| UniProt ID | PUM3_HUMAN | |
|---|---|---|
| UniProt AC | Q15397 | |
| Protein Name | Pumilio homolog 3 {ECO:0000305} | |
| Gene Name | PUM3 {ECO:0000312|HGNC:HGNC:29676} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 648 | |
| Subcellular Localization | Nucleus, nucleolus . Nucleus, nucleoplasm . Chromosome . Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm. | |
| Protein Description | Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. [PubMed: 21266351 Binds to double-stranded RNA or DNA without sequence specificity] | |
| Protein Sequence | MEVKGKKQFTGKSTKTAQEKNRFHKNSDSGSSKTFPTRKVAKEGGPKVTSRNFEKSITKLGKKGVKQFKNKQQGDKSPKNKFQPANKFNKKRKFQPDGRSDESAAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKQMWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQYGNEEQRKQAFEELRDDLVELSKAKYSRNIVKKFLMYGSKPQIAEIIRSFKGHVRKMLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHRTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIISSLPSIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEVRRRELLESISPALLSYLQEHAQEVVLDKSACVLVSDILGSATGDVQPTMNAIASLAATGLHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKENGREGCFAKTLVEHVGMKNLKSWASVNRGAIILSSLLQSCDLEVANKVKAALKSLIPTLEKTKSTSKGIEILLEKLST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Ubiquitination | ----MEVKGKKQFTG ----CCCCCCCCCCC | 24816145 | ||
| 12 | Acetylation | GKKQFTGKSTKTAQE CCCCCCCCCCCHHHH | 25953088 | ||
| 13 | O-linked_Glycosylation | KKQFTGKSTKTAQEK CCCCCCCCCCHHHHH | 30379171 | ||
| 27 | Phosphorylation | KNRFHKNSDSGSSKT HHCCCCCCCCCCCCC | 24719451 | ||
| 29 | Phosphorylation | RFHKNSDSGSSKTFP CCCCCCCCCCCCCCC | 26055452 | ||
| 33 | Acetylation | NSDSGSSKTFPTRKV CCCCCCCCCCCCHHH | 25953088 | ||
| 34 | Phosphorylation | SDSGSSKTFPTRKVA CCCCCCCCCCCHHHH | - | ||
| 37 | Phosphorylation | GSSKTFPTRKVAKEG CCCCCCCCHHHHHCC | - | ||
| 39 | Methylation | SKTFPTRKVAKEGGP CCCCCCHHHHHCCCC | 116252747 | ||
| 42 | Ubiquitination | FPTRKVAKEGGPKVT CCCHHHHHCCCCCCC | 24816145 | ||
| 49 | Phosphorylation | KEGGPKVTSRNFEKS HCCCCCCCCCCHHHH | 29083192 | ||
| 50 | Phosphorylation | EGGPKVTSRNFEKSI CCCCCCCCCCHHHHH | 29083192 | ||
| 56 | Phosphorylation | TSRNFEKSITKLGKK CCCCHHHHHHHHHHH | 24719451 | ||
| 66 | Ubiquitination | KLGKKGVKQFKNKQQ HHHHHHHHHHCCCCC | 30230243 | ||
| 71 | Acetylation | GVKQFKNKQQGDKSP HHHHHCCCCCCCCCC | 7708281 | ||
| 77 | Phosphorylation | NKQQGDKSPKNKFQP CCCCCCCCCCCCCCC | 27422710 | ||
| 79 | Acetylation | QQGDKSPKNKFQPAN CCCCCCCCCCCCCCH | 7708291 | ||
| 87 | Acetylation | NKFQPANKFNKKRKF CCCCCCHHCCCCCCC | 25953088 | ||
| 100 | Phosphorylation | KFQPDGRSDESAAKK CCCCCCCCCHHHHHC | 25159151 | ||
| 103 | Phosphorylation | PDGRSDESAAKKPKW CCCCCCHHHHHCCCH | 25159151 | ||
| 106 | Acetylation | RSDESAAKKPKWDDF CCCHHHHHCCCHHHH | 20167786 | ||
| 107 | Acetylation | SDESAAKKPKWDDFK CCHHHHHCCCHHHHH | 20167786 | ||
| 114 | Acetylation | KPKWDDFKKKKKELK CCCHHHHHHHHHHHH | 20167786 | ||
| 129 | Ubiquitination | QSRQLSDKTNYDIVV HHHCCCCCCCHHHHH | - | ||
| 139 | Ubiquitination | YDIVVRAKQMWEILR HHHHHHHHHHHHHHH | - | ||
| 152 | Ubiquitination | LRRKDCDKEKRVKLM HHCCCCCHHHHHHHH | 24816145 | ||
| 164 | Acetylation | KLMSDLQKLIQGKIK HHHHHHHHHHCCCCC | 25825284 | ||
| 164 | Ubiquitination | KLMSDLQKLIQGKIK HHHHHHHHHHCCCCC | 29967540 | ||
| 171 | 2-Hydroxyisobutyrylation | KLIQGKIKTIAFAHD HHHCCCCCEEEECCC | - | ||
| 196 | Ubiquitination | YGNEEQRKQAFEELR CCCHHHHHHHHHHHH | 29967540 | ||
| 211 | Ubiquitination | DDLVELSKAKYSRNI HHHHHHHHHHHHHHH | 29967540 | ||
| 221 | Malonylation | YSRNIVKKFLMYGSK HHHHHHHHHHHHCCC | 26320211 | ||
| 221 | Ubiquitination | YSRNIVKKFLMYGSK HHHHHHHHHHHHCCC | - | ||
| 227 | Phosphorylation | KKFLMYGSKPQIAEI HHHHHHCCCHHHHHH | 23909892 | ||
| 228 | Acetylation | KFLMYGSKPQIAEII HHHHHCCCHHHHHHH | 26051181 | ||
| 228 | Ubiquitination | KFLMYGSKPQIAEII HHHHHCCCHHHHHHH | - | ||
| 237 | Phosphorylation | QIAEIIRSFKGHVRK HHHHHHHHCHHHHHH | 27067055 | ||
| 239 | 2-Hydroxyisobutyrylation | AEIIRSFKGHVRKML HHHHHHCHHHHHHHH | - | ||
| 257 | Phosphorylation | EASAIVEYAYNDKAI HHHHHHHHHHCCHHH | 18083107 | ||
| 259 | Phosphorylation | SAIVEYAYNDKAILE HHHHHHHHCCHHHHH | 25884760 | ||
| 262 | 2-Hydroxyisobutyrylation | VEYAYNDKAILEQRN HHHHHCCHHHHHHHH | - | ||
| 276 | Phosphorylation | NMLTEELYGNTFQLY HCCHHHHHCCHHHHH | - | ||
| 279 | Phosphorylation | TEELYGNTFQLYKSA HHHHHCCHHHHHHCC | - | ||
| 283 | Phosphorylation | YGNTFQLYKSADHRT HCCHHHHHHCCCCCC | - | ||
| 284 | Ubiquitination | GNTFQLYKSADHRTL CCHHHHHHCCCCCCH | 29967540 | ||
| 285 | Phosphorylation | NTFQLYKSADHRTLD CHHHHHHCCCCCCHH | - | ||
| 290 | Phosphorylation | YKSADHRTLDKVLEV HHCCCCCCHHHHHHC | 20860994 | ||
| 293 | Ubiquitination | ADHRTLDKVLEVQPE CCCCCHHHHHHCCHH | 29967540 | ||
| 293 | 2-Hydroxyisobutyrylation | ADHRTLDKVLEVQPE CCCCCHHHHHHCCHH | - | ||
| 301 | Acetylation | VLEVQPEKLELIMDE HHHCCHHHHHHHHHH | 26051181 | ||
| 301 | Ubiquitination | VLEVQPEKLELIMDE HHHCCHHHHHHHHHH | 29967540 | ||
| 301 | 2-Hydroxyisobutyrylation | VLEVQPEKLELIMDE HHHCCHHHHHHHHHH | - | ||
| 314 | Phosphorylation | DEMKQILTPMAQKEA HHHHHHHCHHHHHHH | - | ||
| 319 | Ubiquitination | ILTPMAQKEAVIKHS HHCHHHHHHHHHHHH | 29967540 | ||
| 324 | Ubiquitination | AQKEAVIKHSLVHKV HHHHHHHHHHHHHHH | 29967540 | ||
| 342 | Ubiquitination | FFTYAPPKLRSEMIE HHHCCCHHHHHHHHH | - | ||
| 357 | Phosphorylation | AIREAVVYLAHTHDG HHHHHHHHHHHCCCC | - | ||
| 386 | Phosphorylation | DRKVIVKTMKTYVEK CCCHHHHHHHHHHHH | - | ||
| 427 | Phosphorylation | IIISEIISSLPSIVN HHHHHHHHCCHHHHC | - | ||
| 436 | Ubiquitination | LPSIVNDKYGRKVLL CHHHHCCCCCCEEEE | - | ||
| 447 | Phosphorylation | KVLLYLLSPRDPAHT EEEEHHHCCCCHHHH | 24719451 | ||
| 464 | Ubiquitination | EIIEVLQKGDGNAHS HHHHHHHCCCCCCCC | 29967540 | ||
| 473 | Ubiquitination | DGNAHSKKDTEVRRR CCCCCCCCCHHHHHH | 24816145 | ||
| 487 | Phosphorylation | RELLESISPALLSYL HHHHHHHHHHHHHHH | - | ||
| 506 | Phosphorylation | QEVVLDKSACVLVSD HHHHCCHHHHHHHHH | - | ||
| 512 | Phosphorylation | KSACVLVSDILGSAT HHHHHHHHHHHCCCC | - | ||
| 517 | Phosphorylation | LVSDILGSATGDVQP HHHHHHCCCCCCCHH | - | ||
| 519 | Phosphorylation | SDILGSATGDVQPTM HHHHCCCCCCCHHHH | - | ||
| 566 | Acetylation | KWLIEQDKKMKENGR HHHHHHHHHHHHHCC | 25953088 | ||
| 579 | Acetylation | GREGCFAKTLVEHVG CCCCCHHHHHHHHHC | 26051181 | ||
| 579 | Ubiquitination | GREGCFAKTLVEHVG CCCCCHHHHHHHHHC | 29967540 | ||
| 588 | Acetylation | LVEHVGMKNLKSWAS HHHHHCCCCCHHHHC | 25953088 | ||
| 588 | Ubiquitination | LVEHVGMKNLKSWAS HHHHHCCCCCHHHHC | 29967540 | ||
| 591 | Acetylation | HVGMKNLKSWASVNR HHCCCCCHHHHCCCH | 25953088 | ||
| 591 | Ubiquitination | HVGMKNLKSWASVNR HHCCCCCHHHHCCCH | - | ||
| 591 | Malonylation | HVGMKNLKSWASVNR HHCCCCCHHHHCCCH | 26320211 | ||
| 592 | Phosphorylation | VGMKNLKSWASVNRG HCCCCCHHHHCCCHH | 24719451 | ||
| 595 | Phosphorylation | KNLKSWASVNRGAII CCCHHHHCCCHHHHH | 20860994 | ||
| 619 | Ubiquitination | LEVANKVKAALKSLI HHHHHHHHHHHHHHH | - | ||
| 623 | Ubiquitination | NKVKAALKSLIPTLE HHHHHHHHHHHHHHH | 29967540 | ||
| 623 | Acetylation | NKVKAALKSLIPTLE HHHHHHHHHHHHHHH | 26051181 | ||
| 637 | Ubiquitination | EKTKSTSKGIEILLE HHHCCCCHHHHHHHH | 29967540 | ||
| 645 | Ubiquitination | GIEILLEKLST---- HHHHHHHHHCC---- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PUM3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PUM3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
| 12 | Acetylation | 13 (1) | S ⇒ N | rs10968457 |
| 23251661 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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