dbPTM

HM20A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HM20A_HUMAN
UniProt AC	Q9NP66
Protein Name	High mobility group protein 20A
Gene Name	HMG20A
Organism	Homo sapiens (Human).
Sequence Length	347
Subcellular Localization	Nucleus .
Protein Description	Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity)..
Protein Sequence	MENLMTSSTLPPLFADEDGSKESNDLATTGLNHPEVPYSSGATSSTNNPEFVEDLSQGQLLQSESSNAAEGNEQRHEDEQRSKRGGWSKGRKRKKPLRDSNAPKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKERYMKELEQYQKTEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETEVKERSVFDIPIFTEEFLNHSKAREAELRQLRKSNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSRNTVLQQHLETLRQVLTSSFASMPLPGSGETPTVDTIDSYMNRLHSIILANPQDNENFIATVREVVNRLDR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MENLMTSSTLPPL --CCCCCCCCCCCCC	23.77	-
7	Phosphorylation	-MENLMTSSTLPPLF -CCCCCCCCCCCCCC	13.83	28348404
8	Phosphorylation	MENLMTSSTLPPLFA CCCCCCCCCCCCCCC	25.46	28348404
9	Phosphorylation	ENLMTSSTLPPLFAD CCCCCCCCCCCCCCC	42.95	28348404
20	Phosphorylation	LFADEDGSKESNDLA CCCCCCCCCCCCCCC	45.64	25159151
100	Phosphorylation	RKKPLRDSNAPKSPL CCCCCCCCCCCCCCC	28.58	25159151
105	Phosphorylation	RDSNAPKSPLTGYVR CCCCCCCCCCHHHHH	24.88	22167270
108	Phosphorylation	NAPKSPLTGYVRFMN CCCCCCCHHHHHHHH	29.83	23927012
110	Phosphorylation	PKSPLTGYVRFMNER CCCCCHHHHHHHHHH	5.34	23927012
152	Phosphorylation	PPEEKQRYLDEADRD CHHHHHHHHHHHHHH	18.93	22817900
163	Phosphorylation	ADRDKERYMKELEQY HHHHHHHHHHHHHHH	17.40	22817900
165	Ubiquitination	RDKERYMKELEQYQK HHHHHHHHHHHHHHH	50.65	-
170	Phosphorylation	YMKELEQYQKTEAYK HHHHHHHHHHHHHHH	11.55	22817900
172	Acetylation	KELEQYQKTEAYKVF HHHHHHHHHHHHHHH	43.32	26051181
172	Ubiquitination	KELEQYQKTEAYKVF HHHHHHHHHHHHHHH	43.32	-
173	Phosphorylation	ELEQYQKTEAYKVFS HHHHHHHHHHHHHHC	15.43	-
176	Phosphorylation	QYQKTEAYKVFSRKT HHHHHHHHHHHCHHH	11.06	-
177	Acetylation	YQKTEAYKVFSRKTQ HHHHHHHHHHCHHHH	43.80	26051181
177	Ubiquitination	YQKTEAYKVFSRKTQ HHHHHHHHHHCHHHH	43.80	-
230	Ubiquitination	EEFLNHSKAREAELR HHHHCHHHHHHHHHH	43.86	-
255	Ubiquitination	ERNAALQKHVESMRT HHHHHHHHHHHHHHH	50.93	-
287	Phosphorylation	VLQQHLETLRQVLTS HHHHHHHHHHHHHHH	33.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HM20A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HM20A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HM20A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHP3_HUMAN	TESC	physical	16189514
MGN2_HUMAN	MAGOHB	physical	16189514
HM20A_HUMAN	HMG20A	physical	16189514
TF2AY_HUMAN	GTF2A1L	physical	20211142
HD_HUMAN	HTT	physical	23275563
HM20A_HUMAN	HMG20A	physical	25416956
RPP30_HUMAN	RPP30	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
SCNM1_HUMAN	SCNM1	physical	25416956
SYTL4_HUMAN	SYTL4	physical	25416956
CFA53_HUMAN	CFAP53	physical	25416956
RSPH9_HUMAN	RSPH9	physical	25416956
HDAC1_HUMAN	HDAC1	physical	26496610
HDAC2_HUMAN	HDAC2	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
PAWR_HUMAN	PAWR	physical	26496610
RAD51_HUMAN	RAD51	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
TCF20_HUMAN	TCF20	physical	26496610
MBD2_HUMAN	MBD2	physical	26496610
MTA2_HUMAN	MTA2	physical	26496610
PHF14_HUMAN	PHF14	physical	26496610
HM20B_HUMAN	HMG20B	physical	26496610
RAI1_HUMAN	RAI1	physical	26496610
KDM1A_HUMAN	KDM1A	physical	26496610
RCOR1_HUMAN	RCOR1	physical	26496610
GSE1_HUMAN	GSE1	physical	26496610
HP1B3_HUMAN	HP1BP3	physical	26496610
PF21A_HUMAN	PHF21A	physical	26496610
P66A_HUMAN	GATAD2A	physical	26496610
BCOR_HUMAN	BCOR	physical	26496610
URFB1_HUMAN	UHRF1BP1	physical	26496610
RCOR3_HUMAN	RCOR3	physical	26496610
P66B_HUMAN	GATAD2B	physical	26496610
HDAC1_HUMAN	HDAC1	physical	28514442
ZC4H2_HUMAN	ZC4H2	physical	28514442
PF21A_HUMAN	PHF21A	physical	28514442
PHF14_HUMAN	PHF14	physical	28514442
GSE1_HUMAN	GSE1	physical	28514442
SMBT1_HUMAN	SFMBT1	physical	28514442
RCOR2_HUMAN	RCOR2	physical	28514442
DTNA_HUMAN	DTNA	physical	28514442
SNTB1_HUMAN	SNTB1	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
HMMR_HUMAN	HMMR	physical	28514442
CEP83_HUMAN	CEP83	physical	28514442
SNTA1_HUMAN	SNTA1	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
SNTB2_HUMAN	SNTB2	physical	28514442
KDM1A_HUMAN	KDM1A	physical	28514442
PAWR_HUMAN	PAWR	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442
PKN3_HUMAN	PKN3	physical	27173435
NCK5L_HUMAN	NCKAP5L	physical	27173435
TFPT_HUMAN	TFPT	physical	27173435
CCHCR_HUMAN	CCHCR1	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
TUFT1_HUMAN	TUFT1	physical	27173435
GOGA5_HUMAN	GOLGA5	physical	27173435
RBG10_HUMAN	RABGAP1L	physical	27173435
RBG1L_HUMAN	RABGAP1L	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
PSMD9_HUMAN	PSMD9	physical	27173435
VPS53_HUMAN	VPS53	physical	27173435
DZIP3_HUMAN	DZIP3	physical	27173435
GRAP1_HUMAN	GRIPAP1	physical	27173435
RCOR1_HUMAN	RCOR1	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
CCD93_HUMAN	CCDC93	physical	27173435
MS18B_HUMAN	OIP5	physical	27173435
PF21A_HUMAN	PHF21A	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
PHLB3_HUMAN	PHLDB3	physical	27173435
HAUS6_HUMAN	HAUS6	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
BMAL1_HUMAN	ARNTL	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435
NUF2_HUMAN	NUF2	physical	27173435
THA11_HUMAN	THAP11	physical	27173435
VPS51_HUMAN	VPS51	physical	27173435
KDM1A_HUMAN	KDM1A	physical	27173435
EIPR1_HUMAN	TSSC1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HM20A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.	19007248 [Abstract]