THUM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THUM3_HUMAN
• UniProt AC: Q9BV44
• Protein Name: THUMP domain-containing protein 3
• Gene Name: THUMPD3
• Organism: Homo sapiens (Human).
• Sequence Length: 507
• Protein Sequence: MCDIEEATNQLLDVNLHENQKSVQVTESDLGSESELLVTIGATVPTGFEQTAADEVREKLGSSCKISRDRGKIYFVISVESLAQVHCLRSVDNLFVVVQEFQDYQFKQTKEEVLKDFEDLAGKLPWSNPLKVWKINASFKKKKAKRKKINQNSSKEKINNGQEVKIDQRNVKKEFTSHALDSHILDYYENPAIKEDVSTLIGDDLASCKDETDESSKEETEPQVLKFRVTCNRAGEKHCFTSNEAARDFGGAVQDYFKWKADMTNFDVEVLLNIHDNEVIVGIALTEESLHRRNITHFGPTTLRSTLAYGMLRLCDPLPYDIIVDPMCGTGAIPIEGATEWSDCFHIAGDNNPLAVNRAANNIASLLTKSQIKEGKPSWGLPIDAVQWDICNLPLRTGSVDIIVTDLPFGKRMGSKKRNWNLYPACLREMSRVCTPTTGRAVLLTQDTKCFTKALSGMRHVWRKVDTVWVNVGGLRAAVYVLIRTPQAFVHPSEQDGERGTLWQCKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Ubiquitination	EKLGSSCKISRDRGK HHHCCCCEEECCCCC	45.74	-
115	Ubiquitination	QTKEEVLKDFEDLAG HCHHHHHHHHHHHCC	66.60	-
123	Ubiquitination	DFEDLAGKLPWSNPL HHHHHCCCCCCCCCC	45.85	-
131	Ubiquitination	LPWSNPLKVWKINAS CCCCCCCCHHEECHH	47.51	-
138	Phosphorylation	KVWKINASFKKKKAK CHHEECHHHHHHHHH	32.86	24719451
153	Phosphorylation	RKKINQNSSKEKINN HHCCCCCCCHHHCCC	32.78	23312004
154	Phosphorylation	KKINQNSSKEKINNG HCCCCCCCHHHCCCC	53.00	28985074
173	Ubiquitination	IDQRNVKKEFTSHAL EECHHHHHHHHHHHH	54.50	-
176	Phosphorylation	RNVKKEFTSHALDSH HHHHHHHHHHHHHHH	22.24	27642862
182	Phosphorylation	FTSHALDSHILDYYE HHHHHHHHHHHHHHC	17.18	28555341
187	Phosphorylation	LDSHILDYYENPAIK HHHHHHHHHCCHHHH	14.83	28796482
188	Phosphorylation	DSHILDYYENPAIKE HHHHHHHHCCHHHHH	14.64	28796482
194	Ubiquitination	YYENPAIKEDVSTLI HHCCHHHHHHHHHHH	50.39	-
198	Phosphorylation	PAIKEDVSTLIGDDL HHHHHHHHHHHCCHH	29.80	20873877
199	Phosphorylation	AIKEDVSTLIGDDLA HHHHHHHHHHCCHHH	23.42	20873877
207	Phosphorylation	LIGDDLASCKDETDE HHCCHHHHCCCCCCC	29.06	25159151
209	Ubiquitination	GDDLASCKDETDESS CCHHHHCCCCCCCCC	56.98	-
212	Phosphorylation	LASCKDETDESSKEE HHHCCCCCCCCCCCC	56.02	25159151
215	Phosphorylation	CKDETDESSKEETEP CCCCCCCCCCCCCCC	49.90	25159151
216	Phosphorylation	KDETDESSKEETEPQ CCCCCCCCCCCCCCC	41.88	25159151
220	Phosphorylation	DESSKEETEPQVLKF CCCCCCCCCCCEEEE	54.80	26657352
226	Ubiquitination	ETEPQVLKFRVTCNR CCCCCEEEEEEEECC	32.06	-
237	Ubiquitination	TCNRAGEKHCFTSNE EECCCCCEEEEECCH	44.76	-
237	Acetylation	TCNRAGEKHCFTSNE EECCCCCEEEEECCH	44.76	25953088
258	Ubiquitination	GAVQDYFKWKADMTN HHHHHHHCEECCCCC	41.37	-
296	Phosphorylation	SLHRRNITHFGPTTL HHHHCCCCCCCCHHH	18.07	28857561
301	Phosphorylation	NITHFGPTTLRSTLA CCCCCCCHHHHHHHH	38.55	28857561
302	Phosphorylation	ITHFGPTTLRSTLAY CCCCCCHHHHHHHHH	24.25	28857561
305	Phosphorylation	FGPTTLRSTLAYGML CCCHHHHHHHHHHHH	30.77	28857561
306	Phosphorylation	GPTTLRSTLAYGMLR CCHHHHHHHHHHHHH	14.69	28857561
309	Phosphorylation	TLRSTLAYGMLRLCD HHHHHHHHHHHHHCC	13.23	27642862
313	Methylation	TLAYGMLRLCDPLPY HHHHHHHHHCCCCCC	25.11	115918437
365	Phosphorylation	RAANNIASLLTKSQI HHHHHHHHHHCHHHH	21.80	24719451
369	Ubiquitination	NIASLLTKSQIKEGK HHHHHHCHHHHHCCC	40.09	21890473
373	Ubiquitination	LLTKSQIKEGKPSWG HHCHHHHHCCCCCCC	53.42	-
376	Ubiquitination	KSQIKEGKPSWGLPI HHHHHCCCCCCCCCC	36.65	-
397	Phosphorylation	ICNLPLRTGSVDIIV ECCCCCCCCCEEEEE	41.30	28348404
399	Phosphorylation	NLPLRTGSVDIIVTD CCCCCCCCEEEEEEC	18.92	28348404
411	Acetylation	VTDLPFGKRMGSKKR EECCCCCCCCCCCCC	39.32	25953088
411	Ubiquitination	VTDLPFGKRMGSKKR EECCCCCCCCCCCCC	39.32	-
417	Acetylation	GKRMGSKKRNWNLYP CCCCCCCCCCCCCHH	53.30	19826983
449	Ubiquitination	VLLTQDTKCFTKALS EEECCCHHHHHHHHH	35.32	-
449	Acetylation	VLLTQDTKCFTKALS EEECCCHHHHHHHHH	35.32	25953088
449	Malonylation	VLLTQDTKCFTKALS EEECCCHHHHHHHHH	35.32	26320211
453	Acetylation	QDTKCFTKALSGMRH CCHHHHHHHHHCCHH	27.38	25953088
456	Phosphorylation	KCFTKALSGMRHVWR HHHHHHHHCCHHHHH	35.09	23403867
464	Ubiquitination	GMRHVWRKVDTVWVN CCHHHHHCCCEEEEE	28.84	-
501	Phosphorylation	EQDGERGTLWQCKE- CCCCCCCCEEEECC-	30.92	-
506	Ubiquitination	RGTLWQCKE------ CCCEEEECC------	51.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THUM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THUM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THUM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS35_HUMAN	VPS35	physical	22939629
VP26A_HUMAN	VPS26A	physical	22939629
ZFR_HUMAN	ZFR	physical	22939629
ZC3HE_HUMAN	ZC3H14	physical	22939629
TR112_HUMAN	TRMT112	physical	22939629
SC24D_HUMAN	SEC24D	physical	22863883
XPO7_HUMAN	XPO7	physical	22863883
METL5_HUMAN	METTL5	physical	26344197
MICU3_HUMAN	MICU3	physical	28514442
MTU1_HUMAN	TRMU	physical	28514442
TRUA_HUMAN	PUS1	physical	28514442
EDRF1_HUMAN	EDRF1	physical	28514442
UBP46_HUMAN	USP46	physical	28514442
TR112_HUMAN	TRMT112	physical	28514442
NSUN3_HUMAN	NSUN3	physical	28514442
CTU2_HUMAN	CTU2	physical	28514442
MICU1_HUMAN	MICU1	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.