dbPTM

FXR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FXR1_HUMAN
UniProt AC	P51114
Protein Name	Fragile X mental retardation syndrome-related protein 1
Gene Name	FXR1
Organism	Homo sapiens (Human).
Sequence Length	621
Subcellular Localization	Cytoplasm .
Protein Description	RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity)..
Protein Sequence	MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAELTVEVR ------CCEEEEEEE	22.10	22814378
11	Phosphorylation	LTVEVRGSNGAFYKG EEEEEECCCCCEEEC	22.86	28348404
17	Acetylation	GSNGAFYKGFIKDVH CCCCCEEECEEEEEC	40.67	26051181
17	Ubiquitination	GSNGAFYKGFIKDVH CCCCCEEECEEEEEC	40.67	-
56	Sumoylation	LPPPPDIKKEISEGD CCCCCCCCCCCCCCC	52.30	28112733
56	Ubiquitination	LPPPPDIKKEISEGD CCCCCCCCCCCCCCC	52.30	21906983
56 (in isoform 1)	Ubiquitination	-	52.30	21906983
56 (in isoform 2)	Ubiquitination	-	52.30	21906983
57	Ubiquitination	PPPPDIKKEISEGDE CCCCCCCCCCCCCCE	61.69	-
60	Phosphorylation	PDIKKEISEGDEVEV CCCCCCCCCCCEEEE	36.30	28985074
68	Phosphorylation	EGDEVEVYSRANDQE CCCEEEEEECCCCCC	4.48	25147952
77	Glutathionylation	RANDQEPCGWWLAKV CCCCCCCCHHEEEEE	7.58	22555962
83	Acetylation	PCGWWLAKVRMMKGE CCHHEEEEEEHHCCC	28.36	26051181
83	Ubiquitination	PCGWWLAKVRMMKGE CCHHEEEEEEHHCCC	28.36	83
83 (in isoform 1)	Ubiquitination	-	28.36	21906983
83 (in isoform 2)	Ubiquitination	-	28.36	21906983
92	Phosphorylation	RMMKGEFYVIEYAAC EHHCCCEEEEEEEEE	9.01	26552605
96	Phosphorylation	GEFYVIEYAACDATY CCEEEEEEEEECCCC	6.59	26552605
102	Phosphorylation	EYAACDATYNEIVTF EEEEECCCCCEEEEE	17.39	26552605
103	Phosphorylation	YAACDATYNEIVTFE EEEECCCCCEEEEEE	16.72	26552605
108	Phosphorylation	ATYNEIVTFERLRPV CCCCEEEEEEEECCC	25.99	26552605
119	Ubiquitination	LRPVNQNKTVKKNTF ECCCCCCCCCCCCCE	44.95	-
128	Ubiquitination	VKKNTFFKCTVDVPE CCCCCEEEEEEECCH	25.46	-
148	Ubiquitination	CANENAHKDFKKAVG HHCCCHHHHHHHHHH	63.55	-
161 (in isoform 3)	Ubiquitination	-	17.69	21906983
179	Ubiquitination	SASEATVKRVNILSD ECCHHCHHHHHHCCH	46.39	-
188 (in isoform 3)	Ubiquitination	-	24.07	21906983
190	Methylation	ILSDMHLRSIRTKLM HCCHHHHHHHHHHHH	18.50	-
191	Phosphorylation	LSDMHLRSIRTKLML CCHHHHHHHHHHHHH	23.84	-
194	Phosphorylation	MHLRSIRTKLMLMSR HHHHHHHHHHHHHHC	27.19	26552605
195	Acetylation	HLRSIRTKLMLMSRN HHHHHHHHHHHHHCC	23.27	25953088
195	Ubiquitination	HLRSIRTKLMLMSRN HHHHHHHHHHHHHCC	23.27	-
200	Phosphorylation	RTKLMLMSRNEEATK HHHHHHHHCCHHHHH	28.17	28851738
206	Phosphorylation	MSRNEEATKHLECTK HHCCHHHHHHHHHHH	23.44	26552605
207	Acetylation	SRNEEATKHLECTKQ HCCHHHHHHHHHHHH	53.92	25953088
207	Ubiquitination	SRNEEATKHLECTKQ HCCHHHHHHHHHHHH	53.92	-
213	Ubiquitination	TKHLECTKQLAAAFH HHHHHHHHHHHHHHC	55.78	-
225 (in isoform 3)	Ubiquitination	-	7.24	21906983
236	Phosphorylation	LMGLAIGTHGSNIQQ HHHHHCCCCCCCHHH	19.56	20873877
239	Phosphorylation	LAIGTHGSNIQQARK HHCCCCCCCHHHHHC	24.13	20873877
240 (in isoform 3)	Ubiquitination	-	40.45	21906983
246	Ubiquitination	SNIQQARKVPGVTAI CCHHHHHCCCCEEEE	56.66	21906983
246 (in isoform 1)	Ubiquitination	-	56.66	21906983
246 (in isoform 2)	Ubiquitination	-	56.66	21906983
265	Phosphorylation	DTGTFRIYGESADAV CCCEEEEEECCHHHH	15.58	28152594
268	Phosphorylation	TFRIYGESADAVKKA EEEEEECCHHHHHHH	27.38	28152594
273	Ubiquitination	GESADAVKKARGFLE ECCHHHHHHHHHHHH	42.30	21906983
273 (in isoform 1)	Ubiquitination	-	42.30	21906983
273 (in isoform 2)	Ubiquitination	-	42.30	21906983
274	Ubiquitination	ESADAVKKARGFLEF CCHHHHHHHHHHHHH	36.40	-
295	Acetylation	VPRNLVGKVIGKNGK CCHHHHHHHHCCCCC	24.17	25953088
295	Malonylation	VPRNLVGKVIGKNGK CCHHHHHHHHCCCCC	24.17	26320211
295	Ubiquitination	VPRNLVGKVIGKNGK CCHHHHHHHHCCCCC	24.17	-
302	Acetylation	KVIGKNGKVIQEIVD HHHCCCCCEEEEEEC	45.63	25953088
302	Ubiquitination	KVIGKNGKVIQEIVD HHHCCCCCEEEEEEC	45.63	-
310	Acetylation	VIQEIVDKSGVVRVR EEEEEECCCCCEEEE	37.91	26051181
310	Ubiquitination	VIQEIVDKSGVVRVR EEEEEECCCCCEEEE	37.91	21906983
310 (in isoform 1)	Ubiquitination	-	37.91	21906983
310 (in isoform 2)	Ubiquitination	-	37.91	21906983
324 (in isoform 3)	Phosphorylation	-	58.37	18669648
325	Acetylation	IEGDNENKLPREDGM EECCCCCCCCCCCCC	54.40	26051181
325	Ubiquitination	IEGDNENKLPREDGM EECCCCCCCCCCCCC	54.40	2190698
325 (in isoform 1)	Ubiquitination	-	54.40	21906983
325 (in isoform 2)	Ubiquitination	-	54.40	21906983
353	Phosphorylation	NVQVLLEYHIAYLKE CHHHHHHHHHHHHHH	9.86	22817900
357	Phosphorylation	LLEYHIAYLKEVEQL HHHHHHHHHHHHHHH	20.08	22817900
360	Methylation	YHIAYLKEVEQLRME HHHHHHHHHHHHHHH	49.01	15782174
365	Methylation	LKEVEQLRMERLQID HHHHHHHHHHHHCHH	25.30	-
368	Methylation	VEQLRMERLQIDEQL HHHHHHHHHCHHHHH	23.66	15782174
376	Methylation	LQIDEQLRQIGSRSY HCHHHHHHHHCCCCC	26.26	-
386	Methylation	GSRSYSGRGRGRRGP CCCCCCCCCCCCCCC	26.20	-
395	Phosphorylation	RGRRGPNYTSGYGTN CCCCCCCCCCCCCCC	12.86	25850435
396	Phosphorylation	GRRGPNYTSGYGTNS CCCCCCCCCCCCCCC	23.47	23401153
397	Phosphorylation	RRGPNYTSGYGTNSE CCCCCCCCCCCCCCC	21.47	23927012
399	Phosphorylation	GPNYTSGYGTNSELS CCCCCCCCCCCCCCC	22.12	23927012
401	Phosphorylation	NYTSGYGTNSELSNP CCCCCCCCCCCCCCC	27.39	23927012
403	Phosphorylation	TSGYGTNSELSNPSE CCCCCCCCCCCCCCC	39.49	23927012
406	Phosphorylation	YGTNSELSNPSETES CCCCCCCCCCCCCHH	42.52	23927012
409	Phosphorylation	NSELSNPSETESERK CCCCCCCCCCHHHHH	62.49	23927012
411	Phosphorylation	ELSNPSETESERKDE CCCCCCCCHHHHHHH	49.50	30278072
413	Phosphorylation	SNPSETESERKDELS CCCCCCHHHHHHHHC	50.55	23927012
416	Ubiquitination	SETESERKDELSDWS CCCHHHHHHHHCHHH	52.05	-
420	Phosphorylation	SERKDELSDWSLAGE HHHHHHHCHHHHCCC	34.68	30266825
423	Phosphorylation	KDELSDWSLAGEDDR HHHHCHHHHCCCCCC	17.21	30266825
432	Phosphorylation	AGEDDRDSRHQRDSR CCCCCCCCCHHHHCC	32.34	30266825
438	Phosphorylation	DSRHQRDSRRRPGGR CCCHHHHCCCCCCCC	29.85	-
445	Dimethylation	SRRRPGGRGRSVSGG CCCCCCCCCCCCCCC	43.18	-
445	Methylation	SRRRPGGRGRSVSGG CCCCCCCCCCCCCCC	43.18	15782174
447	Methylation	RRPGGRGRSVSGGRG CCCCCCCCCCCCCCC	32.31	-
448	Phosphorylation	RPGGRGRSVSGGRGR CCCCCCCCCCCCCCC	24.37	29496963
450	Phosphorylation	GGRGRSVSGGRGRGG CCCCCCCCCCCCCCC	36.46	30177828
453	Dimethylation	GRSVSGGRGRGGPRG CCCCCCCCCCCCCCC	34.85	-
453	Methylation	GRSVSGGRGRGGPRG CCCCCCCCCCCCCCC	34.85	15782174
455	Dimethylation	SVSGGRGRGGPRGGK CCCCCCCCCCCCCCC	45.60	-
455	Methylation	SVSGGRGRGGPRGGK CCCCCCCCCCCCCCC	45.60	-
459	Dimethylation	GRGRGGPRGGKSSIS CCCCCCCCCCCCCHH	70.53	-
459	Methylation	GRGRGGPRGGKSSIS CCCCCCCCCCCCCHH	70.53	-
462	"N6,N6-dimethyllysine"	RGGPRGGKSSISSVL CCCCCCCCCCHHHHH	43.80	-
462	Methylation	RGGPRGGKSSISSVL CCCCCCCCCCHHHHH	43.80	23748837
463	O-linked_Glycosylation	GGPRGGKSSISSVLK CCCCCCCCCHHHHHC	35.86	23301498
463	Phosphorylation	GGPRGGKSSISSVLK CCCCCCCCCHHHHHC	35.86	21945579
464	Phosphorylation	GPRGGKSSISSVLKD CCCCCCCCHHHHHCC	29.94	21945579
466	Phosphorylation	RGGKSSISSVLKDPD CCCCCCHHHHHCCCC	19.15	21945579
467	Phosphorylation	GGKSSISSVLKDPDS CCCCCHHHHHCCCCC	29.78	21945579
470	Acetylation	SSISSVLKDPDSNPY CCHHHHHCCCCCCCC	66.13	26051181
470	Ubiquitination	SSISSVLKDPDSNPY CCHHHHHCCCCCCCC	66.13	-
474	Phosphorylation	SVLKDPDSNPYSLLD HHHCCCCCCCCCCCC	45.13	21945579
477	Phosphorylation	KDPDSNPYSLLDNTE CCCCCCCCCCCCCCC	19.05	21945579
478	Phosphorylation	DPDSNPYSLLDNTES CCCCCCCCCCCCCCC	24.58	21945579
483	Phosphorylation	PYSLLDNTESDQTAD CCCCCCCCCCCCCCC	36.21	21945579
485	Phosphorylation	SLLDNTESDQTADTD CCCCCCCCCCCCCCC	32.74	21945579
488	Phosphorylation	DNTESDQTADTDASE CCCCCCCCCCCCHHH	31.34	21945579
491	Phosphorylation	ESDQTADTDASESHH CCCCCCCCCHHHCHH	30.88	21945579
494	Phosphorylation	QTADTDASESHHSTN CCCCCCHHHCHHHHH	42.30	21945579
496	Phosphorylation	ADTDASESHHSTNRR CCCCHHHCHHHHHHH	24.81	21945579
499	Phosphorylation	DASESHHSTNRRRRS CHHHCHHHHHHHHHH	23.19	21945579
500	Phosphorylation	ASESHHSTNRRRRSR HHHCHHHHHHHHHHH	28.52	21945579
506	Phosphorylation	STNRRRRSRRRRTDE HHHHHHHHHHCCCCC	28.47	-
511	Phosphorylation	RRSRRRRTDEDAVLM HHHHHCCCCCCCEEC	41.76	28985074
511 (in isoform 2)	Phosphorylation	-	41.76	27273156
522	Phosphorylation	AVLMDGMTESDTASV CEECCCCCHHHCCCC	37.56	-
522 (in isoform 2)	Phosphorylation	-	37.56	30266825
524	Phosphorylation	LMDGMTESDTASVNE ECCCCCHHHCCCCCC	30.97	28985074
524 (in isoform 2)	Phosphorylation	-	30.97	30266825
526	Phosphorylation	DGMTESDTASVNENG CCCCHHHCCCCCCCC	30.06	28985074
526 (in isoform 2)	Phosphorylation	-	30.06	30266825
528	Phosphorylation	MTESDTASVNENGLV CCHHHCCCCCCCCCE	27.80	19690332
528 (in isoform 2)	Phosphorylation	-	27.80	30266825
540	Phosphorylation	GLVTVADYISRAESQ CCEEHHHHHHHHHHH	7.34	-
542	Phosphorylation	VTVADYISRAESQSR EEHHHHHHHHHHHHH	21.14	22496350
546	Phosphorylation	DYISRAESQSRQRNL HHHHHHHHHHHHHCC	32.25	26853621
557	Phosphorylation	QRNLPRETLAKNKKE HHCCCHHHHHHCHHH	33.04	28555341
565	Sulfoxidation	LAKNKKEMAKDVIEE HHHCHHHHHHHHHHH	8.46	21406390
567	Acetylation	KNKKEMAKDVIEEHG HCHHHHHHHHHHHHC	51.74	25953088
576	Phosphorylation	VIEEHGPSEKAINGP HHHHHCCCHHHCCCC	57.21	26074081
578	Acetylation	EEHGPSEKAINGPTS HHHCCCHHHCCCCCC	59.93	23236377
584	Phosphorylation	EKAINGPTSASGDDI HHHCCCCCCCCCCCH	38.02	30266825
585	Phosphorylation	KAINGPTSASGDDIS HHCCCCCCCCCCCHH	24.46	30266825
587	Phosphorylation	INGPTSASGDDISKL CCCCCCCCCCCHHHH	42.39	30266825
592	Phosphorylation	SASGDDISKLQRTPG CCCCCCHHHHCCCCC	34.02	30266825
593	Acetylation	ASGDDISKLQRTPGE CCCCCHHHHCCCCCH	49.31	26051181
597	Phosphorylation	DISKLQRTPGEEKIN CHHHHCCCCCHHHHH	23.76	25159151
605	Phosphorylation	PGEEKINTLKEENTQ CCHHHHHHHCHHCHH	42.55	24732914
607	Acetylation	EEKINTLKEENTQEA HHHHHHHCHHCHHHH	62.03	26051181
611	Phosphorylation	NTLKEENTQEAAVLN HHHCHHCHHHHHHHC	30.94	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
420	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO4	Q9UKT5	PMID:29142209

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
445	R	Methylation		-
Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FXR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FMR1_HUMAN	FMR1	physical	7489725
CYFP2_HUMAN	CYFIP2	physical	11438699
DPYL1_HUMAN	CRMP1	physical	16169070
GBP2_HUMAN	GBP2	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
LC7L2_HUMAN	LUC7L2	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
FXR2_HUMAN	FXR2	physical	8668200
FXR2_HUMAN	FXR2	physical	7489725
FXR1_HUMAN	FXR1	physical	7489725
CAPR1_HUMAN	CAPRIN1	physical	24778252
FMR1_HUMAN	FMR1	physical	24778252
FXR2_HUMAN	FXR2	physical	24778252
LRWD1_HUMAN	LRWD1	physical	24778252
ORC2_HUMAN	ORC2	physical	24778252
RANB9_HUMAN	RANBP9	physical	24778252
TDRD3_HUMAN	TDRD3	physical	24778252
TOP3B_HUMAN	TOP3B	physical	24778252
UBAP2_HUMAN	UBAP2	physical	24778252
FBX4_HUMAN	FBXO4	physical	29142209
SKP1_HUMAN	SKP1	physical	29142209
CUL1_HUMAN	CUL1	physical	29142209
RBX1_HUMAN	RBX1	physical	29142209
GSK3B_HUMAN	GSK3B	physical	29142209

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FXR1_HUMAN

Related Literatures of Post-Translational Modification

Methylation
Reference	PubMed
"Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-445, AND MASS SPECTROMETRY.	15782174 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406; SER-409; SER-524;SER-528 AND SER-587, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-409, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-477, AND MASSSPECTROMETRY.	15592455 [Abstract]

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