| UniProt ID | RM39_HUMAN | |
|---|---|---|
| UniProt AC | Q9NYK5 | |
| Protein Name | 39S ribosomal protein L39, mitochondrial | |
| Gene Name | MRPL39 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 338 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | ||
| Protein Sequence | MEALAMGSRALRLWLVAPGGGIKWRFIATSSASQLSPTELTEMRNDLFNKEKARQLSLTPRTEKIEVKHVGKTDPGTVFVMNKNISTPYSCAMHLSEWYCRKSILALVDGQPWDMYKPLTKSCEIKFLTFKDCDPGEVNKAYWRSCAMMMGCVIERAFKDEYMVNLVRAPEVPVISGAFCYDVVLDSKLDEWMPTKENLRSFTKDAHALIYKDLPFETLEVEAKVALEIFQHSKYKVDFIEEKASQNPERIVKLHRIGDFIDVSEGPLIPRTSICFQYEVSAVHNLQPTQPSLIRRFQGVSLPVHLRAHFTIWDKLLERSRKMVTEDQSKATEECTST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Ubiquitination | MEALAMGSRALRLWL CCHHHCCCCEEEEEE | 10.99 | 23503661 | |
| 10 | Ubiquitination | ALAMGSRALRLWLVA HHHCCCCEEEEEEEE | 9.95 | 24816145 | |
| 50 | Ubiquitination | MRNDLFNKEKARQLS HHHHHCCHHHHHHHC | 53.94 | 23503661 | |
| 50 (in isoform 2) | Ubiquitination | - | 53.94 | - | |
| 52 | Ubiquitination | NDLFNKEKARQLSLT HHHCCHHHHHHHCCC | 50.94 | 24816145 | |
| 59 | Phosphorylation | KARQLSLTPRTEKIE HHHHHCCCCCCCEEE | 13.83 | - | |
| 72 | Acetylation | IEVKHVGKTDPGTVF EEEEECCCCCCCCEE | 48.98 | 23236377 | |
| 72 | Ubiquitination | IEVKHVGKTDPGTVF EEEEECCCCCCCCEE | 48.98 | 29967540 | |
| 72 | Succinylation | IEVKHVGKTDPGTVF EEEEECCCCCCCCEE | 48.98 | 27452117 | |
| 72 | Malonylation | IEVKHVGKTDPGTVF EEEEECCCCCCCCEE | 48.98 | 26320211 | |
| 75 | Ubiquitination | KHVGKTDPGTVFVMN EECCCCCCCCEEEEE | 45.66 | 23503661 | |
| 79 | Ubiquitination | KTDPGTVFVMNKNIS CCCCCCEEEEECCCC | 4.30 | 23503661 | |
| 89 | Phosphorylation | NKNISTPYSCAMHLS ECCCCCCCHHHHHHH | 19.23 | 18083107 | |
| 96 | Phosphorylation | YSCAMHLSEWYCRKS CHHHHHHHHHHHCCH | 16.05 | - | |
| 99 | Phosphorylation | AMHLSEWYCRKSILA HHHHHHHHHCCHHHH | 4.37 | 18083107 | |
| 117 (in isoform 2) | Ubiquitination | - | 27.24 | - | |
| 117 | Ubiquitination | GQPWDMYKPLTKSCE CCCCCCCCCCCCCCE | 27.24 | 24816145 | |
| 121 | Ubiquitination | DMYKPLTKSCEIKFL CCCCCCCCCCEEEEE | 61.87 | 23503661 | |
| 126 | Malonylation | LTKSCEIKFLTFKDC CCCCCEEEEEEECCC | 16.42 | 26320211 | |
| 126 | Succinylation | LTKSCEIKFLTFKDC CCCCCEEEEEEECCC | 16.42 | 27452117 | |
| 126 | Acetylation | LTKSCEIKFLTFKDC CCCCCEEEEEEECCC | 16.42 | 19608861 | |
| 131 | Ubiquitination | EIKFLTFKDCDPGEV EEEEEEECCCCHHHC | 52.81 | 29967540 | |
| 131 | Acetylation | EIKFLTFKDCDPGEV EEEEEEECCCCHHHC | 52.81 | 26051181 | |
| 154 | Ubiquitination | AMMMGCVIERAFKDE HHHHHHHHHHHCCCC | 3.27 | 22817900 | |
| 159 | Acetylation | CVIERAFKDEYMVNL HHHHHHCCCCHHEEE | 48.98 | 26822725 | |
| 159 | Ubiquitination | CVIERAFKDEYMVNL HHHHHHCCCCHHEEE | 48.98 | 24816145 | |
| 162 | Ubiquitination | ERAFKDEYMVNLVRA HHHCCCCHHEEEEEC | 19.25 | 23503661 | |
| 170 | Ubiquitination | MVNLVRAPEVPVISG HEEEEECCCCCEEEC | 32.33 | 23503661 | |
| 192 | Ubiquitination | LDSKLDEWMPTKENL HCCCHHHCCCCHHHH | 9.56 | 23503661 | |
| 194 | Ubiquitination | SKLDEWMPTKENLRS CCHHHCCCCHHHHHH | 41.20 | 23503661 | |
| 195 | Phosphorylation | KLDEWMPTKENLRSF CHHHCCCCHHHHHHH | 34.58 | 22985185 | |
| 196 | Ubiquitination | LDEWMPTKENLRSFT HHHCCCCHHHHHHHC | 38.44 | 21906983 | |
| 196 (in isoform 2) | Ubiquitination | - | 38.44 | 21890473 | |
| 196 (in isoform 1) | Ubiquitination | - | 38.44 | 21890473 | |
| 200 | Methylation | MPTKENLRSFTKDAH CCCHHHHHHHCCCCC | 41.11 | 115483777 | |
| 201 | Ubiquitination | PTKENLRSFTKDAHA CCHHHHHHHCCCCCE | 40.20 | 23503661 | |
| 201 | Phosphorylation | PTKENLRSFTKDAHA CCHHHHHHHCCCCCE | 40.20 | 24719451 | |
| 204 | Acetylation | ENLRSFTKDAHALIY HHHHHHCCCCCEEEE | 51.40 | 19608861 | |
| 204 | Malonylation | ENLRSFTKDAHALIY HHHHHHCCCCCEEEE | 51.40 | 26320211 | |
| 204 (in isoform 2) | Ubiquitination | - | 51.40 | - | |
| 204 | Ubiquitination | ENLRSFTKDAHALIY HHHHHHCCCCCEEEE | 51.40 | 19608861 | |
| 212 (in isoform 2) | Ubiquitination | - | 45.88 | - | |
| 212 | Ubiquitination | DAHALIYKDLPFETL CCCEEEECCCCCCEE | 45.88 | 23503661 | |
| 234 | Ubiquitination | LEIFQHSKYKVDFIE HHHHHCCCCCCCHHH | 47.14 | 23503661 | |
| 234 | Acetylation | LEIFQHSKYKVDFIE HHHHHCCCCCCCHHH | 47.14 | 23236377 | |
| 236 | Ubiquitination | IFQHSKYKVDFIEEK HHHCCCCCCCHHHHH | 38.78 | 23503661 | |
| 236 (in isoform 2) | Ubiquitination | - | 38.78 | - | |
| 243 | Ubiquitination | KVDFIEEKASQNPER CCCHHHHHHHCCHHH | 40.31 | 23503661 | |
| 243 (in isoform 2) | Ubiquitination | - | 40.31 | - | |
| 253 | Methylation | QNPERIVKLHRIGDF CCHHHEEEEEEECCE | 35.88 | - | |
| 253 | "N6,N6-dimethyllysine" | QNPERIVKLHRIGDF CCHHHEEEEEEECCE | 35.88 | - | |
| 273 | Ubiquitination | GPLIPRTSICFQYEV CCCCCCEEEEEEEEE | 20.74 | 21890473 | |
| 288 | Ubiquitination | SAVHNLQPTQPSLIR HHHCCCCCCCCHHHH | 35.85 | 24816145 | |
| 315 | Acetylation | AHFTIWDKLLERSRK HHHHHHHHHHHHHHH | 39.72 | 26051181 | |
| 315 (in isoform 1) | Ubiquitination | - | 39.72 | 21890473 | |
| 315 | Ubiquitination | AHFTIWDKLLERSRK HHHHHHHHHHHHHHH | 39.72 | 22817900 | |
| 315 | Ubiquitination | AHFTIWDKLLERSRK HHHHHHHHHHHHHHH | 39.72 | 21890473 | |
| 315 (in isoform 2) | Ubiquitination | - | 39.72 | 21890473 | |
| 325 | Phosphorylation | ERSRKMVTEDQSKAT HHHHHHCCCCHHHHH | 30.28 | - | |
| 329 | Phosphorylation | KMVTEDQSKATEECT HHCCCCHHHHHHHHC | 36.26 | - | |
| 330 | Ubiquitination | MVTEDQSKATEECTS HCCCCHHHHHHHHCC | 54.41 | 24816145 | |
| 332 | Phosphorylation | TEDQSKATEECTST- CCCHHHHHHHHCCC- | 35.73 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RM39_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RM39_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RM39_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-126 AND LYS-204, AND MASSSPECTROMETRY. | |
