| UniProt ID | ATRAP_HUMAN | |
|---|---|---|
| UniProt AC | Q6RW13 | |
| Protein Name | Type-1 angiotensin II receptor-associated protein | |
| Gene Name | AGTRAP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 159 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . Cytoplasmic vesicle membrane Multi-pass membrane protein . Present in perinuclear vesicular membranes, Endoplasmic reticulum, Go |
|
| Protein Description | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.. | |
| Protein Sequence | MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 113 | Methylation | VYHMYRERGGELLVH HHHHHHHCCCEEEEE | 49.79 | - | |
| 119 (in isoform 2) | Phosphorylation | - | 6.24 | 25262027 | |
| 120 (in isoform 2) | Phosphorylation | - | 21.90 | 25262027 | |
| 121 | Phosphorylation | GGELLVHTGFLGSSQ CCEEEEEECCCCCCC | 23.34 | 28060719 | |
| 126 | Phosphorylation | VHTGFLGSSQDRSAY EEECCCCCCCCCHHH | 27.29 | 20873877 | |
| 127 | Phosphorylation | HTGFLGSSQDRSAYQ EECCCCCCCCCHHHH | 34.01 | 21712546 | |
| 131 | Phosphorylation | LGSSQDRSAYQTIDS CCCCCCCHHHHHCCC | 39.35 | 21945579 | |
| 133 | Phosphorylation | SSQDRSAYQTIDSAE CCCCCHHHHHCCCCC | 13.87 | 21945579 | |
| 135 | Phosphorylation | QDRSAYQTIDSAEAP CCCHHHHHCCCCCCC | 17.67 | 21945579 | |
| 138 | Phosphorylation | SAYQTIDSAEAPADP HHHHHCCCCCCCCCC | 24.94 | 21945579 | |
| 153 | Phosphorylation | FAVPEGRSQDARGY- CCCCCCCCCCCCCC- | 43.18 | 28450419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATRAP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATRAP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATRAP_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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