dbPTM

ADDA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ADDA_HUMAN
UniProt AC	P35611
Protein Name	Alpha-adducin
Gene Name	ADD1
Organism	Homo sapiens (Human).
Sequence Length	737
Subcellular Localization	Cytoplasm, cytoskeleton. Cell membrane Peripheral membrane protein Cytoplasmic side.
Protein Description	Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin..
Protein Sequence	MNGDSRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTTNVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGSTNLGVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGGPDNLVLLNPEKYKAKSRSPGSPVGEGTGSPPKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALREKSKKYSDVEVPASVTGYSFASDGDSGTCSPLRHSFQKQQREKTRWLNSGRGDEASEEGQNGSSPKSKTKWTKEDGHRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVVMDRSLVQGELVTASKAIIEKEYQPHVIVSTTGPNPFTTLTDRELEEYRREVERKQKGSEENLDEAREQKEKSPPDQPAVPHPPPSTPIKLEEDLVPEPTTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPSPTEAPTEASPEPAPDPAPVAEEAAPSAVEEGAAADPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNGDSRAA -------CCCCCCCE	13.11	19413330
5	Phosphorylation	---MNGDSRAAVVTS ---CCCCCCCEEECC	25.80	26074081
11	Phosphorylation	DSRAAVVTSPPPTTA CCCCEEECCCCCCCC	28.99	29255136
12	Phosphorylation	SRAAVVTSPPPTTAP CCCEEECCCCCCCCC	24.65	29255136
16	Phosphorylation	VVTSPPPTTAPHKER EECCCCCCCCCCHHH	41.17	30278072
17	Phosphorylation	VTSPPPTTAPHKERY ECCCCCCCCCCHHHH	43.92	30278072
21	Ubiquitination	PPTTAPHKERYFDRV CCCCCCCHHHHHCCC	42.71	-
21	Ubiquitination	PPTTAPHKERYFDRV CCCCCCCHHHHHCCC	42.71	32015554
21 (in isoform 3)	Ubiquitination	-	42.71	-
24	Phosphorylation	TAPHKERYFDRVDEN CCCCHHHHHCCCCCC	15.78	26074081
27	Methylation	HKERYFDRVDENNPE CHHHHHCCCCCCCHH	28.08	-
35	Phosphorylation	VDENNPEYLRERNMA CCCCCHHHHHHHCCC	16.59	29978859
55	Ubiquitination	DFNMMEQKKRVSMIL HHHHHHHHHHHHHHH	29.28	-
55	Ubiquitination	DFNMMEQKKRVSMIL HHHHHHHHHHHHHHH	29.28	21906983
55 (in isoform 1)	Ubiquitination	-	29.28	21906983
55 (in isoform 2)	Ubiquitination	-	29.28	21906983
55 (in isoform 3)	Ubiquitination	-	29.28	21906983
55	Ubiquitination	DFNMMEQKKRVSMIL HHHHHHHHHHHHHHH	29.28	21906983
56	Ubiquitination	FNMMEQKKRVSMILQ HHHHHHHHHHHHHHH	58.70	24816145
59	Phosphorylation	MEQKKRVSMILQSPA HHHHHHHHHHHHCHH	12.25	25159151
64	Phosphorylation	RVSMILQSPAFCEEL HHHHHHHCHHHHHHH	18.10	29496963
73	Phosphorylation	AFCEELESMIQEQFK HHHHHHHHHHHHHHH	33.53	28270605
80	Ubiquitination	SMIQEQFKKGKNPTG HHHHHHHHCCCCHHH	61.38	32015554
133	Phosphorylation	PVNDLRGSDSIAYDK CHHHCCCCCCCCCCC	23.04	21815630
135	Phosphorylation	NDLRGSDSIAYDKGE HHCCCCCCCCCCCCC	15.71	28857561
138	Phosphorylation	RGSDSIAYDKGEKLL CCCCCCCCCCCCHHH	19.27	22985185
140	Acetylation	SDSIAYDKGEKLLRC CCCCCCCCCCHHHHH	57.18	-
140	Ubiquitination	SDSIAYDKGEKLLRC CCCCCCCCCCHHHHH	57.18	-
140	Acetylation	SDSIAYDKGEKLLRC CCCCCCCCCCHHHHH	57.18	23749302
140	Ubiquitination	SDSIAYDKGEKLLRC CCCCCCCCCCHHHHH	57.18	21906983
140 (in isoform 1)	Ubiquitination	-	57.18	21906983
140 (in isoform 2)	Ubiquitination	-	57.18	21906983
140 (in isoform 3)	Ubiquitination	-	57.18	21906983
140	Ubiquitination	SDSIAYDKGEKLLRC CCCCCCCCCCHHHHH	57.18	21906983
143	Ubiquitination	IAYDKGEKLLRCKLA CCCCCCCHHHHHHHH	62.58	-
143	Acetylation	IAYDKGEKLLRCKLA CCCCCCCHHHHHHHH	62.58	25953088
143	Ubiquitination	IAYDKGEKLLRCKLA CCCCCCCHHHHHHHH	62.58	24816145
143 (in isoform 3)	Ubiquitination	-	62.58	-
148	Ubiquitination	GEKLLRCKLAAFYRL CCHHHHHHHHHHHHH	34.42	-
148	Ubiquitination	GEKLLRCKLAAFYRL CCHHHHHHHHHHHHH	34.42	-
148 (in isoform 3)	Ubiquitination	-	34.42	-
166	Phosphorylation	FGWSQLIYNHITTRV HCHHHHHHHHHHHCC	14.85	24719451
170	Phosphorylation	QLIYNHITTRVNSEQ HHHHHHHHHCCCCCC	10.86	24719451
171	Phosphorylation	LIYNHITTRVNSEQE HHHHHHHHCCCCCCC	31.83	24719451
283	Ubiquitination	ILVDEEEKVLIQKNL EECCHHHHHHEECCC	45.69	23000965
288	Ubiquitination	EEKVLIQKNLGPKSK HHHHHEECCCCCCCE	47.34	-
288	Ubiquitination	EEKVLIQKNLGPKSK HHHHHEECCCCCCCE	47.34	23000965
288 (in isoform 3)	Ubiquitination	-	47.34	-
293	Ubiquitination	IQKNLGPKSKVLILR EECCCCCCCEEEEEE	62.20	23000965
331	Phosphorylation	ACEIQVRTLASAGGP EEEEEHHHHHHCCCC	28.02	18669648
334	Phosphorylation	IQVRTLASAGGPDNL EEHHHHHHCCCCCCE	30.47	18669648
348	Ubiquitination	LVLLNPEKYKAKSRS EEEECHHHHCCCCCC	53.99	-
348	Ubiquitination	LVLLNPEKYKAKSRS EEEECHHHHCCCCCC	53.99	2190698
348 (in isoform 1)	Ubiquitination	-	53.99	21906983
348 (in isoform 2)	Ubiquitination	-	53.99	21906983
348 (in isoform 3)	Ubiquitination	-	53.99	21906983
348	Ubiquitination	LVLLNPEKYKAKSRS EEEECHHHHCCCCCC	53.99	21906983
350	Ubiquitination	LLNPEKYKAKSRSPG EECHHHHCCCCCCCC	61.48	-
350 (in isoform 3)	Ubiquitination	-	61.48	-
353	Phosphorylation	PEKYKAKSRSPGSPV HHHHCCCCCCCCCCC	42.73	20201521
355	Phosphorylation	KYKAKSRSPGSPVGE HHCCCCCCCCCCCCC	40.48	23927012
358	Phosphorylation	AKSRSPGSPVGEGTG CCCCCCCCCCCCCCC	21.57	19664994
364	Phosphorylation	GSPVGEGTGSPPKWQ CCCCCCCCCCCCCCC	30.13	23927012
366	Phosphorylation	PVGEGTGSPPKWQIG CCCCCCCCCCCCCCC	37.56	19664994
393	Phosphorylation	NLGYRTGYPYRYPAL HCCCCCCCCCCCHHH	9.11	74103147
395	Phosphorylation	GYRTGYPYRYPALRE CCCCCCCCCCHHHHH	17.81	74103145
404	Phosphorylation	YPALREKSKKYSDVE CHHHHHHCCCCCCCC	29.63	23312004
406	Ubiquitination	ALREKSKKYSDVEVP HHHHHCCCCCCCCCC	58.01	29967540
407	Phosphorylation	LREKSKKYSDVEVPA HHHHCCCCCCCCCCE	17.53	23927012
408	Phosphorylation	REKSKKYSDVEVPAS HHHCCCCCCCCCCEE	44.02	25159151
415	Phosphorylation	SDVEVPASVTGYSFA CCCCCCEEECCEEEC	17.72	23927012
417	Phosphorylation	VEVPASVTGYSFASD CCCCEEECCEEECCC	28.10	22167270
419	Phosphorylation	VPASVTGYSFASDGD CCEEECCEEECCCCC	7.40	23927012
420	Phosphorylation	PASVTGYSFASDGDS CEEECCEEECCCCCC	18.71	22167270
423	Phosphorylation	VTGYSFASDGDSGTC ECCEEECCCCCCCCC	39.87	30266825
427	Phosphorylation	SFASDGDSGTCSPLR EECCCCCCCCCCCCH	41.34	23401153
429	Phosphorylation	ASDGDSGTCSPLRHS CCCCCCCCCCCCHHH	17.48	22167270
431	Phosphorylation	DGDSGTCSPLRHSFQ CCCCCCCCCCHHHHH	27.14	22167270
436	Phosphorylation	TCSPLRHSFQKQQRE CCCCCHHHHHHHHHH	23.96	22167270
439	Ubiquitination	PLRHSFQKQQREKTR CCHHHHHHHHHHHHH	46.52	29967540
445	Phosphorylation	QKQQREKTRWLNSGR HHHHHHHHHHHHCCC	23.48	10209029
450	Phosphorylation	EKTRWLNSGRGDEAS HHHHHHHCCCCHHHC	27.91	23403867
457	Phosphorylation	SGRGDEASEEGQNGS CCCCHHHCCCCCCCC	33.85	23927012
464	Phosphorylation	SEEGQNGSSPKSKTK CCCCCCCCCCCCCCC	51.52	29255136
464 (in isoform 3)	Phosphorylation	-	51.52	19664995
464 (in isoform 5)	Phosphorylation	-	51.52	19664995
464 (in isoform 6)	Phosphorylation	-	51.52	19664995
465	Phosphorylation	EEGQNGSSPKSKTKW CCCCCCCCCCCCCCC	37.43	29255136
465 (in isoform 3)	Phosphorylation	-	37.43	19664995
465 (in isoform 5)	Phosphorylation	-	37.43	19664995
465 (in isoform 6)	Phosphorylation	-	37.43	19664995
468	Phosphorylation	QNGSSPKSKTKWTKE CCCCCCCCCCCCCCC	49.28	26074081
470	Phosphorylation	GSSPKSKTKWTKEDG CCCCCCCCCCCCCCC	38.62	26074081
473	Phosphorylation	PKSKTKWTKEDGHRT CCCCCCCCCCCCCCC	26.55	26074081
480	Phosphorylation	TKEDGHRTSTSAVPN CCCCCCCCCCCCCCC	30.59	23401153
481	Phosphorylation	KEDGHRTSTSAVPNL CCCCCCCCCCCCCCE	21.96	25159151
482	Phosphorylation	EDGHRTSTSAVPNLF CCCCCCCCCCCCCEE	21.79	25159151
483	Phosphorylation	DGHRTSTSAVPNLFV CCCCCCCCCCCCEEE	27.34	25159151
489 (in isoform 3)	Phosphorylation	-	7.27	27251275
489 (in isoform 6)	Phosphorylation	-	7.27	27251275
490 (in isoform 3)	Phosphorylation	-	6.25	27251275
490 (in isoform 6)	Phosphorylation	-	6.25	27251275
494	Phosphorylation	NLFVPLNTNPKEVQE CEEECCCCCHHHHHH	61.66	20068231
497	Ubiquitination	VPLNTNPKEVQEMRN ECCCCCHHHHHHHHH	73.00	24816145
511 (in isoform 3)	Phosphorylation	-	4.90	10209029
511 (in isoform 6)	Phosphorylation	-	4.90	10209029
514	Phosphorylation	REQNLQDIKTAGPQS HHHHHHHHHHHCCHH	2.49	32142685
515	Ubiquitination	EQNLQDIKTAGPQSQ HHHHHHHHHHCCHHH	40.38	24816145
516	Phosphorylation	QNLQDIKTAGPQSQV HHHHHHHHHCCHHHE	36.86	27251275
521	Phosphorylation	IKTAGPQSQVLCGVV HHHHCCHHHEEEEEE	25.95	27251275
528	Ubiquitination	SQVLCGVVMDRSLVQ HHEEEEEEECCHHHC	1.68	24816145
529	Sulfoxidation	QVLCGVVMDRSLVQG HEEEEEEECCHHHCC	3.09	21406390
531	Methylation	LCGVVMDRSLVQGEL EEEEEECCHHHCCCE	17.50	-
532	Phosphorylation	CGVVMDRSLVQGELV EEEEECCHHHCCCEE	28.73	29255136
540	O-linked_Glycosylation	LVQGELVTASKAIIE HHCCCEEECCHHHHH	37.53	23301498
540	Phosphorylation	LVQGELVTASKAIIE HHCCCEEECCHHHHH	37.53	23025827
542	O-linked_Glycosylation	QGELVTASKAIIEKE CCCEEECCHHHHHHH	17.16	23301498
542	Phosphorylation	QGELVTASKAIIEKE CCCEEECCHHHHHHH	17.16	23025827
543	Acetylation	GELVTASKAIIEKEY CCEEECCHHHHHHHH	40.93	25953088
543	Ubiquitination	GELVTASKAIIEKEY CCEEECCHHHHHHHH	40.93	32015554
546	Ubiquitination	VTASKAIIEKEYQPH EECCHHHHHHHHCCC	8.06	24816145
550	Phosphorylation	KAIIEKEYQPHVIVS HHHHHHHHCCCEEEE	38.11	25884760
557	O-linked_Glycosylation	YQPHVIVSTTGPNPF HCCCEEEECCCCCCC	14.77	23301498
557 (in isoform 4)	Phosphorylation	-	14.77	24076635
558	O-linked_Glycosylation	QPHVIVSTTGPNPFT CCCEEEECCCCCCCC	25.52	23301498
559	O-linked_Glycosylation	PHVIVSTTGPNPFTT CCEEEECCCCCCCCC	43.04	23301498
559	Phosphorylation	PHVIVSTTGPNPFTT CCEEEECCCCCCCCC	43.04	46159737
565	O-linked_Glycosylation	TTGPNPFTTLTDREL CCCCCCCCCCCHHHH	23.35	23301498
568	O-linked_Glycosylation	PNPFTTLTDRELEEY CCCCCCCCHHHHHHH	30.80	23301498
574	Ubiquitination	LTDRELEEYRREVER CCHHHHHHHHHHHHH	57.89	32015554
575	Phosphorylation	TDRELEEYRREVERK CHHHHHHHHHHHHHH	12.95	24927040
584	Ubiquitination	REVERKQKGSEENLD HHHHHHHCCCHHHHH	68.39	24816145
586	Phosphorylation	VERKQKGSEENLDEA HHHHHCCCHHHHHHH	49.09	29255136
600	Phosphorylation	AREQKEKSPPDQPAV HHHHHHHCCCCCCCC	42.64	25159151
600 (in isoform 2)	Phosphorylation	-	42.64	30177828
613	Phosphorylation	AVPHPPPSTPIKLEE CCCCCCCCCCCCCCC	53.22	30266825
613 (in isoform 2)	Phosphorylation	-	53.22	22210691
614	Phosphorylation	VPHPPPSTPIKLEED CCCCCCCCCCCCCCC	34.50	30266825
614 (in isoform 2)	Phosphorylation	-	34.50	26657352
615	Ubiquitination	PHPPPSTPIKLEEDL CCCCCCCCCCCCCCC	26.50	24816145
627	Phosphorylation	EDLVPEPTTGDDSDA CCCCCCCCCCCCCCC	41.57	27080861
628	Phosphorylation	DLVPEPTTGDDSDAA CCCCCCCCCCCCCCC	49.70	27080861
628 (in isoform 2)	Phosphorylation	-	49.70	-
631	Phosphorylation	PEPTTGDDSDAATFK CCCCCCCCCCCCCCC	50.16	32142685
631 (in isoform 4)	Phosphorylation	-	50.16	30177828
631 (in isoform 6)	Phosphorylation	-	50.16	30177828
632	Phosphorylation	EPTTGDDSDAATFKP CCCCCCCCCCCCCCC	33.61	21406692
636	Phosphorylation	GDDSDAATFKPTLPD CCCCCCCCCCCCCCC	33.63	27080861
640	Phosphorylation	DAATFKPTLPDLSPD CCCCCCCCCCCCCCC	52.06	21406692
644 (in isoform 4)	Phosphorylation	-	8.27	22210691
644 (in isoform 6)	Phosphorylation	-	8.27	22210691
645	Phosphorylation	KPTLPDLSPDEPSEA CCCCCCCCCCCHHHH	37.37	28192239
645 (in isoform 4)	Phosphorylation	-	37.37	26657352
645 (in isoform 6)	Phosphorylation	-	37.37	26657352
646	Ubiquitination	PTLPDLSPDEPSEAL CCCCCCCCCCHHHHC	58.23	24816145
650	Phosphorylation	DLSPDEPSEALGFPM CCCCCCHHHHCCCCC	33.19	26074081
659 (in isoform 4)	Phosphorylation	-	52.77	-
659 (in isoform 6)	Phosphorylation	-	52.77	-
662	Phosphorylation	FPMLEKEEEAHRPPS CCCCCCHHHHCCCCC	72.11	32142685
669	Phosphorylation	EEAHRPPSPTEAPTE HHHCCCCCCCCCCCC	47.32	28355574
671	Phosphorylation	AHRPPSPTEAPTEAS HCCCCCCCCCCCCCC	49.47	69004617
675	Phosphorylation	PSPTEAPTEASPEPA CCCCCCCCCCCCCCC	51.75	26074081
678	Phosphorylation	TEAPTEASPEPAPDP CCCCCCCCCCCCCCC	24.46	30576142
695	Phosphorylation	VAEEAAPSAVEEGAA CCHHHCCCHHHHCCC	39.97	30576142
707	Phosphorylation	GAAADPGSDGSPGKS CCCCCCCCCCCCCCC	44.16	28355574
710	Phosphorylation	ADPGSDGSPGKSPSK CCCCCCCCCCCCCCH	35.15	17081983
714	Phosphorylation	SDGSPGKSPSKKKKK CCCCCCCCCCHHHCC	40.08	20068230
716	Phosphorylation	GSPGKSPSKKKKKFR CCCCCCCCHHHCCCC	65.29	17081983
724	Phosphorylation	KKKKKFRTPSFLKKS HHHCCCCCHHHHHHH	26.81	30266825
726	Phosphorylation	KKKFRTPSFLKKSKK HCCCCCHHHHHHHHC	42.47	19664994
731	Phosphorylation	TPSFLKKSKKKSDS- CHHHHHHHHCCCCC-	48.39	20835919
734	Ubiquitination	FLKKSKKKSDS---- HHHHHHCCCCC----	64.33	24816145
735	Phosphorylation	LKKSKKKSDS----- HHHHHCCCCC-----	52.55	50563741
737	Phosphorylation	KSKKKSDS------- HHHCCCCC-------	49.57	50563749
765	Ubiquitination	----------------------------------- -----------------------------------		24816145
796	Ubiquitination	------------------------------------------------------------------ ------------------------------------------------------------------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
5	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
12	S	Phosphorylation	Kinase	CDK1	P06493	PSP
59	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
59	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
59	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
59	S	Phosphorylation	Kinase	PKA	-	Uniprot
355	S	Phosphorylation	Kinase	ERK2	P28482	PSP
355	S	Phosphorylation	Kinase	CDK1	P06493	PSP
358	S	Phosphorylation	Kinase	ERK2	P28482	PSP
408	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
408	S	Phosphorylation	Kinase	PKA	-	Uniprot
408	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
408	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
436	S	Phosphorylation	Kinase	PKA	-	Uniprot
436	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
436	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
436	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
445	T	Phosphorylation	Kinase	ROCK-SUBFAMILY	-	GPS
445	T	Phosphorylation	Kinase	ROCK2	O75116	Uniprot
445	T	Phosphorylation	Kinase	ROCK1	Q13464	PSP
445	T	Phosphorylation	Kinase	ROCK_GROUP	-	PhosphoELM
480	T	Phosphorylation	Kinase	ROCK1	Q13464	PSP
480	T	Phosphorylation	Kinase	ROCK_GROUP	-	PhosphoELM
480	T	Phosphorylation	Kinase	ROCK2	O75116	Uniprot
480	T	Phosphorylation	Kinase	ROCK-SUBFAMILY	-	GPS
481	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
481	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
481	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
481	S	Phosphorylation	Kinase	PKA	-	Uniprot
669	S	Phosphorylation	Kinase	ERK2	P28482	PSP
707	S	Phosphorylation	Kinase	ERK2	P28482	PSP
716	S	Phosphorylation	Kinase	PKC	-	Uniprot
716	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
716	S	Phosphorylation	Kinase	PKCA	P05696	PSP
716	S	Phosphorylation	Kinase	PKCA	P04409	PSP
724	T	Phosphorylation	Kinase	CDK5	Q00535	PSP
726	S	Phosphorylation	Kinase	PKCA	P04409	PSP
726	S	Phosphorylation	Kinase	PKACA	P17612	PSP
726	S	Phosphorylation	Kinase	PKCA	P05696	PSP
726	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
726	S	Phosphorylation	Kinase	PKA	-	Uniprot
726	S	Phosphorylation	Kinase	PKC	-	Uniprot
726	S	Phosphorylation	Kinase	PRKCD	Q05655	GPS
726	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
726	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
726	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
726	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
726	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ADDA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ADDA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPTB1_HUMAN	SPTB	physical	8663089
SMCA4_HUMAN	SMARCA4	physical	17074803
SMRC1_HUMAN	SMARCC1	physical	17074803
SMCA2_HUMAN	SMARCA2	physical	17074803
SIN3A_HUMAN	SIN3A	physical	17074803
HDAC1_HUMAN	HDAC1	physical	17074803
HM20A_HUMAN	HMG20A	physical	25416956
ADDG_HUMAN	ADD3	physical	26496610
DYST_HUMAN	DST	physical	26496610
PGBM_HUMAN	HSPG2	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
UBIA1_HUMAN	UBIAD1	physical	26496610
NUP54_HUMAN	NUP54	physical	26496610
INF2_HUMAN	INF2	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ADDA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-355; SER-358; SER-464; SER-465 AND SER-726, ANDMASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-465, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-355; SER-358; SER-464; SER-465 AND SER-726, ANDMASS SPECTROMETRY.	19413330 [Abstract]
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