dbPTM

ESF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ESF1_HUMAN
UniProt AC	Q9H501
Protein Name	ESF1 homolog
Gene Name	ESF1
Organism	Homo sapiens (Human).
Sequence Length	851
Subcellular Localization	Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein Description	May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)..
Protein Sequence	MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQKVK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSKQEIMS ------CCCHHHHHC	46.36	22814378
2	Phosphorylation	------MSSKQEIMS ------CCCHHHHHC	46.36	22964224
4	Sumoylation	----MSSKQEIMSDQ ----CCCHHHHHCCH	44.64	-
4	Acetylation	----MSSKQEIMSDQ ----CCCHHHHHCCH	44.64	22424773
4	Sumoylation	----MSSKQEIMSDQ ----CCCHHHHHCCH	44.64	-
4	Ubiquitination	----MSSKQEIMSDQ ----CCCHHHHHCCH	44.64	22505724
9	Phosphorylation	SSKQEIMSDQRFRRV CCHHHHHCCHHHHHH	35.93	23401153
28	Ubiquitination	RFWEMPEKDRKVKID CHHCCCCCCCCCHHC	57.89	-
51	Phosphorylation	DKKFKLNYAVDKRGR CCCCEEEEEECCCCC	20.59	-
55	2-Hydroxyisobutyrylation	KLNYAVDKRGRPISH EEEEEECCCCCCCCC	50.59	-
55	Ubiquitination	KLNYAVDKRGRPISH EEEEEECCCCCCCCC	50.59	21906983
61	Phosphorylation	DKRGRPISHSTTEDL CCCCCCCCCCCHHHH	17.67	28555341
63	Phosphorylation	RGRPISHSTTEDLKR CCCCCCCCCHHHHHH	30.18	28555341
69	Ubiquitination	HSTTEDLKRFYDLSD CCCHHHHHHHHCCCC	53.43	21906983
72	Phosphorylation	TEDLKRFYDLSDSDS HHHHHHHHCCCCCCC	21.73	30108239
75	Phosphorylation	LKRFYDLSDSDSNLS HHHHHCCCCCCCCCC	31.97	26503892
77	Phosphorylation	RFYDLSDSDSNLSGE HHHCCCCCCCCCCHH	39.29	26503892
79	Phosphorylation	YDLSDSDSNLSGEDS HCCCCCCCCCCHHHH	43.55	26503892
82	Phosphorylation	SDSDSNLSGEDSKAL CCCCCCCCHHHHHHH	44.37	26503892
86	Phosphorylation	SNLSGEDSKALSQKK CCCCHHHHHHHHHHH	18.61	22115753
90	Phosphorylation	GEDSKALSQKKIKKK HHHHHHHHHHHHHHC	44.83	18669648
108	Sumoylation	TKKEIDSKNLVEKKK CHHHHHHHHHHHHHH	51.02	-
108	Sumoylation	TKKEIDSKNLVEKKK CHHHHHHHHHHHHHH	51.02	-
108	Ubiquitination	TKKEIDSKNLVEKKK CHHHHHHHHHHHHHH	51.02	-
123	Ubiquitination	ETKKANHKGSENKTD HHHHCCCCCCCCCCC	65.03	22817900
125	Phosphorylation	KKANHKGSENKTDLD HHCCCCCCCCCCCCC	42.68	23186163
128	Acetylation	NHKGSENKTDLDNSI CCCCCCCCCCCCCCC	39.09	21339330
128	Ubiquitination	NHKGSENKTDLDNSI CCCCCCCCCCCCCCC	39.09	22817900
134	Phosphorylation	NKTDLDNSIGIKKMK CCCCCCCCCCHHCCC	23.12	25159151
138	Acetylation	LDNSIGIKKMKTSCK CCCCCCHHCCCCCCE	41.42	25953088
138	Ubiquitination	LDNSIGIKKMKTSCK CCCCCCHHCCCCCCE	41.42	-
139	Acetylation	DNSIGIKKMKTSCKF CCCCCHHCCCCCCEE	43.65	11924517
150	Phosphorylation	SCKFKIDSNISPKKD CCEEEECCCCCCCCC	39.27	23927012
153	Phosphorylation	FKIDSNISPKKDSKE EEECCCCCCCCCHHH	34.61	29255136
158	Phosphorylation	NISPKKDSKEFTQKN CCCCCCCHHHHHHHH	42.86	26074081
166	Ubiquitination	KEFTQKNKKEKKNIV HHHHHHHHHHHHHHH	70.15	22817900
167	Ubiquitination	EFTQKNKKEKKNIVQ HHHHHHHHHHHHHHH	81.70	22817900
169	Ubiquitination	TQKNKKEKKNIVQHT HHHHHHHHHHHHHHC	61.06	22817900
170	Sumoylation	QKNKKEKKNIVQHTT HHHHHHHHHHHHHCC	53.66	-
170	Sumoylation	QKNKKEKKNIVQHTT HHHHHHHHHHHHHCC	53.66	-
170	Ubiquitination	QKNKKEKKNIVQHTT HHHHHHHHHHHHHCC	53.66	21906983
176	Phosphorylation	KKNIVQHTTDSSLEE HHHHHHHCCCCCHHH	18.40	25159151
177	Phosphorylation	KNIVQHTTDSSLEEK HHHHHHCCCCCHHHH	31.59	29255136
179	Phosphorylation	IVQHTTDSSLEEKQR HHHHCCCCCHHHHHH	34.43	29255136
180	Phosphorylation	VQHTTDSSLEEKQRT HHHCCCCCHHHHHHH	42.48	29255136
184	Acetylation	TDSSLEEKQRTLDSG CCCCHHHHHHHCCCC	35.39	20167786
184	Ubiquitination	TDSSLEEKQRTLDSG CCCCHHHHHHHCCCC	35.39	21906983
187	Phosphorylation	SLEEKQRTLDSGTSE CHHHHHHHCCCCCCH	32.21	23927012
190	Phosphorylation	EKQRTLDSGTSEIVK HHHHHCCCCCCHHHC	47.27	23927012
192	Phosphorylation	QRTLDSGTSEIVKSP HHHCCCCCCHHHCCC	27.43	30278072
193	Phosphorylation	RTLDSGTSEIVKSPR HHCCCCCCHHHCCCC	28.93	30278072
197	Acetylation	SGTSEIVKSPRIECS CCCCHHHCCCCCCCC	61.47	26051181
197	Ubiquitination	SGTSEIVKSPRIECS CCCCHHHCCCCCCCC	61.47	21906983
198	Phosphorylation	GTSEIVKSPRIECSK CCCHHHCCCCCCCCH	14.44	29255136
204	Phosphorylation	KSPRIECSKTRREMQ CCCCCCCCHHHHHHH	25.03	26074081
212	Phosphorylation	KTRREMQSVVQLIMT HHHHHHHHHHHHHHC	23.97	-
219	Phosphorylation	SVVQLIMTRDSDGYE HHHHHHHCCCCCCCC	25.08	28102081
222	Phosphorylation	QLIMTRDSDGYENST HHHHCCCCCCCCCCC	29.64	23663014
225	Phosphorylation	MTRDSDGYENSTDGE HCCCCCCCCCCCCCC	19.54	28985074
228	Phosphorylation	DSDGYENSTDGEMCD CCCCCCCCCCCCCCC	18.88	23927012
229	Phosphorylation	SDGYENSTDGEMCDK CCCCCCCCCCCCCCH	60.65	23927012
272	Phosphorylation	ASGDDDGSEDDEEED CCCCCCCCCCCCCCC	44.86	28290473
290	Phosphorylation	EEDEDEDSEDDDKSD CCCCCCCCCCCCCCC	40.66	28290473
296	Phosphorylation	DSEDDDKSDSGPDLA CCCCCCCCCCCCCHH	43.96	25159151
298	Phosphorylation	EDDDKSDSGPDLARG CCCCCCCCCCCHHCC	60.35	20164059
311	Phosphorylation	RGKGNIETSSEDEDD CCCCCCCCCCCCCCC	33.48	26503892
312	Phosphorylation	GKGNIETSSEDEDDT CCCCCCCCCCCCCCH	20.95	26503892
313	Phosphorylation	KGNIETSSEDEDDTA CCCCCCCCCCCCCHH	57.39	26503892
319	Phosphorylation	SSEDEDDTADLFPEE CCCCCCCHHHCCCCC	34.10	22115753
327	Phosphorylation	ADLFPEESGFEHAWR HHCCCCCCCHHHHHH	47.31	20873877
381	Phosphorylation	PKGGVIFSVKIYPSE CCCCEEEEEEECHHH	16.04	20068231
387	Phosphorylation	FSVKIYPSEFGKERM EEEEECHHHHCHHHH	28.69	20068231
391	Ubiquitination	IYPSEFGKERMKEEQ ECHHHHCHHHHHHHH	47.68	22817900
395	Ubiquitination	EFGKERMKEEQVQGP HHCHHHHHHHHHCCC	65.41	22817900
407	Phosphorylation	QGPVELLSIPEDAPE CCCEEHHCCCCCCCC	49.04	30576142
415	Ubiquitination	IPEDAPEKDWTSREK CCCCCCCCCCCCHHH	58.46	21906983
432	Acetylation	DYQFKRLKYYYAVVD HHHHHCCEEEEEEEE	34.93	26051181
442	Phosphorylation	YAVVDCDSPETASKI EEEEECCCHHHHHHH	30.85	25627689
445	Phosphorylation	VDCDSPETASKIYED EECCCHHHHHHHHHC	39.35	30576142
461	Phosphorylation	DGLEFESSCSFIDLR CCCEEECCCEEEEEE	13.44	30576142
463	Phosphorylation	LEFESSCSFIDLRFI CEEECCCEEEEEEEC	27.47	30576142
485	Phosphorylation	DEPKDVASEVNLTAY CCCCCHHHHCCCCEE	41.76	20873877
490	Phosphorylation	VASEVNLTAYKPKYF HHHHCCCCEECCCCE	23.80	20860994
492	Phosphorylation	SEVNLTAYKPKYFTS HHCCCCEECCCCEEC	23.69	20860994
493	Acetylation	EVNLTAYKPKYFTSA HCCCCEECCCCEECC	32.35	25953088
493	Ubiquitination	EVNLTAYKPKYFTSA HCCCCEECCCCEECC	32.35	29967540
569	Ubiquitination	VEEDGKTKKSQKDDE CCCCCCCCCCCCCHH	54.64	22817900
570	Ubiquitination	EEDGKTKKSQKDDEE CCCCCCCCCCCCHHH	64.45	22817900
573	Ubiquitination	GKTKKSQKDDEEQIA CCCCCCCCCHHHHHH	74.39	22817900
581	Acetylation	DDEEQIAKYRQLLQV CHHHHHHHHHHHHHH	42.46	26051181
581	Ubiquitination	DDEEQIAKYRQLLQV CHHHHHHHHHHHHHH	42.46	21906983
592	Ubiquitination	LLQVIQEKEKKGKEN HHHHHHHHHHCCCCC	59.46	29967540
597	Ubiquitination	QEKEKKGKENDMEME HHHHHCCCCCCCHHH	63.32	-
612	Ubiquitination	IKWVPGLKESAEEMV EEECCCCHHHHHHHH	56.38	-
614	Phosphorylation	WVPGLKESAEEMVKN ECCCCHHHHHHHHHH	39.12	23186163
626	Ubiquitination	VKNKLEGKDKLTPWE HHHHHCCCCCCCHHH	42.17	22817900
628	Ubiquitination	NKLEGKDKLTPWEQF HHHCCCCCCCHHHHH	58.72	21906983
630	Phosphorylation	LEGKDKLTPWEQFLE HCCCCCCCHHHHHHH	31.90	25159151
657	Phosphorylation	KALAEEASEEELPSD HHHHHHHCCCCCCCC	49.15	29255136
663	Phosphorylation	ASEEELPSDVDLNDP HCCCCCCCCCCCCCH	63.99	29255136
671	Phosphorylation	DVDLNDPYFAEEVKQ CCCCCCHHHHHHHHH	20.48	29255136
687	Ubiquitination	GINKKSVKSAKDGTS CCCHHHHCCCCCCCC	52.35	22817900
688	Phosphorylation	INKKSVKSAKDGTSP CCHHHHCCCCCCCCH	38.09	24732914
690	Acetylation	KKSVKSAKDGTSPEE HHHHCCCCCCCCHHH	64.88	26051181
690	Ubiquitination	KKSVKSAKDGTSPEE HHHHCCCCCCCCHHH	64.88	22817900
693	Phosphorylation	VKSAKDGTSPEEEIE HCCCCCCCCHHHHHH	51.77	25159151
694	Phosphorylation	KSAKDGTSPEEEIEI CCCCCCCCHHHHHHH	35.52	25159151
719	Phosphorylation	MMDEDEDSKKHFNYN HCCCCCHHHHHCCHH	41.37	27251275
720	Acetylation	MDEDEDSKKHFNYNK CCCCCHHHHHCCHHH	63.69	30588581
721	Acetylation	DEDEDSKKHFNYNKI CCCCHHHHHCCHHHH	58.33	30588587
721	Ubiquitination	DEDEDSKKHFNYNKI CCCCHHHHHCCHHHH	58.33	29967540
727	Ubiquitination	KKHFNYNKIVEHQNL HHHCCHHHHHHCCCC	37.46	29967540
735	Phosphorylation	IVEHQNLSKKKKKQL HHHCCCCCHHHHHHH	50.40	25159151
736	2-Hydroxyisobutyrylation	VEHQNLSKKKKKQLM HHCCCCCHHHHHHHH	72.31	-
766	Phosphorylation	DARFQAMYTSHLFNL HHHHHHHHHHHHHCC	14.22	24043423
767	Phosphorylation	ARFQAMYTSHLFNLD HHHHHHHHHHHHCCC	9.15	24043423
768	Phosphorylation	RFQAMYTSHLFNLDP HHHHHHHHHHHCCCC	10.74	24043423
776	Phosphorylation	HLFNLDPSDPNFKKT HHHCCCCCCCCHHHH	66.42	24719451
781	Acetylation	DPSDPNFKKTKAMEK CCCCCCHHHHHHHHH	67.20	24431643
783	Phosphorylation	SDPNFKKTKAMEKIL CCCCHHHHHHHHHHH	25.32	20068231
793	2-Hydroxyisobutyrylation	MEKILEEKARQRERK HHHHHHHHHHHHHHH	39.22	-
793	Ubiquitination	MEKILEEKARQRERK HHHHHHHHHHHHHHH	39.22	-
800	Ubiquitination	KARQRERKEQELTQA HHHHHHHHHHHHHHH	60.02	-
805	Phosphorylation	ERKEQELTQAIKKKE HHHHHHHHHHHHHHH	18.40	20068231
809	Ubiquitination	QELTQAIKKKESEIE HHHHHHHHHHHHHHH	61.89	22817900
810	Ubiquitination	ELTQAIKKKESEIEK HHHHHHHHHHHHHHH	56.51	22817900
811	Ubiquitination	LTQAIKKKESEIEKE HHHHHHHHHHHHHHH	62.56	22817900
817	Ubiquitination	KKESEIEKESQRKSI HHHHHHHHHHHHCCH	69.22	-
819	Phosphorylation	ESEIEKESQRKSIDP HHHHHHHHHHCCHHH	46.48	21712546
822	Ubiquitination	IEKESQRKSIDPALS HHHHHHHCCHHHHHH	44.09	29967540
823	Phosphorylation	EKESQRKSIDPALSM HHHHHHCCHHHHHHH	34.12	29255136
829	Phosphorylation	KSIDPALSMLIKSIK CCHHHHHHHHHHHHH	17.41	29396449
830	Sulfoxidation	SIDPALSMLIKSIKT CHHHHHHHHHHHHHH	4.70	21406390
838	Sumoylation	LIKSIKTKTEQFQAR HHHHHHHHHHHHHHH	45.09	-
838	Sumoylation	LIKSIKTKTEQFQAR HHHHHHHHHHHHHHH	45.09	-
838	Ubiquitination	LIKSIKTKTEQFQAR HHHHHHHHHHHHHHH	45.09	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ESF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ESF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ESF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AATF_HUMAN	AATF	physical	26344197
DDX52_HUMAN	DDX52	physical	26344197
PUM3_HUMAN	KIAA0020	physical	26344197
MPP10_HUMAN	MPHOSPH10	physical	26344197
SEPT7_HUMAN	SEPT7	physical	26344197
SAS10_HUMAN	UTP3	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ESF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-77; SER-79;SER-82; SER-153; SER-657; SER-663 AND SER-694, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153; SER-657 ANDSER-663, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-77; SER-79;SER-82; SER-90; SER-153; SER-179; SER-180; SER-198; THR-311; SER-312;SER-313; SER-657; SER-663; THR-693; SER-694 AND SER-823, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-298 ANDTHR-693, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657; SER-663 ANDSER-694, AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-77; SER-79;SER-82; SER-153; SER-296; SER-298; THR-311; SER-312; SER-313; SER-657AND SER-663, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND MASSSPECTROMETRY.	15302935 [Abstract]