| UniProt ID | MTEF3_HUMAN | |
|---|---|---|
| UniProt AC | Q96E29 | |
| Protein Name | Transcription termination factor 3, mitochondrial | |
| Gene Name | MTERF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 417 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Binds promoter DNA and regulates initiation of transcription. [PubMed: 17662942 Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity] | |
| Protein Sequence | MALSAQQIPRWFNSVKLRSLINAAQLTKRFTRPARTLLHGFSAQPQISSDNCFLQWGFKTYRTSSLWNSSQSTSSSSQENNSAQSSLLPSMNEQSQKTQNISSFDSELFLEELDELPPLSPMQPISEEEAIQIIADPPLPPASFTLRDYVDHSETLQKLVLLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSEDLENLKTRVAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFFQKELELSVKKTRDLVVRLPRLLTGSLEPVKENMKVYRLELGFKHNEIQHMITRIPKMLTANKMKLTETFDFVHNVMSIPHHIIVKFPQVFNTRLFKVKERHLFLTYLGRAQYDPAKPNYISLDKLVSIPDEIFCEEIAKASVQDFEKFLKTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 60 | Phosphorylation | FLQWGFKTYRTSSLW EEEECCEEEECHHHC | 24275569 | ||
| 63 | Phosphorylation | WGFKTYRTSSLWNSS ECCEEEECHHHCCCC | 24275569 | ||
| 72 | Phosphorylation | SLWNSSQSTSSSSQE HHCCCCCCCCCCCCC | 24275569 | ||
| 126 | O-linked_Glycosylation | LSPMQPISEEEAIQI CCCCCCCCHHHHHHH | 30379171 | ||
| 126 | Phosphorylation | LSPMQPISEEEAIQI CCCCCCCCHHHHHHH | 22468782 | ||
| 145 | Phosphorylation | PLPPASFTLRDYVDH CCCCCCEEHHHHCCC | 24719451 | ||
| 168 | 2-Hydroxyisobutyrylation | LLGVDLSKIEKHPEA HHCCCHHHHHHCHHH | - | ||
| 171 | Acetylation | VDLSKIEKHPEAANL CCHHHHHHCHHHHHH | 25953088 | ||
| 211 | Ubiquitination | QLGAFLTKNHAIFSE CHHHHHCCCCCCCHH | - | ||
| 217 | Phosphorylation | TKNHAIFSEDLENLK CCCCCCCHHHHHHHH | 25850435 | ||
| 224 | Ubiquitination | SEDLENLKTRVAYLH HHHHHHHHHHHHHHH | - | ||
| 237 | Ubiquitination | LHSKNFSKADVAQMV HHCCCCCHHHHHHHH | - | ||
| 299 | Ubiquitination | EPVKENMKVYRLELG CCCHHCCEEEEEECC | - | ||
| 377 | Phosphorylation | TYLGRAQYDPAKPNY HHHHCCCCCCCCCCE | 20068231 | ||
| 384 | Phosphorylation | YDPAKPNYISLDKLV CCCCCCCEECHHHHC | 20068231 | ||
| 386 | Phosphorylation | PAKPNYISLDKLVSI CCCCCEECHHHHCCC | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTEF3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTEF3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MTEF3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| ATRAP_HUMAN | AGTRAP | physical | 25416956 | |
| CKLF5_HUMAN | CMTM5 | physical | 25416956 | |
| FUND1_HUMAN | FUNDC1 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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