CDKA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDKA1_HUMAN
• UniProt AC: O14519
• Protein Name: Cyclin-dependent kinase 2-associated protein 1
• Gene Name: CDK2AP1
• Organism: Homo sapiens (Human).
• Sequence Length: 115
• Protein Description: specific inhibitor of the cell-cycle kinase CDK2..
• Protein Sequence: MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYKPNLAA ------CCCCCCHHH	41.69	23532336
21	Phosphorylation	AALNAAGSVHSPSTS HHHHHCCCCCCCCCC	16.36	24732914
24	Phosphorylation	NAAGSVHSPSTSMAT HHCCCCCCCCCCCCC	20.56	25159151
26	Phosphorylation	AGSVHSPSTSMATSS CCCCCCCCCCCCCHH	35.81	24732914
27	Phosphorylation	GSVHSPSTSMATSSQ CCCCCCCCCCCCHHH	26.38	25627689
28	Phosphorylation	SVHSPSTSMATSSQY CCCCCCCCCCCHHHH	15.68	20068231
31	Phosphorylation	SPSTSMATSSQYRQL CCCCCCCCHHHHHHH	21.92	20068231
32	Phosphorylation	PSTSMATSSQYRQLL CCCCCCCHHHHHHHH	13.10	20068231
33	Phosphorylation	STSMATSSQYRQLLS CCCCCCHHHHHHHHH	27.20	28634298
35	Phosphorylation	SMATSSQYRQLLSDY CCCCHHHHHHHHHHH	11.41	20068231
46	Phosphorylation	LSDYGPPSLGYTQGT HHHHCCCCCCCCCCC	37.24	24173317
57	Ubiquitination	TQGTGNSQVPQSKYA CCCCCCCCCCHHHHH	55.71	29967540
80	Phosphorylation	LGKEIRPTYAGSKSA HHHHHCCCCCCCHHH	19.02	21406692
81	Phosphorylation	GKEIRPTYAGSKSAM HHHHCCCCCCCHHHH	16.20	21406692
84	Phosphorylation	IRPTYAGSKSAMERL HCCCCCCCHHHHHHH	18.44	28152594
85	Ubiquitination	RPTYAGSKSAMERLK CCCCCCCHHHHHHHH	41.12	29967540
86	Phosphorylation	PTYAGSKSAMERLKR CCCCCCHHHHHHHHH	34.25	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
46	S	Phosphorylation	Kinase	IKBKE	Q14164	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
46	S	Phosphorylation	Phosphorylated in vitro by IKBKE at Ser-46.	22427660

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDKA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMY1_HUMAN	AMY1A	physical	17353931
CDK2_HUMAN	CDK2	physical	10938106
DPOLA_HUMAN	POLA1	physical	10877824
HDAC1_HUMAN	HDAC1	physical	20523938
HDAC2_HUMAN	HDAC2	physical	20523938
RBBP7_HUMAN	RBBP7	physical	20523938
RBBP4_HUMAN	RBBP4	physical	20523938
MBD3_HUMAN	MBD3	physical	20523938
MBD2_HUMAN	MBD2	physical	20523938
CDKA2_HUMAN	CDK2AP2	physical	14985111
ZN420_HUMAN	ZNF420	physical	21988832
CC136_HUMAN	CCDC136	physical	25416956
MR1L1_HUMAN	MRFAP1L1	physical	25416956
ALDOA_HUMAN	ALDOA	physical	26496610
CHD3_HUMAN	CHD3	physical	26496610
CHD4_HUMAN	CHD4	physical	26496610
ERCC6_HUMAN	ERCC6	physical	26496610
HDAC1_HUMAN	HDAC1	physical	26496610
HDAC2_HUMAN	HDAC2	physical	26496610
RBBP4_HUMAN	RBBP4	physical	26496610
RBBP7_HUMAN	RBBP7	physical	26496610
RS15_HUMAN	RPS15	physical	26496610
TCF20_HUMAN	TCF20	physical	26496610
TRPS1_HUMAN	TRPS1	physical	26496610
XRCC1_HUMAN	XRCC1	physical	26496610
MBD2_HUMAN	MBD2	physical	26496610
MTA1_HUMAN	MTA1	physical	26496610
MTA2_HUMAN	MTA2	physical	26496610
PHF14_HUMAN	PHF14	physical	26496610
HM20A_HUMAN	HMG20A	physical	26496610
RAI1_HUMAN	RAI1	physical	26496610
PKCB1_HUMAN	ZMYND8	physical	26496610
IMA7_HUMAN	KPNA6	physical	26496610
ZBT7B_HUMAN	ZBTB7B	physical	26496610
SHLB1_HUMAN	SH3GLB1	physical	26496610
ZN219_HUMAN	ZNF219	physical	26496610
ESF1_HUMAN	ESF1	physical	26496610
MBD3_HUMAN	MBD3	physical	26496610
P66A_HUMAN	GATAD2A	physical	26496610
DDX60_HUMAN	DDX60	physical	26496610
TSR1_HUMAN	TSR1	physical	26496610
TM165_HUMAN	TMEM165	physical	26496610
P66B_HUMAN	GATAD2B	physical	26496610
MTA3_HUMAN	MTA3	physical	26496610
ZN687_HUMAN	ZNF687	physical	26496610
ZBTB2_HUMAN	ZBTB2	physical	26496610
CSN7B_HUMAN	COPS7B	physical	26496610
MEP50_HUMAN	WDR77	physical	26496610
PGBD3_HUMAN	PGBD3	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.