MASU1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MASU1_HUMAN
• UniProt AC: Q96EH3
• Protein Name: Mitochondrial assembly of ribosomal large subunit protein 1
• Gene Name: MALSU1
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Subcellular Localization: Mitochondrion matrix . Colocalizes with MRPL12 (PubMed:22238375) and/or MRPL14 (PubMed:22829778).
• Protein Description: May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome..
• Protein Sequence: MGPGGRVARLLAPLMWRRAVSSVAGSAVGAEPGLRLLAVQRLPVGAAFCRACQTPNFVRGLHSEPGLEERAEGTVNEGRPESDAADHTGPKFDIDMMVSLLRQENARDICVIQVPPEMRYTDYFVIVSGTSTRHLHAMAFYVVKMYKHLKCKRDPHVKIEGKDTDDWLCVDFGSMVIHLMLPETREIYELEKLWTLRSYDDQLAQIAPETVPEDFILGIEDDTSSVTPVELKCE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	VNEGRPESDAADHTG CCCCCCHHHCCCCCC	34.92	-
97	Ubiquitination	PKFDIDMMVSLLRQE CCCCHHHHHHHHHHH	1.32	21890473
123	Phosphorylation	PEMRYTDYFVIVSGT CCCCCCCEEEEEECC	7.61	-
128	Phosphorylation	TDYFVIVSGTSTRHL CCEEEEEECCCCHHH	25.81	-
192	Ubiquitination	REIYELEKLWTLRSY HHHHHHHHHHCCCCC	63.05	21963094
192	Ubiquitination	REIYELEKLWTLRSY HHHHHHHHHHCCCCC	63.05	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MASU1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MASU1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MASU1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP_HUMAN	SSBP1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.