NXP20_HUMAN - dbPTM
NXP20_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NXP20_HUMAN
UniProt AC Q8IWE2
Protein Name Protein NOXP20
Gene Name FAM114A1
Organism Homo sapiens (Human).
Sequence Length 563
Subcellular Localization Cytoplasm.
Protein Description May play a role in neuronal cell development..
Protein Sequence MSDDAGDTLATGDKAEVTEMPNSDSLPEDAEVHCDSAAVSHEPTPADPRGEGHENAAVQGAGAAAIGPPVQPQDANALEPPLNGDVTEDTLAECIDSVSLEAEPRSEIPLQEQNYLAVDSPPSGGGWAGWGSWGKSLLSSASATVGHGLTAVKEKAGATLRIHGVNSGSSEGAQPNTENGVPEITDAATDQGPAESPPTSPSSASRGMLSAITNVVQNTGKSVLTGGLDALEFIGKKTMNVLAESDPGFKRTKTLMERTVSLSQMLREAKEKEKQRLAQQLTMERTAHYGMLFDEYQGLSHLEALEILSNESESKVQSFLASLDGEKLELLKNDLISIKDIFAAKELENEENQEEQGLEEKGEEFARMLTELLFELHVAATPDKLNKAMKRAHDWVEEDQTVVSVDVAKVSEEETKKEEKEEKSQDPQEDKKEEKKTKTIEEVYMSSIESLAEVTARCIEQLHKVAELILHGQEEEKPAQDQAKVLIKLTTAMCNEVASLSKKFTNSLTTVGSNKKAEVLNPMISSVLLEGCNSTTYIQDAFQLLLPVLQVSHIQTSCLKAQP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDDAGDTL
------CCCCCCCCC		44.1725849741
8PhosphorylationMSDDAGDTLATGDKA
CCCCCCCCCCCCCCC		19.8524043423
11PhosphorylationDAGDTLATGDKAEVT
CCCCCCCCCCCCEEE		49.3724043423
23PhosphorylationEVTEMPNSDSLPEDA
EEEECCCCCCCCCCC		23.7825159151
25PhosphorylationTEMPNSDSLPEDAEV
EECCCCCCCCCCCEE		45.7226657352
99PhosphorylationAECIDSVSLEAEPRS
HHHHHHCCCCCCCCC		25.17-
115PhosphorylationIPLQEQNYLAVDSPP
CCCCCCCEEEECCCC		8.8428102081
120UbiquitinationQNYLAVDSPPSGGGW
CCEEEECCCCCCCCC		31.92-
120PhosphorylationQNYLAVDSPPSGGGW
CCEEEECCCCCCCCC		31.9220068231
123PhosphorylationLAVDSPPSGGGWAGW
EEECCCCCCCCCCCC		54.1528857561
132PhosphorylationGGWAGWGSWGKSLLS
CCCCCCCHHHHHHHH		26.5824719451
135MethylationAGWGSWGKSLLSSAS
CCCCHHHHHHHHHCC		31.50-
136PhosphorylationGWGSWGKSLLSSASA
CCCHHHHHHHHHCCC		30.5229514088
139PhosphorylationSWGKSLLSSASATVG
HHHHHHHHHCCCCCC		29.2022199227
140PhosphorylationWGKSLLSSASATVGH
HHHHHHHHCCCCCCC		26.6422199227
142PhosphorylationKSLLSSASATVGHGL
HHHHHHCCCCCCCCH		26.8126657352
144O-linked_GlycosylationLLSSASATVGHGLTA
HHHHCCCCCCCCHHH		25.24OGP
144PhosphorylationLLSSASATVGHGLTA
HHHHCCCCCCCCHHH		25.2428348404
167PhosphorylationLRIHGVNSGSSEGAQ
EEEEECCCCCCCCCC		37.3320068231
169PhosphorylationIHGVNSGSSEGAQPN
EEECCCCCCCCCCCC		25.6620068231
170PhosphorylationHGVNSGSSEGAQPNT
EECCCCCCCCCCCCC		43.5020068231
177PhosphorylationSEGAQPNTENGVPEI
CCCCCCCCCCCCCCC		37.1928450419
185PhosphorylationENGVPEITDAATDQG
CCCCCCCCHHHCCCC		20.2323927012
189PhosphorylationPEITDAATDQGPAES
CCCCHHHCCCCCCCC		30.4923927012
196PhosphorylationTDQGPAESPPTSPSS
CCCCCCCCCCCCCCH		37.9829255136
199PhosphorylationGPAESPPTSPSSASR
CCCCCCCCCCCHHHH		57.5729255136
200PhosphorylationPAESPPTSPSSASRG
CCCCCCCCCCHHHHH		28.6729255136
202PhosphorylationESPPTSPSSASRGML
CCCCCCCCHHHHHHH		38.0029255136
203PhosphorylationSPPTSPSSASRGMLS
CCCCCCCHHHHHHHH		33.3829255136
205PhosphorylationPTSPSSASRGMLSAI
CCCCCHHHHHHHHHH		31.1729255136
208SulfoxidationPSSASRGMLSAITNV
CCHHHHHHHHHHHHH		2.3130846556
210PhosphorylationSASRGMLSAITNVVQ
HHHHHHHHHHHHHHH		14.5628857561
219PhosphorylationITNVVQNTGKSVLTG
HHHHHHHCCCCHHHC		28.9728555341
238O-linked_GlycosylationLEFIGKKTMNVLAES
HHHHCHHHHHHHHHC		19.9130379171
245O-linked_GlycosylationTMNVLAESDPGFKRT
HHHHHHHCCCCCHHH		43.4230379171
245PhosphorylationTMNVLAESDPGFKRT
HHHHHHHCCCCCHHH		43.4227251275
250UbiquitinationAESDPGFKRTKTLME
HHCCCCCHHHHHHHH		66.14-
250AcetylationAESDPGFKRTKTLME
HHCCCCCHHHHHHHH		66.147824151
252PhosphorylationSDPGFKRTKTLMERT
CCCCCHHHHHHHHHH		29.0428857561
254PhosphorylationPGFKRTKTLMERTVS
CCCHHHHHHHHHHCC		30.6229514088
259PhosphorylationTKTLMERTVSLSQML
HHHHHHHHCCHHHHH		10.9226657352
261PhosphorylationTLMERTVSLSQMLRE
HHHHHHCCHHHHHHH		22.9928355574
263PhosphorylationMERTVSLSQMLREAK
HHHHCCHHHHHHHHH		13.1623403867
282PhosphorylationQRLAQQLTMERTAHY
HHHHHHHHHHHHHHH		16.7928857561
283SulfoxidationRLAQQLTMERTAHYG
HHHHHHHHHHHHHHH		4.4530846556
291SulfoxidationERTAHYGMLFDEYQG
HHHHHHHHHHHHHCC		2.3830846556
318PhosphorylationESESKVQSFLASLDG
CCHHHHHHHHHCCCH		25.8020068231
322PhosphorylationKVQSFLASLDGEKLE
HHHHHHHCCCHHHHH		29.1920068231
327UbiquitinationLASLDGEKLELLKND
HHCCCHHHHHHHHHC		53.4421890473
3272-HydroxyisobutyrylationLASLDGEKLELLKND
HHCCCHHHHHHHHHC		53.44-
327UbiquitinationLASLDGEKLELLKND
HHCCCHHHHHHHHHC		53.4421890473
3392-HydroxyisobutyrylationKNDLISIKDIFAAKE
HHCCCCHHHHHHHHH		37.67-
345UbiquitinationIKDIFAAKELENEEN
HHHHHHHHHHCCHHH		60.44-
361UbiquitinationEEQGLEEKGEEFARM
HHHCHHHHHHHHHHH		63.35-
381PhosphorylationFELHVAATPDKLNKA
HHHHHCCCHHHHHHH		23.4520068231
437PhosphorylationDKKEEKKTKTIEEVY
HHHHHHHCHHHHHHH		44.48-
439PhosphorylationKEEKKTKTIEEVYMS
HHHHHCHHHHHHHHH		38.56-
505PhosphorylationASLSKKFTNSLTTVG
HHHCHHHHCCCCCCC		32.55-
5152-HydroxyisobutyrylationLTTVGSNKKAEVLNP
CCCCCCCCHHHHHCH		55.87-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NXP20_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NXP20_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NXP20_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP74_HUMANHSPA4physical
22863883
N4BP1_HUMANN4BP1physical
22863883
RSU1_HUMANRSU1physical
22863883
SC24D_HUMANSEC24Dphysical
22863883
SYTC_HUMANTARSphysical
22863883
THUM3_HUMANTHUMPD3physical
22863883
CKLF5_HUMANCMTM5physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NXP20_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196 AND THR-199, ANDMASS SPECTROMETRY.

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