BCOR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCOR_HUMAN
• UniProt AC: Q6W2J9
• Protein Name: BCL-6 corepressor
• Gene Name: BCOR
• Organism: Homo sapiens (Human).
• Sequence Length: 1755
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2)..
• Protein Sequence: MLSATPLYGNVHSWMNSERVRMCGASEDRKILVNDGDASKARLELREENPLNHNVVDASTAHRIDGLAALSMDRTGLIREGLRVPGNIVYSSLCGLGSEKGREAATSTLGGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAVATAEALGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMYKALLPQQSYSLAQPLYSPVCTNGERFLYLPPPHYVGPHIPSSLASPMRLSTPSASPAIPPLVHCADKSLPWKMGVSPGNPVDSHAYPHIQNSKQPRVPSAKAVTSGLPGDTALLLPPSPRPSPRVHLPTQPAADTYSEFHKHYARISTSPSVALSKPYMTVSSEFPAARLSNGKYPKAPEGGEGAQPVPGHARKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSKVVDVDASKADHMKKMAPTVLVHSRAGSGLVLSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNEENNGKSMSLKNKALDWAIPQQRSSSCPRMGGTDAVITNVSGSVSSAGRPASASPAPNANADGTKTSRSSVETTPSVIQHVGQPPATPAKHSSSTSSKGAKASNPEPSFKANENGLPPSSIFLSPNEAFRSPPIPYPRSYLPYPAPEGIAVSPLSLHGKGPVYPHPVLLPNGSLFPGHLAPKPGLPYGLPTGRPEFVTYQDALGLGMVHPMLIPHTPIEITKEEKPERRSRSHERARYEDPTLRNRFSEILETSSTKLHPDVPTDKNLKPNPNWNQGKTVVKSDKLVYVDLLREEPDAKTDTNVSKPSFAAESVGQSAEPPKPSVEPALQQHRDFIALREELGRISDFHETYTFKQPVFTVSKDSVLAGTNKENLGLPVSTPFLEPPLGSDGPAVTFGKTQEDPKPFCVGSAPPSVDVTPTYTKDGADEAESNDGKVLKPKPSKLAKRIANSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSELEMKEREGGHPATKDSEMCKFSPADWERLKGNQDKKPKSVTLEEAIAEQNESERCEYSVGNKHRDPFEAPEDKDLPVEKYFVERQPVSEPPADQVASDMPHSPTLRVDRKRKVSGDSSHTETTAEEVPEDPLLKAKRRRVSKDDWPEREMTNSSSNHLEDPHYSELTNLKVCIELTGLHPKKQRHLLHLRERWEQQVSAADGKPGRQSRKEVTQATQPEAIPQGTNITEEKPGRKRAEAKGNRSWSEESLKPSDNEQGLPVFSGSPPMKSLSSTSAGGKKQAQPSCAPASRPPAKQQKIKENQKTDVLCADEEEDCQAASLLQKYTDNSEKPSGKRLCKTKHLIPQESRRGLPLTGEYYVENADGKVTVRRFRKRPEPSSDYDLSPAKQEPKPFDRLQQLLPASQSTQLPCSSSPQETTQSRPMPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDYLNDLQGRNDDDASGTWDFYGSSVCEPDDESGYDVLANPPGPEDQDDDDDAYSDVFEFEFSETPLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRCNFPNVEIVTIAEAEFYRQVSASLLFSCSKDLEAFNPESKELLDLVEFTNEIQTLLGSSVEWLHPSDLASDNYW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSATPLYGN -----CCCCCCCCCC	41.79	30631047
5	Phosphorylation	---MLSATPLYGNVH ---CCCCCCCCCCHH	15.51	26552605
8	Phosphorylation	MLSATPLYGNVHSWM CCCCCCCCCCHHHHH	14.09	26552605
13	Phosphorylation	PLYGNVHSWMNSERV CCCCCHHHHHCCCCE	24.60	26552605
17	Phosphorylation	NVHSWMNSERVRMCG CHHHHHCCCCEEECC	15.63	26552605
30	Ubiquitination	CGASEDRKILVNDGD CCCCCCCCEEECCCC	53.35	29967540
40	Ubiquitination	VNDGDASKARLELRE ECCCCHHHHHHHHHH	38.97	32015554
71	Phosphorylation	IDGLAALSMDRTGLI HCHHHHHCCCCCCHH	17.57	28555341
90	Phosphorylation	RVPGNIVYSSLCGLG CCCCCEEEECCCCCC	6.69	29978859
91	Phosphorylation	VPGNIVYSSLCGLGS CCCCEEEECCCCCCC	13.12	29978859
92	Phosphorylation	PGNIVYSSLCGLGSE CCCEEEECCCCCCCH	15.25	29978859
98	Phosphorylation	SSLCGLGSEKGREAA ECCCCCCCHHHHHHH	40.97	-
100	Ubiquitination	LCGLGSEKGREAATS CCCCCCHHHHHHHHH	66.03	29967540
106	Phosphorylation	EKGREAATSTLGGLG HHHHHHHHHHHCCCC	29.32	-
116	Phosphorylation	LGGLGFSSERNPEMQ HCCCCCCCCCCCCCC	38.01	-
128	Phosphorylation	EMQFKPNTPETVEAS CCCCCCCCCCCEEHH	30.91	25002506
131	Phosphorylation	FKPNTPETVEASAVS CCCCCCCCEEHHHHC	25.50	25002506
149	Phosphorylation	PNGFSAIYKTPPGIQ CCCCEEEECCCCCCC	14.44	-
150	Ubiquitination	NGFSAIYKTPPGIQK CCCEEEECCCCCCCH	48.74	29967540
151	Phosphorylation	GFSAIYKTPPGIQKS CCEEEECCCCCCCHH	20.11	28674419
157	Ubiquitination	KTPPGIQKSAVATAE CCCCCCCHHHHHHHH	38.16	29967540
158	Phosphorylation	TPPGIQKSAVATAEA CCCCCCHHHHHHHHH	16.17	20068231
162	Phosphorylation	IQKSAVATAEALGLD CCHHHHHHHHHHCCC	20.59	20068231
173	Phosphorylation	LGLDRPASDKQSPLN HCCCCCCCCCCCCCC	48.28	29214152
175	Ubiquitination	LDRPASDKQSPLNIN CCCCCCCCCCCCCCC	50.62	-
177	Phosphorylation	RPASDKQSPLNINGA CCCCCCCCCCCCCCC	36.78	25159151
185	Phosphorylation	PLNINGASYLRLPWV CCCCCCCCCCCCCCC	26.54	25002506
186	Phosphorylation	LNINGASYLRLPWVN CCCCCCCCCCCCCCC	8.70	25002506
188	Methylation	INGASYLRLPWVNPY CCCCCCCCCCCCCCC	30.39	-
200	Phosphorylation	NPYMEGATPAIYPFL CCCCCCCCCCHHHCC	24.90	-
209	Phosphorylation	AIYPFLDSPNKYSLN CHHHCCCCCCCCCHH	32.30	28348404
226	Phosphorylation	KALLPQQSYSLAQPL HHHCCCCCCCCCCCC	16.08	26552605
227	Phosphorylation	ALLPQQSYSLAQPLY HHCCCCCCCCCCCCC	11.90	19835603
228	Phosphorylation	LLPQQSYSLAQPLYS HCCCCCCCCCCCCCC	23.60	19835603
234	Phosphorylation	YSLAQPLYSPVCTNG CCCCCCCCCCCCCCC	20.01	26552605
235	Phosphorylation	SLAQPLYSPVCTNGE CCCCCCCCCCCCCCC	20.66	19835603
239	Phosphorylation	PLYSPVCTNGERFLY CCCCCCCCCCCEEEE	46.63	26552605
243	Methylation	PVCTNGERFLYLPPP CCCCCCCEEEEECCC	28.41	-
269	Phosphorylation	ASPMRLSTPSASPAI CCCCCCCCCCCCCCC	26.34	21712546
273	Phosphorylation	RLSTPSASPAIPPLV CCCCCCCCCCCCCHH	21.14	21712546
290	Ubiquitination	ADKSLPWKMGVSPGN CCCCCCCCCCCCCCC	24.68	29967540
294	Phosphorylation	LPWKMGVSPGNPVDS CCCCCCCCCCCCCCC	22.74	25159151
294 (in isoform 2)	Phosphorylation	-	22.74	-
294 (in isoform 3)	Phosphorylation	-	22.74	-
301	Phosphorylation	SPGNPVDSHAYPHIQ CCCCCCCCCCCCCCC	15.39	22210691
304	Phosphorylation	NPVDSHAYPHIQNSK CCCCCCCCCCCCCCC	7.01	22210691
310	Phosphorylation	AYPHIQNSKQPRVPS CCCCCCCCCCCCCCC	19.11	22210691
311	Ubiquitination	YPHIQNSKQPRVPSA CCCCCCCCCCCCCCH	72.39	29967540
322	Phosphorylation	VPSAKAVTSGLPGDT CCCHHHHCCCCCCCC	23.18	29978859
323	Phosphorylation	PSAKAVTSGLPGDTA CCHHHHCCCCCCCCE	31.56	29978859
329	Phosphorylation	TSGLPGDTALLLPPS CCCCCCCCEEECCCC	25.72	29978859
336	Phosphorylation	TALLLPPSPRPSPRV CEEECCCCCCCCCCC	31.44	29255136
336 (in isoform 2)	Phosphorylation	-	31.44	-
336 (in isoform 3)	Phosphorylation	-	31.44	-
338	Methylation	LLLPPSPRPSPRVHL EECCCCCCCCCCCCC	48.98	-
340	Phosphorylation	LPPSPRPSPRVHLPT CCCCCCCCCCCCCCC	26.98	25159151
340 (in isoform 2)	Phosphorylation	-	26.98	-
340 (in isoform 3)	Phosphorylation	-	26.98	-
342	Methylation	PSPRPSPRVHLPTQP CCCCCCCCCCCCCCC	32.59	-
347	Phosphorylation	SPRVHLPTQPAADTY CCCCCCCCCCCCCCH	54.25	23312004
353	Phosphorylation	PTQPAADTYSEFHKH CCCCCCCCHHHHHHH	24.99	25332170
354	Phosphorylation	TQPAADTYSEFHKHY CCCCCCCHHHHHHHH	13.52	28796482
355	Phosphorylation	QPAADTYSEFHKHYA CCCCCCHHHHHHHHC	35.56	28796482
361	Phosphorylation	YSEFHKHYARISTSP HHHHHHHHCHHCCCC	11.46	21214269
365	O-linked_Glycosylation	HKHYARISTSPSVAL HHHHCHHCCCCCHHC	19.78	30059200
365	Phosphorylation	HKHYARISTSPSVAL HHHHCHHCCCCCHHC	19.78	25159151
365 (in isoform 2)	O-linked_Glycosylation	-	19.78	-
365 (in isoform 2)	Phosphorylation	-	19.78	-
365 (in isoform 3)	O-linked_Glycosylation	-	19.78	-
365 (in isoform 3)	Phosphorylation	-	19.78	-
366	Phosphorylation	KHYARISTSPSVALS HHHCHHCCCCCHHCC	42.14	22199227
366 (in isoform 2)	Phosphorylation	-	42.14	-
366 (in isoform 3)	Phosphorylation	-	42.14	-
367	Phosphorylation	HYARISTSPSVALSK HHCHHCCCCCHHCCC	14.37	25159151
367 (in isoform 2)	Phosphorylation	-	14.37	-
367 (in isoform 3)	Phosphorylation	-	14.37	-
369	Phosphorylation	ARISTSPSVALSKPY CHHCCCCCHHCCCCC	21.57	22199227
369 (in isoform 2)	Phosphorylation	-	21.57	-
369 (in isoform 3)	Phosphorylation	-	21.57	-
373	Phosphorylation	TSPSVALSKPYMTVS CCCCHHCCCCCEEEC	23.11	20860994
374	Acetylation	SPSVALSKPYMTVSS CCCHHCCCCCEEECC	40.80	23954790
376	Phosphorylation	SVALSKPYMTVSSEF CHHCCCCCEEECCCC	14.78	29449344
378	Phosphorylation	ALSKPYMTVSSEFPA HCCCCCEEECCCCCH	16.05	21214269
389	Phosphorylation	EFPAARLSNGKYPKA CCCHHHHCCCCCCCC	37.67	25159151
392	Acetylation	AARLSNGKYPKAPEG HHHHCCCCCCCCCCC	63.73	19608861
392 (in isoform 2)	Acetylation	-	63.73	-
392 (in isoform 3)	Acetylation	-	63.73	-
412	Ubiquitination	PVPGHARKTAVQDRK CCCCCCCCCCCCCCC	41.44	29967540
413	Phosphorylation	VPGHARKTAVQDRKD CCCCCCCCCCCCCCC	26.89	26074081
422	Phosphorylation	VQDRKDGSSPPLLEK CCCCCCCCCCCCCCC	50.21	29255136
422 (in isoform 2)	Phosphorylation	-	50.21	-
422 (in isoform 3)	Phosphorylation	-	50.21	-
423	Phosphorylation	QDRKDGSSPPLLEKQ CCCCCCCCCCCCCCC	35.75	29255136
423 (in isoform 2)	Phosphorylation	-	35.75	-
423 (in isoform 3)	Phosphorylation	-	35.75	-
431	Phosphorylation	PPLLEKQTVTKDVTD CCCCCCCEECCCCCC	41.01	20068231
431 (in isoform 2)	Phosphorylation	-	41.01	-
431 (in isoform 3)	Phosphorylation	-	41.01	-
433	Phosphorylation	LLEKQTVTKDVTDKP CCCCCEECCCCCCCC	25.55	20068231
434	Ubiquitination	LEKQTVTKDVTDKPL CCCCEECCCCCCCCC	45.95	29967540
439	Acetylation	VTKDVTDKPLDLSSK ECCCCCCCCCCCCCC	37.81	26051181
439	Ubiquitination	VTKDVTDKPLDLSSK ECCCCCCCCCCCCCC	37.81	29967540
446	Acetylation	KPLDLSSKVVDVDAS CCCCCCCCEEECCHH	42.79	26051181
446	Ubiquitination	KPLDLSSKVVDVDAS CCCCCCCCEEECCHH	42.79	29967540
453	O-linked_Glycosylation	KVVDVDASKADHMKK CEEECCHHHHHHHHH	24.74	30059200
454	Ubiquitination	VVDVDASKADHMKKM EEECCHHHHHHHHHH	60.60	29967540
460	Ubiquitination	SKADHMKKMAPTVLV HHHHHHHHHCCEEEE	32.49	29967540
464	Phosphorylation	HMKKMAPTVLVHSRA HHHHHCCEEEEECCC	19.55	-
469	Phosphorylation	APTVLVHSRAGSGLV CCEEEEECCCCCCCE	19.15	22817900
473	Phosphorylation	LVHSRAGSGLVLSGS EEECCCCCCCEECCC	28.15	20068231
473 (in isoform 2)	Phosphorylation	-	28.15	-
473 (in isoform 3)	Phosphorylation	-	28.15	-
478	Phosphorylation	AGSGLVLSGSEIPKE CCCCCEECCCCCCHH	32.56	30108239
480	Phosphorylation	SGLVLSGSEIPKETL CCCEECCCCCCHHHC	29.04	30108239
486	Phosphorylation	GSEIPKETLSPPGNG CCCCCHHHCCCCCCC	38.37	23663014
488	Phosphorylation	EIPKETLSPPGNGCA CCCHHHCCCCCCCEE	36.15	25159151
497	Phosphorylation	PGNGCAIYRSEIIST CCCCEEEECCEEEEC	6.91	30108239
503	Phosphorylation	IYRSEIISTAPSSWV EECCEEEECCCCCCC	24.95	-
528	Ubiquitination	NGKSMSLKNKALDWA CCCCCCHHHHHHHHH	49.44	-
530	Sumoylation	KSMSLKNKALDWAIP CCCCHHHHHHHHHCC	49.06	-
530	Sumoylation	KSMSLKNKALDWAIP CCCCHHHHHHHHHCC	49.06	-
530	Ubiquitination	KSMSLKNKALDWAIP CCCCHHHHHHHHHCC	49.06	29967540
550	Phosphorylation	SCPRMGGTDAVITNV CCCCCCCCCEEEEEC	18.30	23186163
555	O-linked_Glycosylation	GGTDAVITNVSGSVS CCCCEEEEECCCCCC	23.99	30059200
555	Phosphorylation	GGTDAVITNVSGSVS CCCCEEEEECCCCCC	23.99	30576142
558	Phosphorylation	DAVITNVSGSVSSAG CEEEEECCCCCCCCC	27.67	29978859
560	O-linked_Glycosylation	VITNVSGSVSSAGRP EEEECCCCCCCCCCC	16.00	30059200
560	Phosphorylation	VITNVSGSVSSAGRP EEEECCCCCCCCCCC	16.00	29978859
562	Phosphorylation	TNVSGSVSSAGRPAS EECCCCCCCCCCCCC	19.03	29978859
563	Phosphorylation	NVSGSVSSAGRPASA ECCCCCCCCCCCCCC	32.36	29978859
569	Phosphorylation	SSAGRPASASPAPNA CCCCCCCCCCCCCCC	31.78	29255136
571	Phosphorylation	AGRPASASPAPNANA CCCCCCCCCCCCCCC	21.06	29255136
581	Phosphorylation	PNANADGTKTSRSSV CCCCCCCCCCCCHHC	31.53	28450419
586	O-linked_Glycosylation	DGTKTSRSSVETTPS CCCCCCCHHCCCCHH	38.20	30059200
586	Phosphorylation	DGTKTSRSSVETTPS CCCCCCCHHCCCCHH	38.20	25627689
587	Phosphorylation	GTKTSRSSVETTPSV CCCCCCHHCCCCHHH	23.90	25159151
590	Phosphorylation	TSRSSVETTPSVIQH CCCHHCCCCHHHHHH	41.68	20860994
591	Phosphorylation	SRSSVETTPSVIQHV CCHHCCCCHHHHHHC	10.48	26425664
604	Phosphorylation	HVGQPPATPAKHSSS HCCCCCCCCCCCCCC	29.56	26055452
611	Phosphorylation	TPAKHSSSTSSKGAK CCCCCCCCCCCCCCC	35.01	20860994
637	O-linked_Glycosylation	ENGLPPSSIFLSPNE CCCCCCHHHEECCCH	24.12	30059200
641	Phosphorylation	PPSSIFLSPNEAFRS CCHHHEECCCHHHCC	18.22	-
647	Methylation	LSPNEAFRSPPIPYP ECCCHHHCCCCCCCC	56.13	-
648	Phosphorylation	SPNEAFRSPPIPYPR CCCHHHCCCCCCCCH	28.68	26425664
655	Methylation	SPPIPYPRSYLPYPA CCCCCCCHHCCCCCC	31.90	-
656	Phosphorylation	PPIPYPRSYLPYPAP CCCCCCHHCCCCCCC	26.90	27251275
660	Phosphorylation	YPRSYLPYPAPEGIA CCHHCCCCCCCCCEE	14.94	28450419
669	Phosphorylation	APEGIAVSPLSLHGK CCCCEEECCCCCCCC	15.88	28450419
672	Phosphorylation	GIAVSPLSLHGKGPV CEEECCCCCCCCCCC	23.00	28450419
747	Phosphorylation	EEKPERRSRSHERAR CCCCCHHCCCCHHHH	44.34	20068231
749	Phosphorylation	KPERRSRSHERARYE CCCHHCCCCHHHHCC	30.83	20068231
765	Phosphorylation	PTLRNRFSEILETSS HHHHHHHHHHHHCCC	22.08	28555341
770	Phosphorylation	RFSEILETSSTKLHP HHHHHHHCCCCCCCC	25.24	28555341
771	Phosphorylation	FSEILETSSTKLHPD HHHHHHCCCCCCCCC	27.00	21815630
772	Phosphorylation	SEILETSSTKLHPDV HHHHHCCCCCCCCCC	36.66	25627689
773	Phosphorylation	EILETSSTKLHPDVP HHHHCCCCCCCCCCC	37.08	25627689
774	Ubiquitination	ILETSSTKLHPDVPT HHHCCCCCCCCCCCC	46.90	29967540
783	Ubiquitination	HPDVPTDKNLKPNPN CCCCCCCCCCCCCCC	67.66	29967540
786	Sumoylation	VPTDKNLKPNPNWNQ CCCCCCCCCCCCCCC	52.74	-
786	Acetylation	VPTDKNLKPNPNWNQ CCCCCCCCCCCCCCC	52.74	26051181
786	Sumoylation	VPTDKNLKPNPNWNQ CCCCCCCCCCCCCCC	52.74	28112733
786	Ubiquitination	VPTDKNLKPNPNWNQ CCCCCCCCCCCCCCC	52.74	29967540
795	Acetylation	NPNWNQGKTVVKSDK CCCCCCCCEEEECCE	28.51	25953088
795	Ubiquitination	NPNWNQGKTVVKSDK CCCCCCCCEEEECCE	28.51	29967540
802	Acetylation	KTVVKSDKLVYVDLL CEEEECCEEEEEEEE	47.12	18525525
805	Phosphorylation	VKSDKLVYVDLLREE EECCEEEEEEEECCC	9.93	27642862
816	Acetylation	LREEPDAKTDTNVSK ECCCCCCCCCCCCCC	55.07	18525533
823	Acetylation	KTDTNVSKPSFAAES CCCCCCCCHHHCCHH	40.16	26051181
823	Ubiquitination	KTDTNVSKPSFAAES CCCCCCCCHHHCCHH	40.16	29967540
839	Ubiquitination	GQSAEPPKPSVEPAL CCCCCCCCCCCHHHH	61.72	29967540
868	Phosphorylation	RISDFHETYTFKQPV CCCCCCCCEEECCCE	21.20	26074081
869	Phosphorylation	ISDFHETYTFKQPVF CCCCCCCEEECCCEE	13.75	26074081
870	Phosphorylation	SDFHETYTFKQPVFT CCCCCCEEECCCEEE	31.60	26074081
872	Sumoylation	FHETYTFKQPVFTVS CCCCEEECCCEEEEC	45.98	28112733
872	Ubiquitination	FHETYTFKQPVFTVS CCCCEEECCCEEEEC	45.98	22817900
872 (in isoform 1)	Ubiquitination	-	45.98	21890473
872 (in isoform 2)	Ubiquitination	-	45.98	21890473
872 (in isoform 3)	Ubiquitination	-	45.98	21890473
872 (in isoform 4)	Ubiquitination	-	45.98	21890473
877	Phosphorylation	TFKQPVFTVSKDSVL EECCCEEEECCCCEE	24.89	26074081
879	Phosphorylation	KQPVFTVSKDSVLAG CCCEEEECCCCEECC	27.90	26074081
880	Ubiquitination	QPVFTVSKDSVLAGT CCEEEECCCCEECCC	50.08	29967540
882	Phosphorylation	VFTVSKDSVLAGTNK EEEECCCCEECCCCH	23.83	26074081
887	Phosphorylation	KDSVLAGTNKENLGL CCCEECCCCHHHCCC	37.19	26074081
889	Ubiquitination	SVLAGTNKENLGLPV CEECCCCHHHCCCCC	48.06	29967540
913	Phosphorylation	GSDGPAVTFGKTQED CCCCCCEECCCCCCC	28.86	22210691
917	Phosphorylation	PAVTFGKTQEDPKPF CCEECCCCCCCCCCC	37.25	20058876
917 (in isoform 2)	Phosphorylation	-	37.25	-
917 (in isoform 3)	Phosphorylation	-	37.25	-
928	Phosphorylation	PKPFCVGSAPPSVDV CCCCCCCCCCCCCCC	19.73	21712546
932	Phosphorylation	CVGSAPPSVDVTPTY CCCCCCCCCCCCCCC	29.86	21712546
936	Phosphorylation	APPSVDVTPTYTKDG CCCCCCCCCCCCCCC	12.88	21712546
953	Acetylation	EAESNDGKVLKPKPS CCHHCCCCCCCCCHH	47.46	26051181
969	Phosphorylation	LAKRIANSAGYVGDR HHHHHHHHCCCCCCC	17.66	28555341
972	Phosphorylation	RIANSAGYVGDRFKC HHHHHCCCCCCCEEE	10.85	22817900
985	Phosphorylation	KCVTTELYADSSQLS EEEEEHHHCCHHHHH	11.35	29978859
1027	Ubiquitination	MMRFSELEMKEREGG HHHHHHHHHHHHCCC	44.12	29967540
1029	Ubiquitination	RFSELEMKEREGGHP HHHHHHHHHHCCCCC	44.22	29967540
1045	Ubiquitination	TKDSEMCKFSPADWE CCCCHHCCCCHHHHH	47.79	29967540
1047	Phosphorylation	DSEMCKFSPADWERL CCHHCCCCHHHHHHH	12.50	21815630
1064	Phosphorylation	NQDKKPKSVTLEEAI CCCCCCCCCCHHHHH	28.94	27251275
1066	Phosphorylation	DKKPKSVTLEEAIAE CCCCCCCCHHHHHHH	35.23	28348404
1086	Ubiquitination	RCEYSVGNKHRDPFE CCEEECCCCCCCCCC	34.50	21890473
1086 (in isoform 4)	Ubiquitination	-	34.50	21890473
1104	Ubiquitination	DKDLPVEKYFVERQP CCCCCHHHHEEECCC	44.19	22817900
1104 (in isoform 1)	Ubiquitination	-	44.19	21890473
1104 (in isoform 2)	Ubiquitination	-	44.19	21890473
1104 (in isoform 3)	Ubiquitination	-	44.19	21890473
1113	Phosphorylation	FVERQPVSEPPADQV EEECCCCCCCCHHHH	51.58	28387310
1121	Phosphorylation	EPPADQVASDMPHSP CCCHHHHCCCCCCCC	8.32	32645325
1122	Phosphorylation	PPADQVASDMPHSPT CCHHHHCCCCCCCCC	35.27	22167270
1124	Phosphorylation	ADQVASDMPHSPTLR HHHHCCCCCCCCCCC	2.74	33259812
1127	Phosphorylation	VASDMPHSPTLRVDR HCCCCCCCCCCCCCC	17.45	23401153
1127 (in isoform 2)	Phosphorylation	-	17.45	-
1129	Phosphorylation	SDMPHSPTLRVDRKR CCCCCCCCCCCCCCC	30.15	29255136
1129 (in isoform 2)	Phosphorylation	-	30.15	-
1139	Phosphorylation	VDRKRKVSGDSSHTE CCCCCCCCCCCCCCC	39.66	23401153
1142	Phosphorylation	KRKVSGDSSHTETTA CCCCCCCCCCCCCCH	27.78	30266825
1143	Phosphorylation	RKVSGDSSHTETTAE CCCCCCCCCCCCCHH	38.89	30266825
1145	Phosphorylation	VSGDSSHTETTAEEV CCCCCCCCCCCHHHC	36.65	30266825
1147	Phosphorylation	GDSSHTETTAEEVPE CCCCCCCCCHHHCCC	32.25	23927012
1148	Phosphorylation	DSSHTETTAEEVPED CCCCCCCCHHHCCCC	26.32	23927012
1166	Phosphorylation	KAKRRRVSKDDWPER HHHHHCCCCCCCCHH	28.67	19276368
1223	Phosphorylation	ERWEQQVSAADGKPG HHHHHHHHHCCCCCC	17.25	24719451
1228	Acetylation	QVSAADGKPGRQSRK HHHHCCCCCCCHHHH	44.86	26051181
1235 (in isoform 2)	Phosphorylation	-	62.88	-
1237 (in isoform 2)	Phosphorylation	-	5.58	-
1238	Phosphorylation	RQSRKEVTQATQPEA CHHHHHHHHCCCCCC	17.36	23312004
1241	Phosphorylation	RKEVTQATQPEAIPQ HHHHHHCCCCCCCCC	34.53	23312004
1244 (in isoform 2)	Phosphorylation	-	49.79	-
1250	Phosphorylation	PEAIPQGTNITEEKP CCCCCCCCCCCCCCC	20.42	23312004
1253	Phosphorylation	IPQGTNITEEKPGRK CCCCCCCCCCCCCHH	39.91	23312004
1254 (in isoform 2)	Phosphorylation	-	61.29	-
1256	Acetylation	GTNITEEKPGRKRAE CCCCCCCCCCHHHHH	46.68	26051181
1256	Sumoylation	GTNITEEKPGRKRAE CCCCCCCCCCHHHHH	46.68	28112733
1256 (in isoform 2)	Phosphorylation	-	46.68	-
1268	Ubiquitination	RAEAKGNRSWSEESL HHHHCCCCCCCHHHC	48.44	22817900
1269	Phosphorylation	AEAKGNRSWSEESLK HHHCCCCCCCHHHCC	38.67	25159151
1271	Phosphorylation	AKGNRSWSEESLKPS HCCCCCCCHHHCCCC	32.50	28102081
1271	Ubiquitination	AKGNRSWSEESLKPS HCCCCCCCHHHCCCC	32.50	22817900
1273	Ubiquitination	GNRSWSEESLKPSDN CCCCCCHHHCCCCCC	56.72	21963094
1274	Phosphorylation	NRSWSEESLKPSDNE CCCCCHHHCCCCCCC	37.33	23663014
1277	Ubiquitination	WSEESLKPSDNEQGL CCHHHCCCCCCCCCC	52.81	22817900
1278	Phosphorylation	SEESLKPSDNEQGLP CHHHCCCCCCCCCCC	52.02	20068231
1286	Ubiquitination	DNEQGLPVFSGSPPM CCCCCCCCCCCCCCC	7.78	22817900
1288	Phosphorylation	EQGLPVFSGSPPMKS CCCCCCCCCCCCCCC	38.30	19413330
1289	Ubiquitination	QGLPVFSGSPPMKSL CCCCCCCCCCCCCCC	32.48	22817900
1290	Phosphorylation	GLPVFSGSPPMKSLS CCCCCCCCCCCCCCC	25.32	25159151
1291	Ubiquitination	LPVFSGSPPMKSLSS CCCCCCCCCCCCCCC	36.21	21963094
1295	Phosphorylation	SGSPPMKSLSSTSAG CCCCCCCCCCCCCCC	27.51	26074081
1295	Ubiquitination	SGSPPMKSLSSTSAG CCCCCCCCCCCCCCC	27.51	22817900
1297	Phosphorylation	SPPMKSLSSTSAGGK CCCCCCCCCCCCCCC	38.37	27251275
1297	Ubiquitination	SPPMKSLSSTSAGGK CCCCCCCCCCCCCCC	38.37	29967540
1298	Phosphorylation	PPMKSLSSTSAGGKK CCCCCCCCCCCCCCC	31.51	27251275
1299	Phosphorylation	PMKSLSSTSAGGKKQ CCCCCCCCCCCCCCC	21.15	27251275
1300	Phosphorylation	MKSLSSTSAGGKKQA CCCCCCCCCCCCCCC	27.19	27251275
1302	Ubiquitination	SLSSTSAGGKKQAQP CCCCCCCCCCCCCCC	48.50	22817900
1304	Acetylation	SSTSAGGKKQAQPSC CCCCCCCCCCCCCCC	40.57	25953088
1305	Ubiquitination	STSAGGKKQAQPSCA CCCCCCCCCCCCCCC	54.89	22817900
1307	Ubiquitination	SAGGKKQAQPSCAPA CCCCCCCCCCCCCCC	31.93	21963094
1311	Ubiquitination	KKQAQPSCAPASRPP CCCCCCCCCCCCCCC	7.18	22817900
1314	Ubiquitination	AQPSCAPASRPPAKQ CCCCCCCCCCCCHHH	10.31	29967540
1315	Ubiquitination	QPSCAPASRPPAKQQ CCCCCCCCCCCHHHH	44.24	29967540
1320	Ubiquitination	PASRPPAKQQKIKEN CCCCCCHHHHHHHHC	60.06	22817900
1323	"N6,N6-dimethyllysine"	RPPAKQQKIKENQKT CCCHHHHHHHHCCCC	53.93	-
1323	Methylation	RPPAKQQKIKENQKT CCCHHHHHHHHCCCC	53.93	-
1323	Ubiquitination	RPPAKQQKIKENQKT CCCHHHHHHHHCCCC	53.93	22817900
1325	"N6,N6-dimethyllysine"	PAKQQKIKENQKTDV CHHHHHHHHCCCCCC	58.61	-
1325	Methylation	PAKQQKIKENQKTDV CHHHHHHHHCCCCCC	58.61	-
1325	Ubiquitination	PAKQQKIKENQKTDV CHHHHHHHHCCCCCC	58.61	21963094
1329	Ubiquitination	QKIKENQKTDVLCAD HHHHHCCCCCCEECC	59.27	21906983
1332	Ubiquitination	KENQKTDVLCADEEE HHCCCCCCEECCHHH	5.98	29967540
1345	Phosphorylation	EEDCQAASLLQKYTD HHHHHHHHHHHHHCC	32.40	-
1349	Ubiquitination	QAASLLQKYTDNSEK HHHHHHHHHCCCCCC	50.52	29967540
1366	Ubiquitination	GKRLCKTKHLIPQES CCCCCCCCCCCCHHH	23.16	29967540
1370 (in isoform 2)	Phosphorylation	-	37.94	-
1376 (in isoform 2)	Phosphorylation	-	30.45	-
1380	Phosphorylation	SRRGLPLTGEYYVEN HHCCCCCCEEEEEEC	26.48	28555341
1404	Phosphorylation	FRKRPEPSSDYDLSP ECCCCCCCCCCCCCH	33.89	25159151
1405	Phosphorylation	RKRPEPSSDYDLSPA CCCCCCCCCCCCCHH	51.40	25159151
1407	Phosphorylation	RPEPSSDYDLSPAKQ CCCCCCCCCCCHHHC	22.26	23663014
1408	Neddylation	PEPSSDYDLSPAKQE CCCCCCCCCCHHHCC	45.74	32015554
1408	Ubiquitination	PEPSSDYDLSPAKQE CCCCCCCCCCHHHCC	45.74	23000965
1408 (in isoform 4)	Ubiquitination	-	45.74	21890473
1410	Phosphorylation	PSSDYDLSPAKQEPK CCCCCCCCHHHCCCC	21.66	10997877
1413	Sumoylation	DYDLSPAKQEPKPFD CCCCCHHHCCCCCCH	59.59	28112733
1426	Neddylation	FDRLQQLLPASQSTQ CHHHHHHCCCCCCCC	2.64	32015554
1426	Ubiquitination	FDRLQQLLPASQSTQ CHHHHHHCCCCCCCC	2.64	23000965
1426 (in isoform 2)	Ubiquitination	-	2.64	21890473
1429	Phosphorylation	LQQLLPASQSTQLPC HHHHCCCCCCCCCCC	23.79	30576142
1431	Phosphorylation	QLLPASQSTQLPCSS HHCCCCCCCCCCCCC	18.67	27732954
1432	Phosphorylation	LLPASQSTQLPCSSS HCCCCCCCCCCCCCC	26.87	27732954
1437	Phosphorylation	QSTQLPCSSSPQETT CCCCCCCCCCCCCCC	31.73	23401153
1438	Phosphorylation	STQLPCSSSPQETTQ CCCCCCCCCCCCCCC	53.40	23663014
1439	Phosphorylation	TQLPCSSSPQETTQS CCCCCCCCCCCCCCC	17.82	23663014
1442	Ubiquitination	PCSSSPQETTQSRPM CCCCCCCCCCCCCCC	58.15	23000965
1443	Phosphorylation	CSSSPQETTQSRPMP CCCCCCCCCCCCCCC	25.53	23663014
1444	Phosphorylation	SSSPQETTQSRPMPP CCCCCCCCCCCCCCH	24.64	23663014
1446	Phosphorylation	SPQETTQSRPMPPEA CCCCCCCCCCCCHHH	35.94	23663014
1460	Sumoylation	ARRLIVNKNAGETLL HHHHHEECCHHHHHH	36.96	-
1460	Acetylation	ARRLIVNKNAGETLL HHHHHEECCHHHHHH	36.96	25953088
1460	Neddylation	ARRLIVNKNAGETLL HHHHHEECCHHHHHH	36.96	32015554
1460	Sumoylation	ARRLIVNKNAGETLL HHHHHEECCHHHHHH	36.96	-
1460	Ubiquitination	ARRLIVNKNAGETLL HHHHHEECCHHHHHH	36.96	23000965
1460 (in isoform 1)	Ubiquitination	-	36.96	21890473
1519	Phosphorylation	IVRHLLEYGADVNCS HHHHHHHHCCCCCCC	19.99	-
1526	Phosphorylation	YGADVNCSAQDGTRP HCCCCCCCCCCCCCC	24.62	-
1531	Phosphorylation	NCSAQDGTRPLHDAV CCCCCCCCCCHHHHH	37.09	-
1667	Phosphorylation	PRNWLLLSDVLKKLK CCCEEHHHHHHHHHC	26.16	24719451
1702	Phosphorylation	AEFYRQVSASLLFSC HHHHHHHHHHHHHHC	12.10	21406692
1704	Phosphorylation	FYRQVSASLLFSCSK HHHHHHHHHHHHCCC	20.35	21406692
1708	Phosphorylation	VSASLLFSCSKDLEA HHHHHHHHCCCCHHH	19.90	21406692
1710	Phosphorylation	ASLLFSCSKDLEAFN HHHHHHCCCCHHHHC	28.18	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BCOR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCOR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCOR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AF9_HUMAN	MLLT3	physical	12776190
BCL6_HUMAN	BCL6	physical	10898795
HDAC1_HUMAN	HDAC1	physical	10898795
HDAC3_HUMAN	HDAC3	physical	10898795
HDAC4_HUMAN	HDAC4	physical	10898795
HDAC6_HUMAN	HDAC6	physical	10898795
PCGF1_HUMAN	PCGF1	physical	16943429
KDM2B_HUMAN	KDM2B	physical	16943429
HSP74_HUMAN	HSPA4	physical	16943429
RING1_HUMAN	RING1	physical	16943429
RING2_HUMAN	RNF2	physical	16943429
RYBP_HUMAN	RYBP	physical	16943429
SKP1_HUMAN	SKP1	physical	16943429
BCOR_HUMAN	BCOR	physical	20807888
BCL6_HUMAN	BCL6	physical	18280243
BCL6_HUMAN	BCL6	physical	15004558
NCOR2_HUMAN	NCOR2	physical	23911289
PCGF5_HUMAN	PCGF5	physical	25416956
BCL6_HUMAN	BCL6	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
RING1_HUMAN	RING1	physical	26496610
RING2_HUMAN	RNF2	physical	26496610
TFE2_HUMAN	TCF3	physical	26496610
UBP7_HUMAN	USP7	physical	26496610
KCAB2_HUMAN	KCNAB2	physical	26496610
NFS1_HUMAN	NFS1	physical	26496610
YAF2_HUMAN	YAF2	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610
KDM2B_HUMAN	KDM2B	physical	26496610
PCGF1_HUMAN	PCGF1	physical	26496610
CC124_HUMAN	CCDC124	physical	26496610
ACACB_HUMAN	ACACB	physical	26687479
KAD2_HUMAN	AK2	physical	26687479
ANGE2_HUMAN	ANGEL2	physical	26687479
ATGA1_HUMAN	ATG101	physical	26687479
BCOR_HUMAN	BCOR	physical	26687479
C2D2B_HUMAN	C10orf131	physical	26687479
SGF29_HUMAN	CCDC101	physical	26687479
CDKA1_HUMAN	CDK2AP1	physical	26687479
CISY_HUMAN	CS	physical	26687479
DDB1_HUMAN	DDB1	physical	26687479
DC1L1_HUMAN	DYNC1LI1	physical	26687479
EIF3D_HUMAN	EIF3D	physical	26687479
ERCC8_HUMAN	ERCC8	physical	26687479
IBTK_HUMAN	IBTK	physical	26687479
IDH3G_HUMAN	IDH3G	physical	26687479
ING4_HUMAN	ING4	physical	26687479
ERD22_HUMAN	KDELR2	physical	26687479
KDM2B_HUMAN	KDM2B	physical	26687479
LTMD1_HUMAN	LETMD1	physical	26687479
NAA50_HUMAN	NAA50	physical	26687479
NP1L4_HUMAN	NAP1L4	physical	26687479
CND1_HUMAN	NCAPD2	physical	26687479
NSF_HUMAN	NSF	physical	26687479
OTX2_HUMAN	OTX2	physical	26687479
PCGF1_HUMAN	PCGF1	physical	26687479
PCGF2_HUMAN	PCGF2	physical	26687479
PIMT_HUMAN	PCMT1	physical	26687479
PQBP1_HUMAN	PQBP1	physical	26687479
PCP_HUMAN	PRCP	physical	26687479
RING1_HUMAN	RING1	physical	26687479
RING2_HUMAN	RNF2	physical	26687479
RYBP_HUMAN	RYBP	physical	26687479
SALL1_HUMAN	SALL1	physical	26687479
SATB2_HUMAN	SATB2	physical	26687479
SCAFB_HUMAN	SCAF11	physical	26687479
SENP2_HUMAN	SENP2	physical	26687479
SKP1_HUMAN	SKP1	physical	26687479
SMC4_HUMAN	SMC4	physical	26687479
ELOC_HUMAN	TCEB1	physical	26687479
TCPA_HUMAN	TCP1	physical	26687479
TIA1_HUMAN	TIA1	physical	26687479
TKT_HUMAN	TKT	physical	26687479
TMTC1_HUMAN	TMTC1	physical	26687479
TRPM1_HUMAN	TRPM1	physical	26687479
UBP42_HUMAN	USP42	physical	26687479
UBP7_HUMAN	USP7	physical	26687479
YAF2_HUMAN	YAF2	physical	26687479

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300166: Microphthalmia, syndromic, 2 (MCOPS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-392, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-1139, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-1290, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND SER-1410, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469; SER-473 ANDSER-480, AND MASS SPECTROMETRY.
PubMed: 18187866

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423, AND MASSSPECTROMETRY.
PubMed: 15302935