NPM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPM_HUMAN
• UniProt AC: P06748
• Protein Name: Nucleophosmin
• Gene Name: NPM1
• Organism: Homo sapiens (Human).
• Sequence Length: 294
• Subcellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found
• Protein Description: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. [PubMed: 22528486 In complex with MYC enhances the transcription of MYC target genes]
• Protein Sequence: MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDSMDMD -------CCCCCCCC	13.41	20068231
4	Phosphorylation	----MEDSMDMDMSP ----CCCCCCCCCCC	11.90	29255136
10	Phosphorylation	DSMDMDMSPLRPQNY CCCCCCCCCCCCCCE	19.27	29255136
17	Phosphorylation	SPLRPQNYLFGCELK CCCCCCCEEEEEEEE	9.73	22617229
24	Acetylation	YLFGCELKADKDYHF EEEEEEEECCCCCEE	32.04	23954790
24	Ubiquitination	YLFGCELKADKDYHF EEEEEEEECCCCCEE	32.04	-
27	Sumoylation	GCELKADKDYHFKVD EEEEECCCCCEEEEC	66.11	-
27	2-Hydroxyisobutyrylation	GCELKADKDYHFKVD EEEEECCCCCEEEEC	66.11	-
27	Acetylation	GCELKADKDYHFKVD EEEEECCCCCEEEEC	66.11	23954790
27	Succinylation	GCELKADKDYHFKVD EEEEECCCCCEEEEC	66.11	23954790
27	Sumoylation	GCELKADKDYHFKVD EEEEECCCCCEEEEC	66.11	25218447
27	Ubiquitination	GCELKADKDYHFKVD EEEEECCCCCEEEEC	66.11	19608861
27 (in isoform 2)	Ubiquitination	-	66.11	-
29	Phosphorylation	ELKADKDYHFKVDND EEECCCCCEEEECCC	18.20	20090780
32	Ubiquitination	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	21890473
32	Sumoylation	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	-
32	2-Hydroxyisobutyrylation	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	-
32	Acetylation	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	19608861
32	Malonylation	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	26320211
32	Sumoylation	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	19608861
32	Ubiquitination	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	21890473
32 (in isoform 1)	Ubiquitination	-	35.05	21890473
32 (in isoform 2)	Ubiquitination	-	35.05	21890473
32	Ubiquitination	ADKDYHFKVDNDENE CCCCCEEEECCCCCC	35.05	21890473
43	Phosphorylation	DENEHQLSLRTVSLG CCCCEEEEEEEEECC	14.83	23401153
45	Methylation	NEHQLSLRTVSLGAG CCEEEEEEEEECCCC	29.70	115485503
46	Phosphorylation	EHQLSLRTVSLGAGA CEEEEEEEEECCCCC	21.53	21712546
48	Phosphorylation	QLSLRTVSLGAGAKD EEEEEEEECCCCCCC	22.07	25159151
54	2-Hydroxyisobutyrylation	VSLGAGAKDELHIVE EECCCCCCCEEEEEE	51.31	-
54	Acetylation	VSLGAGAKDELHIVE EECCCCCCCEEEEEE	51.31	23954790
54	Sumoylation	VSLGAGAKDELHIVE EECCCCCCCEEEEEE	51.31	-
54	Ubiquitination	VSLGAGAKDELHIVE EECCCCCCCEEEEEE	51.31	21906983
54 (in isoform 1)	Ubiquitination	-	51.31	21890473
54 (in isoform 2)	Ubiquitination	-	51.31	21890473
65	Sulfoxidation	HIVEAEAMNYEGSPI EEEEEECCCCCCCCE	4.06	30846556
67	Nitration	VEAEAMNYEGSPIKV EEEECCCCCCCCEEE	14.47	-
67	Phosphorylation	VEAEAMNYEGSPIKV EEEECCCCCCCCEEE	14.47	22167270
67 (in isoform 2)	Phosphorylation	-	14.47	18669648
70	Phosphorylation	EAMNYEGSPIKVTLA ECCCCCCCCEEEEEE	16.12	29255136
70 (in isoform 2)	Phosphorylation	-	16.12	18669648
73	2-Hydroxyisobutyrylation	NYEGSPIKVTLATLK CCCCCCEEEEEEEEE	32.33	-
73	Acetylation	NYEGSPIKVTLATLK CCCCCCEEEEEEEEE	32.33	26051181
73	Sumoylation	NYEGSPIKVTLATLK CCCCCCEEEEEEEEE	32.33	-
73	Ubiquitination	NYEGSPIKVTLATLK CCCCCCEEEEEEEEE	32.33	-
75	O-linked_Glycosylation	EGSPIKVTLATLKMS CCCCEEEEEEEEEEE	12.98	23301498
75	Phosphorylation	EGSPIKVTLATLKMS CCCCEEEEEEEEEEE	12.98	22167270
75 (in isoform 2)	Phosphorylation	-	12.98	18669648
78	Phosphorylation	PIKVTLATLKMSVQP CEEEEEEEEEEEECC	29.98	22167270
78 (in isoform 2)	Phosphorylation	-	29.98	18669648
80	Ubiquitination	KVTLATLKMSVQPTV EEEEEEEEEEECCEE	25.44	-
80 (in isoform 2)	Ubiquitination	-	25.44	-
81	Sulfoxidation	VTLATLKMSVQPTVS EEEEEEEEEECCEEE	5.51	28183972
82	Phosphorylation	TLATLKMSVQPTVSL EEEEEEEEECCEEEE	18.93	29255136
86	Phosphorylation	LKMSVQPTVSLGGFE EEEEECCEEEECCEE	12.97	29255136
88	O-linked_Glycosylation	MSVQPTVSLGGFEIT EEECCEEEECCEEEC	24.63	23301498
88	Phosphorylation	MSVQPTVSLGGFEIT EEECCEEEECCEEEC	24.63	29255136
88 (in isoform 2)	Phosphorylation	-	24.63	18220336
95	Phosphorylation	SLGGFEITPPVVLRL EECCEEECCCEEEEE	17.84	25159151
95 (in isoform 2)	Phosphorylation	-	17.84	18669648
101	Methylation	ITPPVVLRLKCGSGP ECCCEEEEEEECCCC	22.08	116265613
106	O-linked_Glycosylation	VLRLKCGSGPVHISG EEEEEECCCCEEECC	49.77	23301498
106	Phosphorylation	VLRLKCGSGPVHISG EEEEEECCCCEEECC	49.77	23927012
112	O-linked_Glycosylation	GSGPVHISGQHLVAV CCCCEEECCEEEEEE	19.95	23301498
112	Phosphorylation	GSGPVHISGQHLVAV CCCCEEECCEEEEEE	19.95	23927012
125	O-linked_Glycosylation	AVEEDAESEDEEEED EEECCCCCCCCHHHH	52.66	23301498
125	Phosphorylation	AVEEDAESEDEEEED EEECCCCCCCCHHHH	52.66	29255136
125 (in isoform 2)	Phosphorylation	-	52.66	18669648
134	Sumoylation	DEEEEDVKLLSISGK CCHHHHEEEEEEECC	56.91	-
135	Phosphorylation	EEEEDVKLLSISGKR CHHHHEEEEEEECCC	4.57	-
137	Phosphorylation	EEDVKLLSISGKRSA HHHEEEEEEECCCCC	25.74	23927012
137 (in isoform 2)	Phosphorylation	-	25.74	18669648
138	Phosphorylation	EDVKLLSISGKRSAP HHEEEEEEECCCCCC	6.76	-
139	Phosphorylation	DVKLLSISGKRSAPG HEEEEEEECCCCCCC	34.58	22167270
139 (in isoform 2)	Phosphorylation	-	34.58	18669648
141	Ubiquitination	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	21890473
141	Sumoylation	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	-
141	2-Hydroxyisobutyrylation	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	-
141	Acetylation	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	23954790
141	Malonylation	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	26320211
141	Methylation	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	68493
141	Sumoylation	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	28112733
141	Ubiquitination	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	21890473
141 (in isoform 1)	Ubiquitination	-	36.07	21890473
141 (in isoform 2)	Ubiquitination	-	36.07	21890473
141	Ubiquitination	KLLSISGKRSAPGGG EEEEEECCCCCCCCC	36.07	21890473
143	Phosphorylation	LSISGKRSAPGGGSK EEEECCCCCCCCCCC	42.15	22617229
149	Phosphorylation	RSAPGGGSKVPQKKV CCCCCCCCCCCHHHE	33.48	26657352
150	Sumoylation	SAPGGGSKVPQKKVK CCCCCCCCCCHHHEE	62.30	-
150	2-Hydroxyisobutyrylation	SAPGGGSKVPQKKVK CCCCCCCCCCHHHEE	62.30	-
150	Acetylation	SAPGGGSKVPQKKVK CCCCCCCCCCHHHEE	62.30	16916647
150	Sumoylation	SAPGGGSKVPQKKVK CCCCCCCCCCHHHEE	62.30	28112733
150	Ubiquitination	SAPGGGSKVPQKKVK CCCCCCCCCCHHHEE	62.30	19608861
152	Phosphorylation	PGGGSKVPQKKVKLA CCCCCCCCHHHEEEC	43.97	-
154	Acetylation	GGSKVPQKKVKLAAD CCCCCCHHHEEECCC	54.16	16916647
155	Acetylation	GSKVPQKKVKLAADE CCCCCHHHEEECCCC	39.08	7303085
155	Ubiquitination	GSKVPQKKVKLAADE CCCCCHHHEEECCCC	39.08	21906983
155 (in isoform 1)	Ubiquitination	-	39.08	21890473
155 (in isoform 2)	Ubiquitination	-	39.08	21890473
156	Phosphorylation	SKVPQKKVKLAADED CCCCHHHEEECCCCC	8.71	-
157	Acetylation	KVPQKKVKLAADEDD CCCHHHEEECCCCCC	41.09	26051181
157	Ubiquitination	KVPQKKVKLAADEDD CCCHHHEEECCCCCC	41.09	21906983
157 (in isoform 1)	Ubiquitination	-	41.09	21890473
157 (in isoform 2)	Ubiquitination	-	41.09	21890473
164	Phosphorylation	KLAADEDDDDDDEED EECCCCCCCCCCCCC	60.22	-
189	Acetylation	DDEEAEEKAPVKKSI CHHHHHHHCCCCHHH	49.88	26051181
189	Ubiquitination	DDEEAEEKAPVKKSI CHHHHHHHCCCCHHH	49.88	1890473
189 (in isoform 1)	Ubiquitination	-	49.88	21890473
189 (in isoform 2)	Ubiquitination	-	49.88	21890473
191	Phosphorylation	EEAEEKAPVKKSIRD HHHHHHCCCCHHHCC	49.91	-
193	Acetylation	AEEKAPVKKSIRDTP HHHHCCCCHHHCCCH	39.48	26051181
193	Ubiquitination	AEEKAPVKKSIRDTP HHHHCCCCHHHCCCH	39.48	21906983
193 (in isoform 1)	Ubiquitination	-	39.48	21890473
193 (in isoform 2)	Ubiquitination	-	39.48	21890473
195	Phosphorylation	EKAPVKKSIRDTPAK HHCCCCHHHCCCHHH	19.69	30266825
197	Methylation	APVKKSIRDTPAKNA CCCCHHHCCCHHHHH	49.17	115485495
198 (in isoform 2)	Phosphorylation	-	56.20	20068231
199	Phosphorylation	VKKSIRDTPAKNAQK CCHHHCCCHHHHHHH	18.46	23927012
202	Sumoylation	SIRDTPAKNAQKSNQ HHCCCHHHHHHHHCC	54.76	-
202	Acetylation	SIRDTPAKNAQKSNQ HHCCCHHHHHHHHCC	54.76	19666589
202	Sumoylation	SIRDTPAKNAQKSNQ HHCCCHHHHHHHHCC	54.76	-
202	Ubiquitination	SIRDTPAKNAQKSNQ HHCCCHHHHHHHHCC	54.76	21906983
202 (in isoform 1)	Ubiquitination	-	54.76	21890473
207	ADP-ribosylation	PAKNAQKSNQNGKDS HHHHHHHHCCCCCCC	31.41	28190768
207	Phosphorylation	PAKNAQKSNQNGKDS HHHHHHHHCCCCCCC	31.41	26074081
208 (in isoform 2)	Phosphorylation	-	46.50	25159151
212	Acetylation	QKSNQNGKDSKPSST HHHCCCCCCCCCCCC	67.39	16916647
212	Succinylation	QKSNQNGKDSKPSST HHHCCCCCCCCCCCC	67.39	23954790
214	Phosphorylation	SNQNGKDSKPSSTPR HCCCCCCCCCCCCCC	50.37	21601212
215	Sumoylation	NQNGKDSKPSSTPRS CCCCCCCCCCCCCCH	60.08	-
215	Acetylation	NQNGKDSKPSSTPRS CCCCCCCCCCCCCCH	60.08	23954790
215	Sumoylation	NQNGKDSKPSSTPRS CCCCCCCCCCCCCCH	60.08	28112733
217	Phosphorylation	NGKDSKPSSTPRSKG CCCCCCCCCCCCHHH	51.05	25159151
218	Phosphorylation	GKDSKPSSTPRSKGQ CCCCCCCCCCCHHHH	51.46	30278072
219	Phosphorylation	KDSKPSSTPRSKGQE CCCCCCCCCCHHHHH	27.36	30278072
219 (in isoform 2)	Ubiquitination	-	27.36	21890473
221 (in isoform 2)	Ubiquitination	-	51.60	21890473
222	Phosphorylation	KPSSTPRSKGQESFK CCCCCCCHHHHHHHH	42.20	30576142
223	Sumoylation	PSSTPRSKGQESFKK CCCCCCHHHHHHHHC	66.93	-
223	2-Hydroxyisobutyrylation	PSSTPRSKGQESFKK CCCCCCHHHHHHHHC	66.93	-
223	Acetylation	PSSTPRSKGQESFKK CCCCCCHHHHHHHHC	66.93	23749302
223	Sumoylation	PSSTPRSKGQESFKK CCCCCCHHHHHHHHC	66.93	-
223	Ubiquitination	PSSTPRSKGQESFKK CCCCCCHHHHHHHHC	66.93	-
227	Phosphorylation	PRSKGQESFKKQEKT CCHHHHHHHHCCCCC	34.18	23401153
228 (in isoform 2)	Ubiquitination	-	12.94	21890473
229	Sumoylation	SKGQESFKKQEKTPK HHHHHHHHCCCCCCC	63.93	-
229	2-Hydroxyisobutyrylation	SKGQESFKKQEKTPK HHHHHHHHCCCCCCC	63.93	-
229	Acetylation	SKGQESFKKQEKTPK HHHHHHHHCCCCCCC	63.93	16107701
229	Succinylation	SKGQESFKKQEKTPK HHHHHHHHCCCCCCC	63.93	23954790
229	Sumoylation	SKGQESFKKQEKTPK HHHHHHHHCCCCCCC	63.93	16107701
229	Ubiquitination	SKGQESFKKQEKTPK HHHHHHHHCCCCCCC	63.93	-
230	Sumoylation	KGQESFKKQEKTPKT HHHHHHHCCCCCCCC	62.77	-
230	Acetylation	KGQESFKKQEKTPKT HHHHHHHCCCCCCCC	62.77	16107701
230	Sumoylation	KGQESFKKQEKTPKT HHHHHHHCCCCCCCC	62.77	25114211
234	Phosphorylation	SFKKQEKTPKTPKGP HHHCCCCCCCCCCCC	29.30	20201521
237	Phosphorylation	KQEKTPKTPKGPSSV CCCCCCCCCCCCCCH	31.28	20201521
238 (in isoform 2)	Ubiquitination	-	45.81	21890473
239	Sumoylation	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	-
239	2-Hydroxyisobutyrylation	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	-
239	Acetylation	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	26051181
239	Malonylation	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	26320211
239	Succinylation	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	23954790
239	Sumoylation	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	-
239	Ubiquitination	EKTPKTPKGPSSVED CCCCCCCCCCCCHHH	84.45	-
242	Phosphorylation	PKTPKGPSSVEDIKA CCCCCCCCCHHHHHH	56.54	29255136
243	Phosphorylation	KTPKGPSSVEDIKAK CCCCCCCCHHHHHHH	32.43	29255136
243 (in isoform 3)	Phosphorylation	-	32.43	25849741
244 (in isoform 2)	Ubiquitination	-	10.07	21890473
248	Sumoylation	PSSVEDIKAKMQASI CCCHHHHHHHHHHHH	55.03	-
248	Acetylation	PSSVEDIKAKMQASI CCCHHHHHHHHHHHH	55.03	23749302
248	Malonylation	PSSVEDIKAKMQASI CCCHHHHHHHHHHHH	55.03	30639696
248	Methylation	PSSVEDIKAKMQASI CCCHHHHHHHHHHHH	55.03	72662745
248	Sumoylation	PSSVEDIKAKMQASI CCCHHHHHHHHHHHH	55.03	28112733
248	Ubiquitination	PSSVEDIKAKMQASI CCCHHHHHHHHHHHH	55.03	21906983
248 (in isoform 1)	Ubiquitination	-	55.03	21890473
250	Sumoylation	SVEDIKAKMQASIEK CHHHHHHHHHHHHHC	26.92	-
250	2-Hydroxyisobutyrylation	SVEDIKAKMQASIEK CHHHHHHHHHHHHHC	26.92	-
250	Acetylation	SVEDIKAKMQASIEK CHHHHHHHHHHHHHC	26.92	16107701
250	Sumoylation	SVEDIKAKMQASIEK CHHHHHHHHHHHHHC	26.92	28112733
250	Ubiquitination	SVEDIKAKMQASIEK CHHHHHHHHHHHHHC	26.92	21906983
250 (in isoform 1)	Ubiquitination	-	26.92	21890473
254	Phosphorylation	IKAKMQASIEKGGSL HHHHHHHHHHCCCCC	17.87	29255136
254 (in isoform 3)	Phosphorylation	-	17.87	26055452
257	Acetylation	KMQASIEKGGSLPKV HHHHHHHCCCCCCHH	67.89	19608861
257	Malonylation	KMQASIEKGGSLPKV HHHHHHHCCCCCCHH	67.89	26320211
257	Sumoylation	KMQASIEKGGSLPKV HHHHHHHCCCCCCHH	67.89	19608861
257	Ubiquitination	KMQASIEKGGSLPKV HHHHHHHCCCCCCHH	67.89	21906983
257 (in isoform 1)	Ubiquitination	-	67.89	21890473
257 (in isoform 3)	Acetylation	-	67.89	19608861
260	Phosphorylation	ASIEKGGSLPKVEAK HHHHCCCCCCHHHHH	50.60	23927012
263	Sumoylation	EKGGSLPKVEAKFIN HCCCCCCHHHHHHHH	58.98	-
263	Acetylation	EKGGSLPKVEAKFIN HCCCCCCHHHHHHHH	58.98	26051181
263	Sumoylation	EKGGSLPKVEAKFIN HCCCCCCHHHHHHHH	58.98	15897463
263	Ubiquitination	EKGGSLPKVEAKFIN HCCCCCCHHHHHHHH	58.98	-
267	Ubiquitination	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	21890473
267	Sumoylation	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	-
267	Acetylation	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	19608861
267	Malonylation	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	30639696
267	Succinylation	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	23954790
267	Sumoylation	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	19608861
267	Ubiquitination	SLPKVEAKFINYVKN CCCHHHHHHHHHHHH	33.02	21890473
267 (in isoform 1)	Ubiquitination	-	33.02	21890473
273	Ubiquitination	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	21890473
273	2-Hydroxyisobutyrylation	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	-
273	Acetylation	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	19608861
273	Malonylation	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	26320211
273	Methylation	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	68521
273	Succinylation	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	23954790
273	Sumoylation	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	28112733
273	Ubiquitination	AKFINYVKNCFRMTD HHHHHHHHHHHHCCC	37.32	21890473
273 (in isoform 1)	Ubiquitination	-	37.32	21890473
278	Sulfoxidation	YVKNCFRMTDQEAIQ HHHHHHHCCCHHHHH	2.13	30846556
279	Phosphorylation	VKNCFRMTDQEAIQD HHHHHHCCCHHHHHH	30.21	25159151
292	Acetylation	QDLWQWRKSL----- HHHHHHHHHC-----	53.82	16107701
292	Sumoylation	QDLWQWRKSL----- HHHHHHHHHC-----	53.82	16107701
293	Phosphorylation	DLWQWRKSL------ HHHHHHHHC------	30.64	29496963
338	Phosphorylation	--------------------------------------------------- ---------------------------------------------------		-
342	Phosphorylation	------------------------------------------------------- -------------------------------------------------------		-
343	Phosphorylation	-------------------------------------------------------- --------------------------------------------------------		-
419	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------		-
497	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
567	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
644	Phosphorylation	--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-
664	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	S	Phosphorylation	Kinase	PLK3	Q9H4B4	PSP
4	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
4	S	Phosphorylation	Kinase	PLK1	P53350	Uniprot
48	S	Phosphorylation	Kinase	AKT1	P31749	PSP
70	S	Phosphorylation	Kinase	NEK2	P51955	PSP
70	S	Phosphorylation	Kinase	CDK1	P06493	PSP
70	S	Phosphorylation	Kinase	CDK2	P24941	PSP
88	S	Phosphorylation	Kinase	NEK2	P51955	PSP
125	S	Phosphorylation	Kinase	ATR	Q13535	PSP
125	S	Phosphorylation	Kinase	AURA	O14965	PSP
125	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
125	S	Phosphorylation	Kinase	CDK2	P24941	Uniprot
125	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
137	S	Phosphorylation	Kinase	CDC7	O00311	PSP
199	T	Phosphorylation	Kinase	CDK2	P24941	Uniprot
199	T	Phosphorylation	Kinase	MAP3K8	P41279	GPS
199	T	Phosphorylation	Kinase	CDK6	Q00534	Uniprot
199	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
199	T	Phosphorylation	Kinase	CDC7	O00311	PSP
219	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
227	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
227	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
234	T	Phosphorylation	Kinase	CDK2	P24941	PSP
234	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
237	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:15126367
-	K	Ubiquitination	E3 ubiquitin ligase	BRCA1	P38398	PMID:15184379
-	K	Ubiquitination	E3 ubiquitin ligase	RNF144B	Q7Z419	PMID:20864535

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
4	S	Phosphorylation	Phosphorylated at Ser-4 by PLK1 and PLK2.	15388344
4	S	Phosphorylation	Phosphorylation at Ser-4 by PLK1 takes place during mitosis.	15388344
4	S	Phosphorylation	Phosphorylation at Ser-4 by PLK2 in S phase is required for centriole duplication and is sufficient to trigger centriole replication.	15388344
70	S	Phosphorylation	May be phosphorylated at Ser-70 by NEK2.	15388344
125	S	Phosphorylation	Phosphorylated by CDK2 at Ser-125 and Thr-199.	15388344
199	T	Phosphorylation	CDK6 triggers Thr-199 phosphorylation when complexed to Kaposi's sarcoma herpesvirus (KSHV) V-cyclin, leading to viral reactivation by reducing viral LANA levels.	15388344
199	T	Phosphorylation	Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis.	15388344
199	T	Phosphorylation	Phosphorylated by CDK2 at Ser-125 and Thr-199.	15388344
199	T	Phosphorylation	Phosphorylation at Thr-199 may trigger initiation of centrosome duplication.	15388344
199	T	Phosphorylation	The Thr-199 phosphorylated form has higher affinity for ROCK2.	15388344
219	T	Phosphorylation	Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis.	15388344
234	T	Phosphorylation	Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis.	15388344
237	T	Phosphorylation	Phosphorylated by CDK1 at Thr-199, Thr-219, Thr-234 and Thr-237 during cell mitosis.	15388344

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H31T_HUMAN	HIST3H3	physical	11602260
AKT1_HUMAN	AKT1	physical	18931307
GRB2_HUMAN	GRB2	physical	14968112
CENPF_HUMAN	CENPF	physical	14968112
CSKI1_HUMAN	CASKIN1	physical	14968112
CC14A_HUMAN	CDC14A	physical	14968112
P85A_HUMAN	PIK3R1	physical	14968112
NUP98_HUMAN	NUP98	physical	14968112
PPID_HUMAN	PPID	physical	14968112
GRB7_HUMAN	GRB7	physical	14968112
CND3_HUMAN	NCAPG	physical	14968112
NUMA1_HUMAN	NUMA1	physical	14968112
PADI4_HUMAN	PADI4	physical	19843866
BRCA1_HUMAN	BRCA1	physical	15184379
BARD1_HUMAN	BARD1	physical	15184379
TYY1_HUMAN	YY1	physical	16170350
H31_HUMAN	HIST1H3A	physical	16107701
H2A2C_HUMAN	HIST2H2AC	physical	16107701
H2B2E_HUMAN	HIST2H2BE	physical	16107701
FANCA_HUMAN	FANCA	physical	20864535
FANCC_HUMAN	FANCC	physical	20864535
AP2A_HUMAN	TFAP2A	physical	17318229
HDAC1_HUMAN	HDAC1	physical	17318229
HDAC2_HUMAN	HDAC2	physical	17318229
NUCL_HUMAN	NCL	physical	20431927
ACACA_HUMAN	ACACA	physical	20431927
HNRPM_HUMAN	HNRNPM	physical	20431927
HNRPU_HUMAN	HNRNPU	physical	20431927
DDX21_HUMAN	DDX21	physical	20431927
H12_HUMAN	HIST1H1C	physical	20431927
SIR1_HUMAN	SIRT1	physical	20431927
YBOX1_HUMAN	YBX1	physical	20431927
PYC_HUMAN	PC	physical	20431927
YBOX3_HUMAN	YBX3	physical	20431927
H1X_HUMAN	H1FX	physical	20431927
H11_HUMAN	HIST1H1A	physical	20431927
P53_MOUSE	Trp53	physical	17277230
CDN2A_MOUSE	Cdkn2a	physical	17277230
ARF_MOUSE	Cdkn2a	physical	17277230
ZN668_HUMAN	ZNF668	physical	21852383
UBP36_HUMAN	USP36	physical	19679658
CTCF_HUMAN	CTCF	physical	14759373
CDN1A_HUMAN	CDKN1A	physical	19221506
SENP3_HUMAN	SENP3	physical	18259216
CDN2A_HUMAN	CDKN2A	physical	18259216
ARF_HUMAN	CDKN2A	physical	18259216
RB_HUMAN	RB1	physical	18259216
PARP1_HUMAN	PARP1	physical	18259216
H31_HUMAN	HIST1H3A	physical	18259216
CENPA_HUMAN	CENPA	physical	20080577
H31_HUMAN	HIST1H3A	physical	20080577
NPM3_HUMAN	NPM3	physical	22362753
NPM_HUMAN	NPM1	physical	22362753
UBC_HUMAN	UBC	physical	20713529
P53_HUMAN	TP53	physical	15144954
PA2G4_HUMAN	PA2G4	physical	17951246
MDM2_HUMAN	MDM2	physical	23039052
PLCG1_HUMAN	PLCG1	physical	9819383
GRB2_HUMAN	GRB2	physical	9819383
P53_HUMAN	TP53	physical	16376884
G3P_HUMAN	GAPDH	physical	23027902
SIAH1_HUMAN	SIAH1	physical	23027902
A4_HUMAN	APP	physical	21832049
NUCL_HUMAN	NCL	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RL24_HUMAN	RPL24	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
PRP6_HUMAN	PRPF6	physical	22939629
SURF4_HUMAN	SURF4	physical	22939629
RL10L_HUMAN	RPL10L	physical	22939629
ZYX_HUMAN	ZYX	physical	22939629
NUP62_HUMAN	NUP62	physical	16648475
NUP50_HUMAN	NUP50	physical	16648475
RL5_HUMAN	RPL5	physical	16648475
NUCL_HUMAN	NCL	physical	16648475
P53_HUMAN	TP53	physical	12080348
CPSF6_HUMAN	CPSF6	physical	21822216
HNRH1_HUMAN	HNRNPH1	physical	21822216
PAPOG_HUMAN	PAPOLG	physical	21822216
JUNB_HUMAN	JUNB	physical	21822216
MC4R_HUMAN	MC4R	physical	21822216
ZEP2_HUMAN	HIVEP2	physical	21822216
CPSF1_HUMAN	CPSF1	physical	21822216
CPSF2_HUMAN	CPSF2	physical	21822216
CPSF4_HUMAN	CPSF4	physical	21822216
CPSF3_HUMAN	CPSF3	physical	21822216
E2AK2_HUMAN	EIF2AK2	physical	16957780
KPCZ_HUMAN	PRKCZ	physical	23402259
KIF11_HUMAN	KIF11	physical	23402259
SQSTM_HUMAN	SQSTM1	physical	23402259
FLNA_HUMAN	FLNA	physical	23402259
L2GL1_HUMAN	LLGL1	physical	23402259
HS90A_HUMAN	HSP90AA1	physical	23402259
RO52_HUMAN	TRIM21	physical	23402259
TBA1C_HUMAN	TUBA1C	physical	23402259
HS90B_HUMAN	HSP90AB1	physical	23402259
PAR6B_HUMAN	PARD6B	physical	23402259
CDC37_HUMAN	CDC37	physical	23402259
TBB3_HUMAN	TUBB3	physical	23402259
RM46_HUMAN	MRPL46	physical	23402259
KCTD2_HUMAN	KCTD2	physical	23402259
CLH1_HUMAN	CLTC	physical	23402259
RM50_HUMAN	MRPL50	physical	23402259
TERA_HUMAN	VCP	physical	23402259
KCTD5_HUMAN	KCTD5	physical	23402259
RM12_HUMAN	MRPL12	physical	23402259
GRP78_HUMAN	HSPA5	physical	23402259
NPM_HUMAN	NPM1	physical	23402259
CAVN1_HUMAN	PTRF	physical	23402259
RM52_HUMAN	MRPL52	physical	23402259
EF1A1_HUMAN	EEF1A1	physical	23402259
KCD17_HUMAN	KCTD17	physical	23402259
TAB1_HUMAN	TAB1	physical	23402259
BAG2_HUMAN	BAG2	physical	23402259
ANXA2_HUMAN	ANXA2	physical	23402259
IF5A1_HUMAN	EIF5A	physical	23402259
PPIL4_HUMAN	PPIL4	physical	23402259
RM38_HUMAN	MRPL38	physical	23402259
STK38_HUMAN	STK38	physical	23402259
G3P_HUMAN	GAPDH	physical	23402259
FLNB_HUMAN	FLNB	physical	23402259
LEG1_HUMAN	LGALS1	physical	23402259
C1QBP_HUMAN	C1QBP	physical	23402259
COPB_HUMAN	COPB1	physical	23402259
RM37_HUMAN	MRPL37	physical	23402259
RM49_HUMAN	MRPL49	physical	23402259
KEAP1_HUMAN	KEAP1	physical	23402259
PRDX4_HUMAN	PRDX4	physical	23402259
WDR26_HUMAN	WDR26	physical	23402259
PRS6B_HUMAN	PSMC4	physical	23402259
CAVN2_HUMAN	SDPR	physical	23402259
NPM3_HUMAN	NPM3	physical	23402259
MPCP_HUMAN	SLC25A3	physical	23402259
RS12_HUMAN	RPS12	physical	23402259
EF1B_HUMAN	EEF1B2	physical	23402259
NIPS1_HUMAN	NIPSNAP1	physical	23402259
EF1G_HUMAN	EEF1G	physical	23402259
RM39_HUMAN	MRPL39	physical	23402259
DDX3X_HUMAN	DDX3X	physical	23402259
RINI_HUMAN	RNH1	physical	23402259
OSBL1_HUMAN	OSBPL1A	physical	23402259
EIF3H_HUMAN	EIF3H	physical	23402259
RM54_HUMAN	MRPL54	physical	23402259
ENOA_HUMAN	ENO1	physical	23402259
MYCBP_HUMAN	MYCBP	physical	23402259
RM18_HUMAN	MRPL18	physical	23402259
MAP1B_HUMAN	MAP1B	physical	23402259
PSMD1_HUMAN	PSMD1	physical	23402259
EF1D_HUMAN	EEF1D	physical	23402259
DJC13_HUMAN	DNAJC13	physical	23402259
HSPB1_HUMAN	HSPB1	physical	23402259
COF1_HUMAN	CFL1	physical	23402259
FLNC_HUMAN	FLNC	physical	23402259
PP1G_HUMAN	PPP1CC	physical	23402259
RLA1_HUMAN	RPLP1	physical	23402259
CE152_HUMAN	CEP152	physical	23402259
SMD1_HUMAN	SNRPD1	physical	23402259
ATPA_HUMAN	ATP5A1	physical	23402259
RHG05_HUMAN	ARHGAP5	physical	23402259
KAP0_HUMAN	PRKAR1A	physical	23402259
RM53_HUMAN	MRPL53	physical	23402259
GID8_HUMAN	GID8	physical	23402259
1433Z_HUMAN	YWHAZ	physical	23402259
TCPB_HUMAN	CCT2	physical	23402259
EIF3E_HUMAN	EIF3E	physical	23402259
LAMB2_HUMAN	LAMB2	physical	23402259
DICER_HUMAN	DICER1	physical	23402259
MIA40_HUMAN	CHCHD4	physical	23402259
RM19_HUMAN	MRPL19	physical	23402259
SMD2_HUMAN	SNRPD2	physical	23402259
GRWD1_HUMAN	GRWD1	physical	23402259
TPR_HUMAN	TPR	physical	23402259
PSMD4_HUMAN	PSMD4	physical	23402259
PRS8_HUMAN	PSMC5	physical	23402259
PP2AA_HUMAN	PPP2CA	physical	23402259
UNC5C_HUMAN	UNC5C	physical	23402259
ADT2_HUMAN	SLC25A5	physical	23402259
PTN14_HUMAN	PTPN14	physical	23402259
RS5_HUMAN	RPS5	physical	23402259
TTC27_HUMAN	TTC27	physical	23402259
BOLA2_HUMAN	BOLA2	physical	23402259
IF4A1_HUMAN	EIF4A1	physical	23402259
EFTU_HUMAN	TUFM	physical	23402259
S10AA_HUMAN	S100A10	physical	23402259
IMPG1_HUMAN	IMPG1	physical	23402259
CPSF5_HUMAN	NUDT21	physical	23402259
UTRO_HUMAN	UTRN	physical	23402259
RM44_HUMAN	MRPL44	physical	23402259
EIF3M_HUMAN	EIF3M	physical	23402259
RM43_HUMAN	MRPL43	physical	23402259
KPYM_HUMAN	PKM	physical	23402259
IMDH2_HUMAN	IMPDH2	physical	23402259
TRRAP_HUMAN	TRRAP	physical	23402259
MIC25_HUMAN	CHCHD6	physical	23402259
RNBP6_HUMAN	RANBP6	physical	23402259
EIF3I_HUMAN	EIF3I	physical	23402259
TAB2_HUMAN	TAB2	physical	23402259
RM24_HUMAN	MRPL24	physical	23402259
1433E_HUMAN	YWHAE	physical	23402259
DZIP1_HUMAN	DZIP1	physical	23402259
IPO5_HUMAN	IPO5	physical	23402259
AGR2_HUMAN	AGR2	physical	23402259
RT30_HUMAN	MRPS30	physical	23402259
ICT1_HUMAN	ICT1	physical	23402259
PRDX6_HUMAN	PRDX6	physical	23402259
TCPA_HUMAN	TCP1	physical	23402259
RCOR1_HUMAN	RCOR1	physical	23402259
GRN_HUMAN	GRN	physical	23402259
THIO_HUMAN	TXN	physical	23402259
RLA0_HUMAN	RPLP0	physical	23402259
PCBP1_HUMAN	PCBP1	physical	23402259
RM28_HUMAN	MRPL28	physical	23402259
RM10_HUMAN	MRPL10	physical	23402259
TAF3_HUMAN	TAF3	physical	23402259
EPAS1_HUMAN	EPAS1	physical	23402259
MIC19_HUMAN	CHCHD3	physical	23402259
TXD12_HUMAN	TXNDC12	physical	23402259
ELMO2_HUMAN	ELMO2	physical	23402259
SRRT_HUMAN	SRRT	physical	23402259
RM11_HUMAN	MRPL11	physical	23402259
IF2A_HUMAN	EIF2S1	physical	23402259
RUXF_HUMAN	SNRPF	physical	23402259
KTN1_HUMAN	KTN1	physical	23402259
FGD6_HUMAN	FGD6	physical	23402259
QCR6_HUMAN	UQCRH	physical	23402259
RBBP4_HUMAN	RBBP4	physical	23402259
DNJA1_HUMAN	DNAJA1	physical	23402259
SRC8_HUMAN	CTTN	physical	23402259
UBP15_HUMAN	USP15	physical	23402259
NUDC1_HUMAN	NUDCD1	physical	23402259
RS28_HUMAN	RPS28	physical	23402259
JAK1_HUMAN	JAK1	physical	23402259
PROS_HUMAN	PROS1	physical	23402259
PYGB_HUMAN	PYGB	physical	23402259
VGFR2_HUMAN	KDR	physical	23402259
EF2_HUMAN	EEF2	physical	23402259
FAS_HUMAN	FASN	physical	23402259
AKA11_HUMAN	AKAP11	physical	23402259
CSK2B_HUMAN	CSNK2B	physical	23402259
DNJA2_HUMAN	DNAJA2	physical	23402259
EIF3G_HUMAN	EIF3G	physical	23402259
DHX15_HUMAN	DHX15	physical	23402259
RT26_HUMAN	MRPS26	physical	23402259
ROA0_HUMAN	HNRNPA0	physical	23402259
DOCK4_HUMAN	DOCK4	physical	23402259
KPCI_HUMAN	PRKCI	physical	23402259
VASP_HUMAN	VASP	physical	23402259
COPE_HUMAN	COPE	physical	23402259
SAM50_HUMAN	SAMM50	physical	23402259
TEX15_HUMAN	TEX15	physical	23402259
PSME3_HUMAN	PSME3	physical	23402259
PPM1G_HUMAN	PPM1G	physical	23402259
COPG1_HUMAN	COPG1	physical	23402259
CALU_HUMAN	CALU	physical	23402259
S10AB_HUMAN	S100A11	physical	23402259
HSP74_HUMAN	HSPA4	physical	23402259
PSD12_HUMAN	PSMD12	physical	23402259
RPAB1_HUMAN	POLR2E	physical	23402259
TIF1B_HUMAN	TRIM28	physical	23402259
YBOX1_HUMAN	YBX1	physical	23402259
SLAI2_HUMAN	SLAIN2	physical	23402259
RL10_HUMAN	RPL10	physical	23402259
GOGA2_HUMAN	GOLGA2	physical	23402259
GOGA3_HUMAN	GOLGA3	physical	23402259
KPCA_HUMAN	PRKCA	physical	23402259
IPO9_HUMAN	IPO9	physical	23402259
PARK7_HUMAN	PARK7	physical	23402259
SPIN1_HUMAN	SPIN1	physical	23402259
IPYR_HUMAN	PPA1	physical	23402259
BANP_HUMAN	BANP	physical	23402259
DEST_HUMAN	DSTN	physical	23402259
HMGA1_HUMAN	HMGA1	physical	18850631
HMGA2_HUMAN	HMGA2	physical	18850631
PRS6B_HUMAN	PSMC4	physical	21988832
TF65_HUMAN	RELA	physical	21988832
QCR6_HUMAN	UQCRH	physical	21988832
1433T_HUMAN	YWHAQ	physical	20618440
IMA5_HUMAN	KPNA1	physical	22863883
TRM61_HUMAN	TRMT61A	physical	22863883
CDN2A_HUMAN	CDKN2A	physical	24769896
ARF_HUMAN	CDKN2A	physical	24769896
ELF4_HUMAN	ELF4	physical	23393136
NPM2_HUMAN	NPM2	physical	25416956
RL26L_HUMAN	RPL26L1	physical	26186194
NIP7_HUMAN	NIP7	physical	26186194
RL4_HUMAN	RPL4	physical	26186194
RPF1_HUMAN	RPF1	physical	26186194
CC137_HUMAN	CCDC137	physical	26186194
KNOP1_HUMAN	KNOP1	physical	26186194
RBM28_HUMAN	RBM28	physical	26186194
RL7A_HUMAN	RPL7A	physical	26186194
POP1_HUMAN	POP1	physical	26186194
DDX24_HUMAN	DDX24	physical	26186194
SPB1_HUMAN	FTSJ3	physical	26186194
DDX21_HUMAN	DDX21	physical	26186194
RRS1_HUMAN	RRS1	physical	26186194
HJURP_HUMAN	HJURP	physical	26186194
ZN668_HUMAN	ZNF668	physical	26186194
RL3_HUMAN	RPL3	physical	26186194
ZFP62_HUMAN	ZFP62	physical	26186194
ZN512_HUMAN	ZNF512	physical	26186194
RL5_HUMAN	RPL5	physical	26186194
DDX56_HUMAN	DDX56	physical	26186194
DDX27_HUMAN	DDX27	physical	26186194
GLYR1_HUMAN	GLYR1	physical	26186194
MAK16_HUMAN	MAK16	physical	26186194
CEBPZ_HUMAN	CEBPZ	physical	26186194
RL1D1_HUMAN	RSL1D1	physical	26186194
HP1B3_HUMAN	HP1BP3	physical	26186194
REXO4_HUMAN	REXO4	physical	26186194
DDX31_HUMAN	DDX31	physical	26186194
MBB1A_HUMAN	MYBBP1A	physical	26186194
NOP16_HUMAN	NOP16	physical	26186194
NEPRO_HUMAN	C3orf17	physical	26186194
RRP8_HUMAN	RRP8	physical	26186194
NOG2_HUMAN	GNL2	physical	26186194
PAPD5_HUMAN	PAPD5	physical	26186194
RLP24_HUMAN	RSL24D1	physical	26186194
SURF6_HUMAN	SURF6	physical	26186194
NOG1_HUMAN	GTPBP4	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
NOP2_HUMAN	NOP2	physical	26186194
NVL_HUMAN	NVL	physical	26186194
NOP53_HUMAN	GLTSCR2	physical	26186194
NPA1P_HUMAN	URB1	physical	26186194
RL23A_HUMAN	RPL23A	physical	26186194
TEX10_HUMAN	TEX10	physical	26186194
RS8_HUMAN	RPS8	physical	26186194
NOC3L_HUMAN	NOC3L	physical	26186194
BRX1_HUMAN	BRIX1	physical	26186194
DDX54_HUMAN	DDX54	physical	26186194
LYAR_HUMAN	LYAR	physical	26186194
PWP1_HUMAN	PWP1	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
NMNA1_HUMAN	NMNAT1	physical	26186194
CENPC_HUMAN	CENPC	physical	26186194
SENP5_HUMAN	SENP5	physical	26186194
RL36L_HUMAN	RPL36AL	physical	26186194
PK1IP_HUMAN	PAK1IP1	physical	26186194
ZN800_HUMAN	ZNF800	physical	26186194
RL7L_HUMAN	RPL7L1	physical	26186194
RL37A_HUMAN	RPL37A	physical	26186194
RPF2_HUMAN	RPF2	physical	26186194
PELP1_HUMAN	PELP1	physical	26186194
NOC2L_HUMAN	NOC2L	physical	26186194
RPP40_HUMAN	RPP40	physical	26186194
RBMX2_HUMAN	RBMX2	physical	26186194
H2AX_HUMAN	H2AFX	physical	26186194
CENPV_HUMAN	CENPV	physical	26186194
SDA1_HUMAN	SDAD1	physical	26186194
RPP38_HUMAN	RPP38	physical	26186194
RPP25_HUMAN	RPP25	physical	26186194
NPM3_HUMAN	NPM3	physical	26186194
SPT2_HUMAN	SPTY2D1	physical	26186194
RP25L_HUMAN	RPP25L	physical	26186194
POP7_HUMAN	POP7	physical	26186194
BYST_HUMAN	BYSL	physical	26496610
CHD1_HUMAN	CHD1	physical	26496610
DDX1_HUMAN	DDX1	physical	26496610
DDX3X_HUMAN	DDX3X	physical	26496610
DECR_HUMAN	DECR1	physical	26496610
IF1AX_HUMAN	EIF1AX	physical	26496610
IF4G2_HUMAN	EIF4G2	physical	26496610
FBRL_HUMAN	FBL	physical	26496610
UBIM_HUMAN	FAU	physical	26496610
H12_HUMAN	HIST1H1C	physical	26496610
H13_HUMAN	HIST1H1D	physical	26496610
H15_HUMAN	HIST1H1B	physical	26496610
HNRPU_HUMAN	HNRNPU	physical	26496610
EIF3E_HUMAN	EIF3E	physical	26496610
RSSA_HUMAN	RPSA	physical	26496610
KI67_HUMAN	MKI67	physical	26496610
3MG_HUMAN	MPG	physical	26496610
NP1L4_HUMAN	NAP1L4	physical	26496610
RL10A_HUMAN	RPL10A	physical	26496610
NVL_HUMAN	NVL	physical	26496610
PA2G4_HUMAN	PA2G4	physical	26496610
EXOSX_HUMAN	EXOSC10	physical	26496610
RL3_HUMAN	RPL3	physical	26496610
RL4_HUMAN	RPL4	physical	26496610
RL5_HUMAN	RPL5	physical	26496610
RL6_HUMAN	RPL6	physical	26496610
RL7_HUMAN	RPL7	physical	26496610
RL7A_HUMAN	RPL7A	physical	26496610
RL8_HUMAN	RPL8	physical	26496610
RL9_HUMAN	RPL9	physical	26496610
RL10_HUMAN	RPL10	physical	26496610
RL11_HUMAN	RPL11	physical	26496610
RL13_HUMAN	RPL13	physical	26496610
RL15_HUMAN	RPL15	physical	26496610
RL17_HUMAN	RPL17	physical	26496610
RL18_HUMAN	RPL18	physical	26496610
RL18A_HUMAN	RPL18A	physical	26496610
RL19_HUMAN	RPL19	physical	26496610
RL21_HUMAN	RPL21	physical	26496610
RL22_HUMAN	RPL22	physical	26496610
RL23A_HUMAN	RPL23A	physical	26496610
RL24_HUMAN	RPL24	physical	26496610
RL27_HUMAN	RPL27	physical	26496610
RL27A_HUMAN	RPL27A	physical	26496610
RL29_HUMAN	RPL29	physical	26496610
RL32_HUMAN	RPL32	physical	26496610
RL37_HUMAN	RPL37	physical	26496610
RL37A_HUMAN	RPL37A	physical	26496610
RL38_HUMAN	RPL38	physical	26496610
RS2_HUMAN	RPS2	physical	26496610
RS3_HUMAN	RPS3	physical	26496610
RS3A_HUMAN	RPS3A	physical	26496610
RS4X_HUMAN	RPS4X	physical	26496610
RS5_HUMAN	RPS5	physical	26496610
RS6_HUMAN	RPS6	physical	26496610
RS8_HUMAN	RPS8	physical	26496610
RS9_HUMAN	RPS9	physical	26496610
RS10_HUMAN	RPS10	physical	26496610
RS11_HUMAN	RPS11	physical	26496610
RS13_HUMAN	RPS13	physical	26496610
RS14_HUMAN	RPS14	physical	26496610
RS15_HUMAN	RPS15	physical	26496610
RS16_HUMAN	RPS16	physical	26496610
RS17_HUMAN	RPS17	physical	26496610
RS18_HUMAN	RPS18	physical	26496610
RS19_HUMAN	RPS19	physical	26496610
RS20_HUMAN	RPS20	physical	26496610
RS21_HUMAN	RPS21	physical	26496610
RS23_HUMAN	RPS23	physical	26496610
RS24_HUMAN	RPS24	physical	26496610
RS25_HUMAN	RPS25	physical	26496610
RS27_HUMAN	RPS27	physical	26496610
RS28_HUMAN	RPS28	physical	26496610
RS29_HUMAN	RPS29	physical	26496610
SKIV2_HUMAN	SKIV2L	physical	26496610
SRP72_HUMAN	SRP72	physical	26496610
XPC_HUMAN	XPC	physical	26496610
IFRD2_HUMAN	IFRD2	physical	26496610
H2B2E_HUMAN	HIST2H2BE	physical	26496610
SMCA5_HUMAN	SMARCA5	physical	26496610
CGBP1_HUMAN	CGGBP1	physical	26496610
EIF3A_HUMAN	EIF3A	physical	26496610
EIF3C_HUMAN	EIF3C	physical	26496610
PABP4_HUMAN	PABPC4	physical	26496610
H1X_HUMAN	H1FX	physical	26496610
RL14_HUMAN	RPL14	physical	26496610
UBP10_HUMAN	USP10	physical	26496610
TTC37_HUMAN	TTC37	physical	26496610
JADE3_HUMAN	JADE3	physical	26496610
PUM3_HUMAN	KIAA0020	physical	26496610
ABCF2_HUMAN	ABCF2	physical	26496610
G3BP1_HUMAN	G3BP1	physical	26496610
NPM3_HUMAN	NPM3	physical	26496610
RACK1_HUMAN	GNB2L1	physical	26496610
NEP1_HUMAN	EMG1	physical	26496610
MBB1A_HUMAN	MYBBP1A	physical	26496610
NOP56_HUMAN	NOP56	physical	26496610
IF2B3_HUMAN	IGF2BP3	physical	26496610
PSIP1_HUMAN	PSIP1	physical	26496610
SP16H_HUMAN	SUPT16H	physical	26496610
RL35_HUMAN	RPL35	physical	26496610
RRP5_HUMAN	PDCD11	physical	26496610
LAR4B_HUMAN	LARP4B	physical	26496610
RRP12_HUMAN	RRP12	physical	26496610
LARP1_HUMAN	LARP1	physical	26496610
RL13A_HUMAN	RPL13A	physical	26496610
NOG1_HUMAN	GTPBP4	physical	26496610
RL36_HUMAN	RPL36	physical	26496610
C1TM_HUMAN	MTHFD1L	physical	26496610
ELYS_HUMAN	AHCTF1	physical	26496610
FA98A_HUMAN	FAM98A	physical	26496610
PAIRB_HUMAN	SERBP1	physical	26496610
RL1D1_HUMAN	RSL1D1	physical	26496610
GNL3_HUMAN	GNL3	physical	26496610
SND1_HUMAN	SND1	physical	26496610
NOB1_HUMAN	NOB1	physical	26496610
NOG2_HUMAN	GNL2	physical	26496610
HP1B3_HUMAN	HP1BP3	physical	26496610
RS27L_HUMAN	RPS27L	physical	26496610
DDX47_HUMAN	DDX47	physical	26496610
EIF3L_HUMAN	EIF3L	physical	26496610
RTCB_HUMAN	RTCB	physical	26496610
TR112_HUMAN	TRMT112	physical	26496610
DHX29_HUMAN	DHX29	physical	26496610
TEX10_HUMAN	TEX10	physical	26496610
NSUN2_HUMAN	NSUN2	physical	26496610
PAPD1_HUMAN	MTPAP	physical	26496610
NAT10_HUMAN	NAT10	physical	26496610
TSR1_HUMAN	TSR1	physical	26496610
NKRF_HUMAN	NKRF	physical	26496610
MEPCE_HUMAN	MEPCE	physical	26496610
BCCIP_HUMAN	BCCIP	physical	26496610
PNO1_HUMAN	PNO1	physical	26496610
RT22_HUMAN	MRPS22	physical	26496610
DDX24_HUMAN	DDX24	physical	26496610
WDR18_HUMAN	WDR18	physical	26496610
SFR19_HUMAN	SCAF1	physical	26496610
NOL6_HUMAN	NOL6	physical	26496610
DDX50_HUMAN	DDX50	physical	26496610
CCD86_HUMAN	CCDC86	physical	26496610
MUS81_HUMAN	MUS81	physical	26496610
DOT1L_HUMAN	DOT1L	physical	26496610
ZN622_HUMAN	ZNF622	physical	26496610
DHX57_HUMAN	DHX57	physical	26496610
H2AV_HUMAN	H2AFV	physical	26496610
LARP4_HUMAN	LARP4	physical	26496610
BUD23_HUMAN	WBSCR22	physical	26496610
DNJB4_HUMAN	DNAJB4	physical	20145123
NPM_HUMAN	NPM1	physical	20145123
TF65_HUMAN	RELA	physical	19074833
SP1_HUMAN	SP1	physical	19074833
AP2A_HUMAN	TFAP2A	physical	19074833
CD24_HUMAN	CD24	physical	25600590
CDN2A_HUMAN	CDKN2A	physical	25600590
ARF_HUMAN	CDKN2A	physical	25600590
NEPRO_HUMAN	C3orf17	physical	28514442
RPP25_HUMAN	RPP25	physical	28514442
RP25L_HUMAN	RPP25L	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
RPP40_HUMAN	RPP40	physical	28514442
NMNA1_HUMAN	NMNAT1	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
ZN800_HUMAN	ZNF800	physical	28514442
RPP38_HUMAN	RPP38	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
NPM3_HUMAN	NPM3	physical	28514442
NVL_HUMAN	NVL	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
RPF1_HUMAN	RPF1	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
PAPD5_HUMAN	PAPD5	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
SPT2_HUMAN	SPTY2D1	physical	28514442
RL7L_HUMAN	RPL7L1	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442
POP7_HUMAN	POP7	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
NOC3L_HUMAN	NOC3L	physical	28514442
SENP5_HUMAN	SENP5	physical	28514442
NPA1P_HUMAN	URB1	physical	28514442
HJURP_HUMAN	HJURP	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
NOP53_HUMAN	GLTSCR2	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
TEX10_HUMAN	TEX10	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
NOC2L_HUMAN	NOC2L	physical	28514442
POP1_HUMAN	POP1	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
RL23A_HUMAN	RPL23A	physical	28514442
SURF6_HUMAN	SURF6	physical	28514442
ZFP62_HUMAN	ZFP62	physical	28514442
DDX51_HUMAN	DDX51	physical	28514442
RL7A_HUMAN	RPL7A	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
MAK16_HUMAN	MAK16	physical	28514442
NUCL_HUMAN	NCL	physical	28514442
CENPC_HUMAN	CENPC	physical	28514442
E2AK2_HUMAN	EIF2AK2	physical	12882984
P53_HUMAN	TP53	physical	15964625
CDN1A_HUMAN	CDKN1A	physical	15964625
CDN2A_HUMAN	CDKN2A	physical	16679321
ARF_HUMAN	CDKN2A	physical	16679321
FBXW7_HUMAN	FBXW7	physical	28920929
CENPW_HUMAN	CENPW	physical	28920929
TAT_HV1H2	tat	physical	28920929

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-4; SER-10; THR-95; SER-125; SER-139 ANDSER-254, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-32; LYS-150; LYS-257;LYS-267 AND LYS-273, AND MASS SPECTROMETRY.
PubMed: 19608861

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-150; LYS-154 AND LYS-212,AND MASS SPECTROMETRY.
PubMed: 16916647

Phosphorylation

"Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4triggers centriole duplication.";
Krause A., Hoffmann I.;
PLoS ONE 5:E9849-E9849(2010).
Cited for: FUNCTION, PHOSPHORYLATION AT SER-4 BY PLK2, AND MUTAGENESIS OF SER-4;THR-95; SER-125 AND THR-199.
PubMed: 20352051

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70 AND SER-125, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-125, ANDMASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-4; SER-10; THR-95; SER-125; SER-139 ANDSER-254, AND MASS SPECTROMETRY.
PubMed: 19413330

"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND MASSSPECTROMETRY.
PubMed: 18318008

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; THR-75; THR-95;SER-125; SER-139; THR-234; THR-237; SER-243; SER-254; SER-260 ANDTHR-279, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-125 AND SER-254,AND MASS SPECTROMETRY.
PubMed: 18691976

"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125, AND MASSSPECTROMETRY.
PubMed: 19367720

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-88; SER-125 ANDTHR-279, AND MASS SPECTROMETRY.
PubMed: 18220336

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-70; SER-125;SER-243; SER-254 AND SER-260, AND MASS SPECTROMETRY.
PubMed: 19007248

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-125; SER-137;THR-199; THR-234; THR-237 AND SER-260, AND MASS SPECTROMETRY.
PubMed: 17287340

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; THR-75; THR-95;SER-137; THR-199; SER-254 AND SER-260, AND MASS SPECTROMETRY.
PubMed: 17924679

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-125 AND SER-254,AND MASS SPECTROMETRY.
PubMed: 16565220

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-10; SER-70;THR-95; THR-199 AND SER-254, AND MASS SPECTROMETRY.
PubMed: 17081983

"B23/nucleophosmin serine 4 phosphorylation mediates mitotic functionsof polo-like kinase 1.";
Zhang H., Shi X., Paddon H., Hampong M., Dai W., Pelech S.;
J. Biol. Chem. 279:35726-35734(2004).
Cited for: PHOSPHORYLATION AT SER-4 BY PLK1.
PubMed: 15190079

"Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHVlatency.";
Sarek G., Jaerviluoma A., Moore H.M., Tojkander S., Vartia S.,Biberfeld P., Laiho M., Ojala P.M.;
PLoS Pathog. 6:E1000818-E1000818(2010).
Cited for: PHOSPHORYLATION AT THR-199 BY CDK6.
PubMed: 20333249

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-199, AND MASSSPECTROMETRY.
PubMed: 16083285

Sumoylation

"Sumoylation induced by the Arf tumor suppressor: a p53-independentfunction.";
Tago K., Chiocca S., Sherr C.J.;
Proc. Natl. Acad. Sci. U.S.A. 102:7689-7694(2005).
Cited for: SUMOYLATION AT LYS-230 AND LYS-263.
PubMed: 15897463