CLU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLU_HUMAN
• UniProt AC: O75153
• Protein Name: Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013}
• Gene Name: CLUH
• Organism: Homo sapiens (Human).
• Sequence Length: 1309
• Subcellular Localization: Cytoplasm . Cytoplasmic granule . A fraction colocalizes with tyrosinated tubulin and can be detected close to mitochondria.
• Protein Description: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis..
• Protein Sequence: MLLNGDCPESLKKEAAAAEPPRENGLDEAGPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQVLMDREDTCHRTCFSLHLDGNVLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMYLFVITAEDRQVSITASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISPTFKKNFAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPLKILRHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECARAGFPRAHRHKLCCLRQELVDAFVEHRYLLFMKLAALQLMQQNASQLETPSSLENGGPSSLESKSEDPPGQEAGSEEEGSSASGLAKVKELAETIAADDGTDPRSREVIRNACKAVGSISSTAFDIRFNPDIFSPGVRFPESCQDEVRDQKQLLKDAAAFLLSCQIPGLVKDCMEHAVLPVDGATLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYPNPVAHLPADELVSKKRNKRRKNRPPGAADNTAWAVMTPQELWKNICQEAKNYFDFDLECETVDQAVETYGLQKITLLREISLKTGIQVLLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQAVALQRTMNEIYRNGSSANIPPLKFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARRHQLQEASRNRDRAEEPMATEPAPAGAPGDLGSQPPAAKDPSPSVQG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LNGDCPESLKKEAAA CCCCCCHHHHHHHHH		21815630
50	Ubiquitination	IQDTGFSVKILAPGI EECCCCEEEEECCCC		32015554
61	Phosphorylation	APGIEPFSLQVSPQE CCCCCCCCCCCCHHH		24043423
65	Phosphorylation	EPFSLQVSPQEMVQE CCCCCCCCHHHHHHH		24043423
102	Phosphorylation	GNVLDHFSELRSVEG CCHHHHHHHHHCCCC		24719451
175	Ubiquitination	GDSGKRKKGLEMDPI CCCCCCCCCCCCCCC		-
179	Sulfoxidation	KRKKGLEMDPIDCTP CCCCCCCCCCCCCCC		30846556
210	Ubiquitination	QPQNRDWKPLQCLKV CCCCCCCCCHHHEEE		-
238	Phosphorylation	KMHGDLMYLFVITAE CCCCCEEEEEEEEEC		25954137
250	Phosphorylation	TAEDRQVSITASTRG EECCCEEEEEEECCE		25954137
252	Phosphorylation	EDRQVSITASTRGFY CCCEEEEEEECCEEE		20068231
254	Phosphorylation	RQVSITASTRGFYLN CEEEEEEECCEEEEC		20068231
255	Phosphorylation	QVSITASTRGFYLNQ EEEEEEECCEEEECC		20068231
263	Phosphorylation	RGFYLNQSTAYHFNP CEEEECCCCEECCCC		28152594
264	Phosphorylation	GFYLNQSTAYHFNPK EEEECCCCEECCCCC		28152594
266	Phosphorylation	YLNQSTAYHFNPKPA EECCCCEECCCCCCC		28152594
279	Phosphorylation	PASPRFLSHSLVELL CCCCHHHHHHHHHHH		18669648
281	Phosphorylation	SPRFLSHSLVELLNQ CCHHHHHHHHHHHHH		18669648
294	Acetylation	NQISPTFKKNFAVLQ HHHCHHHHHCHHHHH		24469387
295	Ubiquitination	QISPTFKKNFAVLQK HHCHHHHHCHHHHHH		-
302	Ubiquitination	KNFAVLQKKRVQRHP HCHHHHHHHCHHCCC		-
303	Ubiquitination	NFAVLQKKRVQRHPF CHHHHHHHCHHCCCC		-
320	Phosphorylation	IATPFQVYSWTAPQA CCCCCEEEEEECCCH		-
321	Phosphorylation	ATPFQVYSWTAPQAE CCCCEEEEEECCCHH		-
323	Phosphorylation	PFQVYSWTAPQAEHA CCEEEEEECCCHHHH		-
341	Phosphorylation	VRAEDAYTSRLGYEE CHHHHHHHHCCCCCC		28555341
346	Phosphorylation	AYTSRLGYEEHIPGQ HHHHCCCCCCCCCCC		28152594
384	Methylation	LRERAIFKVHSDFTA HHHHHHHHHCCCHHH		-
394	Phosphorylation	SDFTAAATRGAMAVI CCHHHHHCCCCEEEE		-
411	Phosphorylation	NVMAINPSEETKMQM CEEEECCCHHHHCHH		20068231
414	Phosphorylation	AINPSEETKMQMFIW EECCCHHHHCHHEEE		20068231
437	Ubiquitination	FDVRDHYKDFGGDVA CCHHHHHHHHCCCEE		-
499	Phosphorylation	LERDQEQSVIYGSID HCCCCCCCEEEEEEE		29083192
502	Phosphorylation	DQEQSVIYGSIDFGK CCCCCEEEEEEECCC		29083192
504	Phosphorylation	EQSVIYGSIDFGKTV CCCEEEEEEECCCCH		29083192
517	Phosphorylation	TVVSHPRYLELLERT CHHCCHHHHHHHHHC		30576142
524	Phosphorylation	YLELLERTSRPLKIL HHHHHHHCCCCHHHH		30576142
525	Phosphorylation	LELLERTSRPLKILR HHHHHHCCCCHHHHH		30576142
529	Ubiquitination	ERTSRPLKILRHQVL HHCCCCHHHHHHHHH		21963094
552	Ubiquitination	LCSSVECKGIIGNDG CCCEEEEEEEECCCC		21906983
562	Phosphorylation	IGNDGRHYILDLLRT ECCCCHHHHHHHHHH		28152594
634	Phosphorylation	QLMQQNASQLETPSS HHHHHCHHHCCCCHH		27251275
638	Phosphorylation	QNASQLETPSSLENG HCHHHCCCCHHHCCC		29523821
640	Phosphorylation	ASQLETPSSLENGGP HHHCCCCHHHCCCCC		22199227
641	Phosphorylation	SQLETPSSLENGGPS HHCCCCHHHCCCCCC		22199227
648	Phosphorylation	SLENGGPSSLESKSE HHCCCCCCCCCCCCC		22199227
649	Phosphorylation	LENGGPSSLESKSED HCCCCCCCCCCCCCC		28188228
652	Phosphorylation	GGPSSLESKSEDPPG CCCCCCCCCCCCCCC		22199227
654	Phosphorylation	PSSLESKSEDPPGQE CCCCCCCCCCCCCCC		29255136
664	Phosphorylation	PPGQEAGSEEEGSSA CCCCCCCCCCCCCCC		29255136
669	Phosphorylation	AGSEEEGSSASGLAK CCCCCCCCCCCHHHH		29255136
670	Phosphorylation	GSEEEGSSASGLAKV CCCCCCCCCCHHHHH		29255136
672	Phosphorylation	EEEGSSASGLAKVKE CCCCCCCCHHHHHHH		29255136
676	Ubiquitination	SSASGLAKVKELAET CCCCHHHHHHHHHHH		21906983
678	Ubiquitination	ASGLAKVKELAETIA CCHHHHHHHHHHHHH		22817900
702	Phosphorylation	REVIRNACKAVGSIS HHHHHHHHHHHCCCC		33259812
703	Ubiquitination	EVIRNACKAVGSISS HHHHHHHHHHCCCCC		32015554
709	Phosphorylation	CKAVGSISSTAFDIR HHHHCCCCCCCCEEE		25850435
710	Phosphorylation	KAVGSISSTAFDIRF HHHCCCCCCCCEEEC		25850435
711	Phosphorylation	AVGSISSTAFDIRFN HHCCCCCCCCEEECC		25850435
723	Phosphorylation	RFNPDIFSPGVRFPE ECCCCCCCCCCCCCH		25850435
740	Ubiquitination	QDEVRDQKQLLKDAA HHHHHHHHHHHHHHH		-
742	Ubiquitination	EVRDQKQLLKDAAAF HHHHHHHHHHHHHHH		32015554
753	S-nitrosocysteine	AAAFLLSCQIPGLVK HHHHHHHCCCCHHHH		-
791	Ubiquitination	INMRYLGKVLELVLR CCHHHHHHHHHHHHC		33845483
818	Phosphorylation	IGIGELITRSAKHIF ECHHHHHHHHHHHHH		20068231
830	Ubiquitination	HIFKTYLQGVELSGL HHHHHHHHCCCCHHH		33845483
946	Phosphorylation	IQVLLKEYSFDSRHK HHHHHHHCCCCCCCC		-
947	Phosphorylation	QVLLKEYSFDSRHKP HHHHHHCCCCCCCCC		-
950	Phosphorylation	LKEYSFDSRHKPAFT HHHCCCCCCCCCCCC		-
953	Ubiquitination	YSFDSRHKPAFTEED CCCCCCCCCCCCHHH		-
969	Ubiquitination	LNIFPVVKHVNPKAS HHHHHHCCCCCCCCH		22817900
970	Ubiquitination	NIFPVVKHVNPKASD HHHHHCCCCCCCCHH		22817900
974	Ubiquitination	VVKHVNPKASDAFHF HCCCCCCCCHHHHHH		22817900
975	Ubiquitination	VKHVNPKASDAFHFF CCCCCCCCHHHHHHH		21890473
988	Ubiquitination	FFQSGQAKVQQGFLK HHHHCCHHHHHCHHH		-
1013	Ubiquitination	NLFNNVYGAMHVETC HHHHHCHHHHHHHHH		33845483
1123	Phosphorylation	GVMEYDLSLRFLENA HHHHCHHHHHHHHHH		24719451
1156	Phosphorylation	HHLVARVYESKAEFR HHHHHHHHHCHHHHH		28064214
1159	2-Hydroxyisobutyrylation	VARVYESKAEFRSAL HHHHHHCHHHHHHHH		-
1159	Ubiquitination	VARVYESKAEFRSAL HHHHHHCHHHHHHHH		24816145
1160	Ubiquitination	ARVYESKAEFRSALQ HHHHHCHHHHHHHHH		24816145
1170	2-Hydroxyisobutyrylation	RSALQHEKEGYTIYK HHHHHHHHCCCEEEE		-
1170	Acetylation	RSALQHEKEGYTIYK HHHHHHHHCCCEEEE		23236377
1170	Ubiquitination	RSALQHEKEGYTIYK HHHHHHHHCCCEEEE		-
1177	Ubiquitination	KEGYTIYKTQLGEDH HCCCEEEEEECCCCH		-
1186	Ubiquitination	QLGEDHEKTKESSEY ECCCCHHHHHHHHHH		33845483
1187	Phosphorylation	LGEDHEKTKESSEYL CCCCHHHHHHHHHHH		-
1195	Ubiquitination	KESSEYLKCLTQQAV HHHHHHHHHHHHHHH		32015554
1212	Phosphorylation	QRTMNEIYRNGSSAN HHHHHHHHHCCCCCC		-
1216	Phosphorylation	NEIYRNGSSANIPPL HHHHHCCCCCCCCCC		23186163
1217	Phosphorylation	EIYRNGSSANIPPLK HHHHCCCCCCCCCCC		23186163
1224	Ubiquitination	SANIPPLKFTAPSMA CCCCCCCCCCCCHHH		33845483
1225	Ubiquitination	ANIPPLKFTAPSMAS CCCCCCCCCCCHHHH		33845483
1234	Ubiquitination	APSMASVLEQLNVIN CCHHHHHHHHHCCCC		32015554
1251	Ubiquitination	LFIPLSQKDLENLKA EEEECCHHHHHHHHH		23000965
1252	Ubiquitination	FIPLSQKDLENLKAE EEECCHHHHHHHHHH		23000965
1257	Ubiquitination	QKDLENLKAEVARRH HHHHHHHHHHHHHHH		23000965
1258	Ubiquitination	KDLENLKAEVARRHQ HHHHHHHHHHHHHHH		23000965
1295	Phosphorylation	GAPGDLGSQPPAAKD CCCCCCCCCCCCCCC		23312004
1296	Ubiquitination	APGDLGSQPPAAKDP CCCCCCCCCCCCCCC		33845483
1301	Ubiquitination	GSQPPAAKDPSPSVQ CCCCCCCCCCCCCCC		24816145
1302	Ubiquitination	SQPPAAKDPSPSVQG CCCCCCCCCCCCCCC		24816145
1304	Phosphorylation	PPAAKDPSPSVQG-- CCCCCCCCCCCCC--		28985074
1306	Phosphorylation	AAKDPSPSVQG---- CCCCCCCCCCC----		18669648

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLU_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLU_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DP13A_HUMAN	APPL1	physical	22863883
CYFP1_HUMAN	CYFIP1	physical	22863883
NCKP1_HUMAN	NCKAP1	physical	22863883
ABCF2_HUMAN	ABCF2	physical	26344197
DC1L1_HUMAN	DYNC1LI1	physical	26344197
DC1L2_HUMAN	DYNC1LI2	physical	26344197
ERCC2_HUMAN	ERCC2	physical	26344197
UBL7_HUMAN	UBL7	physical	26344197
SYYC_HUMAN	YARS	physical	26344197
FTM_HUMAN	RPGRIP1L	physical	27173435
TEFM_HUMAN	TEFM	physical	27173435
RP25L_HUMAN	RPP25L	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.