dbPTM

TBL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBL3_HUMAN
UniProt AC	Q12788
Protein Name	Transducin beta-like protein 3
Gene Name	TBL3
Organism	Homo sapiens (Human).
Sequence Length	808
Subcellular Localization	Nucleus, nucleolus .
Protein Description
Protein Sequence	MAETAAGVGRFKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEKLEATMLRLRRDQKEALLRFCVTWNTNSRHCHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAFLDFLWHNMKLPVPAAAPTPWETHKGALP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAETAAGVG ------CCCCCCCCC	23.89	22814378
4	Phosphorylation	----MAETAAGVGRF ----CCCCCCCCCCC	16.57	20068231
12	Acetylation	AAGVGRFKTNYAVER CCCCCCCCCCCCCCC	34.20	26051181
12	Methylation	AAGVGRFKTNYAVER CCCCCCCCCCCCCCC	34.20	115980105
12	Ubiquitination	AAGVGRFKTNYAVER CCCCCCCCCCCCCCC	34.20	29967540
13	Phosphorylation	AGVGRFKTNYAVERK CCCCCCCCCCCCCCC	30.65	-
15	Phosphorylation	VGRFKTNYAVERKIE CCCCCCCCCCCCCCC	19.77	29496907
20	Sumoylation	TNYAVERKIEPFYKG CCCCCCCCCCCCCCC	37.60	-
20	Ubiquitination	TNYAVERKIEPFYKG CCCCCCCCCCCCCCC	37.60	29967540
25	Phosphorylation	ERKIEPFYKGGKAQL CCCCCCCCCCCEEEE	21.31	24732914
26	Acetylation	RKIEPFYKGGKAQLD CCCCCCCCCCEEEEC	62.66	19608861
26	Ubiquitination	RKIEPFYKGGKAQLD CCCCCCCCCCEEEEC	62.66	22817900
29	Ubiquitination	EPFYKGGKAQLDQTG CCCCCCCEEEECCCC	41.44	21963094
105	Ubiquitination	GSVTRLWKAIHTAPV CCHHHHHHHHHHCCC	41.89	-
105	Acetylation	GSVTRLWKAIHTAPV CCHHHHHHHHHHCCC	41.89	26051181
142	Phosphorylation	VWDIVRHYGTHHFRG HHHHHHHHCCCCCCC	17.10	25867546
144	Phosphorylation	DIVRHYGTHHFRGSP HHHHHHCCCCCCCCC	12.66	25867546
150	Phosphorylation	GTHHFRGSPGVVHLV CCCCCCCCCCEEEEE	17.77	25867546
170	O-linked_Glycosylation	PTRLLLFSSATDAAI CCEEEEEEECCHHHH	21.02	23301498
173	O-linked_Glycosylation	LLLFSSATDAAIRVW EEEEEECCHHHHHHH	28.28	23301498
257	Phosphorylation	VSQLGVKSPGLYFLT HHHCCCCCCCEEEEE	23.07	29255136
261	Phosphorylation	GVKSPGLYFLTAGDQ CCCCCCEEEEECCCC	11.49	26074081
264	Phosphorylation	SPGLYFLTAGDQGTL CCCEEEEECCCCCEE	20.78	26074081
328	Ubiquitination	ARSLRLQKQFAGYSE HHHHHHHHHHCCCCC	52.56	21906983
387	Acetylation	LALDVFRKGWLFASC EEEHHHHCCCCCHHC	42.87	26051181
396	Acetylation	WLFASCAKDQSVRIW CCCHHCCCCCCEEEE	61.70	26051181
407	Ubiquitination	VRIWRMNKAGQVMCV EEEEEECCCCCEEEE	44.55	21963094
407	Sumoylation	VRIWRMNKAGQVMCV EEEEEECCCCCEEEE	44.55	28112733
407	Acetylation	VRIWRMNKAGQVMCV EEEEEECCCCCEEEE	44.55	26051181
418	Phosphorylation	VMCVAQGSGHTHSVG EEEEEECCCCCCCHH	18.47	-
433	Acetylation	TVCCSRLKESFLVTG HEEECCCCCCEEECC	50.64	26051181
433	Ubiquitination	TVCCSRLKESFLVTG HEEECCCCCCEEECC	50.64	29967540
435	Phosphorylation	CCSRLKESFLVTGSQ EECCCCCCEEECCCC	23.46	20068231
439	Phosphorylation	LKESFLVTGSQDCTV CCCCEEECCCCCCEE	33.01	20068231
441	Phosphorylation	ESFLVTGSQDCTVKL CCEEECCCCCCEEEE	17.30	20068231
445	Phosphorylation	VTGSQDCTVKLWPLP ECCCCCCEEEEEECC	29.03	20068231
453	Ubiquitination	VKLWPLPKALLSKNT EEEEECCHHHHCCCC	60.39	21906983
458	Ubiquitination	LPKALLSKNTAPDNG CCHHHHCCCCCCCCC	59.28	21906983
460	Phosphorylation	KALLSKNTAPDNGPI HHHHCCCCCCCCCCE	43.22	28555341
480	Ubiquitination	TTQRCHDKDINSVAI ECCCCCCCCCCEEEE	36.52	29967540
480	Acetylation	TTQRCHDKDINSVAI ECCCCCCCCCCEEEE	36.52	25953088
492	Ubiquitination	VAIAPNDKLLATGSQ EEECCCCCEECCCCC	52.63	21906983
496	Phosphorylation	PNDKLLATGSQDRTA CCCCEECCCCCCHHH	37.02	20860994
501	Methylation	LATGSQDRTAKLWAL ECCCCCCHHHHHHCC	29.01	115918301
502	Phosphorylation	ATGSQDRTAKLWALP CCCCCCHHHHHHCCC	36.11	25599653
504	Ubiquitination	GSQDRTAKLWALPQC CCCCHHHHHHCCCCC	43.90	-
504	Acetylation	GSQDRTAKLWALPQC CCCCHHHHHHCCCCC	43.90	26051181
557	Ubiquitination	LQDFSCLKTFEGHDA ECCCCCCCEECCCCC	56.34	21963094
557	Acetylation	LQDFSCLKTFEGHDA ECCCCCCCEECCCCC	56.34	26051181
588	Ubiquitination	SGSDGLVKLWTIKNN CCCCCEEEEEEEECC	43.26	23503661
593	Ubiquitination	LVKLWTIKNNECVRT EEEEEEEECCEEEEE	46.47	23503661
593	Acetylation	LVKLWTIKNNECVRT EEEEEEEECCEEEEE	46.47	25953088
607	Acetylation	TLDAHEDKVWGLHCS EEECCCCCEEEEEEC	36.58	25825284
607	Ubiquitination	TLDAHEDKVWGLHCS EEECCCCCEEEEEEC	36.58	29967540
622	Phosphorylation	RLDDHALTGASDSRV CCCCCCCCCCCCCEE	31.33	20068231
625	Phosphorylation	DHALTGASDSRVILW CCCCCCCCCCEEEEE	37.15	20068231
633	Acetylation	DSRVILWKDVTEAEQ CCEEEEEEECHHHHH	38.58	26051181
633	Ubiquitination	DSRVILWKDVTEAEQ CCEEEEEEECHHHHH	38.58	21906983
636	Phosphorylation	VILWKDVTEAEQAEE EEEEEECHHHHHHHH	39.34	20068231
664	Acetylation	LDNLLHEKRYLRALG HHHHHHHHHHHHHHC	35.28	25953088
664	Ubiquitination	LDNLLHEKRYLRALG HHHHHHHHHHHHHHC	35.28	21906983
666	Phosphorylation	NLLHEKRYLRALGLA HHHHHHHHHHHHCHH	16.17	24043423
675	Phosphorylation	RALGLAISLDRPHTV HHHCHHHCCCCCHHH	20.71	24043423
698	Ubiquitination	RDPEACEKLEATMLR HCHHHHHHHHHHHHH	52.06	21963094
698	Acetylation	RDPEACEKLEATMLR HCHHHHHHHHHHHHH	52.06	23749302
702	Phosphorylation	ACEKLEATMLRLRRD HHHHHHHHHHHHHHH	13.83	29083192
711	Acetylation	LRLRRDQKEALLRFC HHHHHHHHHHHHHHH	49.60	26822725
711	Ubiquitination	LRLRRDQKEALLRFC HHHHHHHHHHHHHHH	49.60	22817900
750	Phosphorylation	APEELLAYEGVRAAL CCHHHHHHHHHHHHH	17.12	28152594
763	Phosphorylation	ALEALLPYTERHFQR HHHHHHHHHHHHHHH	22.62	28152594
764	Phosphorylation	LEALLPYTERHFQRL HHHHHHHHHHHHHHH	25.30	28152594
798	Phosphorylation	PVPAAAPTPWETHKG CCCCCCCCCCCCCCC	35.99	28555341
804	Ubiquitination	PTPWETHKGALP--- CCCCCCCCCCCC---	53.98	21906983
804	Methylation	PTPWETHKGALP--- CCCCCCCCCCCC---	53.98	42372497

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TBL3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TBL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AATF_HUMAN	AATF	physical	26344197
MPP10_HUMAN	MPHOSPH10	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBL3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-26, AND MASS SPECTROMETRY.	19608861 [Abstract]