UniProt ID | MPP10_HUMAN | |
---|---|---|
UniProt AC | O00566 | |
Protein Name | U3 small nucleolar ribonucleoprotein protein MPP10 | |
Gene Name | MPHOSPH10 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 681 | |
Subcellular Localization | Nucleus, nucleolus . Chromosome . Fibrillar region of the nucleolus (PubMed:9450966). After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase (PubMed:9450966). In telophase localized to s | |
Protein Description | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.. | |
Protein Sequence | MAPQVWRRRTLERCLTEVGKATGRPECFLTIQEGLASKFTSLTKVLYDFNKILENGRIHGSPLQKLVIENFDDEQIWQQLELQNEPILQYFQNAVSETINDEDISLLPESEEQEREEDGSEIEADDKEDLEDLEEEEVSDMGNDDPEMGERAENSSKSDLRKSPVFSDEDSDLDFDISKLEQQSKVQNKGQGKPREKSIVDDKFFKLSEMEAYLENIEKEEERKDDNDEEEEDIDFFEDIDSDEDEGGLFGSKKLKSGKSSRNLKYKDFFDPVESDEDITNVHDDELDSNKEDDEIAEEEAEELSISETDEDDDLQENEDNKQHKESLKRVTFALPDDAETEDTGVLNVKKNSDEVKSSFEKRQEKMNEKIASLEKELLEKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYIKLNQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDIKTAAEKTATDKKRERRKKKYQKRMKIKEKEKRRKLLEKSSVDQAGKYSKTVASEKLKQLTKTGKASFIKDEGKDKALKSSQAFFSKLQDQVKMQINDAKKTEKKKKKRQDISVHKLKL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
10 | Phosphorylation | PQVWRRRTLERCLTE CHHHHHHHHHHHHHH | 31.03 | 23882029 | |
16 | Phosphorylation | RTLERCLTEVGKATG HHHHHHHHHHHHHCC | 32.05 | 23882029 | |
22 | Phosphorylation | LTEVGKATGRPECFL HHHHHHHCCCCHHEE | 36.89 | 20068231 | |
27 | Glutathionylation | KATGRPECFLTIQEG HHCCCCHHEEEECHH | 3.62 | 22555962 | |
30 | Phosphorylation | GRPECFLTIQEGLAS CCCHHEEEECHHHHH | 10.60 | 20068231 | |
37 | Phosphorylation | TIQEGLASKFTSLTK EECHHHHHHHHHHHH | 33.09 | 20068231 | |
38 | Ubiquitination | IQEGLASKFTSLTKV ECHHHHHHHHHHHHH | 47.24 | 29967540 | |
38 | Acetylation | IQEGLASKFTSLTKV ECHHHHHHHHHHHHH | 47.24 | 25953088 | |
41 | Phosphorylation | GLASKFTSLTKVLYD HHHHHHHHHHHHHHC | 36.85 | 20068231 | |
43 | Phosphorylation | ASKFTSLTKVLYDFN HHHHHHHHHHHHCHH | 20.90 | 27251275 | |
51 | Ubiquitination | KVLYDFNKILENGRI HHHHCHHHHHHCCCC | 48.97 | - | |
61 | Phosphorylation | ENGRIHGSPLQKLVI HCCCCCCCCCCEEEE | 14.31 | 25159151 | |
120 | Phosphorylation | QEREEDGSEIEADDK HHCCCCCCCCCCCCH | 47.96 | 28355574 | |
127 | Acetylation | SEIEADDKEDLEDLE CCCCCCCHHHHHHHH | 54.39 | 26051181 | |
139 | Phosphorylation | DLEEEEVSDMGNDDP HHHHHHHHHCCCCCH | 25.76 | 28355574 | |
158 | Phosphorylation | RAENSSKSDLRKSPV HHHCCCHHHHHCCCC | 43.77 | 21955146 | |
163 | Phosphorylation | SKSDLRKSPVFSDED CHHHHHCCCCCCCCC | 21.62 | 29255136 | |
167 | Phosphorylation | LRKSPVFSDEDSDLD HHCCCCCCCCCCCCC | 40.08 | 29255136 | |
171 | Phosphorylation | PVFSDEDSDLDFDIS CCCCCCCCCCCCCHH | 37.72 | 29255136 | |
178 | Phosphorylation | SDLDFDISKLEQQSK CCCCCCHHHHHHHHH | 32.79 | 23927012 | |
184 | Phosphorylation | ISKLEQQSKVQNKGQ HHHHHHHHHHCCCCC | 34.19 | 24732914 | |
185 | Sumoylation | SKLEQQSKVQNKGQG HHHHHHHHHCCCCCC | 43.43 | - | |
185 | Sumoylation | SKLEQQSKVQNKGQG HHHHHHHHHCCCCCC | 43.43 | - | |
189 | Acetylation | QQSKVQNKGQGKPRE HHHHHCCCCCCCCCC | 35.20 | 21466224 | |
193 | Acetylation | VQNKGQGKPREKSIV HCCCCCCCCCCCHHC | 32.77 | 21466224 | |
197 | Acetylation | GQGKPREKSIVDDKF CCCCCCCCHHCCHHC | 46.92 | 25953088 | |
198 | Phosphorylation | QGKPREKSIVDDKFF CCCCCCCHHCCHHCH | 24.08 | 27251275 | |
203 | Ubiquitination | EKSIVDDKFFKLSEM CCHHCCHHCHHHHHH | 48.51 | 29967540 | |
203 | 2-Hydroxyisobutyrylation | EKSIVDDKFFKLSEM CCHHCCHHCHHHHHH | 48.51 | - | |
208 | Phosphorylation | DDKFFKLSEMEAYLE CHHCHHHHHHHHHHH | 35.17 | 19651622 | |
242 | Phosphorylation | DFFEDIDSDEDEGGL CHHHCCCCCCCCCCC | 43.14 | 30266825 | |
252 | Phosphorylation | DEGGLFGSKKLKSGK CCCCCCCCCCCCCCC | 21.20 | 23663014 | |
257 | Phosphorylation | FGSKKLKSGKSSRNL CCCCCCCCCCCCCCC | 62.99 | 26074081 | |
260 | Phosphorylation | KKLKSGKSSRNLKYK CCCCCCCCCCCCCCC | 37.75 | 26074081 | |
261 | Phosphorylation | KLKSGKSSRNLKYKD CCCCCCCCCCCCCCH | 28.77 | 26074081 | |
266 | Phosphorylation | KSSRNLKYKDFFDPV CCCCCCCCCHHCCCC | 20.96 | 26074081 | |
275 | Phosphorylation | DFFDPVESDEDITNV HHCCCCCCCCCCCCC | 46.67 | 20164059 | |
280 | Phosphorylation | VESDEDITNVHDDEL CCCCCCCCCCCHHHC | 43.44 | 20873877 | |
289 | Phosphorylation | VHDDELDSNKEDDEI CCHHHCCCCCCCCHH | 63.53 | 20164059 | |
305 | Phosphorylation | EEEAEELSISETDED HHHHHHCCCCCCCCC | 27.61 | 27362937 | |
307 | Phosphorylation | EAEELSISETDEDDD HHHHCCCCCCCCCCC | 30.94 | 27362937 | |
309 | Phosphorylation | EELSISETDEDDDLQ HHCCCCCCCCCCCCC | 37.59 | - | |
332 | Phosphorylation | KESLKRVTFALPDDA HHHHHHHEEECCCCC | 13.76 | 28555341 | |
341 | Phosphorylation | ALPDDAETEDTGVLN ECCCCCCCCCCCEEE | 40.66 | 23312004 | |
344 | Phosphorylation | DDAETEDTGVLNVKK CCCCCCCCCEEEECC | 23.98 | 23312004 | |
350 | Sumoylation | DTGVLNVKKNSDEVK CCCEEEECCCCHHHH | 45.20 | 28112733 | |
373 | Phosphorylation | KMNEKIASLEKELLE HHHHHHHHHHHHHHH | 40.30 | 29214152 | |
376 | Ubiquitination | EKIASLEKELLEKKP HHHHHHHHHHHHCCC | 59.98 | 29967540 | |
382 | Sumoylation | EKELLEKKPWQLQGE HHHHHHCCCCCCCCC | 41.96 | 28112733 | |
382 | Sumoylation | EKELLEKKPWQLQGE HHHHHHCCCCCCCCC | 41.96 | - | |
382 | Acetylation | EKELLEKKPWQLQGE HHHHHHCCCCCCCCC | 41.96 | 26051181 | |
394 | Sumoylation | QGEVTAQKRPENSLL CCCEECCCCCCCCHH | 68.41 | 28112733 | |
399 | Phosphorylation | AQKRPENSLLEETLH CCCCCCCCHHHHHHC | 32.44 | 20068231 | |
404 | Phosphorylation | ENSLLEETLHFDHAV CCCHHHHHHCCCHHH | 19.02 | 20068231 | |
418 | Phosphorylation | VRMAPVITEETTLQL HHCCCCCCHHHHCCH | 28.18 | 20068231 | |
421 | Phosphorylation | APVITEETTLQLEDI CCCCCHHHHCCHHHH | 26.95 | 20068231 | |
422 | Phosphorylation | PVITEETTLQLEDII CCCCHHHHCCHHHHH | 18.78 | 20068231 | |
446 | Acetylation | DDVVRKEKPKEDAYE HHHHHCCCCCHHHHH | 65.51 | 25953088 | |
448 | Ubiquitination | VVRKEKPKEDAYEYK HHHCCCCCHHHHHHH | 78.33 | 24816145 | |
452 | Phosphorylation | EKPKEDAYEYKKRLT CCCCHHHHHHHHHHC | 31.92 | 22817900 | |
454 | Phosphorylation | PKEDAYEYKKRLTLD CCHHHHHHHHHHCCC | 14.77 | 22817900 | |
455 | 2-Hydroxyisobutyrylation | KEDAYEYKKRLTLDH CHHHHHHHHHHCCCH | 21.34 | - | |
459 | Phosphorylation | YEYKKRLTLDHEKSK HHHHHHHCCCHHHHC | 33.89 | 20860994 | |
464 | 2-Hydroxyisobutyrylation | RLTLDHEKSKLSLAE HHCCCHHHHCCCHHH | 49.85 | - | |
466 | Ubiquitination | TLDHEKSKLSLAEIY CCCHHHHCCCHHHHH | 53.84 | 29967540 | |
468 | Phosphorylation | DHEKSKLSLAEIYEQ CHHHHCCCHHHHHHH | 29.30 | 28555341 | |
473 | Phosphorylation | KLSLAEIYEQEYIKL CCCHHHHHHHHHHHH | 11.76 | 27642862 | |
477 | Phosphorylation | AEIYEQEYIKLNQQK HHHHHHHHHHHHHHC | 11.75 | - | |
479 | Ubiquitination | IYEQEYIKLNQQKTA HHHHHHHHHHHHCCC | 40.25 | 22817900 | |
484 | Ubiquitination | YIKLNQQKTAEEENP HHHHHHHCCCCHHCH | 39.68 | 22817900 | |
498 | Ubiquitination | PEHVEIQKMMDSLFL HHHHHHHHHHHHHHH | 41.68 | 29967540 | |
502 | Phosphorylation | EIQKMMDSLFLKLDA HHHHHHHHHHHHHHH | 11.79 | 20860994 | |
518 | Acetylation | SNFHFIPKPPVPEIK CCCCCCCCCCCCCEE | 58.08 | 26051181 | |
518 | Ubiquitination | SNFHFIPKPPVPEIK CCCCCCCCCCCCCEE | 58.08 | 23000965 | |
555 | Sumoylation | LLAPEEIKEKNKAGD HHCHHHHHHHCCCCC | 66.95 | 28112733 | |
559 | Acetylation | EEIKEKNKAGDIKTA HHHHHHCCCCCHHHH | 65.89 | 7708155 | |
564 | Acetylation | KNKAGDIKTAAEKTA HCCCCCHHHHHHHHH | 36.53 | 7708165 | |
574 | Acetylation | AEKTATDKKRERRKK HHHHHHHHHHHHHHH | 49.75 | 7708175 | |
601 | 2-Hydroxyisobutyrylation | KRRKLLEKSSVDQAG HHHHHHHHCCHHHHH | 48.26 | - | |
602 | Phosphorylation | RRKLLEKSSVDQAGK HHHHHHHCCHHHHHC | 26.64 | 20860994 | |
603 | Phosphorylation | RKLLEKSSVDQAGKY HHHHHHCCHHHHHCH | 40.56 | 22210691 | |
609 | Acetylation | SSVDQAGKYSKTVAS CCHHHHHCHHHHHHH | 49.74 | 19608861 | |
609 | 2-Hydroxyisobutyrylation | SSVDQAGKYSKTVAS CCHHHHHCHHHHHHH | 49.74 | - | |
610 | Phosphorylation | SVDQAGKYSKTVASE CHHHHHCHHHHHHHH | 17.93 | 22468782 | |
611 | Phosphorylation | VDQAGKYSKTVASEK HHHHHCHHHHHHHHH | 25.90 | 22468782 | |
613 | Phosphorylation | QAGKYSKTVASEKLK HHHCHHHHHHHHHHH | 18.50 | 22468782 | |
616 | Phosphorylation | KYSKTVASEKLKQLT CHHHHHHHHHHHHHH | 30.81 | 20860994 | |
618 | Acetylation | SKTVASEKLKQLTKT HHHHHHHHHHHHHHH | 59.49 | 25953088 | |
618 | 2-Hydroxyisobutyrylation | SKTVASEKLKQLTKT HHHHHHHHHHHHHHH | 59.49 | - | |
629 | Phosphorylation | LTKTGKASFIKDEGK HHHHCCCHHCCCCCH | 30.87 | 19691289 | |
632 | Sumoylation | TGKASFIKDEGKDKA HCCCHHCCCCCHHHH | 47.95 | 28112733 | |
632 | Sumoylation | TGKASFIKDEGKDKA HCCCHHCCCCCHHHH | 47.95 | - | |
641 | Methylation | EGKDKALKSSQAFFS CCHHHHHHHHHHHHH | 53.58 | 115973209 | |
649 | Sumoylation | SSQAFFSKLQDQVKM HHHHHHHHHHHHHHH | 45.04 | 28112733 | |
649 | Acetylation | SSQAFFSKLQDQVKM HHHHHHHHHHHHHHH | 45.04 | 26051181 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
332 | T | Phosphorylation | Kinase | AURKB | Q96GD4 | GPS |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MPP10_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MPP10_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
DDX52_HUMAN | DDX52 | physical | 26344197 | |
DDX56_HUMAN | DDX56 | physical | 26344197 | |
DKC1_HUMAN | DKC1 | physical | 26344197 | |
IMP3_HUMAN | IMP3 | physical | 26344197 | |
IMP4_HUMAN | IMP4 | physical | 26344197 | |
NOL10_HUMAN | NOL10 | physical | 26344197 | |
NOL6_HUMAN | NOL6 | physical | 26344197 | |
RS7_HUMAN | RPS7 | physical | 26344197 | |
UT14A_HUMAN | UTP14A | physical | 26344197 | |
UTP15_HUMAN | UTP15 | physical | 26344197 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...
Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-609, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-171 ANDSER-242, AND MASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; SER-167; SER-171AND SER-242, AND MASS SPECTROMETRY. | |
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-139, ANDMASS SPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; SER-167; SER-171;SER-242; SER-275 AND SER-289, AND MASS SPECTROMETRY. |