CYFP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYFP1_HUMAN
• UniProt AC: Q7L576
• Protein Name: Cytoplasmic FMR1-interacting protein 1
• Gene Name: CYFIP1 {ECO:0000312|HGNC:HGNC:13759}
• Organism: Homo sapiens (Human).
• Sequence Length: 1253
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Cell projection, lamellipodium . Cell projection, ruffle . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also en
• Protein Description: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers..
• Protein Sequence: MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7 (in isoform 2)	Phosphorylation	-	6.19	-
13	Ubiquitination	TLEDALSNVDLLEEL CHHHHHHCCCHHHCC	31.97	22817900
16 (in isoform 2)	Phosphorylation	-	5.89	20860994
17	Ubiquitination	ALSNVDLLEELPLPD HHHCCCHHHCCCCCC	4.09	22817900
18	Ubiquitination	LSNVDLLEELPLPDQ HHCCCHHHCCCCCCC	65.86	22817900
28	Ubiquitination	PLPDQQPCIEPPPSS CCCCCCCCCCCCCCH	4.84	22505724
54	Phosphorylation	EDRNAFVTGIARYIE HHHHHHHHHHHHHHH	19.20	23403867
60	Ubiquitination	VTGIARYIEQATVHS HHHHHHHHHHHHHCH	2.36	29967540
64	Phosphorylation	ARYIEQATVHSSMNE HHHHHHHHHCHHHHH	20.60	23403867
67	Ubiquitination	IEQATVHSSMNEMLE HHHHHHCHHHHHHHH	27.26	24816145
73 (in isoform 3)	Ubiquitination	-	4.40	21890473
75	Ubiquitination	SMNEMLEEGQEYAVM HHHHHHHHHHHHHHH	63.31	29967540
80	Ubiquitination	LEEGQEYAVMLYTWR HHHHHHHHHHHHHHH	4.58	22817900
97	Ubiquitination	SRAIPQVKCNEQPNR HCCCCCCCCCCCCCC	26.54	24816145
108	Phosphorylation	QPNRVEIYEKTVEVL CCCCEEEEEHHHHHH	9.62	19605366
110	Ubiquitination	NRVEIYEKTVEVLEP CCEEEEEHHHHHHCH	40.68	22817900
110 (in isoform 1)	Ubiquitination	-	40.68	21890473
116	Ubiquitination	EKTVEVLEPEVTKLM EHHHHHHCHHHHHHH	44.59	22505724
120	Ubiquitination	EVLEPEVTKLMNFMY HHHCHHHHHHHHHHH	19.46	22505724
131	Ubiquitination	NFMYFQRNAIERFCG HHHHHHHHHHHHHHH	34.19	24816145
142	Ubiquitination	RFCGEVRRLCHAERR HHHHHHHHHHHHHHH	47.01	33845483
142 (in isoform 2)	Ubiquitination	-	47.01	21890473
144	Ubiquitination	CGEVRRLCHAERRKD HHHHHHHHHHHHHHC	2.44	22817900
146	Ubiquitination	EVRRLCHAERRKDFV HHHHHHHHHHHHCCC	15.82	22817900
147	Ubiquitination	VRRLCHAERRKDFVS HHHHHHHHHHHCCCC	29.38	22817900
148	Ubiquitination	RRLCHAERRKDFVSE HHHHHHHHHHCCCCH	52.30	29967540
150	Ubiquitination	LCHAERRKDFVSEAY HHHHHHHHCCCCHHH	62.83	22505724
152	Ubiquitination	HAERRKDFVSEAYLI HHHHHHCCCCHHHHH	7.95	29967540
154	Phosphorylation	ERRKDFVSEAYLITL HHHHCCCCHHHHHHH	19.26	-
155	Ubiquitination	RRKDFVSEAYLITLG HHHCCCCHHHHHHHH	35.71	22817900
163	Ubiquitination	AYLITLGKFINMFAV HHHHHHHHHHHHHHH	46.30	29967540
165	Ubiquitination	LITLGKFINMFAVLD HHHHHHHHHHHHHHH	4.10	22817900
167	Ubiquitination	TLGKFINMFAVLDEL HHHHHHHHHHHHHHH	1.63	29967540
180	Phosphorylation	ELKNMKCSVKNDHSA HHHCCCCCCCCCHHH	30.52	25367160
182	Acetylation	KNMKCSVKNDHSAYK HCCCCCCCCCHHHHH	40.12	23749302
182	Ubiquitination	KNMKCSVKNDHSAYK HCCCCCCCCCHHHHH	40.12	29967540
184	Ubiquitination	MKCSVKNDHSAYKRA CCCCCCCCHHHHHHH	31.25	22505724
189	Acetylation	KNDHSAYKRAAQFLR CCCHHHHHHHHHHHH	34.97	12437899
191	Ubiquitination	DHSAYKRAAQFLRKM CHHHHHHHHHHHHHH	11.06	33845483
197	Acetylation	RAAQFLRKMADPQSI HHHHHHHHHCCHHHH	40.36	12437907
197	Ubiquitination	RAAQFLRKMADPQSI HHHHHHHHHCCHHHH	40.36	29967540
198	Ubiquitination	AAQFLRKMADPQSIQ HHHHHHHHCCHHHHH	4.06	22817900
207	Ubiquitination	DPQSIQESQNLSMFL CHHHHHHHHCHHHHH	14.16	22817900
216	Ubiquitination	NLSMFLANHNKITQS CHHHHHHCHHHHHHH	41.22	29967540
218	Ubiquitination	SMFLANHNKITQSLQ HHHHHCHHHHHHHHH	36.91	21963094
231	Ubiquitination	LQQQLEVISGYEELL HHHHHHHHHCHHHHH	1.61	29967540
247 (in isoform 3)	Ubiquitination	-	39.02	21890473
254	Phosphorylation	DYYENRMYLTPSEKH HHHCCCCCCCHHHHH	12.27	-
256	Phosphorylation	YENRMYLTPSEKHML HCCCCCCCHHHHHHH	13.79	-
260	Ubiquitination	MYLTPSEKHMLLKVM CCCCHHHHHHHHHHH	38.36	24816145
277 (in isoform 3)	Ubiquitination	-	20.36	21890473
284	Ubiquitination	SVSNIYKLDAKKRIN CCCCEEECCHHHCCC	4.31	22817900
284 (in isoform 2)	Ubiquitination	-	4.31	21890473
286	Ubiquitination	SNIYKLDAKKRINLS CCEEECCHHHCCCHH	29.70	22817900
290	Ubiquitination	KLDAKKRINLSKIDK ECCHHHCCCHHHHHH	9.27	22817900
294	Ubiquitination	KKRINLSKIDKYFKQ HHCCCHHHHHHHHHH	59.08	22817900
294 (in isoform 2)	Ubiquitination	-	59.08	21890473
295	Ubiquitination	KRINLSKIDKYFKQL HCCCHHHHHHHHHHC	5.05	22817900
298	Phosphorylation	NLSKIDKYFKQLQVV CHHHHHHHHHHCCCE	16.56	-
299	Ubiquitination	LSKIDKYFKQLQVVP HHHHHHHHHHCCCEE	5.11	22817900
300	Ubiquitination	SKIDKYFKQLQVVPL HHHHHHHHHCCCEEC	47.19	21963094
304	Ubiquitination	KYFKQLQVVPLFGDM HHHHHCCCEECCCCH	6.96	21963094
319	Ubiquitination	QIELARYIKTSAHYE HHHHHHHHHHHHCCC	3.06	22817900
320	Ubiquitination	IELARYIKTSAHYEE HHHHHHHHHHHCCCC	27.74	27667366
320 (in isoform 1)	Ubiquitination	-	27.74	21890473
320 (in isoform 2)	Ubiquitination	-	27.74	21890473
322	Phosphorylation	LARYIKTSAHYEENK HHHHHHHHHCCCCCC	14.19	24719451
325	Phosphorylation	YIKTSAHYEENKSRW HHHHHHCCCCCCCCE	25.34	28796482
329	Ubiquitination	SAHYEENKSRWTCTS HHCCCCCCCCEEECC	44.68	22817900
329 (in isoform 1)	Ubiquitination	-	44.68	21890473
332	Ubiquitination	YEENKSRWTCTSSGS CCCCCCCEEECCCCC	11.70	21963094
347	Ubiquitination	SPQYNICEQMIQIRE CCCCCHHHHHHHHHH	39.11	21963094
347 (in isoform 2)	Ubiquitination	-	39.11	21890473
348	Ubiquitination	PQYNICEQMIQIRED CCCCHHHHHHHHHHH	29.84	24816145
352	Ubiquitination	ICEQMIQIREDHMRF HHHHHHHHHHHHHHH	3.44	24816145
354	Ubiquitination	EQMIQIREDHMRFIS HHHHHHHHHHHHHHH	54.63	22817900
363	Ubiquitination	HMRFISELARYSNSE HHHHHHHHHHHCCCC	2.34	22817900
366	Phosphorylation	FISELARYSNSEVVT HHHHHHHHCCCCCCC	13.44	24719451
367	Phosphorylation	ISELARYSNSEVVTG HHHHHHHCCCCCCCC	28.46	24719451
382	Ubiquitination	SGRQEAQKTDAEYRK CCHHHHHHCCHHHHH	56.26	24816145
388	Ubiquitination	QKTDAEYRKLFDLAL HHCCHHHHHHHHHHH	22.24	21963094
392	Ubiquitination	AEYRKLFDLALQGLQ HHHHHHHHHHHHHHH	41.28	27667366
394	Ubiquitination	YRKLFDLALQGLQLL HHHHHHHHHHHHHHH	10.32	33845483
396	Ubiquitination	KLFDLALQGLQLLSQ HHHHHHHHHHHHHHH	44.97	21963094
404 (in isoform 3)	Ubiquitination	-	8.29	21890473
415	Ubiquitination	VMEVYSWKLVHPTDK HHHHHHEEEECCCCC	34.39	29967540
416	Ubiquitination	MEVYSWKLVHPTDKY HHHHHEEEECCCCCC	3.30	24816145
418	Ubiquitination	VYSWKLVHPTDKYSN HHHEEEECCCCCCCC	29.94	23000965
420	Phosphorylation	SWKLVHPTDKYSNKD HEEEECCCCCCCCCC	30.19	24719451
421 (in isoform 3)	Ubiquitination	-	52.96	21890473
422	Ubiquitination	KLVHPTDKYSNKDCP EEECCCCCCCCCCCC	53.72	21906983
422 (in isoform 1)	Ubiquitination	-	53.72	21890473
424	Ubiquitination	VHPTDKYSNKDCPDS ECCCCCCCCCCCCCC	43.05	23000965
426	Ubiquitination	PTDKYSNKDCPDSAE CCCCCCCCCCCCCHH	55.56	21963094
430	Ubiquitination	YSNKDCPDSAEEYER CCCCCCCCCHHHHHH	67.80	21963094
431	Phosphorylation	SNKDCPDSAEEYERA CCCCCCCCHHHHHHH	23.79	28060719
448	Ubiquitination	YNYTSEEKFALVEVI CCCCHHHHHHHHHHH	31.70	22817900
448 (in isoform 2)	Ubiquitination	-	31.70	21890473
451	Ubiquitination	TSEEKFALVEVIAMI CHHHHHHHHHHHHHH	3.67	33845483
455	Ubiquitination	KFALVEVIAMIKGLQ HHHHHHHHHHHHHHH	1.05	22817900
456	Ubiquitination	FALVEVIAMIKGLQV HHHHHHHHHHHHHHH	9.98	21963094
460	Ubiquitination	EVIAMIKGLQVLMGR HHHHHHHHHHHHHHC	15.49	21963094
461	Ubiquitination	VIAMIKGLQVLMGRM HHHHHHHHHHHHHCH	2.43	21963094
478	Ubiquitination	VFNHAIRHTVYAALQ HHHHHHHHHHHHHHC	17.36	33845483
482	Ubiquitination	AIRHTVYAALQDFSQ HHHHHHHHHHCCCHH	9.43	33845483
486	Ubiquitination	TVYAALQDFSQVTLR HHHHHHCCCHHCCCH	46.12	33845483
488	Ubiquitination	YAALQDFSQVTLREP HHHHCCCHHCCCHHH	31.84	23000965
492	Phosphorylation	QDFSQVTLREPLRQA CCCHHCCCHHHHHHH	6.49	32645325
493	Ubiquitination	DFSQVTLREPLRQAI CCHHCCCHHHHHHHH	33.84	23000965
503	Ubiquitination	LRQAIKKKKNVIQSV HHHHHHHHHHHHHHH	44.57	29967540
506	Ubiquitination	AIKKKKNVIQSVLQA HHHHHHHHHHHHHHH	6.06	23000965
507	Ubiquitination	IKKKKNVIQSVLQAI HHHHHHHHHHHHHHH	3.36	29967540
510	Ubiquitination	KKNVIQSVLQAIRKT HHHHHHHHHHHHHHH	2.35	23000965
512	Ubiquitination	NVIQSVLQAIRKTVC HHHHHHHHHHHHHHC	32.37	23000965
516	Ubiquitination	SVLQAIRKTVCDWET HHHHHHHHHHCCCCC	38.91	23000965
523	Ubiquitination	KTVCDWETGHEPFND HHHCCCCCCCCCCCC	39.31	27667366
537	Ubiquitination	DPALRGEKDPKSGFD CHHHCCCCCCCCCCC	80.36	29967540
539	Ubiquitination	ALRGEKDPKSGFDIK HHCCCCCCCCCCCCC	43.72	33845483
540	Ubiquitination	LRGEKDPKSGFDIKV HCCCCCCCCCCCCCC	73.65	23000965
543	Ubiquitination	EKDPKSGFDIKVPRR CCCCCCCCCCCCCHH	13.01	33845483
544	Ubiquitination	KDPKSGFDIKVPRRA CCCCCCCCCCCCHHH	43.24	22817900
546	Ubiquitination	PKSGFDIKVPRRAVG CCCCCCCCCCHHHCC	48.29	23000965
546 (in isoform 1)	Ubiquitination	-	48.29	21890473
547	Ubiquitination	KSGFDIKVPRRAVGP CCCCCCCCCHHHCCC	4.56	22817900
548	Ubiquitination	SGFDIKVPRRAVGPS CCCCCCCCHHHCCCC	18.29	22817900
550	Ubiquitination	FDIKVPRRAVGPSST CCCCCCHHHCCCCHH	27.79	33845483
555	Phosphorylation	PRRAVGPSSTQLYMV CHHHCCCCHHHHHHH	39.84	21406692
556	Phosphorylation	RRAVGPSSTQLYMVR HHHCCCCHHHHHHHH	24.25	21406692
557	Phosphorylation	RAVGPSSTQLYMVRT HHCCCCHHHHHHHHH	27.25	21406692
559	Ubiquitination	VGPSSTQLYMVRTML CCCCHHHHHHHHHHH	2.78	21963094
560	Phosphorylation	GPSSTQLYMVRTMLE CCCHHHHHHHHHHHH	5.46	21945579
564	Phosphorylation	TQLYMVRTMLESLIA HHHHHHHHHHHHHHC	18.07	20068231
568	Phosphorylation	MVRTMLESLIADKSG HHHHHHHHHHCCCCC	22.55	20068231
571	Ubiquitination	TMLESLIADKSGSKK HHHHHHHCCCCCCCC	24.38	29967540
573	Ubiquitination	LESLIADKSGSKKTL HHHHHCCCCCCCCHH	47.93	22817900
573 (in isoform 1)	Ubiquitination	-	47.93	21890473
574	Phosphorylation	ESLIADKSGSKKTLR HHHHCCCCCCCCHHH	49.17	20068231
574	Ubiquitination	ESLIADKSGSKKTLR HHHHCCCCCCCCHHH	49.17	23000965
576	Phosphorylation	LIADKSGSKKTLRSS HHCCCCCCCCHHHHH	37.76	20068231
577	Ubiquitination	IADKSGSKKTLRSSL HCCCCCCCCHHHHHC	53.99	22817900
578	Ubiquitination	ADKSGSKKTLRSSLE CCCCCCCCHHHHHCC	55.26	22817900
579	Phosphorylation	DKSGSKKTLRSSLEG CCCCCCCHHHHHCCC	31.01	23403867
580	Ubiquitination	KSGSKKTLRSSLEGP CCCCCCHHHHHCCCC	7.40	23000965
582	Phosphorylation	GSKKTLRSSLEGPTI CCCCHHHHHCCCCEE	42.24	30278072
583	Phosphorylation	SKKTLRSSLEGPTIL CCCHHHHHCCCCEEE	24.81	30278072
588	Phosphorylation	RSSLEGPTILDIEKF HHHCCCCEEEEHHHH	45.06	23403867
593	Ubiquitination	GPTILDIEKFHRESF CCEEEEHHHHHHHHH	49.70	22817900
603	Ubiquitination	HRESFFYTHLINFSE HHHHHHHHHHCCHHH	12.68	22817900
607	Ubiquitination	FFYTHLINFSETLQQ HHHHHHCCHHHHHHH	40.53	33845483
611	Ubiquitination	HLINFSETLQQCCDL HHCCHHHHHHHHCCH	28.77	22817900
612	Ubiquitination	LINFSETLQQCCDLS HCCHHHHHHHHCCHH	2.65	22817900
615	Ubiquitination	FSETLQQCCDLSQLW HHHHHHHHCCHHHHH	0.95	27667366
617	Ubiquitination	ETLQQCCDLSQLWFR HHHHHHCCHHHHHHH	57.91	23000965
621	Phosphorylation	QCCDLSQLWFREFFL HHCCHHHHHHHHHHH	4.14	32645325
622	Ubiquitination	CCDLSQLWFREFFLE HCCHHHHHHHHHHHH	5.21	23000965
622 (in isoform 2)	Ubiquitination	-	5.21	21890473
628	Ubiquitination	LWFREFFLELTMGRR HHHHHHHHHHHCCCC	6.82	29967540
629	Ubiquitination	WFREFFLELTMGRRI HHHHHHHHHHCCCCC	36.72	33845483
637	Ubiquitination	LTMGRRIQFPIEMSM HHCCCCCCCEEECCC	35.93	27667366
642	Ubiquitination	RIQFPIEMSMPWILT CCCCEEECCCHHHHC	4.27	27667366
649	Phosphorylation	MSMPWILTDHILETK CCCHHHHCHHHHHCC	19.19	27067055
650	Ubiquitination	SMPWILTDHILETKE CCHHHHCHHHHHCCH	24.31	21890473
652	Ubiquitination	PWILTDHILETKEAS HHHHCHHHHHCCHHH	4.07	27667366
652 (in isoform 2)	Ubiquitination	-	4.07	21890473
655	Phosphorylation	LTDHILETKEASMME HCHHHHHCCHHHHHH	30.64	27067055
656	Ubiquitination	TDHILETKEASMMEY CHHHHHCCHHHHHHH	41.74	21963094
664	Ubiquitination	EASMMEYVLYSLDLY HHHHHHHHHHHHCCC	2.29	22817900
667	Ubiquitination	MMEYVLYSLDLYNDS HHHHHHHHHCCCCCC	15.96	22817900
681	Ubiquitination	SAHYALTRFNKQFLY CHHHHHHHHCHHHHH	33.71	22817900
685	Ubiquitination	ALTRFNKQFLYDEIE HHHHHCHHHHHHHHH	34.38	22817900
691	Ubiquitination	KQFLYDEIEAEVNLC HHHHHHHHHHHHHHH	5.77	22817900
695	Ubiquitination	YDEIEAEVNLCFDQF HHHHHHHHHHHHHHH	9.51	22817900
706	Ubiquitination	FDQFVYKLADQIFAY HHHHHHHHHHHHHHH	3.30	22817900
710	Ubiquitination	VYKLADQIFAYYKVM HHHHHHHHHHHHHHH	1.88	22817900
711	Ubiquitination	YKLADQIFAYYKVMA HHHHHHHHHHHHHHH	2.73	22817900
715	Ubiquitination	DQIFAYYKVMAGSLL HHHHHHHHHHHHHHH	16.92	22817900
715 (in isoform 1)	Ubiquitination	-	16.92	21890473
717	Sulfoxidation	IFAYYKVMAGSLLLD HHHHHHHHHHHHHHC	2.82	21406390
717	Ubiquitination	IFAYYKVMAGSLLLD HHHHHHHHHHHHHHC	2.82	33845483
721	Ubiquitination	YKVMAGSLLLDKRLR HHHHHHHHHHCHHHH	5.57	33845483
725	Ubiquitination	AGSLLLDKRLRSECK HHHHHHCHHHHHHHH	53.99	21906983
725 (in isoform 1)	Ubiquitination	-	53.99	21890473
740	Ubiquitination	NQGATIHLPPSNRYE HCCCEEECCCCCHHH	6.20	22817900
744	Ubiquitination	TIHLPPSNRYETLLK EEECCCCCHHHHHHH	57.22	21963094
745	Ubiquitination	IHLPPSNRYETLLKQ EECCCCCHHHHHHHH	34.69	22817900
747	Ubiquitination	LPPSNRYETLLKQRH CCCCCHHHHHHHHHH	29.73	22817900
748	Ubiquitination	PPSNRYETLLKQRHV CCCCHHHHHHHHHHH	28.58	21963094
749	Ubiquitination	PSNRYETLLKQRHVQ CCCHHHHHHHHHHHH	3.62	22817900
751	Ubiquitination	NRYETLLKQRHVQLL CHHHHHHHHHHHHHH	48.69	27667366
751 (in isoform 1)	Ubiquitination	-	48.69	21890473
757	Ubiquitination	LKQRHVQLLGRSIDL HHHHHHHHHCCCCCH	5.49	22817900
759	Ubiquitination	QRHVQLLGRSIDLNR HHHHHHHCCCCCHHH	29.86	22817900
766	Acetylation	GRSIDLNRLITQRVS CCCCCHHHHHHHHHH	34.46	19608861
766	Ubiquitination	GRSIDLNRLITQRVS CCCCCHHHHHHHHHH	34.46	27667366
769	Phosphorylation	IDLNRLITQRVSAAM CCHHHHHHHHHHHHH	18.21	-
770	Ubiquitination	DLNRLITQRVSAAMY CHHHHHHHHHHHHHH	36.46	21963094
771	Ubiquitination	LNRLITQRVSAAMYK HHHHHHHHHHHHHHH	18.73	27667366
778	Ubiquitination	RVSAAMYKSLELAIG HHHHHHHHHHHHHHC	35.16	21906983
778 (in isoform 1)	Ubiquitination	-	35.16	21890473
779	Phosphorylation	VSAAMYKSLELAIGR HHHHHHHHHHHHHCC	15.02	29457462
779	Ubiquitination	VSAAMYKSLELAIGR HHHHHHHHHHHHHCC	15.02	21890473
779 (in isoform 2)	Ubiquitination	-	15.02	21890473
783	Ubiquitination	MYKSLELAIGRFESE HHHHHHHHHCCCCCC	7.88	22817900
785	Ubiquitination	KSLELAIGRFESEDL HHHHHHHCCCCCCCC	23.71	33845483
793	Ubiquitination	RFESEDLTSIVELDG CCCCCCCHHHHHHHH	28.82	22817900
796	Ubiquitination	SEDLTSIVELDGLLE CCCCHHHHHHHHHHH	6.31	22817900
796 (in isoform 2)	Ubiquitination	-	6.31	21890473
808	Phosphorylation	LLEINRMTHKLLSRY HHHHHHHHHHHHHHH	16.78	20068231
810	Ubiquitination	EINRMTHKLLSRYLT HHHHHHHHHHHHHHC	41.79	21963094
812	Ubiquitination	NRMTHKLLSRYLTLD HHHHHHHHHHHHCCC	3.06	21963094
813	Phosphorylation	RMTHKLLSRYLTLDG HHHHHHHHHHHCCCH	29.34	20068231
833	Phosphorylation	REANHNVSAPYGRIT HHHCCCCCCCCCEEE	28.92	28152594
836	Phosphorylation	NHNVSAPYGRITLHV CCCCCCCCCEEEEEE	20.82	28152594
845	Ubiquitination	RITLHVFWELNYDFL EEEEEEEEECCCCCC	14.21	22817900
848	Ubiquitination	LHVFWELNYDFLPNY EEEEEECCCCCCCCC	23.86	22817900
849	Ubiquitination	HVFWELNYDFLPNYC EEEEECCCCCCCCCC	22.24	22817900
858	Ubiquitination	FLPNYCYNGSTNRFV CCCCCCCCCCCCCEE	34.08	21963094
862	Ubiquitination	YCYNGSTNRFVRTVL CCCCCCCCCEEEHHH	36.77	21963094
868	Ubiquitination	TNRFVRTVLPFSQEF CCCEEEHHHCCCHHH	4.47	21963094
872	Phosphorylation	VRTVLPFSQEFQRDK EEHHHCCCHHHHHCC	27.19	25850435
879	Ubiquitination	SQEFQRDKQPNAQPQ CHHHHHCCCCCCCCC	70.60	22817900
879 (in isoform 1)	Ubiquitination	-	70.60	21890473
882	Ubiquitination	FQRDKQPNAQPQYLH HHHCCCCCCCCCHHC	49.03	22817900
884	Ubiquitination	RDKQPNAQPQYLHGS HCCCCCCCCCHHCHH	32.06	22817900
887	Phosphorylation	QPNAQPQYLHGSKAL CCCCCCCHHCHHHHH	13.83	29759185
891	Phosphorylation	QPQYLHGSKALNLAY CCCHHCHHHHHHHHH	12.19	29759185
892	Ubiquitination	PQYLHGSKALNLAYS CCHHCHHHHHHHHHH	62.58	21963094
900	Phosphorylation	ALNLAYSSIYGSYRN HHHHHHHHHHHCHHC	13.73	-
911	Ubiquitination	SYRNFVGPPHFQVIC CHHCCCCCCHHHHHH	17.56	21963094
913	Ubiquitination	RNFVGPPHFQVICRL HCCCCCCHHHHHHHH	28.98	22817900
916	Ubiquitination	VGPPHFQVICRLLGY CCCCHHHHHHHHCCC	4.33	33845483
918	Ubiquitination	PPHFQVICRLLGYQG CCHHHHHHHHCCCHH	2.35	22817900
924	Ubiquitination	ICRLLGYQGIAVVME HHHHCCCHHHHHHHH	34.71	21963094
926	Ubiquitination	RLLGYQGIAVVMEEL HHCCCHHHHHHHHHH	1.23	23000965
930	Phosphorylation	YQGIAVVMEELLKVV CHHHHHHHHHHHHHH	2.38	32645325
931	Ubiquitination	QGIAVVMEELLKVVK HHHHHHHHHHHHHHH	33.61	23000965
935	Ubiquitination	VVMEELLKVVKSLLQ HHHHHHHHHHHHHHH	58.57	-
939	Phosphorylation	ELLKVVKSLLQGTIL HHHHHHHHHHHHHHH	23.78	29978859
944	Phosphorylation	VKSLLQGTILQYVKT HHHHHHHHHHHHHHH	12.93	29978859
945	Ubiquitination	KSLLQGTILQYVKTL HHHHHHHHHHHHHHH	2.63	21963094
948	Phosphorylation	LQGTILQYVKTLMEV HHHHHHHHHHHHHHH	10.64	29978859
956	Ubiquitination	VKTLMEVMPKICRLP HHHHHHHHHHHHCCC	1.46	21963094
960	Ubiquitination	MEVMPKICRLPRHEY HHHHHHHHCCCCHHH	4.57	21963094
961	Ubiquitination	EVMPKICRLPRHEYG HHHHHHHCCCCHHHC	51.72	27667366
967	Phosphorylation	CRLPRHEYGSPGILE HCCCCHHHCCCCHHH	19.44	-
986	Phosphorylation	QLKDIVEYAELKTVC HHHHHHHHHHHHHHH	8.42	-
990	Ubiquitination	IVEYAELKTVCFQNL HHHHHHHHHHHCHHH	30.34	21963094
1004	Ubiquitination	LREVGNAILFCLLIE HHHHHHHHHHHHHHH	3.34	33845483
1008	Ubiquitination	GNAILFCLLIEQSLS HHHHHHHHHHHHCCC	4.18	33845483
1012	Ubiquitination	LFCLLIEQSLSLEEV HHHHHHHHCCCHHHH	42.55	22817900
1014	Ubiquitination	CLLIEQSLSLEEVCD HHHHHHCCCHHHHHH	7.28	23000965
1016	Ubiquitination	LIEQSLSLEEVCDLL HHHHCCCHHHHHHHH	8.69	27667366
1018	Phosphorylation	EQSLSLEEVCDLLHA HHCCCHHHHHHHHHH	54.46	32645325
1018	Ubiquitination	EQSLSLEEVCDLLHA HHCCCHHHHHHHHHH	54.46	23000965
1019	Ubiquitination	QSLSLEEVCDLLHAA HCCCHHHHHHHHHHC	1.94	23000965
1022	Phosphorylation	SLEEVCDLLHAAPFQ CHHHHHHHHHHCCCC	2.98	32645325
1022	Ubiquitination	SLEEVCDLLHAAPFQ CHHHHHHHHHHCCCC	2.98	21963094
1023	Ubiquitination	LEEVCDLLHAAPFQN HHHHHHHHHHCCCCC	1.32	23000965
1024	Ubiquitination	EEVCDLLHAAPFQNI HHHHHHHHHCCCCCC	27.43	21963094
1025	Ubiquitination	EVCDLLHAAPFQNIL HHHHHHHHCCCCCCC	19.46	21963094
1038	Ubiquitination	ILPRVHVKEGERLDA CCCCCCCCCCCHHHH	45.16	33845483
1046	Ubiquitination	EGERLDAKMKRLESK CCCHHHHHHHHHHHH	44.62	22817900
1048	Ubiquitination	ERLDAKMKRLESKYA CHHHHHHHHHHHHCC	53.80	23000965
1049	Ubiquitination	RLDAKMKRLESKYAP HHHHHHHHHHHHCCC	39.94	27667366
1052	Phosphorylation	AKMKRLESKYAPLHL HHHHHHHHHCCCHHH	35.24	24719451
1053	Acetylation	KMKRLESKYAPLHLV HHHHHHHHCCCHHHH	35.74	26051181
1053	Ubiquitination	KMKRLESKYAPLHLV HHHHHHHHCCCHHHH	35.74	23000965
1053 (in isoform 1)	Ubiquitination	-	35.74	21890473
1054	Phosphorylation	MKRLESKYAPLHLVP HHHHHHHCCCHHHHH	23.80	28152594
1059	Ubiquitination	SKYAPLHLVPLIERL HHCCCHHHHHHHHHH	5.82	21963094
1066	Ubiquitination	LVPLIERLGTPQQIA HHHHHHHHCCHHHHH	6.09	29967540
1068	Phosphorylation	PLIERLGTPQQIAIA HHHHHHCCHHHHHHH	23.63	25159151
1070	Ubiquitination	IERLGTPQQIAIARE HHHHCCHHHHHHHHC	47.34	27667366
1072	Ubiquitination	RLGTPQQIAIAREGD HHCCHHHHHHHHCCC	2.23	33845483
1075	Ubiquitination	TPQQIAIAREGDLLT CHHHHHHHHCCCCCC	8.41	27667366
1078	Ubiquitination	QIAIAREGDLLTKER HHHHHHCCCCCCHHH	25.88	27667366
1080	Ubiquitination	AIAREGDLLTKERLC HHHHCCCCCCHHHHH	10.86	23000965
1082	Ubiquitination	AREGDLLTKERLCCG HHCCCCCCHHHHHHH	37.85	23000965
1083	Acetylation	REGDLLTKERLCCGL HCCCCCCHHHHHHHH	40.58	25953088
1083	Ubiquitination	REGDLLTKERLCCGL HCCCCCCHHHHHHHH	40.58	27667366
1083 (in isoform 1)	Ubiquitination	-	40.58	21890473
1085	Ubiquitination	GDLLTKERLCCGLSM CCCCCHHHHHHHHHH	34.28	23000965
1086	Phosphorylation	DLLTKERLCCGLSMF CCCCHHHHHHHHHHH	2.73	32645325
1087	Ubiquitination	LLTKERLCCGLSMFE CCCHHHHHHHHHHHH	1.85	23000965
1088	Ubiquitination	LTKERLCCGLSMFEV CCHHHHHHHHHHHHH	7.91	21890473
1102	Ubiquitination	VILTRIRSFLDDPIW HHHHHHHHHCCCCCC	27.99	22817900
1105	Ubiquitination	TRIRSFLDDPIWRGP HHHHHHCCCCCCCCC	58.59	22817900
1115	Ubiquitination	IWRGPLPSNGVMHVD CCCCCCCCCCCCCHH	54.63	22817900
1117	Ubiquitination	RGPLPSNGVMHVDEC CCCCCCCCCCCHHHH	23.59	27667366
1123	Ubiquitination	NGVMHVDECVEFHRL CCCCCHHHHHHHHHH	39.10	21963094
1154	Ubiquitination	FTVEQCFGDGLHWAG EEHHHHHCCCCHHHH	35.39	29967540
1157	Ubiquitination	EQCFGDGLHWAGCMI HHHHCCCCHHHHEEE	3.47	21963094
1158	Ubiquitination	QCFGDGLHWAGCMII HHHCCCCHHHHEEEE	20.19	29967540
1163	Ubiquitination	GLHWAGCMIIVLLGQ CCHHHHEEEEHHHCC	1.99	27667366
1167	Ubiquitination	AGCMIIVLLGQQRRF HHEEEEHHHCCHHHH	2.91	27667366
1168	Ubiquitination	GCMIIVLLGQQRRFA HEEEEHHHCCHHHHH	3.94	27667366
1171	Ubiquitination	IIVLLGQQRRFAVLD EEHHHCCHHHHHHHH	36.40	27667366
1172	Ubiquitination	IVLLGQQRRFAVLDF EHHHCCHHHHHHHHH	28.00	27667366
1176	Ubiquitination	GQQRRFAVLDFCYHL CCHHHHHHHHHHHHH	4.91	21890473
1179	Ubiquitination	RRFAVLDFCYHLLKV HHHHHHHHHHHHHHH	3.78	27667366
1180	Ubiquitination	RFAVLDFCYHLLKVQ HHHHHHHHHHHHHHH	1.77	21890473
1181	Ubiquitination	FAVLDFCYHLLKVQK HHHHHHHHHHHHHHH	8.76	23000965
1186	Ubiquitination	FCYHLLKVQKHDGKD HHHHHHHHHHCCCCC	10.39	23000965
1188	Acetylation	YHLLKVQKHDGKDEI HHHHHHHHCCCCCCH	46.80	26210075
1188	Ubiquitination	YHLLKVQKHDGKDEI HHHHHHHHCCCCCCH	46.80	29967540
1190	Ubiquitination	LLKVQKHDGKDEIIK HHHHHHCCCCCCHHH	73.25	22817900
1192	2-Hydroxyisobutyrylation	KVQKHDGKDEIIKNV HHHHCCCCCCHHHCC	59.24	-
1193	Ubiquitination	VQKHDGKDEIIKNVP HHHCCCCCCHHHCCC	58.83	22817900
1194	Ubiquitination	QKHDGKDEIIKNVPL HHCCCCCCHHHCCCH	50.53	22817900
1197	Acetylation	DGKDEIIKNVPLKKM CCCCCHHHCCCHHHH	58.51	23236377
1197	Ubiquitination	DGKDEIIKNVPLKKM CCCCCHHHCCCHHHH	58.51	27667366
1202	Ubiquitination	IIKNVPLKKMVERIR HHHCCCHHHHHHHHH	32.52	27667366
1205	Ubiquitination	NVPLKKMVERIRKFQ CCCHHHHHHHHHHHH	6.50	27667366
1210	Ubiquitination	KMVERIRKFQILNDE HHHHHHHHHHHCCHH	38.97	22817900
1210 (in isoform 1)	Ubiquitination	-	38.97	21890473
1213	Ubiquitination	ERIRKFQILNDEIIT HHHHHHHHCCHHHHH	4.34	27667366
1215	Ubiquitination	IRKFQILNDEIITIL HHHHHHCCHHHHHHH	46.64	23000965
1216	Ubiquitination	RKFQILNDEIITILD HHHHHCCHHHHHHHH	45.05	22817900
1220	Ubiquitination	ILNDEIITILDKYLK HCCHHHHHHHHHHHH	22.58	23000965
1222	Ubiquitination	NDEIITILDKYLKSG CHHHHHHHHHHHHCC	3.30	29967540
1224	Ubiquitination	EIITILDKYLKSGDG HHHHHHHHHHHCCCC	49.38	22817900
1225	Phosphorylation	IITILDKYLKSGDGE HHHHHHHHHHCCCCC	21.01	28258704
1227	Ubiquitination	TILDKYLKSGDGEGT HHHHHHHHCCCCCCC	49.67	22817900
1227 (in isoform 1)	Ubiquitination	-	49.67	21890473
1228	Phosphorylation	ILDKYLKSGDGEGTP HHHHHHHCCCCCCCC	39.25	29255136
1229	Ubiquitination	LDKYLKSGDGEGTPV HHHHHHCCCCCCCCC	45.41	27667366
1231	Ubiquitination	KYLKSGDGEGTPVEH HHHHCCCCCCCCCCC	38.47	27667366
1234	Phosphorylation	KSGDGEGTPVEHVRC HCCCCCCCCCCCEEE	21.62	23401153
1234	Ubiquitination	KSGDGEGTPVEHVRC HCCCCCCCCCCCEEE	21.62	27667366
1236	Ubiquitination	GDGEGTPVEHVRCFQ CCCCCCCCCCEEECC	8.79	27667366
1242	Ubiquitination	PVEHVRCFQPPIHQS CCCCEEECCCCHHHH	9.53	21890473
1244	Ubiquitination	EHVRCFQPPIHQSLA CCEEECCCCHHHHHH	15.01	21890473
1249	Phosphorylation	FQPPIHQSLASS--- CCCCHHHHHHCC---	16.25	23312004
1250	Ubiquitination	QPPIHQSLASS---- CCCHHHHHHCC----	4.27	22817900
1252	Phosphorylation	PIHQSLASS------ CHHHHHHCC------	41.70	25627689
1253	Phosphorylation	IHQSLASS------- HHHHHHCC-------	38.34	22617229
1256	Ubiquitination	SLASS---------- HHHCC----------		22817900
1258	Ubiquitination	ASS------------ HCC------------		22817900
1259	Ubiquitination	SS------------- CC-------------		22817900
1261	Ubiquitination	--------------- ---------------		22817900
1330	Ubiquitination	------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------		27667366
1335	Ubiquitination	----------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------		27667366
1343	Ubiquitination	------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------		21890473
1357	Ubiquitination	--------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------		22817900
1360	Ubiquitination	------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------		22817900
1364	Ubiquitination	---------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------		27667366
1369	Ubiquitination	--------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------		27667366
1377	Ubiquitination	----------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------		21890473
1391	Ubiquitination	------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------		22817900
1394	Ubiquitination	---------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYFP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYFP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYFP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FMR1_HUMAN	FMR1	physical	11438699
FXR1_HUMAN	FXR1	physical	11438699
FXR2_HUMAN	FXR2	physical	11438699
NUCL_HUMAN	NCL	physical	11438699
RFX6_HUMAN	RFX6	physical	21988832
GBB1_HUMAN	GNB1	physical	21988832
SCTR_HUMAN	SCTR	physical	21988832
U5S1_HUMAN	EFTUD2	physical	21988832
NCKP1_HUMAN	NCKAP1	physical	22863883
EFHC2_HUMAN	EFHC2	physical	24722188
MEOX1_HUMAN	MEOX1	physical	24722188
BZW2_HUMAN	BZW2	physical	26344197
FBP1L_HUMAN	FNBP1L	physical	26344197
CIP4_HUMAN	TRIP10	physical	26344197
WASF1_HUMAN	WASF1	physical	26344197
WASF2_HUMAN	WASF2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1197, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1068, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-108, AND MASSSPECTROMETRY.
PubMed: 18083107