dbPTM

UTP15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UTP15_HUMAN
UniProt AC	Q8TED0
Protein Name	U3 small nucleolar RNA-associated protein 15 homolog
Gene Name	UTP15
Organism	Homo sapiens (Human).
Sequence Length	518
Subcellular Localization	Nucleus, nucleolus . Found predominantly at the fibrillar center.
Protein Description	Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I..
Protein Sequence	MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGYKPVAI ------CCCCCCEEE	29.98	19413330
4	Phosphorylation	----MAGYKPVAIQT ----CCCCCCEEEEE	11.55	28509920
5	Ubiquitination	---MAGYKPVAIQTY ---CCCCCCEEEEEC	31.90	-
5	Ubiquitination	---MAGYKPVAIQTY ---CCCCCCEEEEEC	31.90	-
11	Phosphorylation	YKPVAIQTYPILGEK CCCEEEEECCCCCCE	25.75	28509920
12	Phosphorylation	KPVAIQTYPILGEKI CCEEEEECCCCCCEE	3.34	25159151
25	Phosphorylation	KITQDTLYWNNYKTP EECCCCCCCCCCCCC	14.26	29496907
30	Acetylation	TLYWNNYKTPVQIKE CCCCCCCCCCEEEEE	48.77	26051181
30	Ubiquitination	TLYWNNYKTPVQIKE CCCCCCCCCCEEEEE	48.77	23000965
31	Phosphorylation	LYWNNYKTPVQIKEF CCCCCCCCCEEEEEC	20.52	29496907
36	Ubiquitination	YKTPVQIKEFGAVSK CCCCEEEEECCCEEE	29.87	21890473
36	Ubiquitination	YKTPVQIKEFGAVSK CCCCEEEEECCCEEE	29.87	21890473
36	Acetylation	YKTPVQIKEFGAVSK CCCCEEEEECCCEEE	29.87	26051181
36	Ubiquitination	YKTPVQIKEFGAVSK CCCCEEEEECCCEEE	29.87	23000965
55	Ubiquitination	PQPPYNYAVTASSRI CCCCCCEEEECCCEE	6.64	29967540
59	Ubiquitination	YNYAVTASSRIHIYG CCEEEECCCEEEEEE	15.70	29967540
61	Ubiquitination	YAVTASSRIHIYGRY EEEECCCEEEEEECC	23.24	-
61	Ubiquitination	YAVTASSRIHIYGRY EEEECCCEEEEEECC	23.24	33845483
74	Acetylation	RYSQEPIKTFSRFKD CCCCCCCCCCHHCCC	54.99	26051181
80	Acetylation	IKTFSRFKDTAYCAT CCCCHHCCCCEEEEE	53.73	25825284
80	Ubiquitination	IKTFSRFKDTAYCAT CCCCHHCCCCEEEEE	53.73	33845483
82	Phosphorylation	TFSRFKDTAYCATFR CCHHCCCCEEEEEEE	21.81	28152594
84	Phosphorylation	SRFKDTAYCATFRQD HHCCCCEEEEEEEEC	5.68	28152594
87	Phosphorylation	KDTAYCATFRQDGRL CCCEEEEEEEECCCE	18.78	28152594
115	Ubiquitination	DISGRAPLRQFEGHT EECCCCCCCEEECCC	7.02	29967540
133	Ubiquitination	HTVDFTADKYHVVSG EEEECCCCCEEEECC	49.33	24816145
134	Acetylation	TVDFTADKYHVVSGA EEECCCCCEEEECCC	34.49	25825284
134	Ubiquitination	TVDFTADKYHVVSGA EEECCCCCEEEECCC	34.49	29967540
135	Phosphorylation	VDFTADKYHVVSGAD EECCCCCEEEECCCC	10.61	20068231
136	Ubiquitination	DFTADKYHVVSGADD ECCCCCEEEECCCCC	21.17	-
136	Ubiquitination	DFTADKYHVVSGADD ECCCCCEEEECCCCC	21.17	33845483
142	Ubiquitination	YHVVSGADDYTVKLW EEEECCCCCEEEEEE	53.64	-
142	Ubiquitination	YHVVSGADDYTVKLW EEEECCCCCEEEEEE	53.64	23503661
144	Phosphorylation	VVSGADDYTVKLWDI EECCCCCEEEEEEEC	17.61	-
145	Phosphorylation	VSGADDYTVKLWDIP ECCCCCEEEEEEECC	20.40	-
152	Ubiquitination	TVKLWDIPNSKEILT EEEEEECCCCCEEEE	36.25	27667366
155	Ubiquitination	LWDIPNSKEILTFKE EEECCCCCEEEEEEC	56.25	21890473
155	Ubiquitination	LWDIPNSKEILTFKE EEECCCCCEEEEEEC	56.25	21890473
155	Ubiquitination	LWDIPNSKEILTFKE EEECCCCCEEEEEEC	56.25	21906983
161	Ubiquitination	SKEILTFKEHSDYVR CCEEEEEECCCCCEE	49.64	23503661
168	Ubiquitination	KEHSDYVRCGCASKL ECCCCCEEECCCHHC	12.60	29967540
169	Ubiquitination	EHSDYVRCGCASKLN CCCCCEEECCCHHCC	3.61	-
169	Ubiquitination	EHSDYVRCGCASKLN CCCCCEEECCCHHCC	3.61	29967540
171	Ubiquitination	SDYVRCGCASKLNPD CCCEEECCCHHCCCC	4.41	-
171	Ubiquitination	SDYVRCGCASKLNPD CCCEEECCCHHCCCC	4.41	23503661
174	Acetylation	VRCGCASKLNPDLFI EEECCCHHCCCCEEE	33.48	26051181
179	Ubiquitination	ASKLNPDLFITGSYD CHHCCCCEEEEECCC	3.36	-
185	Ubiquitination	DLFITGSYDHTVKMF CEEEEECCCCEEEEE	17.06	-
190	Ubiquitination	GSYDHTVKMFDARTS ECCCCEEEEEECCCC	34.70	23503661
198	Ubiquitination	MFDARTSESVLSVEH EEECCCCCCEEEECC	44.23	-
198	Ubiquitination	MFDARTSESVLSVEH EEECCCCCCEEEECC	44.23	33845483
208	Ubiquitination	LSVEHGQPVESVLLF EEECCCCEEEEEEEE	36.11	-
208	Ubiquitination	LSVEHGQPVESVLLF EEECCCCEEEEEEEE	36.11	21890473
226	Ubiquitination	GLLVSAGGRYVKVWD CEEEEECCCEEEEEE	19.91	29967540
230	Acetylation	SAGGRYVKVWDMLKG EECCCEEEEEEEECC	28.77	26051181
230	Ubiquitination	SAGGRYVKVWDMLKG EECCCEEEEEEEECC	28.77	29967540
245	Acetylation	GQLLVSLKNHHKTVT CEEEEEECCCCCEEE	46.88	26051181
245	Ubiquitination	GQLLVSLKNHHKTVT CEEEEEECCCCCEEE	46.88	29967540
249	Acetylation	VSLKNHHKTVTCLCL EEECCCCCEEEEEEE	36.82	26051181
249	Sumoylation	VSLKNHHKTVTCLCL EEECCCCCEEEEEEE	36.82	28112733
249	Ubiquitination	VSLKNHHKTVTCLCL EEECCCCCEEEEEEE	36.82	29967540
270	Methylation	LLSGSLDRKVKVYST HHHCCCCCCEEEEEE	51.46	115919705
271	Acetylation	LSGSLDRKVKVYSTT HHCCCCCCEEEEEEC	46.18	30593297
282	Ubiquitination	YSTTSYKVVHSFDYA EEECCEEEEECHHHH	3.39	-
282	Ubiquitination	YSTTSYKVVHSFDYA EEECCEEEEECHHHH	3.39	22817900
285	Phosphorylation	TSYKVVHSFDYAASI CCEEEEECHHHHHHH	14.27	23286773
288	Phosphorylation	KVVHSFDYAASILSL EEEECHHHHHHHHHH	11.32	-
291	Phosphorylation	HSFDYAASILSLALA ECHHHHHHHHHHHHH	18.85	23286773
294	Phosphorylation	DYAASILSLALAHED HHHHHHHHHHHHCCC	15.21	-
303	Phosphorylation	ALAHEDETIVVGMTN HHHCCCCEEEEEECC	31.24	-
304	Ubiquitination	LAHEDETIVVGMTNG HHCCCCEEEEEECCC	1.91	24816145
307	Ubiquitination	EDETIVVGMTNGILS CCCEEEEEECCCEEE	13.30	-
307	Ubiquitination	EDETIVVGMTNGILS CCCEEEEEECCCEEE	13.30	22817900
314	Phosphorylation	GMTNGILSVKHRKSE EECCCEEEECCCCCH	27.48	23286773
323	Ubiquitination	KHRKSEAKKESLPRR CCCCCHHHHHCCCCC	53.69	24816145
324	Ubiquitination	HRKSEAKKESLPRRR CCCCHHHHHCCCCCC	60.63	29967540
337	Phosphorylation	RRRPAYRTFIKGKNY CCCHHHHHHHCCCCH	19.62	-
339	Ubiquitination	RPAYRTFIKGKNYMK CHHHHHHHCCCCHHH	5.94	29967540
340	Ubiquitination	PAYRTFIKGKNYMKQ HHHHHHHCCCCHHHH	60.69	29967540
342	Ubiquitination	YRTFIKGKNYMKQRD HHHHHCCCCHHHHCC	39.64	27667366
358	Ubiquitination	ILINRPAKKHLELYD EEECCCCHHHHHHHH	43.33	29967540
359	Ubiquitination	LINRPAKKHLELYDR EECCCCHHHHHHHHC	56.37	29967540
366	Methylation	KHLELYDRDLKHFRI HHHHHHHCCCCHHHH	37.29	115919709
369	Ubiquitination	ELYDRDLKHFRISKA HHHHCCCCHHHHHHH	45.01	33845483
375	Ubiquitination	LKHFRISKALDRVLD CCHHHHHHHHHHHCC	51.07	-
379	Ubiquitination	RISKALDRVLDPTCT HHHHHHHHHCCCCCC	31.57	21890473
388	Ubiquitination	LDPTCTIKTPEITVS CCCCCCCCCCCCHHH	39.61	33845483
389	Phosphorylation	DPTCTIKTPEITVSI CCCCCCCCCCCHHHH	23.46	20068231
393	Phosphorylation	TIKTPEITVSIIKEL CCCCCCCHHHHHHHH	13.41	20068231
395	Phosphorylation	KTPEITVSIIKELNR CCCCCHHHHHHHHHH	15.22	24719451
398	Ubiquitination	EITVSIIKELNRRGV CCHHHHHHHHHHCCH	55.25	21890473
398	Ubiquitination	EITVSIIKELNRRGV CCHHHHHHHHHHCCH	55.25	21890473
398	Acetylation	EITVSIIKELNRRGV CCHHHHHHHHHHCCH	55.25	26051181
398	Ubiquitination	EITVSIIKELNRRGV CCHHHHHHHHHHCCH	55.25	21890473
416	Acetylation	ALAGRDEKEISHVLN HHCCCCHHHHHHHHH	65.71	26051181
419	Phosphorylation	GRDEKEISHVLNFLI CCCHHHHHHHHHHHH	14.50	20068231
430	Phosphorylation	NFLIRNLSQPRFAPV HHHHHCCCCCCCHHH	41.51	24719451
453	Ubiquitination	IDIYLPVIGQSPVVD HEECCHHCCCCCCCC	3.82	22817900
472	Ubiquitination	LLQGLVEKEIDYQRE HHHHHHHHHHHHHHH	53.11	22817900
478	Ubiquitination	EKEIDYQRELLETLG HHHHHHHHHHHHHHC	30.24	22817900
495	Ubiquitination	DMLFATMRRKEGTSV HHHHHHHHHHCCCCC	42.01	29967540
497	Ubiquitination	LFATMRRKEGTSVLE HHHHHHHHCCCCCCE	50.56	22817900
506	Phosphorylation	GTSVLEHTSDGFPEN CCCCCEECCCCCCCC	21.09	30266825
507	Phosphorylation	TSVLEHTSDGFPENK CCCCEECCCCCCCCC	37.33	30266825
514	Ubiquitination	SDGFPENKKIES--- CCCCCCCCCCCC---	54.16	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UTP15_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UTP15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UTP15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
NPM_HUMAN	NPM1	physical	26344197
TBL3_HUMAN	TBL3	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UTP15_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]