GBP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBP2_HUMAN
• UniProt AC: P32456
• Protein Name: Guanylate-binding protein 2
• Gene Name: GBP2
• Organism: Homo sapiens (Human).
• Sequence Length: 591
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Golgi apparatus membrane . Membrane; Lipid-anchor . GBP2-GBP5 dimers localize to the Golgi apparatus.
• Protein Description: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. [PubMed: 8706832 Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity]
• Protein Sequence: MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	AIVGLYRTGKSYLMN EEEEHHHHCHHHHHH	35.09	23312004
52	Phosphorylation	GLYRTGKSYLMNKLA EHHHHCHHHHHHHHC	25.50	24719451
53	Phosphorylation	LYRTGKSYLMNKLAG HHHHCHHHHHHHHCC	17.29	23312004
66	Phosphorylation	AGKKNGFSLGSTVKS CCCCCCCCCCHHCHH	32.97	30624053
69	Phosphorylation	KNGFSLGSTVKSHTK CCCCCCCHHCHHCCC	35.01	30624053
70	Phosphorylation	NGFSLGSTVKSHTKG CCCCCCHHCHHCCCE	30.10	30624053
73	Phosphorylation	SLGSTVKSHTKGIWM CCCHHCHHCCCEEEE	31.86	30624053
75	Phosphorylation	GSTVKSHTKGIWMWC CHHCHHCCCEEEEEE	37.75	30624053
242	Acetylation	VFDWPAPKKYLAHLE EECCCCCHHHHHHHH	57.04	7479749
242	Ubiquitination	VFDWPAPKKYLAHLE EECCCCCHHHHHHHH	57.04	-
281	Phosphorylation	HSNVKTLSGGIPVNG CCCCCEECCCCCCCC	39.96	28787133
333	Phosphorylation	VEKAIAHYEQQMGQK HHHHHHHHHHHCCCC	13.35	-
446	Phosphorylation	QELKNKYYQVPRKGI HHHHHHCCCCCCCCC	12.49	-
483	Acetylation	TDQSLSEKEKAIEVE CCCCHHHHHHHHHHH	62.23	23954790
485	Acetylation	QSLSEKEKAIEVERI CCHHHHHHHHHHHHH	66.77	7925267
501	Acetylation	AESAEAAKKMLEEIQ HHHHHHHHHHHHHHH	45.85	7925277
521	Phosphorylation	MMEQKEKSYQEHVKQ HHHHHHHHHHHHHHH	32.89	24719451
522	Phosphorylation	MEQKEKSYQEHVKQL HHHHHHHHHHHHHHH	29.05	25072903
530	Phosphorylation	QEHVKQLTEKMERDR HHHHHHHHHHHHHHH	30.94	25072903
551	2-Hydroxyisobutyrylation	QEKTLALKLQEQERL HHHHHHHHHHHHHHH	42.38	-
568	Ubiquitination	EGFENESKRLQKDIW HCCCCHHHHHHHHHH	51.45	-
588	Methylation	SKSLEPICNIL---- HCCCCCHHHCC----	3.66	-
588	Geranylgeranylation	SKSLEPICNIL---- HCCCCCHHHCC----	3.66	21151871
588	Geranylgeranylation	SKSLEPICNIL---- HCCCCCHHHCC----	3.66	21151871

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASSY_HUMAN	ASS1	physical	22863883
AGAL_HUMAN	GLA	physical	22863883
MVD1_HUMAN	MVD	physical	22863883
KS6A1_HUMAN	RPS6KA1	physical	22863883
SQSTM_HUMAN	SQSTM1	physical	26417105
GBP3_HUMAN	GBP3	physical	28514442
GBP7_HUMAN	GBP7	physical	28514442
ADDG_HUMAN	ADD3	physical	28514442
ADDA_HUMAN	ADD1	physical	28514442
HS90B_HUMAN	HSP90AB1	physical	28514442
PCBP3_HUMAN	PCBP3	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.