHCC		44.53-
172PhosphorylationRIQEGVESLAGYADI
HHHHHHHHHHHCHHH		22.5521406692
176PhosphorylationGVESLAGYADIFLRN
HHHHHHHCHHHHHCC		8.7621406692
232UbiquitinationITGPDVVKSVTNEDV
EECCCCEEECCCCCC		38.7723503661
233PhosphorylationTGPDVVKSVTNEDVT
ECCCCEEECCCCCCC		23.6722798277
235PhosphorylationPDVVKSVTNEDVTQE
CCCEEECCCCCCCHH		39.73-
248SuccinylationQEELGGAKTHTTMSG
HHHHCCCCCCCCHHH		44.08-
248SuccinylationQEELGGAKTHTTMSG
HHHHCCCCCCCCHHH		44.08-
248UbiquitinationQEELGGAKTHTTMSG
HHHHCCCCCCCCHHH		44.0823503661
252UbiquitinationGGAKTHTTMSGVAHR
CCCCCCCCHHHHHHH		11.1823503661
268UbiquitinationFENDVDALCNLRDFF
HHCCHHHHHCHHHHH		1.4023503661
322PhosphorylationNMVDIIHSVVDEREF
HHHHHHHHHCCHHHH		17.27-
360UbiquitinationGIVGNQPKVASGCLD
EEECCCCCCCCCCEE		40.44-
363PhosphorylationGNQPKVASGCLDINS
CCCCCCCCCCEECCC		32.7821406692
370PhosphorylationSGCLDINSSVKGARF
CCCEECCCCCCCHHH		36.5221406692
371PhosphorylationGCLDINSSVKGARFV
CCEECCCCCCCHHHH		24.3021406692
433UbiquitinationKVTVITRKAYGGAYD
EEEEEEEEECCCHHH		36.99-
445UbiquitinationAYDVMSSKHLCGDTN
HHHHHCCCCCCCCCC		33.03-
474SuccinylationGAVEIIFKGHENVEA
CEEEEEEECCCCHHH		49.28-
474AcetylationGAVEIIFKGHENVEA
CEEEEEEECCCCHHH		49.28-
474SuccinylationGAVEIIFKGHENVEA
CEEEEEEECCCCHHH		49.28-
486PhosphorylationVEAAQAEYIEKFANP
HHHHHHHHHHHHCCC		19.86-
489UbiquitinationAQAEYIEKFANPFPA
HHHHHHHHHCCCCHH		39.9729967540
489SuccinylationAQAEYIEKFANPFPA
HHHHHHHHHCCCCHH		39.97-
489AcetylationAQAEYIEKFANPFPA
HHHHHHHHHCCCCHH		39.97-
489SuccinylationAQAEYIEKFANPFPA
HHHHHHHHHCCCCHH		39.97-
509UbiquitinationVDDIIQPSSTRARIC
HCHHCCCCCHHHEEE		28.1529967540
509PhosphorylationVDDIIQPSSTRARIC
HCHHCCCCCHHHEEE		28.1522210691
510PhosphorylationDDIIQPSSTRARICC
CHHCCCCCHHHEEEC		28.7022210691
511PhosphorylationDIIQPSSTRARICCD
HHCCCCCHHHEEECC		32.4622210691
5252-HydroxyisobutyrylationDLDVLASKKVQRPWR
CHHHHHCCCCCCCHH		51.89-
526AcetylationLDVLASKKVQRPWRK
HHHHHCCCCCCCHHH		40.9020167786
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCCB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCCB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCCB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LYPA1_HUMANLYPLA1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
606054Propionic acidemia type II (PA-2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00121Biotin
DB00161L-Valine
Regulatory Network of PCCB_HUMAN

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Related Literatures of Post-Translational Modification

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