WDR36_HUMAN - dbPTM
WDR36_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR36_HUMAN
UniProt AC Q8NI36
Protein Name WD repeat-containing protein 36
Gene Name WDR36
Organism Homo sapiens (Human).
Sequence Length 951
Subcellular Localization Nucleus, nucleolus .
Protein Description Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2..
Protein Sequence MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTCQTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALFLKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationCLQLWQRTVPLDTLK
HHHHHCCCCCHHHHC		16.0424719451
44PhosphorylationGLGTCFPSGPELRGA
CCCCCCCCCHHHCHH		46.8824719451
67O-linked_GlycosylationASERRTASALFAGFR
HHHHHHHHHHHHHHH		25.5428510447
97PhosphorylationSALKRRFYVTTCVGK
HHHCCEEEEEEEECC		8.6228509920
99PhosphorylationLKRRFYVTTCVGKSF
HCCEEEEEEEECCCC		11.7828509920
159UbiquitinationKEIVHTFKGHKAEIH
CCEEEEECCCCEEEE		62.3529967540
159AcetylationKEIVHTFKGHKAEIH
CCEEEEECCCCEEEE		62.3525825284
224PhosphorylationLNKILLGSEQGSLQL
HHHHHHCCCCCCEEE		27.0719845377
235AcetylationSLQLWNVKSNKLLYT
CEEEEEECCCCEEEE		45.1326051181
235UbiquitinationSLQLWNVKSNKLLYT
CEEEEEECCCCEEEE		45.1321906983
236PhosphorylationLQLWNVKSNKLLYTF
EEEEEECCCCEEEEE		34.6129083192
238AcetylationLWNVKSNKLLYTFPG
EEEECCCCEEEEECC		47.1326051181
238UbiquitinationLWNVKSNKLLYTFPG
EEEECCCCEEEEECC		47.1322817900
241PhosphorylationVKSNKLLYTFPGWKV
ECCCCEEEEECCCCC		19.4419845377
242PhosphorylationKSNKLLYTFPGWKVG
CCCCEEEEECCCCCC		24.2719845377
284UbiquitinationKFNETLMKFRQDWGP
EECHHHHHHHCCCCC		40.2723000965
284AcetylationKFNETLMKFRQDWGP
EECHHHHHHHCCCCC		40.2727452117
284UbiquitinationKFNETLMKFRQDWGP
EECHHHHHHHCCCCC		40.2721890473
293PhosphorylationRQDWGPITSISFRTD
HCCCCCCCEEEEECC		24.1220068231
296PhosphorylationWGPITSISFRTDGHP
CCCCCEEEEECCCCE		14.4024719451
322AcetylationGLWDLEDKKLINQMR
EECCCCCHHHHHHHH		39.8526051181
322UbiquitinationGLWDLEDKKLINQMR
EECCCCCHHHHHHHH		39.8523503661
323UbiquitinationLWDLEDKKLINQMRN
ECCCCCHHHHHHHHH		67.9123503661
333PhosphorylationNQMRNAHSTAIAGLT
HHHHHHHHHHHHHCE		19.6820068231
334PhosphorylationQMRNAHSTAIAGLTF
HHHHHHHHHHHHCEE		16.5321406692
340PhosphorylationSTAIAGLTFLHREPL
HHHHHHCEEECCCCE		24.1920068231
413UbiquitinationSFSTVHEKFNKSLGH
CHHHHHHHHHHHHCC		39.0821890473
413UbiquitinationSFSTVHEKFNKSLGH
CHHHHHHHHHHHHCC		39.0821906983
413AcetylationSFSTVHEKFNKSLGH
CHHHHHHHHHHHHCC		39.0826051181
416MethylationTVHEKFNKSLGHGLI
HHHHHHHHHHCCCCC		50.6383048793
416UbiquitinationTVHEKFNKSLGHGLI
HHHHHHHHHHCCCCC		50.6322817900
4252-HydroxyisobutyrylationLGHGLINKKRVKRKG
HCCCCCCHHHHHCCC		34.66-
425UbiquitinationLGHGLINKKRVKRKG
HCCCCCCHHHHHCCC		34.6629967540
425AcetylationLGHGLINKKRVKRKG
HCCCCCCHHHHHCCC		34.6623236377
426UbiquitinationGHGLINKKRVKRKGL
CCCCCCHHHHHCCCC		58.91-
431UbiquitinationNKKRVKRKGLQNTMS
CHHHHHCCCCCCCCC		59.2524816145
431MethylationNKKRVKRKGLQNTMS
CHHHHHCCCCCCCCC		59.25115978659
438PhosphorylationKGLQNTMSVRLPPIT
CCCCCCCCCCCCCCH		11.3128857561
446UbiquitinationVRLPPITKFAAEEAR
CCCCCCHHHCHHHHH		33.4521890473
446UbiquitinationVRLPPITKFAAEEAR
CCCCCCHHHCHHHHH		33.4527667366
446AcetylationVRLPPITKFAAEEAR
CCCCCCHHHCHHHHH		33.4526051181
455PhosphorylationAAEEARESDWDGIIA
CHHHHHHCCCCCEEE		38.1530266825
467UbiquitinationIIACHQGKLSCSTWN
EEEEECCEEEEECCC		30.5629967540
467AcetylationIIACHQGKLSCSTWN
EEEEECCEEEEECCC		30.5625953088
469PhosphorylationACHQGKLSCSTWNYQ
EEECCEEEEECCCCC		14.9829083192
471PhosphorylationHQGKLSCSTWNYQKS
ECCEEEEECCCCCCC		32.8429083192
472PhosphorylationQGKLSCSTWNYQKST
CCEEEEECCCCCCCC		23.2729083192
475PhosphorylationLSCSTWNYQKSTIGA
EEEECCCCCCCCEEE		14.6329083192
477MethylationCSTWNYQKSTIGAYF
EECCCCCCCCEEEEE		38.93115978667
478PhosphorylationSTWNYQKSTIGAYFL
ECCCCCCCCEEEEEE		15.1029083192
479PhosphorylationTWNYQKSTIGAYFLK
CCCCCCCCEEEEEEC		30.3929083192
483PhosphorylationQKSTIGAYFLKPKEL
CCCCEEEEEECHHHC		12.3029083192
486AcetylationTIGAYFLKPKELKKD
CEEEEEECHHHCCCC		44.1125953088
486UbiquitinationTIGAYFLKPKELKKD
CEEEEEECHHHCCCC		44.11-
488UbiquitinationGAYFLKPKELKKDDI
EEEEECHHHCCCCCC		74.2729967540
534UbiquitinationIHRGSFGKDQAHKGS
CCCCCCCCCCCCCCC		44.6627667366
539UbiquitinationFGKDQAHKGSVRGVA
CCCCCCCCCCCEEEE		56.76-
569AcetylationLLKFWNFKNKILIHS
HEEEEECCCCEEEEE		54.8625825284
571AcetylationKFWNFKNKILIHSVS
EEEECCCCEEEEEEE		39.2126051181
571UbiquitinationKFWNFKNKILIHSVS
EEEECCCCEEEEEEE		39.21-
611PhosphorylationISVLDIETRKIVREF
EEEEEHHHHHHHHHH		37.28-
645PhosphorylationISAAMDCSIRTWDLP
HHHHHCCCCCCCCCC		15.73-
763UbiquitinationLLPESRWKNLLNLDV
HCCHHHHHHHCCHHH		36.2921963094
772UbiquitinationLLNLDVIKKKNKPKE
HCCHHHHHHCCCCCC		58.5029967540
774UbiquitinationNLDVIKKKNKPKEPP
CHHHHHHCCCCCCCC		66.26-
778AcetylationIKKKNKPKEPPKVPK
HHHCCCCCCCCCCCC		81.8918529911
785UbiquitinationKEPPKVPKSAPFFIP
CCCCCCCCCCCCCCC		63.3429967540
786PhosphorylationEPPKVPKSAPFFIPT
CCCCCCCCCCCCCCC		34.7925106551
800DimethylationTIPGLVPRYAAPEQN
CCCCCCCCCCCCCCC		26.66-
800MethylationTIPGLVPRYAAPEQN
CCCCCCCCCCCCCCC		26.6626494837
801PhosphorylationIPGLVPRYAAPEQNN
CCCCCCCCCCCCCCC		10.8828152594
813PhosphorylationQNNDPQQSKVVNLGV
CCCCHHHHCEEEHHH		23.3621712546
814UbiquitinationNNDPQQSKVVNLGVL
CCCHHHHCEEEHHHH		45.9521906983
814AcetylationNNDPQQSKVVNLGVL
CCCHHHHCEEEHHHH		45.9526051181
824UbiquitinationNLGVLAQKSDFCLKL
EHHHHHHCCCEEEEH		46.5121963094
824AcetylationNLGVLAQKSDFCLKL
EHHHHHHCCCEEEEH		46.5126051181
830UbiquitinationQKSDFCLKLEEGLVN
HCCCEEEEHHHHCCC		55.8429967540
830AcetylationQKSDFCLKLEEGLVN
HCCCEEEEHHHHCCC		55.8426051181
839UbiquitinationEEGLVNNKYDTALNL
HHHCCCCCHHHHHHH		39.0221906983
839AcetylationEEGLVNNKYDTALNL
HHHCCCCCHHHHHHH		39.0226051181
840PhosphorylationEGLVNNKYDTALNLL
HHCCCCCHHHHHHHH		22.2027642862
848UbiquitinationDTALNLLKESGPSGI
HHHHHHHHHHCCCCH		53.6621906983
861PhosphorylationGIETELRSLSPDCGG
CHHHHHHHCCCCCCC		45.9124850871
863PhosphorylationETELRSLSPDCGGSI
HHHHHHCCCCCCCCH		21.6827050516
875PhosphorylationGSIEVMQSFLKMIGM
CCHHHHHHHHHHHHH		17.9124719451
887UbiquitinationIGMMLDRKRDFELAQ
HHHHHCCCCCHHHHH		56.8622817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR36_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR36_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR36_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNAQ_HUMANGNAQphysical
21940795
TA2R_HUMANTBXA2Rphysical
21940795
UTP6_HUMANUTP6physical
22434888
AATF_HUMANAATFphysical
26344197
PYRG1_HUMANCTPS1physical
26344197
DDX56_HUMANDDX56physical
26344197
DUS3L_HUMANDUS3Lphysical
26344197
GRWD1_HUMANGRWD1physical
26344197
MPP10_HUMANMPHOSPH10physical
26344197
MK67I_HUMANNIFKphysical
26344197
NOB1_HUMANNOB1physical
26344197
NOC2L_HUMANNOC2Lphysical
26344197
TBL3_HUMANTBL3physical
26344197
UTP15_HUMANUTP15physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
609887Glaucoma 1, open angle, G (GLC1G)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR36_HUMAN

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Related Literatures of Post-Translational Modification

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